A Quantile Survival Model for Censored Data

In this paper we propose a quantile survival model to analyze censored data. This approach provides a very effective way to construct a proper model for the survival time conditional on some covariates. Once a quantile survival model for the censored data is established, the survival density, survival or hazard functions of the survival time can be obtained easily. For illustration purposes, we focus on a model that is based on the generalized lambda distribution (GLD). The GLD and many other quantile function models are defined only through their quantile functions, no closed‐form expressions are available for other equivalent functions. We also develop a Bayesian Markov Chain Monte Carlo (MCMC) method for parameter estimation. Extensive simulation studies have been conducted. Both simulation study and application results show that the proposed quantile survival models can be very useful in practice.     

On boundary correction in kernel density estimation

It is well known now that kernel density estimators are not consistent when estimating a density near the finite end points of the support of the density to be estimated. This is due to boundary effects that occur in nonparametric curve estimation problems. A number of proposals have been made in the kernel density estimation context with some success. As of yet there appears to be no single dominating solution that corrects the boundary problem for all shapes of densities. In this paper, we propose a new general method of boundary correction for univariate kernel density estimation. The proposed method generates a class of boundary corrected estimators. They all possess desirable properties such as local adaptivity and non-negativity. In simulation, it is observed that the proposed method perform quite well when compared with other existing methods available in the literature for most shapes of densities, showing a very important robustness property of the method. The theory behind the new approach and the bias and variance of the proposed estimators are given. Results of a data analysis are also given.     

Absolute error criteria for bandwidth selection in density estimation from censored data

In Kernel density estimation, a criticism of bandwidth selection techniques which minimize squared error expressions is that they perform poorly when estimating tails of probability density functions. Techniques minimizing absolute error expressions are thought to result in more uniform performance and be potentially superior. An asympotic mean absolute error expression for nonparametric kernel density estimators from right-censored data is developed here. This expression is used to obtain local and global bandwidths that are optimal in the sense that they minimize asymptotic mean absolute error and integrated asymptotic mean absolute error, respectively. These estimators are illustrated fro eight data sets from known distributions. Computer simulation results are discussed, comparing the estimation methods with squared-error-based bandwidth selection for right-censored data.     

Estimation for Location-Scale Models with Censored Data

This article considers a class of estimators for the location and scale parameters in the location-scale model based on ‘synthetic data’ when the observations are randomly censored on the right. The asymptotic normality of the estimators is established using counting process and martingale techniques when the censoring distribution is known and unknown, respectively. In the case when the censoring distribution is known, we show that the asymptotic variances of this class of estimators depend on the data transformation and have a lower bound which is not achievable by this class of estimators. However, in the case that the censoring distribution is unknown and estimated by the Kaplan–Meier estimator, this class of estimators has the same asymptotic variance and attains the lower bound for variance for the case of known censoring distribution. This is different from censored regression analysis, where asymptotic variances depend on the data transformation. Our method has three valuable advantages over the method of maximum likelihood estimation. First, our estimators are available in a closed form and do not require an iterative algorithm. Second, simulation studies show that our estimators being moment-based are comparable to maximum likelihood estimators and outperform them when sample size is small and censoring rate is high. Third, our estimators are more robust to model misspecification than maximum likelihood estimators. Therefore, our method can serve as a competitive alternative to the method of maximum likelihood in estimation for location-scale models with censored data. A numerical example is presented to illustrate the proposed method.     

Rank Regression Analysis of Multivariate Failure Time Data Based on Marginal Linear Models

Abstract.  Multivariate failure time data arises when each study subject can potentially ex-perience several types of failures or recurrences of a certain phenomenon, or when failure times are sampled in clusters. We formulate the marginal distributions of such multivariate data with semiparametric accelerated failure time models (i.e. linear regression models for log-transformed failure times with arbitrary error distributions) while leaving the dependence structures for related failure times completely unspecified. We develop rank-based monotone estimating functions for the regression parameters of these marginal models based on right-censored observations. The estimating equations can be easily solved via linear programming. The resultant estimators are consistent and asymptotically normal. The limiting covariance matrices can be readily estimated by a novel resampling approach, which does not involve non-parametric density estimation or evaluation of numerical derivatives. The proposed estimators represent consistent roots to the potentially non-monotone estimating equations based on weighted log-rank statistics. Simulation studies show that the new inference procedures perform well in small samples. Illustrations with real medical data are provided.     

Efficient estimation in partially linear single‐index models for longitudinal data

In this paper, we consider the estimation of both the parameters and the nonparametric link function in partially linear single‐index models for longitudinal data that may be unbalanced. In particular, a new three‐stage approach is proposed to estimate the nonparametric link function using marginal kernel regression and the parametric components with generalized estimating equations. The resulting estimators properly account for the within‐subject correlation. We show that the parameter estimators are asymptotically semiparametrically efficient. We also show that the asymptotic variance of the link function estimator is minimized when the working error covariance matrices are correctly specified. The new estimators are more efficient than estimators in the existing literature. These asymptotic results are obtained without assuming normality. The finite‐sample performance of the proposed method is demonstrated by simulation studies. In addition, two real‐data examples are analyzed to illustrate the methodology.     

Probability density estimation with data missing at random when covariables are present

This paper addresses the problem of the probability density estimation in the presence of covariates when data are missing at random (MAR). The inverse probability weighted method is used to define a nonparametric and a semiparametric weighted probability density estimators. A regression calibration technique is also used to define an imputed estimator. It is shown that all the estimators are asymptotically normal with the same asymptotic variance as that of the inverse probability weighted estimator with known selection probability function and weights. Also, we establish the mean squared error (MSE) bounds and obtain the MSE convergence rates. A simulation is carried out to assess the proposed estimators in terms of the bias and standard error.     

Asymptotic normality of kernel estimators based upon incomplete data

In this paper, we are concerned with nonparametric estimation of the density and the failure rate functions of a random variable X which is at risk of being censored. First, we establish the asymptotic normality of a kernel density estimator in a general censoring setup. Then, we apply our result in order to derive the asymptotic normality of both the density and the failure rate estimators in the cases of right, twice and doubly censored data. Finally, the performance and the asymptotic Gaussian behaviour of the studied estimators, based on either doubly or twice censored data, are illustrated through a simulation study.     

Nonparametric curve estimation with missing data: A general empirical process approach

A general nonparametric imputation procedure, based on kernel regression, is proposed to estimate points as well as set- and function-indexed parameters when the data are missing at random (MAR). The proposed method works by imputing a specific function of a missing value (and not the missing value itself), where the form of this specific function is dictated by the parameter of interest. Both single and multiple imputations are considered. The associated empirical processes provide the right tool to study the uniform convergence properties of the resulting estimators. Our estimators include, as special cases, the imputation estimator of the mean, the estimator of the distribution function proposed by Cheng and Chu [1996. Kernel estimation of distribution functions and quantiles with missing data. Statist. Sinica 6, 63–78], imputation estimators of a marginal density, and imputation estimators of regression functions.     

Multivariate generalized Birnbaum—Saunders kernel density estimators

In this article, we first propose the classical multivariate generalized Birnbaum–Saunders kernel estimator for probability density function estimation in the context of multivariate non negative data. Then, we apply two multiplicative bias correction (MBC) techniques for multivariate kernel density estimator. Some properties (bias, variance, and mean integrated squared error) of the corresponding estimators are also investigated. Finally, the performances of the classical and MBC estimators based on family of generalized Birnbaum–Saunders kernels are illustrated by a simulation study.     

Parameter estimation of three-parameter Weibull distribution based on progressively Type-II censored samples

In this paper, the estimation of parameters for a three-parameter Weibull distribution based on progressively Type-II right censored sample is studied. Different estimation procedures for complete sample are generalized to the case with progressively censored data. These methods include the maximum likelihood estimators (MLEs), corrected MLEs, weighted MLEs, maximum product spacing estimators and least squares estimators. We also proposed the use of a censored estimation method with one-step bias-correction to obtain reliable initial estimates for iterative procedures. These methods are compared via a Monte Carlo simulation study in terms of their biases, root mean squared errors and their rates of obtaining reliable estimates. Recommendations are made from the simulation results and a numerical example is presented to illustrate all of the methods of inference developed here.     

Logspline Density Estimation under Censoring and Truncation

ABSTRACT. In this paper we consider logspline density estimation for data that may be left-truncated or right-censored. For randomly left-truncated and right-censored data the product-limit estimator is known to be a consistent estimator of the survivor function, having a faster rate of convergence than many density estimators. The product-limit estimator and B-splines are used to construct the logspline density estimate for possibly censored or truncated data. Rates of convergence are established when the log-density function is assumed to be in a Besov space. An algorithm involving a procedure similar to maximum likelihood, stepwise knot addition, and stepwise knot deletion is proposed for the estimation of the density function based upon sample data. Numerical examples are used to show the finite-sample performance of inference based on the logspline density estimation.     

Product-limit Estimators and Cox Regression with Missing Censoring Information

The Kaplan–Meier estimator of a survival function requires that the censoring indicator is always observed. A method of survival function estimation is developed when the censoring indicators are missing completely at random (MCAR). The resulting estimator is a smooth functional of the Nelson–Aalen estimators of certain cumulative transition intensities. The asymptotic properties of this estimator are derived. A simulation study shows that the proposed estimator has greater efficiency than competing MCAR-based estimators. The approach is extended to the Cox model setting for the estimation of a conditional survival function given a covariate.     

Boundary Aware Estimators of Integrated Density Derivative Products

Integrated squared density derivatives are important to the plug-in type of bandwidth selector for kernel density estimation. Conventional estimators of these quantities are inefficient when there is a non-smooth boundary in the support of the density. We introduce estimators that utilize density derivative estimators obtained from local polynomial fitting. They retain the rates of convergence in mean-squared error that are familiar from non-boundary cases, and the constant coefficients have similar forms. The estimators and the formula for their asymptotically optimal bandwidths, which depend on integrated products of density derivatives, are applied to automatic bandwidth selection for local linear density estimation. Simulation studies show that the constructed bandwidth rule and the Sheather–Jones bandwidth are competitive in non-boundary cases, but the former overcomes boundary problems whereas the latter does not.     

Nonconcave penalized estimation for partially linear models with longitudinal data

A nonconcave penalized estimation method is proposed for partially linear models with longitudinal data when the number of parameters diverges with the sample size. The proposed procedure can simultaneously estimate the parameters and select the important variables. Under some regularity conditions, the rate of convergence and asymptotic normality of the resulting estimators are established. In addition, an iterative algorithm is proposed to implement the proposed estimators. To improve efficiency for regression coefficients, the estimation of the covariance function is integrated in the iterative algorithm. Simulation studies are carried out to demonstrate that the proposed method performs well, and a real data example is analysed to illustrate the proposed procedure.     

Variable kernel density estimation

This paper considers the problem of selecting optimal bandwidths for variable (sample‐point adaptive) kernel density estimation. A data‐driven variable bandwidth selector is proposed, based on the idea of approximating the log‐bandwidth function by a cubic spline. This cubic spline is optimized with respect to a cross‐validation criterion. The proposed method can be interpreted as a selector for either integrated squared error (ISE) or mean integrated squared error (MISE) optimal bandwidths. This leads to reflection upon some of the differences between ISE and MISE as error criteria for variable kernel estimation. Results from simulation studies indicate that the proposed method outperforms a fixed kernel estimator (in terms of ISE) when the target density has a combination of sharp modes and regions of smooth undulation. Moreover, some detailed data analyses suggest that the gains in ISE may understate the improvements in visual appeal obtained using the proposed variable kernel estimator. These numerical studies also show that the proposed estimator outperforms existing variable kernel density estimators implemented using piecewise constant bandwidth functions.     

Some Asymptotic Results of Kernel Density Estimators Under Random Left-Truncation and Dependent Data

Problems with truncated data arise frequently in survival analyses and reliability applications. The estimation of the density function of the lifetimes is often of interest. In this article, the estimation of density function by the kernel method is considered, when truncated data are showing some kind of dependence. We apply the strong Gaussian approximation technique to study the strong uniform consistency for kernel estimators of the density function under a truncated dependent model. We also apply the strong approximation results to study the integrated square error properties of the kernel density estimators under the truncated dependent scheme.     

Estimation of bivariate and marginal distributions with censored data

Summary. Consider a pair of random variables, both subject to random right censoring. New estimators for the bivariate and marginal distributions of these variables are proposed. The estimators of the marginal distributions are not the marginals of the corresponding estimator of the bivariate distribution. Both estimators require estimation of the conditional distribution when the conditioning variable is subject to censoring. Such a method of estimation is proposed. The weak convergence of the estimators proposed is obtained. A small simulation study suggests that the estimators of the marginal and bivariate distributions perform well relatively to respectively the Kaplan–Meier estimator for the marginal distribution and the estimators of Pruitt and van der Laan for the bivariate distribution. The use of the estimators in practice is illustrated by the analysis of a data set.     

An Extended Single‐index Model with Missing Response at Random

An extended single‐index model is considered when responses are missing at random. A three‐step estimation procedure is developed to define an estimator for the single‐index parameter vector by a joint estimating equation. The proposed estimator is shown to be asymptotically normal. An algorithm for computing this estimator is proposed. This algorithm only involves one‐dimensional nonparametric smoothers, thereby avoiding the data sparsity problem caused by high model dimensionality. Some simulation studies are conducted to investigate the finite sample performances of the proposed estimators.     

Monitoring multivariate simple linear profiles using robust estimators

Brief Abstract

This article focuses on estimation of multivariate simple linear profiles. While outliers may hamper the expected performance of the ordinary regression estimators, this study resorts to robust estimators as the remedy of the estimation problem in presence of contaminated observations. More specifically, three robust estimators M, S and MM are employed. Extensive simulation runs show that in the absence of outliers or for small amount of contamination, the robust methods perform as well as the classical least square method, while for medium and large amounts of contamination the proposed estimators perform considerably better than classical method.