Inferences on partial linear models with right censored data by empirical likelihood

ABSTRACT

This article considers inference for partial linear models with right censored data. We use empirical likelihood based on the Buckley and James (1979 Buckley, J., James, I. (1979). Linear regression with censored data. Biometrika 66:429–436.[Crossref], [Web of Science ®] , [Google Scholar]) estimating equation to derive the confidence region for the regression parameter. We introduce an adjusted empirical likelihood ratio statistic for the parameter of interest and show that its limiting distribution is standard chi-square. A simulation is carried out to compare our method with the synthetic data approach in Wang and Li (2002 Wang, Q.-H., Li, G. (2002). Empirical Likelihood Semiparametric Regression Analysis under Random Censorship. J. Multivariate Anal. 83:469–486.[Crossref], [Web of Science ®] , [Google Scholar]).     

Asymptotic Normality for the Partially Linear EV Models with Longitudinal Data

In this article, we consider a partially linear EV regression model under longitudinal data. By using a weighted kernel method and modified least-squared method, the estimators of unknown parameter, the unknown function are constructed and the asymptotic normality of the estimators are derived. Simulation studies are conducted to illustrate the finite-sample performance of the proposed method.     

A large-scale monte carlo study of the buckley-james estimator with censored data

Estimation in the presence of censoring is an important problem. In the linear model, the Buckley-James method proceeds iteratively by estimating the censored values than re-estimating the regression coeffi- cients. A large-scale Monte Carlo simulation technique has been developed to test the performance of the Buckley-James (denoted B-J) estimator. One hundred and seventy two randomly generated data sets, each with three thousand replications, based on four failure distributions, four censoring patterns, three sample sizes and four censoring rates have been investigated, and the results are presented. It is found that, except for Type I1 censoring, the B-J estimator is essentially unbiased, even when the data sets with small sample sizes are subjected to a high censoring rate. The variance formula suggested by Buckley and James (1979) is shown to be sensitive to the failure distribution. If the censoring rate is kept constant along the covariate line, the sample variance of the estimator appears to be insensitive to the censoring pattern with a selected failure distribution. Oscillation of the convergence values associated with the B-J estimator is illustrated and thoroughly discussed.     

Estimation for Location-Scale Models with Censored Data

This article considers a class of estimators for the location and scale parameters in the location-scale model based on ‘synthetic data’ when the observations are randomly censored on the right. The asymptotic normality of the estimators is established using counting process and martingale techniques when the censoring distribution is known and unknown, respectively. In the case when the censoring distribution is known, we show that the asymptotic variances of this class of estimators depend on the data transformation and have a lower bound which is not achievable by this class of estimators. However, in the case that the censoring distribution is unknown and estimated by the Kaplan–Meier estimator, this class of estimators has the same asymptotic variance and attains the lower bound for variance for the case of known censoring distribution. This is different from censored regression analysis, where asymptotic variances depend on the data transformation. Our method has three valuable advantages over the method of maximum likelihood estimation. First, our estimators are available in a closed form and do not require an iterative algorithm. Second, simulation studies show that our estimators being moment-based are comparable to maximum likelihood estimators and outperform them when sample size is small and censoring rate is high. Third, our estimators are more robust to model misspecification than maximum likelihood estimators. Therefore, our method can serve as a competitive alternative to the method of maximum likelihood in estimation for location-scale models with censored data. A numerical example is presented to illustrate the proposed method.     

Estimation and goodness-of-fit for the Cox model with various types of censored data

The currently existing estimation methods and goodness-of-fit tests for the Cox model mainly deal with right censored data, but they do not have direct extension to other complicated types of censored data, such as doubly censored data, interval censored data, partly interval-censored data, bivariate right censored data, etc. In this article, we apply the empirical likelihood approach to the Cox model with complete sample, derive the semiparametric maximum likelihood estimators (SPMLE) for the Cox regression parameter and the baseline distribution function, and establish the asymptotic consistency of the SPMLE. Via the functional plug-in method, these results are extended in a unified approach to doubly censored data, partly interval-censored data, and bivariate data under univariate or bivariate right censoring. For these types of censored data mentioned, the estimation procedures developed here naturally lead to Kolmogorov-Smirnov goodness-of-fit tests for the Cox model. Some simulation results are presented.     

Exponential tilt models for two-group comparison with censored data

We study application of the Exponential Tilt Model (ETM) to compare survival distributions in two groups. The ETM assumes a parametric form for the density ratio of the two distributions. It accommodates a broad array of parametric models such as the log-normal and gamma models and can be sufficiently flexible to allow for crossing hazard and crossing survival functions. We develop a nonparametric likelihood approach to estimate ETM parameters in the presence of censoring and establish related asymptotic results. We compare the ETM to the Proportional Hazards Model (PHM) in simulation studies. When the proportional hazards assumption is not satisfied but the ETM assumption is, the ETM has better power for testing the hypothesis of no difference between the two groups. And, importantly, when the ETM relation is not satisfied but the PHM assumption is, the ETM can still have power reasonably close to that of the PHM. Application of the ETM is illustrated by a gastrointestinal tumor study.     

Estimation of the area under ROC curve with censored data

The area under the receiver operating characteristic curve is the most commonly used summary measure of diagnostic accuracy for a continuous-scale diagnostic test. In this paper, we develop methods to estimate the area under the curve (AUC) with censored data. Based on two different integration representations of this parameter, two nonparametric estimators are defined by the “plug in” method. Both the proposed estimators are shown to be asymptotically normal based on counting process and martingale theory. A simulation study is conducted to evaluate the performances of the proposed estimators.     

A modified chi-square test for Bertholon model with censored data

In this work, we propose the construction of a chi-squared goodness-of-fit test in censored data case, for Bertholon model which can analyse various competing risks of failure or death. This test is based on a modification of the Nikulin-Rao-Robson (NRR) statistic proposed by Bagdonavicius and Nikulin (2011a Bagdonavicius, V., Nikulin, M. (2011a). Chi-squared tests for general composite hypotheses from censored samples. Comptes Rendus Mathématiques: Series I 349(3–4):219–223. [Google Scholar], 2011b Bagdonavicius, V., Nikulin, M. (2011b). Chi-squared goodness-of-fit test for right censored data. International Journal of Applied Mathematics and Statistics 24:30–50. [Google Scholar]) for censored data. We applied this test to numerical examples from simulated samples and real data.     

Estimation in linear mixed models for longitudinal data under linear restricted conditions

In the paper, we consider a linear mixed model (LMM) for longitudinal data under linear restriction and find the estimators for the parameters of interest. The strong consistency and asymptotic normality of the estimators are obtained under some regularity conditions. Besides, we derive the strong consistent estimator of the fourth moment for the error which is useful for statistical inference for random effects and error variance. Simulations and an example are reported for illustration.     

Testing for serial correlation in linear model with validation data

In this paper, we investigate the testing for serial correlation in a linear model with validation data, then we apply the empirical likelihood method to construct the test statistic and derive the asymptotic distribution of the test statistic under null hypothesis. Simulation results show that our method performs well both in size and power with finite same size.     

Estimation of conditional mode with truncated,censored, and dependent data

In this paper, we studied the uniform convergence with rates for the kernel estimator of the conditional mode function for a left truncated and right censored model. It is assumed that the lifetime observations with multivariate covariates form a stationary α-mixing sequence. Also, the asymptotic normality of the estimator is established.     

The LAD estimation of the change-point linear model with randomly censored data

Abstract

In this paper, a change-point linear model with randomly censored data is investigated. We propose the least absolute deviation estimation procedure for regression and change-point parameters simultaneously. The asymptotic properties of the change-point and regression parameter estimators are obtained. We show that the resulting regression parameter estimator is asymptotically normal, and the change-point estimator converges weakly to the minimizer of a given random process. The extensive simulation studies and the analysis of an acute myocardial infarction data set are conducted to illustrate the finite sample performance of the proposed method.     

General partially linear varying-coefficient transformation model with right censored data

In this paper, a unified maximum marginal likelihood estimation procedure is proposed for the analysis of right censored data using general partially linear varying-coefficient transformation models (GPLVCTM), which are flexible enough to include many survival models as its special cases. Unknown functional coefficients in the models are approximated by cubic B-spline polynomial. We estimate B-spline coefficients and regression parameters by maximizing marginal likelihood function. One advantage of this procedure is that it is free of both baseline and censoring distribution. Through simulation studies and a real data application (VA data from the Veteran's Administration Lung Cancer Study Clinical Trial), we illustrate that the proposed estimation procedure is accurate, stable and practical.     

Aalen's linear model for doubly censored data

Double censoring often occurs in registry studies when left censoring is present in addition to right censoring. In this work, we examine estimation of Aalen's nonparametric regression coefficients based on doubly censored data. We propose two estimation techniques. The first type of estimators, including ordinary least squared (OLS) estimator and weighted least squared (WLS) estimators, are obtained using martingale arguments. The second type of estimator, the maximum likelihood estimator (MLE), is obtained via expectation-maximization (EM) algorithms that treat the survival times of left censored observations as missing. Asymptotic properties, including the uniform consistency and weak convergence, are established for the MLE. Simulation results demonstrate that the MLE is more efficient than the OLS and WLS estimators.     

Maximum likelihood estimators in finite mixture models with censored data

The consistency of estimators in finite mixture models has been discussed under the topology of the quotient space obtained by collapsing the true parameter set into a single point. In this paper, we extend the results of Cheng and Liu (2001) to give conditions under which the maximum likelihood estimator (MLE) is strongly consistent in such a sense in finite mixture models with censored data. We also show that the fitted model tends to the true model under a weak condition as the sample size tends to infinity.     

Empirical likelihood for parameters in an additive partially linear errors-in-variables model with longitudinal data

Empirical likelihood inferences for the parameter component in an additive partially linear errors-in-variables model with longitudinal data are investigated in this article. A corrected-attenuation block empirical likelihood procedure is used to estimate the regression coefficients, a corrected-attenuation block empirical log-likelihood ratio statistic is suggested and its asymptotic distribution is obtained. Compared with the method based on normal approximations, our proposed method does not require any consistent estimator for the asymptotic variance and bias. Simulation studies indicate that our proposed method performs better than the method based on normal approximations in terms of relatively higher coverage probabilities and smaller confidence regions. Furthermore, an example of an air pollution and health data set is used to illustrate the performance of the proposed method.     

Confidence sets in a linear regression model for interval data

The construction of confidence sets for the parameters of a flexible simple linear regression model for interval-valued random sets is addressed. For that purpose, the asymptotic distribution of the least-squares estimators is analyzed. A simulation study is conducted to investigate the performance of those confidence sets. In particular, the empirical coverages are examined for various interval linear models. The applicability of the procedure is illustrated by means of a real-life case study.     

Quantile regression for interval censored data

As direct generalization of the quantile regression for complete observed data, an estimation method for quantile regression models with interval censored data is proposed, and the property of consistency is obtained. The property of asymptotic normality is also established with a bias converging to zero, and to reduce the bias, two bias correction methods are proposed. Methods proposed in this paper do not require the censoring vectors to be identically distributed, and can be applied to models with various covariates. Simulation results show that the proposed methods work well.     

Empirical likelihood ratio tests for the linear regression model with inequality constraints

Abstract

In this article, empirical likelihood is applied to the linear regression model with inequality constraints. We prove that asymptotic distribution of the adjusted empirical likelihood ratio test statistic is a weighted mixture of chi-square distribution.