Promotion Time Cure Rate Model with Bivariate Random Effects

In this article, we consider the inclusion of random effects in both the survival function for at-risk subjects and the cure probability assuming a bivariate normal distribution for those effects in each cluster. For parameter estimation, we implemented the restricted maximum likelihood (REML) approach. We consider Weibull and Piecewise Exponential distributions to model the survival function for non-cured individuals. Simulation studies are performed, and based on a real database we evaluate the performance of our proposed model. Effect of different follow-up times and the effect of considering independent random effects instead of bivariate random effects are also studied.     

An alternative to confidence intervals constructed after a Hausman pretest in panel data

Consider panel data modelled by a linear random intercept model that includes a time‐varying covariate. Suppose that our aim is to construct a confidence interval for the slope parameter. Commonly, a Hausman pretest is used to decide whether this confidence interval is constructed using the random effects model or the fixed effects model. This post‐model‐selection confidence interval has the attractive features that it (a) is relatively short when the random effects model is correct and (b) reduces to the confidence interval based on the fixed effects model when the data and the random effects model are highly discordant. However, this confidence interval has the drawbacks that (i) its endpoints are discontinuous functions of the data and (ii) its minimum coverage can be far below its nominal coverage probability. We construct a new confidence interval that possesses these attractive features, but does not suffer from these drawbacks. This new confidence interval provides an intermediate between the post‐model‐selection confidence interval and the confidence interval obtained by always using the fixed effects model. The endpoints of the new confidence interval are smooth functions of the Hausman test statistic, whereas the endpoints of the post‐model‐selection confidence interval are discontinuous functions of this statistic.     

Editorial collaborators

Traditionally, the bioequivalence of a generic drug with the innovator's product is assessed by comparing their pharmacokinetic profiles determined from the blood or plasma concentration-time curves. This method may only be applicable to formulations where blood drug or metabolites levels adequately characterize absorption and metabolism. For non-systematic drugs categorized by the lack of systemic presence, such as metered dose inhalers (MDI), anti-ulcer agents and topical antifungals and vaginal antifungals, new definition of therapeutic equivalency and criteria for acceptance should be used. When pharmacologic effects of the drugs can be easily measured, pharmacodynamic effect studies can be used to assess the therapeutic equivalence of non-systemic drugs. When analytical methods or other tests cannot be developed to permit use of the pharmacodynamic method, clinical trials to compare one or several clinical endpoints may be the only suitable method to establishing therapeutic equivalence. In this paper we evaluate by Monte-Carlo simulations the fixed sample performances of some two one-sided tests procedures which may be used to assess the therapeutic equivalence of non-systemic drugs with binary clinical endpoints. Formulae of sample size determination for therapeutic equivalence clinical trials are also given.     

Editorial collaborators

Confidence intervals obtained by bootstrap methods and normal approximation are compared, based on output data from terminating and steady-state simulations. Bootstrap intervals are equal or better than normal approximation intervals in actual probability coverages. Furthermore, bootstrap methods capture the skewness in the distribution of outputs and, therefore, are more desirable than normal approximation.     

Covariance structure selection in general mixed models

This article describes a unified approach to variance modeling and inference in the context of a general form of the normal-theory linear mixed model. The primary variance modeling objects are parameterized covari-ance structures, examples being diagonal, compound-symmetry, unstructured, timeseries, and spatial. These structures can enter in two different places in the general mixed model, and the combination of one or both of these places with the variety of structures provides a rich class of variance models. The approach is likelihood-based, and involves the use of both maximum likelihood and restricted maximum likelihood. Two examples provide illustration.     

A note on the difference between two likelihood based methods in growth curves

A new result is proved on the difference between ML and REML in the classical growth curve model, concerning the estimated variances of the regression coefficients. Simulations indicate that REML provides estimated variances closer to their true corresponding values, giving confidence intervals which are not misleadingly short.     

SURVIVAL ANALYSIS WITH TIME DEPENDENT FRAILTY USING A LONGITUDINAL MODEL

A method of estimation for generalised mixed models is applied to the estimation of regression parameters in a proportional hazards model with time dependent frailty. A parameter representing change over time is introduced and is modelled in turn into a fixed effect, a normally distributed random effect and a longitudinal effect in which the random component relates to the patient characteristics. Both maximum likelihood and residual maximum likelihood estimators are given.     

Recursive computation for repeated measures models with patterned variance matrices

A convenient recursive computational method for repeated measures analysis, provided by McGilchrist and Cullis (1990), has been extended by the authors to heterogeneous error structures and also to the repeated measures model with random coefficients. The approach is outlined briefly in this paper. A computing program for the approach has been written and used to obtain results for simulated data having various error structures. A summary of the results is given. The computing program together with some subroutines is available from the authors.     

Frailty modeling for clustered survival data: an application to birth interval in Bangladesh

The present work demonstrates an application of random effects model for analyzing birth intervals that are clustered into geographical regions. Observations from the same cluster are assumed to be correlated because usually they share certain unobserved characteristics between them. Ignoring the correlations among the observations may lead to incorrect standard errors of the estimates of parameters of interest. Beside making the comparisons between Cox's proportional hazards model and random effects model for analyzing geographically clustered time-to-event data, important demographic and socioeconomic factors that may affect the length of birth intervals of Bangladeshi women are also reported in this paper.     

Analysis of Contingency Tables with Clustered Observations

A new approach is presented for testing independence in contingency tables with clustered observations. The approach is based on the framework of generalized linear mixed models. Under the multinomial logistic link function, the category counts are modelled with random cluster effects and a modified likelihood ratio statistic is used for testing independence. The method is applicable to multi-way tables, and can accommodate multiple levels of clustering. It is illustrated using a benchmark dataset.     

Robustness of Parameter Estimation Procedures in Multilevel Models When Random Effects are MEP Distributed

In this paper we examine maximum likelihood estimation procedures in multilevel models for two level nesting structures. Usually, for fixed effects and variance components estimation, level-one error terms and random effects are assumed to be normally distributed. Nevertheless, in some circumstances this assumption might not be realistic, especially as concerns random effects. Thus we assume for random effects the family of multivariate exponential power distributions (MEP); subsequently, by means of Monte Carlo simulation procedures, we study robustness of maximum likelihood estimators under normal assumption when, actually, random effects are MEP distributed.     

A frailty modeling approach for parental effects in animal breeding

Survival models involving frailties are commonly applied in studies where correlated event time data arise due to natural or artificial clustering. In this paper we present an application of such models in the animal breeding field. Specifically, a mixed survival model with a multivariate correlated frailty term is proposed for the analysis of data from over 3611 Brazilian Nellore cattle. The primary aim is to evaluate parental genetic effects on the trait length in days that their progeny need to gain a commercially specified standard weight gain. This trait is not measured directly but can be estimated from growth data. Results point to the importance of genetic effects and suggest that these models constitute a valuable data analysis tool for beef cattle breeding.     

A zero-augmented gamma mixed model for longitudinal data with many zeros

In many occupational safety interventions, the objective is to reduce the injury incidence as well as the mean claims cost once injury has occurred. The claims cost data within a period typically contain a large proportion of zero observations (no claim). The distribution thus comprises a point mass at 0 mixed with a non-degenerate parametric component. Essentially, the likelihood function can be factorized into two orthogonal components. These two components relate respectively to the effect of covariates on the incidence of claims and the magnitude of claims, given that claims are made. Furthermore, the longitudinal nature of the intervention inherently imposes some correlation among the observations. This paper introduces a zero-augmented gamma random effects model for analysing longitudinal data with many zeros. Adopting the generalized linear mixed model (GLMM) approach reduces the original problem to the fitting of two independent GLMMs. The method is applied to evaluate the effectiveness of a workplace risk assessment teams program, trialled within the cleaning services of a Western Australian public hospital.     

组内相关系数的理论基础及建模应用

对用于测度数据可靠性的统计指标组内相关系数进行了理论基础论证、建模步骤分析、软件实现说明和实际数据统计分析;对组内相关系数建模中涉及的方差分析模型选择、相对一致性和绝对一致性区分、分析结果解释等都进行了详细说明。     

MODELLING TRUNCATED AND CLUSTERED COUNT DATA

Count response data often exhibit departures from the assumptions of standard Poisson generalized linear models. In particular, cluster level correlation of the data and truncation at zero are two common characteristics of such data. This paper describes a random components truncated Poisson model that can be applied to clustered and zero‐truncated count data. Residual maximum likelihood method estimators for the parameters of this model are developed and their use is illustrated using a dataset of non‐zero counts of sheets with edge‐strain defects in iron sheets produced by the Mobarekeh Steel Complex, Iran. The paper also reports on a small‐scale simulation study that supports the estimation procedure.     

Analyzing multivariate longitudinal binary data: A generalized estimating equations approach

The authors consider regression analysis for binary data collected repeatedly over time on members of numerous small clusters of individuals sharing a common random effect that induces dependence among them. They propose a mixed model that can accommodate both these structural and longitudinal dependencies. They estimate the parameters of the model consistently and efficiently using generalized estimating equations. They show through simulations that their approach yields significant gains in mean squared error when estimating the random effects variance and the longitudinal correlations, while providing estimates of the fixed effects that are just as precise as under a generalized penalized quasi‐likelihood approach. Their method is illustrated using smoking prevention data.     

Mixed models and unbalanced data: wherefrom,whereat and whereto?

A brief history of the early years (1820-1947) of random effects models and the estimation of variance components is followed by a personal evaluation of M.L, REML and MINQUE estimation. A method is suggested for combining ML estimator obtained from subsets of a large data set, and comments are made on the need for simulation studies to assess the degree of approximation in using asymptotic properties of ML-type estimators as if they were exact for finite-sized unbalanced data sets.     

Kernel density estimation for hierarchical data

Abstract

Multistage sampling is a common sampling technique employed in many studies. In this setting, observations are identically distributed but not independent, thus many traditional kernel smoothing techniques, which assume that the data are independent and identically distributed (i.i.d.), may not produce reasonable density estimates. In this paper, we sample repeatedly with replacement from each cluster, create multiple i.i.d. samples containing one observation from each cluster, and then create a kernel density estimate from each i.i.d. sample. These estimates will then be combined to form an estimate of the marginal probability density function of the population.     

Confidence intervals on the intraclass correlation in the unbalanced one-way classification

Several methods are compared for constructing confidence intervals on the intraclass correlation coefficient in the unbalanced one-way classification. The results suggest that a conservative approximation of the exact procedure developed by Wald (1940) can be used for hand calculations, When the exact solution is desired, a solution procedure is recommended that is computationally convenient and allows the investigator to determine the precision of the estimate. In cases where a prior estimate of the correlation is available, researchers may select intervals based on either the analysis of variance or unweighted sums of squares estimator.     

On MCMC sampling in hierarchical longitudinal models

Markov chain Monte Carlo (MCMC) algorithms have revolutionized Bayesian practice. In their simplest form (i.e., when parameters are updated one at a time) they are, however, often slow to converge when applied to high-dimensional statistical models. A remedy for this problem is to block the parameters into groups, which are then updated simultaneously using either a Gibbs or Metropolis-Hastings step. In this paper we construct several (partially and fully blocked) MCMC algorithms for minimizing the autocorrelation in MCMC samples arising from important classes of longitudinal data models. We exploit an identity used by Chib (1995) in the context of Bayes factor computation to show how the parameters in a general linear mixed model may be updated in a single block, improving convergence and producing essentially independent draws from the posterior of the parameters of interest. We also investigate the value of blocking in non-Gaussian mixed models, as well as in a class of binary response data longitudinal models. We illustrate the approaches in detail with three real-data examples.