Asymptotic expaxsioxs for the joint distribution of cirrelated hotellings t2 statlstics under normality

Let T² _i=z′_iS^?1z_i, i==,…k be correlated Hotelling's T² statistics under normality. where z=(z′_i,…,z′_k)′ and nS are independently distributed as N_kp((O,ρ?∑) and Wishart distribution W_p(∑, n), respectively. The purpose of this paper is to study the distribution function F(x₁,…,x_k) of (T² _i,…,T² _k) when n is large. First we derive an asymptotic expansion of the characteristic function of (T² _i,…,T² _k) up to the order n^?2. Next we give asymptotic expansions for (T² _i,…,T² _k) in two cases (i)ρ=I_k and (ii) k=2 by inverting the expanded characteristic function up to the orders n^?2 and n^?1, respectively. Our results can be applied to the distribution function of max (T² _i,…,T² _k) as a special case.     

ON ASYMPTOTIC OPTIMALITY OF SOME TESTS FOR EXPONENTIAL DISTRIBUTIONS

The probability density function (pdf) of a two parameter exponential distribution is given by f(x; p, s?) =s?^-1 exp {-(x - ρ)/s?} for x≥ρ and 0 elsewhere, where 0 < ρ < ∞ and 0 < s?∞. Suppose we have k independent random samples where the ith sample is drawn from the ith population having the pdf f(x; ρ_i, s?_i), 0 < ρ_i < ∞, 0 < s?_i < s?_i < and f(x; ρ, s?) is as given above. Let X_i1 < X_i2 <… < X_iri denote the first r_i order statistics in a random sample of size n_i, drawn from the ith population with pdf f(x; ρ_i, s?_i), i = 1, 2,…, k. In this paper we show that the well known tests of hypotheses about the parameters ρ_i, s?_i, i = 1, 2,…, k based on the above observations are asymptotically optimal in the sense of Bahadur efficiency. Our results are similar to those for normal distributions.     

D-Optimal Axial Designs for Quadratic and Cubic Additive Mixture Models

The paper discusses D-optimal axial designs for the additive quadratic and cubic mixture models σ_1≤i≤q(β_ix_i + β_iix²_i) and σ_1≤i≤q(β_ix_i + β_iix²_i + β_iiix³_i), where x_i≥ 0, x₁ + . . . + x_q = 1. For the quadratic model, a saturated symmetric axial design is used, in which support points are of the form (x₁, . . . , x_q) = [1 ? (q?1)δ_i, δ_i, . . . , δ_i], where i = 1, 2 and 0 ≤δ₂ <_{δ1 ≤} 1/(q ?1). It is proved that when 3 ≤q≤ 6, the above design is D-optimal if δ₂ = 0 and δ₁ = 1/(q?1), and when q≥ 7 it is D-optimal if δ₂ = 0 and δ₁ = [5q?1 ? (9q²?10q + 1)^1/2]/(4q²). Similar results exist for the cubic model, with support points of the form (x₁, . . . , x_q) = [1 ? (q?1)δ_i, δ_i, . . . , δ_i], where i = 1, 2, 3 and 0 = δ₃ <_δ2 < δ_{1 ≤}1/(q?1). The saturated D-optimal axial design and D-optimal design for the quadratic model are compared in terms of their efficiency and uniformity.     

A fully nonparametric diagnostic test for homogeneity of variances

The authors propose a new nonparametric diagnostic test for checking the constancy of the conditional variance function σ²(x) in the regression model Y_i = m(x_i) + σ(x_i)?_i, i = 1,…, m. Their test, which does not assume a known parametric form for the conditional mean function m(x), is inspired by a recent asymptotic theory in the analysis of variance when the number of factor levels is large. The authors demonstrate through simulations the good finite‐sample properties of the test and illustrate its use in a study on the effect of drug utilization on health care costs.     

OPTIMAL DESIGNS FOR FITTING A PROPORTIONAL HAZARDS REGRESSION MODEL TO DATA SUBJECT TO CENSORING

Suppose the probability model for failure time data, subject to censoring, is specified by the hazard function λ(t)exp(β_T x), where x is a vector of covariates. Analytical difficulties involved in finding the optimal design are avoided by assuming that λ is completely specified and by using D-optimality based on the information matrix for β Optimal designs are found to depend on β, but some results of practical consequence are obtained. It is found that censoring does not affect the choice of design appreciably when β^T x ≥ 0 for all points of the feasible region, but may have an appreciable effect when β_ix_i 0, for all i and all points in the feasible experimental region. The nature of the effect is discussed in detail for the cases of one and two parameters. It is argued that in practical biomedical situations the optimal design is almost always the same as for uncensored data.     

Nonparametric Estimation of a Regression Function: Limiting Distribution2

Consider the regression model Y_i= g(x_i) + e_i, i = 1,…, n, where g is an unknown function defined on [0, 1], 0 = x₀ < x₁ < … < x_n≤ 1 are chosen so that max_1≤i≤n(x_i-x_{i- 1}) = 0(n^-1), and where {e_i} are i.i.d. with Ee₁= 0 and Var e₁ - s?². In a previous paper, Cheng & Lin (1979) study three estimators of g, namely, g_1n of Cheng & Lin (1979), g_2n of Clark (1977), and g_3n of Priestley & Chao (1972). Consistency results are established and rates of strong uniform convergence are obtained. In the current investigation the limiting distribution of &_in, i = 1, 2, 3, and that of the isotonic estimator g**_n are considered.     

Pooling operators with the marginalization property

In this paper, we consider the problem of combining a number of opinions which have been expressed as probability measures P₁, …, P_n, over some space. It is shown that a pooling formula which has the marginalization property of McConway (1981) must be of the form T = Σⁿ_i=₁W_i P_i + (1 - Σⁿ_i =₁W_i)Q, where Q is an arbitrary measure and W₁, …, W_n ϵ [—1,1] are weights such that| Σ_J Σ _j w_j | ≤ 1 for every subset J of {1, …, n}. If, in addition, T is required to preserve the independence of arbitrary events A and B whenever these events are independent under each P_i, then either T = P_i for some 1 ≤ i ≤ n or T = Q, in which case Q takes values in {0, l}.     

Berry–Esseen type bounds in heteroscedastic errors-in-variables model

ABSTRACT

Consider the heteroscedastic partially linear errors-in-variables (EV) model y_i = x_iβ + g(t_i) + ε_i, ξ_i = x_i + μ_i (1 ? i ? n), where ε_i = σ_ie_i are random errors with mean zero, σ²_i = f(u_i), (x_i, t_i, u_i) are non random design points, x_i are observed with measurement errors μ_i. When f( · ) is known, we derive the Berry–Esseen type bounds for estimators of β and g( · ) under {e_i,?1 ? i ? n} is a sequence of stationary α-mixing random variables, when f( · ) is unknown, the Berry–Esseen type bounds for estimators of β, g( · ), and f( · ) are discussed under independent errors.     

Sequential experimental design and response optimisation

We consider the situation where one wants to maximise a functionf(θ,x) with respect tox, with θ unknown and estimated from observationsy _k . This may correspond to the case of a regression model, where one observesy _k =f(θ,x _k )+ε _k , with ε _k some random error, or to the Bernoulli case wherey _k ∈{0, 1}, with Pr[y _k =1|θ,x _k |=f(θ,x _k ). Special attention is given to sequences given by , with an estimated value of θ obtained from (x₁, y₁),...,(x _k ,y _k ) andd _k (x) a penalty for poor estimation. Approximately optimal rules are suggested in the linear regression case with a finite horizon, where one wants to maximize ∑ _i=1 ^N w _i f(θ, x _i ) with {w _i } a weighting sequence. Various examples are presented, with a comparison with a Polya urn design and an up-and-down method for a binary response problem.     

Uniform asymptotic linearity of a process based on a signed rank statistic

Consider the process with, cf. (1.2) on page 265 in B1, X₁, …, X_N a sample from a distribution F and, for i = 1, …, N, R${}_{\text{|x}{}_{\text{1}}\text{, - q}{}_{\text{1}}\text{ø|}}$ , the rank of |X₁ - q₁ø| among |X₁ - q₁ø|, …, |X_N - q_Nø|. It is shown that, under certain regularity conditions on F and on the constants p_i and q_i, T^ø_N(t) is asymptotically approximately a linear function of ø uniformly in t and in ø for |ø| ≤ C. The special case where the p_i and the q_i, are independent of i is considered.     

A new class of bivariate lifetime distributions

This paper introduces a new class of bivariate lifetime distributions. Let {X_i}_{i ? 1} and {Y_i}_{i ? 1} be two independent sequences of independent and identically distributed positive valued random variables. Define T₁ = min?(X₁, …, X_M) and T₂ = min?(Y₁, …, Y_N), where (M, N) has a discrete bivariate phase-type distribution, independent of {X_i}_{i ? 1} and {Y_i}_{i ? 1}. The joint survival function of (T₁, T₂) is studied.     

MODELING THE LIFETIME OF LONGITUDINAL ELEMENTS

In the study of the stochastic behaviour of the lifetime of an element as a function of its length, it is often observed that the failure time (or lifetime) decreases as the length increases. In probabilistic terms, such an idea can be expressed as follows. Let T be the lifetime of a specimen of length x, so the survival function, which denotes the probability that an element of length x survives till time t, will be given by S_T (t, x) = P(T > t/α(x), where α(x) is a monotonically decreasing function. In particular, it is often assumed that T has a Weibull distribution. In this paper, we propose a generalization of this Weibull model by assuming that the distribution of T is Generalized gamma (GG). Since the GG model contains the Weibull, Gamma and Lognormal models as special and limiting cases, a GG regression model is an appropriate tool for describing the size effect on the lifetime and for selecting among the embedded models. Maximum likelihood estimates are obtained for the GG regression model with α(x) = cx^b . As a special case this provide an alternative to the usual approach to estimation for the GG distribution which involves reparametrization. Related parametric inference issues are addressed and illustrated using two experimental data sets. Some discussion of censored data is also provided.     

GEOMETRIC DECAY OF THE STEADY-STATE PROBABILITIES IN A QUASI-BIRTH-AND-DEATH PROCESS WITH A COUNTABLE NUMBER OF PHASES

A sufficient condition is proved for geometric decay of the steady-state probabilities in a quasi-birth-and-death process having a countable number of phases in each level. If there is a positive number η and positive vectors x = (x _i) and y = (y _j ) satisfying some equations and inequalities, the steady-state probability π _mi decays geometrically with rate η in the sense π _mi ～ cη ^m x _i as m → ∞. As an example, the result is applied to a two-queue system with shorter queue discipline.     

Distributions of patterns of two successes separated by a string of <Emphasis Type="Italic">k</Emphasis>-2 failures

Let Z ₁, Z ₂, . . . be a sequence of independent Bernoulli trials with constant success and failure probabilities p = Pr(Z _t  = 1) and q = Pr(Z _t  = 0) = 1 − p, respectively, t = 1, 2, . . . . For any given integer k ≥ 2 we consider the patterns E₁{\mathcal{E}_{1}}: two successes are separated by at most k−2 failures, E₂{\mathcal{E}_{2}}: two successes are separated by exactly k −2 failures, and E₃{\mathcal{E}_{3}} : two successes are separated by at least k − 2 failures. Denote by N_n,k⁽ⁱ⁾{ N_{n,k}^{(i)}} (respectively M_n,k⁽ⁱ⁾{M_{n,k}^{(i)}}) the number of occurrences of the pattern E_i{\mathcal{E}_{i}} , i = 1, 2, 3, in Z ₁, Z ₂, . . . , Z _n when the non-overlapping (respectively overlapping) counting scheme for runs and patterns is employed. Also, let T_r,k⁽ⁱ⁾{T_{r,k}^{(i)}} (resp. W_r,k⁽ⁱ⁾){W_{r,k}^{(i)})} be the waiting time for the r − th occurrence of the pattern E_i{\mathcal{E}_{i}}, i = 1, 2, 3, in Z ₁, Z ₂, . . . according to the non-overlapping (resp. overlapping) counting scheme. In this article we conduct a systematic study of N_n,k⁽ⁱ⁾{N_{n,k}^{(i)}}, M_n,k⁽ⁱ⁾{M_{n,k}^{(i)}}, T_r,k⁽ⁱ⁾{T_{r,k}^{(i)}} and W_r,k⁽ⁱ⁾{W_{r,k}^{(i)}} (i = 1, 2, 3) obtaining exact formulae, explicit or recursive, for their probability generating functions, probability mass functions and moments. An application is given.     

A distribution-free approach to qdantal response assays

A nonparametric method is developed to estimate the minimum dosage level required to induce a given response rate in an experiment. The only assumption used about the response rate is that it is a nondecreasing function with respect to the dosage level. Let n_isubjects be independently tested at dosage level x_ix₁x₂x_k. This paper presents methodology for the estimation of the smallest i such that the response probability at x_i is no less than a required level p. A comparison with well-known nonparametric methods shows that this method is better in some cases. A design of minimum required sample size for a given accuracy is also developed.     

Combining unbiased estimates —a further examination of some old estimators

This paper considers the problem of combining k unbiased estimates, x _i of a parameter,μ, where each estimate, x _i is the average of n _i + l independent normal observations with unknown mean, μ, and unknown variance, σ _i ². The behavior of several commonly used estimators of μ is studied by means of an empirical sampling study, and the empirical results of this experiment are interpreted in terms of previous theoretical results. Finally, some extrapolations are made as to how these estimators might behave under varying conditions, and some new estimators are proposed which might have higher efficiencies under certain conditions than those which are generally used.     

Optimal spacing of the selected sample quantiles for the joint estimation of the location and scale parameters of a symmetric distribution

We are considering the ABLUE’s – asymptotic best linear unbiased estimators – of the location parameter μ and the scale parameter σ of the population jointly based on a set of selected k sample quantiles, when the population distribution has the density of the form

where the standardized function f(u) being of a known functional form.A set of selected sample quantiles with a designated spacing

or in terms of u=(x−μ)/σ

where

λ_i=∫_−∞^u_if(t) dt, i=1,2,…,k

are given by

x(n₁)<x(n₂)<<x(n_k),

where

Asymptotic distribution of the k sample quantiles when n is very large is given by

h(x(n₁),x(n₂),…,x(n_k);μ,σ)=(2πσ²)^−k/2[λ₁(λ₂−λ₁)(λ_k−λ_k−1)(1−λ_k)]^−1/2n^k/2 exp(−nS/2σ²),

where

f_i=f(u_i), i=0,1,…,k,k+1,

f₀=f_k+1=0, λ₀=0, λ_k+1=1.

The relative efficiency of the joint estimation is given by

where

and κ being independent of the spacing . The optimal spacing is the spacing which maximizes the relative efficiency η(μ,σ).We will prove the following rather remarkable theorem. Theorem. The optimal spacing for the joint estimation is symmetric, i.e.

λ_i+λ_k−i+1=1,

or

u_i+u_k−i+1=0, i=1,2,…,k,

if the standardized density f(u) of the population is differentiable infinitely many times and symmetric

f(−u)=f(u), f′(−u)=−f′(u).

     

Uniform asymptotic linearity in a regression parameter of a process based on a rank statistic

For X₁, …, X_N a random sample from a distribution F, let the process S^δ_N(t) be defined as where K²_N = σ^N_i=1(c_i ? c?)² and R x_i, + Δd, is the rank of X_i + Δd_i, among X₁ + Δd₁, …, X_N + Δd_N. The purpose of this note is to prove that, under certain regularity conditions on F and on the constants c_i and d_i, S^Δ_N (t) is asymptotically approximately a linear function of Δ, uniformly in t and in Δ, |Δ| ≤ C. The special case of two samples is considered.     

Improved bootstrap confidence intervals in certain toxicological experiments

The bootstrap, the jackknife, and classical methods are compared through their confidence intervals for the proportion of affected fetuses in a common type of animal experiment. Specifically, suppose that for the ith of M pregnant animals, there are x _i affected fetuses out of n _i total in the litter. The conditional distribution of x _i given n _i is sometimes modeled as binomial (n _i p _i ), where p _i is a realization from some unknown continuous density. The p _i are not observable and it is of interest in some toxicological experiments to find confidence intervals for E(p). Theory suggests that the proposed parametric bootstrap should produce higher order agreement between the nominal and actual coverage than that exhibited by the usual nonparametric bootstrap. Some simulation results provide additional evidence of this superiority of the modified parametric bootstrap over the jack-knife and classical approaches. The proposed resampling is flexible enough to handle a more general model allowing correlation between p _i and n _i .