Conflict of interest reporting in biomedical journals published in China

This study aimed to investigate the current status and policy of Conflict of interest (COI) reporting in biomedical journals in China. Thirty Chinese-language medical journals and 37 English-language biomedical journals indexed by Journal Citation Reports categories were included into this study. These 67 journals were all published in China. All articles published in the most recent two issues were checked for identifying the disclosure statement in the text or not. Twenty-one of 30 (70%) Chinese-language journals required a disclosure of author’s potential COI. No journals require editors or referees to disclose the conflicts of interest to the readers. In total, 1,212 publications in Chinese-language were evaluated. Only two journals reported COI in their publications. For the 37 English-language journals, 32 (86.5%) required author’s potential COI disclosure, and four of them required only research articles or original articles to disclose COI. A total of 1,170 publications were evaluated. Among them, 50% editorials, 79.3% review articles, and 73.6% original articles reported presence or absence of COI. In our studied journals, the percentage of the policies requiring author COI disclosure is still low. Biomedical journals published in China should enforce COI disclosure policies to authors, editors, and referees.     

Declaring Conflict of Interest – Current State of Affairs in the Ophthalmic Literature

The importance of transparency with financial ties in biomedical research is widely recognized, and most peer-reviewed journals require declarations of Conflicts of Interest (COI). Nonetheless, variability in the consistency of declarations of COI has been sparsely assessed. To assess consistency and rates of COI declarations in the ophthalmic literature and the effectiveness of journal COI policies. We analyzed consistency and completeness of declaration of COI in the ophthalmic literature and compared the levels of completeness to specific journal requirements. Six-hundred forty-two peer reviewed articles satisfied the inclusion criteria. In 64%, COIs were unreported, in 25% declaration of COI was incomplete, and 11% of the articles reviewed had complete declaration of COI. Of the 33 journals in which the most frequently published authors’ articles appeared, 10 required the authors to complete the International Committee of Medical Journal Editors (ICMJE) form or an equivalent form, but this did not affect the rates of COI declaration. In a random sampling of the most frequently published authors in the field of ophthalmology, declaration of COI was low and highly inconsistent. Requiring a standardized COI form has no significant effect on the rate of accurate COI reporting. Our findings lend support to the growing body of literature that shows that journals and editors may need to take a more active role in ensuring accurate and consistent COI reporting.     

Research Misconduct Policies of Scientific Journals

The purpose of this study was to gather information on the misconduct policies of scientific journals. We contacted editors from a random sample of 399 journals drawn from the ISI Web of Knowledge database. We received 197 responses (49.4% response rate): 54.8% had a policy, and 47.7% had a formal (written) policy; 28.9% had a policy that only outlined procedures for handling misconduct, 15.7% had a policy that only defined misconduct, 10.2% had a policy that included both a definition and procedures; 26.9% of journals had a policy that was generated by the publisher, 13.2% had a policy that was generated by the journal, and 14.7% had a policy that was generated by another source, such as a professional association. We analyzed the relationship between having a policy and impact factor, field of science, publishing house, and nationality. Impact factor was the only variable with a statistically significant association with having a policy. Impact factor was slightly positively associated with whether or not the publisher had a policy, with an odds ratio of 1.49 (P < .0004) per 10 units increase in the impact factor, with a 95% confidence interval (1.20, 1.88). Our research indicates that more than half of scientific journals have developed misconduct policies, but that most of these policies do not define research misconduct and most of these policies were not generated by the journal.     

Research Misconduct Policies of Social Science Journals and Impact Factor

In this study we gathered data on the misconduct policies of social science journals and combined it with the data from our previous study on journal misconduct policies, which did not include enough social science journals for data analysis. Consistent with our earlier finding, impact factor of the journal was the only variable significantly associated with whether a journal had a formal (written) misconduct policy with an odds-ratio of 1.72 (p < 0.01). We did not find that type of science (physical, biomedical, or social) or publisher had a significant effect on whether a journal had a policy. Another important finding is that less than half of the journals that responded to the survey had a formal misconduct policy.     

Monetary policy in the New-Keynesian model: An application to the Euro Area

This paper analyzes monetary policy in a stylized New-Keynesian model. A number of issues are focused upon: (i) optimal monetary policy under commitment or discretion versus ad-hoc monetary policy based on simple rules, (ii) the effects of fiscal policies and foreign variables on monetary policy, (iii) the effects of fiscal deficit and interest rate smoothing objectives and the role of forward-backward linkages in the model. The model is estimated for the Euro Area. Using simulations of the estimated model, it is analyzed how these aspects might affect monetary policy of the ECB and macroeconomic fluctuations in the Euro Area.     

The Inclusion of Minority Groups in Clinical Trials: Problems of Under Representation and Under Reporting of Data

Objective: To evaluate the representation of minority groups in randomized control trials (RCTs), and the frequency with which this information is reported.

Study Design: Reviewers collected data on the racial/ethnic composition of study samples from all RCTs published in six leading medical journals in 1999.

Results: Of the 280 RCTs, most (204, 71.3%) provided no information on the race/ethnicity of participants. Of the 89 U.S.-based RCTs, 50 (56.1%) reported their minority distribution. Relative to other trials, those funded by the National Institute of Health (NIH) (n = 52) were more likely to report race/ethnicity data (55.8% vs. 23.7%; χ² = 20.9, p ≤ 0.001) and to include nonwhite participants (13.5% vs. 12.5%; χ² = 22.7, p ≤ 0.001).

Conclusion: Minority groups are currently under-represented in clinical trials. Information on the race and ethnicity of clinical trial participants is currently underreported in six leading medical journals. Reporting of minority group information was significantly better only in NIH funded trials, which also were more likely to include nonwhite participants. This suggests that mandatory reporting policies may have a positive effect on both reporting and representation.     

Under the Influence: The Interplay among Industry,Publishing, and Drug Regulation

The relationships among academe, publishing, and industry can facilitate commercial bias in how drug efficacy and safety data are obtained, interpreted, and presented to regulatory bodies and prescribers. Through a critique of published and unpublished trials submitted to the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for approval of a new antidepressant, vortioxetine, we present a case study of the “ghost management” of the information delivery process. We argue that currently accepted practices undermine regulatory safeguards aimed at protecting the public from unsafe or ineffective medicines. The economies of influence that may intentionally and unintentionally produce evidence-biased—rather than evidence-based—medicine are identified. This is not a simple story of author financial conflicts of interest, but rather a complex tale of ghost management of the entire process of bringing a drug to market. This case study shows how weak regulatory policies allow for design choices and reporting strategies that can make marginal products look novel, more effective, and safer than they are, and how the selective and imbalanced reporting of clinical trial data in medical journals results in the marketing of expensive “me-too” drugs with questionable risk/benefit profiles. We offer solutions for neutralizing these economies of influence.     

The inclusion of minority groups in clinical trials: problems of under representation and under reporting of data

Objective: To evaluate the representation of minority groups in randomized control trials (RCTs), and the frequency with which this information is reported. Study Design: Reviewers collected data on the racial/ethnic composition of study samples from all RCTs published in six leading medical journals in 1999. Results: Of the 280 RCTs, most (204, 71.3%) provided no information on the race/ethnicity of participants. Of the 89 U.S.-based RCTs, 50 (56.1%) reported their minority distribution. Relative to other trials, those funded by the National Institute of Health (NIH) (n = 52) were more likely to report race/ethnicity data (55.8% vs. 23.7%; x2 = 20.9, p <_0.001) and to include nonwhite participants (13.5 % vs. 12.5%; x2=22.7, p<_0.001). Conclusion: Minority groups are currently under-represented in clinical trials. Information on the race and ethnicity of clinical trial participants is currently underreported in six leading medical journals. Reporting of minority group information was significantly better only in NIH funded trials, which also were more likely to include nonwhite participants. This suggests that mandatory reporting policies may have a positive effect on both reporting and representation.     

Fiscal and monetary policy rules revisited

Why have automatic procedures designed to limit or eliminate the discretion of policy-makers become popular in recent years? The first part of the paper addresses fiscal policy rules by analyzing their political appeal as restrainers, symbols, partisan weapons, and ideological statements. The second part of the paper considers monetary policy rules and their rationales, and critiques them. We argue that fiscal and monetary policy rules may not be as efficacious as their supporters claim, and they raise new problems stemming from their biases, rigidity, and antidemocratic implications.     

Comparison of Conflict of Interest Policies and Reported Practices in Academic Medical Centers in the United States

The authors reviewed the conflict of interest policies of 9 academic medical centers in the United States and interviewed members of the Institutional Review Boards (IRBs) and Conflict of Interest Committees (COICs) at those institutions. They found that many institutions used processes for reporting and managing conflicts of interest that were more decentralized than the processes described in their policies. Also, most institutions had no clear and comprehensive policy to guide investigators regarding disclosure of conflicts of interest to potential research participants. Considerable differences in understanding of conflict of interest policies were observed between IRB and COIC officials.     

Comparison of conflict of interest policies and reported practices in academic medical centers in the United States

The authors reviewed the conflict of interest policies of 9 academic medical centers in the United States and interviewed members of the Institutional Review Boards (IRBs) and Conflict of Interest Committees (COICs) at those institutions. They found that many institutions used processes for reporting and managing conflicts of interest that were more decentralized than the processes described in their policies. Also, most institutions had no clear and comprehensive policy to guide investigators regarding disclosure of conflicts of interest to potential research participants. Considerable differences in understanding of conflict of interest policies were observed between IRB and COIC officials.     

后金融危机时期美国的货币政策对中非经济合作的启示

量化宽松的货币政策是后金融危机时期美国货币政策的主基调,自2009年3月份以来,美国先后推出了两轮量化宽松的货币政策,即QE1与QE2。美国量化宽松的货币政策所造成的国际大宗商品价格上涨、美元贬值、贸易摩擦以及热钱流入等问题,对全球经济尤其是中国与非洲各国经济带来了非常大的冲击,这对于中非各国促进双边贸易、开展本币互换试点、加快中非经贸合作区建设、加强金融监管合作以及推进货币整合的基础性研究等方面有着重要的启示。     

Capital mobility among advanced countries

Mobility of capital has been studied by examining savings–investment correlations, real interest rates differentials, covered and uncovered interest parity, and equity home bias. All these examine the capital mobility question indirectly. This paper directly tests the return/total flow specification of the Mundell–Fleming model. It finds that while portfolio equity and debt flows are, direct investment is not; and in every case, the inclusion of direct investment makes the aggregative-capital variable unresponsive to interest rates. Asset-based exchange rate models may benefit by looking at the composition of cross-border assets, countries can have independent monetary policies with full capital mobility, and macroeconomic policy trilemma for open economies disappears.     

Are there monetary clusters in the Eurozone? The impact of ECB policy

This paper analyses what effects the monetary policy of the European Central Bank have on the economic activity of Eurozone countries. We identify groups of countries which exhibit different economic responses to monetary policy and the factors driving such spatial differences. We distinguish three periods, spanning from 2001 to 2017 and examine conventional as well as unconventional monetary policies in different economic backgrounds of expansion and crisis. We find problems of spatially asymmetric transmission of monetary policy in the period 2008M10–2014M12 and note that different spatial responses might operate in favour of monetary policy or be indifferent to this policy.     

谈期刊应遵守的宣传纪律

期刊是思想文化阵地的重要组成部分之一 ,在弘扬和传播优秀文化 ,帮助人们树立正确的世界观、人生观、价值观和理想信念 ,提高民族素质等方面 ,有着重大作用。正因如此 ,党和政府十分重视期刊事业 ,提供了大量人力、物力、财力资源 ,为期刊打下了坚实的物质基础 ;为期刊从业者提供宽松的政治环境 ,使之有着纵横驰骋的天地。同时 ,为确保期刊出版导向的正确 ,使之真正代表中国先进文化前进方向 ,党又为期刊工作制定了一些宣传纪律、制度。期刊工作在遵守办刊法规的同时 ,还必须模范遵守宣传纪律 ,这是社会主义期刊的性质及其党性原则所决定的     

宏观金融博弈分析与我国货币政策实践

西方经济学界将博弈分析方法推广到金融领域取得了理论成果,尤其以宏观金融博弈分析在20世纪90年代的最新发展为主要内容.完全信息动态博弈和不完全信息动态博弈两类模型,对货币政策的连贯性与可信度以及中央银行声誉做出了重新解释,货币政策目标、货币政策操作程序、中央银行独立性及政策透明度等热点问题在我国金融体制改革实践中的作用是至关重要的.