Purposes, methods, philosophies

Peter Armitage has enjoyed a long and distinguished career in biostatistics, and has also given considerable thought to the way in which statistics is taught to non-mathematicians, perhaps because, he says jokingly, he always found maths a bit difficult himself. Now in retirement, he is still communicating statistical ideas in his rôle as Editor of the Encyclopedia of Biostatistics .     

New block bootstrap methods: Sufficient and/or ordered

In this study, we propose sufficient time series bootstrap methods that achieve better results than conventional non-overlapping block bootstrap, but with less computing time and lower standard errors of estimation. Also, we propose using a new technique using ordered bootstrapped blocks, to better preserve the dependency structure of the original data. The performance of the proposed methods are compared in a simulation study for MA(2) and AR(2) processes and in an example. The results show that our methods are good competitors that often exhibit improved performance over the conventional block methods.     

Randomization,balance, and the validity and efficiency of design-adaptive allocation methods

Few topics have stirred as much discussion and controversy as randomization. A reading of the literature suggests that clinical trialists generally feel randomization is necessary for valid inference, while biostatisticians using model-based inference often appear to prefer nearly optimal designs irrespective of any induced randomness. Dissection of the methods of treatment assignment shows that there are five basic approaches; pure randomizers, true randomizers, quasi-randomizers, permutation testers, and conventional modelers. Four of these have coherent design and analysis strategies, even though they are not mutually consistent, but the fifth and most prevalent approach (quasi-randomization) has little to recommend it. Design-adaptive allocation is defined, it is shown to provide valid inference, and a simulation indicates its efficiency advantage. In small studies, or large studies with many important prognostic covariates or analytic subgroups, design-adaptive allocation is an extremely attractive method of treatment assignment.