A Simple Derivation of Deletion Diagnostic Results for the General Linear Model with Correlated Errors

A general, simple and intuitive derivation is provided for diagnostics associated with the deletion of arbitrary subsets for the linear model with general covariance structure. These are seen to be most simply expressed, even for the well-studied case of independent and identically distributed data, in terms of a residual known variously as the conditional residual, the deletion prediction residual and the cross-validation residual. Particularly simple specializations arise when the subsets are of size 1 and of size 2, but the method is easy to apply for all subsets and to conditional deletions.     

Conditional residual lifetimes of coherent systems under double monitoring

In this paper, we obtain a mixture representation for the reliability function of the conditional residual lifetime of a coherent system with n independent and identically distributed (i.i.d.) components under double monitoring. We suppose that at time t₁, j components have failed while at time t₂ the system is still alive. Based on these mixture representation, we then study stochastic comparisons of the conditional residual lifetimes of two coherent systems with independent and identical components.     

Inference Methods for Correlated Left Truncated Lifetimes: Parent and Offspring Relations in an Adoption Study

The associations in mortality of adult adoptees and their biological or adoptive parents have been studied in order to separate genetic and environmental influences. The 1003 Danish adoptees born 1924–26 have previously been analysed in a Cox regression model, using dichotomised versions of the parents’ lifetimes as covariates. This model will be referred to as the conditional Cox model, as it analyses lifetimes of adoptees conditional on parental lifetimes. Shared frailty models may be more satisfactory by using the entire observed lifetime of the parents. In a simulation study, sample size, distribution of lifetimes, truncation- and censoring patterns were chosen to illustrate aspects of the adoption dataset, and were generated from the conditional Cox model or a shared frailty model with gamma distributed frailties. First, efficiency was compared in the conditional Cox model and a shared frailty model, based on the conditional approach. For data with type 1 censoring the models showed no differences, whereas in data with random or no censoring, the models had different power in favour of the one from which data were generated. Secondly, estimation in the shared frailty model by a conditional approach or a two-stage copula approach was compared. Both approaches worked well, with no sign of dependence upon the truncation pattern, but some sign of bias depending on the censoring. For frailty parameters close to zero, we found bias when the estimation procedure used did not allow negative estimates. Based on this evaluation, we prefer to use frailty models allowing for negative frailty parameter estimates. The conclusions from earlier analyses of the adoption study were confirmed, though without greater precision than using the conditional Cox model. Analyses of associations between parental lifetimes are also presented.     

A note on the conditional residual lifetime of a coherent system under double monitoring

In this note, we derive some mixture representations for the reliability function of the conditional residual lifetime of a coherent system with n independent and identically distributed (i.i.d.) components under the condition that at time t₁ the jth failures has occurred and at time t₂ the kth failures (j < k) have not occurred yet. Based on the mixture representations, we then discuss the stochastic comparisons of the conditional residual lifetimes of two coherent systems with i.i.d. components.     

A linear model-based test for the heterogeneity of conditional correlations

Current methods of testing the equality of conditional correlations of bivariate data on a third variable of interest (covariate) are limited due to discretizing of the covariate when it is continuous. In this study, we propose a linear model approach for estimation and hypothesis testing of the Pearson correlation coefficient, where the correlation itself can be modeled as a function of continuous covariates. The restricted maximum likelihood method is applied for parameter estimation, and the corrected likelihood ratio test is performed for hypothesis testing. This approach allows for flexible and robust inference and prediction of the conditional correlations based on the linear model. Simulation studies show that the proposed method is statistically more powerful and more flexible in accommodating complex covariate patterns than the existing methods. In addition, we illustrate the approach by analyzing the correlation between the physical component summary and the mental component summary of the MOS SF-36 form across a fair number of covariates in the national survey data.     

A model for k-out-of-m load-sharing systems

ABSTRACT

In a load-sharing system, the failure of a component affects the residual lifetime of the surviving components. We propose a model for the load-sharing phenomenon in k-out-of-m systems. The model is based on exponentiated conditional distributions of the order statistics formed by the failure times of the components. For an illustration, we consider two component parallel systems with the initial lifetimes of the components having Weibull and linear failure rate distributions. We analyze one data set to show that the proposed model may be a better fit than the model based on sequential order statistics.     

Censored quantile regression for residual lifetimes

We propose a regression method that studies covariate effects on the conditional quantiles of residual lifetimes at a certain followup time point. This can be particularly useful in cancer studies, where more patients survive cancers initially and a patient’s residual life expectancy is used to compare the efficacy of secondary or adjuvant therapies. The new method provides a consistent estimator that often exhibits smaller standard error in real and simulated examples, compared to the existing method of Jung et al. (2009). It also provides a simple empirical likelihood inference method that does not require estimating the covariance matrix of the estimator or resampling. We apply the new method to a breast cancer study (NSABP Protocol B-04, Fisher et al. (2002)) and estimate median residual lifetimes at various followup time points, adjusting for important prognostic factors.     

A multi-index model for quantile regression with ordinal data

In this paper, we propose a quantile approach to the multi-index semiparametric model for an ordinal response variable. Permitting non-parametric transformation of the response, the proposed method achieves a root-n rate of convergence and has attractive robustness properties. Further, the proposed model allows additional indices to model the remaining correlations between covariates and the residuals from the single-index, considerably reducing the error variance and thus leading to more efficient prediction intervals (PIs). The utility of the model is demonstrated by estimating PIs for functional status of the elderly based on data from the second longitudinal study of aging. It is shown that the proposed multi-index model provides significantly narrower PIs than competing models. Our approach can be applied to other areas in which the distribution of future observations must be predicted from ordinal response data.     

Exact inference for a simple step-stress model with Type-I hybrid censored data from the exponential distribution

In reliability and life-testing experiments, the researcher is often interested in the effects of extreme or varying stress factors such as temperature, voltage and load on the lifetimes of experimental units. Step-stress test, which is a special class of accelerated life-tests, allows the experimenter to increase the stress levels at fixed times during the experiment in order to obtain information on the parameters of the life distributions more quickly than under normal operating conditions. In this paper, we consider the simple step-stress model under the exponential distribution when the available data are Type-I hybrid censored. We derive the maximum likelihood estimators (MLEs) of the parameters assuming a cumulative exposure model with lifetimes being exponentially distributed. The exact distributions of the MLEs of parameters are obtained through the use of conditional moment generating functions. We also derive confidence intervals for the parameters using these exact distributions, asymptotic distributions of the MLEs and the parametric bootstrap methods, and assess their performance through a Monte Carlo simulation study. Finally, we present two examples to illustrate all the methods of inference discussed here.     

Nonparametric estimation of the conditional mean residual life function with censored data

The conditional mean residual life (MRL) function is the expected remaining lifetime of a system given survival past a particular time point and the values of a set of predictor variables. This function is a valuable tool in reliability and actuarial studies when the right tail of the distribution is of interest, and can be more informative than the survivor function. In this paper, we identify theoretical limitations of some semi-parametric conditional MRL models, and propose two nonparametric methods of estimating the conditional MRL function. Asymptotic properties such as consistency and normality of our proposed estimators are established. We investigate via simulation study the empirical properties of the proposed estimators, including bootstrap pointwise confidence intervals. Using Monte Carlo simulations we compare the proposed nonparametric estimators to two popular semi-parametric methods of analysis, for varying types of data. The proposed estimators are demonstrated on the Veteran’s Administration lung cancer trial.     

Some results on the mean residual waiting time of records

Often, in reliability theory, risk analysis, renewal processes and actuarial studies, mean residual life function or life expectancy plays an important role in studying the conditional tail measure of lifetime data. In this paper, we introduce the notion of the mean residual waiting time of records and present some monotonic and aging properties. Sharp bounds for the mean residual waiting time of records are also investigated.     

Efficient estimation for the conditional autoregressive model

Recently, spatial regression models have been attracting a great deal of attention in areas ranging from effect of traffic congestion on accident rates to the analysis of trends in gastric cancer mortality. In this paper, we propose efficient estimators for the regression coefficients of the spatial conditional autoregressive model, when uncertain auxiliary information is available about these coefficients. We provide efficiency comparisons of the proposed estimators based on asymptotic risk analysis and Monte Carlo simulations. We apply the proposed methods to real data on Boston housing prices and illustrate how a bootstrapping approach can be employed to compute prediction errors of the estimators.     

Analysis of progressively type-I interval censored competing risks data for a class of an exponential distribution

ABSTRACT

In this paper, we consider some problems of point estimation and point prediction when the competing risks data from a class of exponential distribution are progressive type-I interval censored. The maximum likelihood estimation and mid-point approximation method are proposed for the estimations of parameters. Also several point predictors of censored units such as the maximum likelihood predictor, the best unbiased predictor and the conditional median predictor are obtained. The methods discussed here are applied when the lifetime distributions of the latent failure times are independent and Weibull-distributed. Finally a simulation study is given by using Monte-Carlo simulations to compare the performances of the different methods and one data analysis has been presented for illustrative purposes.     

Parameter Change Test for Poisson Autoregressive Models

In this paper, we consider the problem of testing for a parameter change in Poisson autoregressive models. We suggest two types of cumulative sum (CUSUM) tests, namely, those based on estimates and residuals. We first demonstrate that the conditional maximum likelihood estimator (CMLE) is strongly consistent and asymptotically normal and then construct the CMLE‐based CUSUM test. It is shown that under regularity conditions, its limiting null distribution is a function of independent Brownian bridges. Next, we construct the residual‐based CUSUM test and derive its limiting null distribution. Simulation results are provided for illustration. A real‐data analysis is performed on data for polio incidence and campylobacteriosis infections.     

Conditional covariance penalties for mixed models

The prediction error for mixed models can have a conditional or a marginal perspective depending on the research focus. We introduce a novel conditional version of the optimism theorem for mixed models linking the conditional prediction error to covariance penalties for mixed models. Different possibilities for estimating these conditional covariance penalties are introduced. These are bootstrap methods, cross-validation, and a direct approach called Steinian. The behavior of the different estimation techniques is assessed in a simulation study for the binomial-, the t-, and the gamma distribution and for different kinds of prediction error. Furthermore, the impact of the estimation techniques on the prediction error is discussed based on an application to undernutrition in Zambia.     

Bayesian prediction of minimal repair times of a series system based on hybrid censored sample of components’ lifetimes under Rayleigh distribution

In this paper, we develop Bayesian predictive inferential procedures for prediction of repair times of a series system, applying a minimal repair strategy, using the information contained in an independent observed hybrid censored sample of the lifetimes of the components of the system, assuming the underlying distribution of the lifetimes to be Rayleigh distribution. An illustrative real data example and a simulation study are presented for the purpose of illustration and comparison of the proposed predictors.     

Prediction intervals for hypergeometric distributions

Abstract

The problem of constructing prediction intervals (PIs) for a future sample from a hypergeometric distribution is addressed. Simple closed-form approximate PIs based on the Wald approach, the joint sampling approach, and a fiducial approach are proposed and compared in terms of coverage probability and precision. Construction of the proposed PIs are illustrated using an example.     

GARCH-type forecasting models for volatility of stock market and MCS test

The prediction of time-changing volatility is an important task in the modeling of financial data. In the paper, a comprehensive analysis of the mean return and conditional variance of SSE380 index is performed to use GARCH, EGARCH and TGARCH models with Normal innovation and Student's t innovation. Conducting a bootstrap simulation study which shows the Model Confidence Set (MCS) captures the superior models across a range of significance levels. The experimental results show that, under various loss functions, the GARCH using Student's t innovation model is the best model for volatility predictions of SSE380 among the six models.     

The partial Koziol–Green model with covariates

Two important models in survival analysis are that of general random censorship and the proportional hazards submodel of Koziol and Green. The difference between the two models is the way in which the lifetime variable is censored (informative versus non-informative censoring). In this paper the two viewpoints are combined into a new model which allows the lifetimes to be censored by two types of variables, one of which censors in an informative way and the other one in a non-informative way. The lifetimes and the censoring times are also allowed to depend on covariates in a very general way. The estimator for the conditional distribution of the lifetimes generalizes that of Gather and Pawlitschko (1998. Metrika 48, 189–209), who recently studied the situation without covariate information. Results obtained are the uniform strong consistency (with rate), an almost sure asymptotic representation and the weak convergence of the process.     

Effect of tuberculosis on immune restoration among HIV-infected patients receiving antiretroviral therapy

In this article, time to immune recovery during antiretroviral therapy was estimated and compared between HIV-infected children with and without tuberculosis (TB). CD4?T-cell restoration was used as a criterion for determining immune recovery. The median residual lifetime function, which is more intuitive and robust compared to the frequently used measures of lifetime data, was used to estimate time to CD4?T-cell restoration. The median residual lifetime is not influenced by extreme observations and heavy-tailed distributions which are commonly encountered in clinical studies. Permutation-based methods were used to compare the CD4?T-cell restoration times between the two groups of patients. Our results indicate that children with TB had uniformly higher median residual lifetimes to immune recovery compared to those without TB. Although TB was associated with slower CD4?T-cell restoration, the differences between the restoration times of the two groups were not statistically significant.