Disparity,Shortfall, and Twice-Endogenous HARA Utility

We derive a mapping between the shortfall-minimizing portfolio selection based on higher-order entropy measures and expected utility theory. We show that the family of HARA utility functions has a minimum-divergence, shortfall-based representation. This facilitates an interpretation in which the risk aversion parameters and the type of risk aversion arise endogenously. We provide a numerical example illustrating this interpretation.     

Optimal investment and consumption with unknown parameters

An investment and consumption problem is formulated and its optimal strategy is investigated. We assume the basic binary model, but with unknown parameters. We apply the parametric Bayesian approach to formulate the problem as a sequential stochastic optimization model and use the technique of dynamic programming to characterize the optimal strategy. It is discovered that despite unknown parameters, when the power and logarithmic utility functions are treated, the optimal value function is of the same form of the utility function. The random finite horizon model is formulated as an infinite horizon model. Our results are similar to the ones in the literature having different return functions with constant relative risk aversion.     

RISK PREFERENCES UNDER PRICE UNCERTAINTIES AND PRODUCTION RISK

This paper deals with estimation of risk preferences of producers when they face uncertainties in output and input prices, in addition to uncertainty in production (usually labeled as production risk). All these uncertainty components are modeled in the context of production theory where the producers maximize expected utility of anticipated profit. Risk preference functions associated with these uncertainties are derived without assuming a specific form of the utility function. Moreover, no distributional assumptions are made on the distributions of the random variables representing price and production uncertainties. A multi-stage estimation procedure is developed to estimate the parameters of the production function and risk preference functions associated with output price uncertainty, input price uncertainty and production risk. Production risk is specified in such a way that one can identify inputs with increasing, decreasing and constant production risks. Similarly, risk aversion behavior is specified in such a way that one can test for different types of risk aversion behavior.     

Adaptive Bayesian compound designs for dose finding studies

We consider the problem of how to efficiently and safely design dose finding studies. Both current and novel utility functions are explored using Bayesian adaptive design methodology for the estimation of a maximum tolerated dose (MTD). In particular, we explore widely adopted approaches such as the continual reassessment method and minimizing the variance of the estimate of an MTD. New utility functions are constructed in the Bayesian framework and are evaluated against current approaches. To reduce computing time, importance sampling is implemented to re-weight posterior samples thus avoiding the need to draw samples using Markov chain Monte Carlo techniques. Further, as such studies are generally first-in-man, the safety of patients is paramount. We therefore explore methods for the incorporation of safety considerations into utility functions to ensure that only safe and well-predicted doses are administered. The amalgamation of Bayesian methodology, adaptive design and compound utility functions is termed adaptive Bayesian compound design (ABCD). The performance of this amalgamation of methodology is investigated via the simulation of dose finding studies. The paper concludes with a discussion of results and extensions that could be included into our approach.     

Ambiguity in the Cross-Section of Expected Returns: An Empirical Assessment

This article estimates and tests the smooth ambiguity model of Klibanoff, Marinacci, and Mukerji based on stock market data. We introduce a novel methodology to estimate the conditional expectation, which characterizes the impact of a decision maker’s ambiguity attitude on asset prices. Our point estimates of the ambiguity parameter are between 25 and 60, whereas our risk aversion estimates are considerably lower. The substantial difference indicates that market participants are ambiguity averse. Furthermore, we evaluate if ambiguity aversion helps explaining the cross-section of expected returns. Compared with Epstein and Zin preferences, we find that incorporating ambiguity into the decision model improves the fit to the data while keeping relative risk aversion at more reasonable levels. Supplementary materials for this article are available online.     

Sensitivity analysis in statistical decision theory: A decision analytic view

Sensitivity analysis provides a way to mitigate traditional criticisms of Bayesian statistical decision theory, concerning dependence on subjective inputs. We suggest a general framework for sensitivity analysis allowing for perturbations in both the utility function and the prior distribution. Perturbations are constrained to classes modelling imprecision in judgements The framework discards first definitely bad alternatives; then, identifies alternatives that may share optimality with a current one; and, finally, detects least changes in the inputs leading to changes in ranking. The associated computational problems and their implementation are discussed.     

Asset Prices Under Habit Formation and Reference-Dependent Preferences

This article explains the high level and the countercyclical variation of the equity premium in a consumption-based asset pricing model with low large-scale risk aversion. Investors have gain-loss utility over consumption relative to slowly time-varying habit. Stocks deliver low returns in recessions when consumption falls below habit; investors therefore require a high premium for holding stocks. The model's conditional moment restrictions are tested on consumption and asset returns data. The empirical estimate of large-scale risk aversion is low, whereas the estimate of loss aversion agrees with prior experimental evidence.     

Efficient Bayesian sampling plans for exponential distributions with random censoring

This paper considers Bayesian sampling plans for exponential distribution with random censoring. The efficient Bayesian sampling plan for a general loss function is derived. This sampling plan possesses the property that it may make decisions prior to the end of the life test experiment, and its decision function is the same as the Bayes decision function which makes decisions based on data collected at the end of the life test experiment. Compared with the optimal Bayesian sampling plan of Chen et al. (2004), the efficient Bayesian sampling plan has the smaller Bayes risk due to the less duration time of life test experiment. Computations of the efficient Bayes risks for the conjugate prior are given. Numerical comparisons between the proposed efficient Bayesian sampling plan and the optimal Bayesian sampling plan of Chen et al. (2004) under two special decision losses, including the quadratic decision loss, are provided. Numerical results also demonstrate that the performance of the proposed efficient sampling plan is superior to that of the optimal sampling plan by Chen et al. (2004).     

Expected utility within a generalized concept of probability — a comprehensive framework for decision making under ambiguity

It has often been complained that the standard framework of decision theory is insufficient. In most applications, neither the maximin paradigm (relving on complete ignorance on the states of natures) nor the classical Bayesian paradigm (assuming perfect probabilistic information on the states of nature) reflect the situation under consideration adequately. Typically one possesses some, but incomplete, knowledge on the stochastic behaviour of the states of nature. In this paper first steps towards a comprehensive framework for decision making under such complex uncertainty will be provided. Common expected utility theory will be extended to interval probability, a generalized probabilistic setting which has the power to express incomplete stochastic knowledge and to take the extent of ambiguity (non-stochastic uncertainty) into account. Since two-monotone and totally monotone capacities are special cases of general interval probatility, wher Choquet integral and interval-valued expectation correspond to one another, the results also show, as a welcome by-product, how to deal efficiently with Choquet Expected Utility and how to perform a neat decision analysis in the case of belief functions. Received: March 2000; revised version: July 2001     

Verallgemeinerte bayes-verfahren bei sequentiellen testproblemen

In this paper, problems of sequential decision theory are taken into consideration by extending the definition of the BAYES rule and treating BAYES rules. This generalisation is quite useful for practice. In many cases only BAYES rules can be calculated. The conditions under which such sequential decision procedures exist are demonstrated, as well as how to construct them on a scheme of backward induction resulting in the conclusion that the existence of BAYES rules needs essentially weaker assumptions than the existence of BAYES rules.Futhermore, methods are searched to simplify the construction of optimal stopping rules. Some illustrative examples are given.     

Marginal Likelihood Estimation with the Cross-Entropy Method

We consider an adaptive importance sampling approach to estimating the marginal likelihood, a quantity that is fundamental in Bayesian model comparison and Bayesian model averaging. This approach is motivated by the difficulty of obtaining an accurate estimate through existing algorithms that use Markov chain Monte Carlo (MCMC) draws, where the draws are typically costly to obtain and highly correlated in high-dimensional settings. In contrast, we use the cross-entropy (CE) method, a versatile adaptive Monte Carlo algorithm originally developed for rare-event simulation. The main advantage of the importance sampling approach is that random samples can be obtained from some convenient density with little additional costs. As we are generating independent draws instead of correlated MCMC draws, the increase in simulation effort is much smaller should one wish to reduce the numerical standard error of the estimator. Moreover, the importance density derived via the CE method is grounded in information theory, and therefore, is in a well-defined sense optimal. We demonstrate the utility of the proposed approach by two empirical applications involving women's labor market participation and U.S. macroeconomic time series. In both applications, the proposed CE method compares favorably to existing estimators.     

Clinical utility estimation for assay cutoffs in early phase oncology enrichment trials

Predictive enrichment strategies use biomarkers to selectively enroll oncology patients into clinical trials to more efficiently demonstrate therapeutic benefit. Because the enriched population differs from the patient population eligible for screening with the biomarker assay, there is potential for bias when estimating clinical utility for the screening eligible population if the selection process is ignored. We write estimators of clinical utility as integrals averaging regression model predictions over the conditional distribution of the biomarker scores defined by the assay cutoff and discuss the conditions under which consistent estimation can be achieved while accounting for some nuances that may arise as the biomarker assay progresses toward a companion diagnostic. We outline and implement a Bayesian approach in estimating these clinical utility measures and use simulations to illustrate performance and the potential biases when estimation naively ignores enrichment. Results suggest that the proposed integral representation of clinical utility in combination with Bayesian methods provide a practical strategy to facilitate cutoff decision‐making in this setting. Copyright © 2015 John Wiley & Sons, Ltd.     

Bayesian randomized clinical trials: A decision‐theoretic sequential design

The authors propose a Bayesian decision‐theoretic framework justifying randomization in clinical trials. Noting that the decision maker is often unable or unwilling to specify a unique utility function, they develop a sequential myopic design that includes randomization justified by the consideration of a set of utility functions. Randomization is introduced over all nondominated treatments, allowing for interim removal of treatments and early stopping. The authors illustrate their approach in the context of a study to find the optimal dose of pegylated interferon for platinum resistant ovarian cancer. They also develop an algorithm to implement their methodology in a phase II clinical trial comparing several competing experimental treatments.     

Curtailed Bayesian sampling plans for exponential distributions based on Type-II censored samples

This paper studies the problem of designing a curtailed Bayesian sampling plan (CBSP) with Type-II censored data. We first derive the Bayesian sampling plan (BSP) for exponential distributions based on Type-II censored samples in a general loss function. For the conjugate prior with quadratic loss function, an explicit expression for the Bayes decision function is derived. Using the property of monotonicity of the Bayes decision function, a new Bayesian sampling plan modified by the curtailment procedure, called a CBSP, is proposed. It is shown that the risk of CBSP is less than or equal to that of BSP. Comparisons among some existing BSPs and the proposed CBSP are given. Monte Carlo simulations are conducted, and numerical results indicate that the CBSP outperforms those early existing sampling plans if the time loss is considered in the loss function.     

Semi-supervised Bayesian adaptive multiresolution shrinkage for wavelet-based denoising

We can use wavelet shrinkage to estimate a possibly multivariate regression function g under the general regression setup, y = g + ε. We propose an enhanced wavelet-based denoising methodology based on Bayesian adaptive multiresolution shrinkage, an effective Bayesian shrinkage rule in addition to the semi-supervised learning mechanism. The Bayesian shrinkage rule is advanced by utilizing the semi-supervised learning method in which the neighboring structure of a wavelet coefficient is adopted and an appropriate decision function is derived. According to decision function, wavelet coefficients follow one of two prespecified Bayesian rules obtained using varying related parameters. The decision of a wavelet coefficient depends not only on its magnitude, but also on the neighboring structure on which the coefficient is located. We discuss the theoretical properties of the suggested method and provide recommended parameter settings. We show that the proposed method is often superior to several existing wavelet denoising methods through extensive experimentation.     

An adaptive approach to compound multiple decisions

We will investigate a multiple decision problem (m.d.p.). In particular, situations in which a number of related m.d.p. ’s are to be analyzed simultaneously, called the compound multiple decision problem (c.m.d.p.), are considered.

Within the Bayesian framework the usual assumption that the random parameter vector is a random sample from some distribution is modified. An adaptive analysis of the resulting c.m.d.p. is discussed. This discussion includes a simulation of a compound test of normal means where an adaptive (empirical Bayes) rule is analyzed as well as a simulation of a compound selection problem. An illustration considering yields of 7 corn varieties at each of 6 test sites is given.     

Adaptive designs for selecting drug combinations based on efficacy–toxicity response

We propose a new adaptive procedure for dose-finding in clinical trials with combination of two drugs when both efficacy and toxicity responses are available. We model the distribution of this bivariate binary endpoint using the bivariate probit model. The analytic formulae for the Fisher information matrix are obtained, that form the basis for derivation of the locally optimal, minimax, Bayesian, and adaptive designs in the framework of optimal design theory.     

Optimal two-stage group-sequential designs

We derive optimal two-stage adaptive group-sequential designs for normally distributed data which achieve the minimum of a mixture of expected sample sizes at the range of plausible values of a normal mean. Unlike standard group-sequential tests, our method is adaptive in that it allows the group size at the second look to be a function of the observed test statistic at the first look. Using optimality criteria, we construct two-stage designs which we show have advantage over other popular adaptive methods. The employed computational method is a modification of the backward induction algorithm applied to a Bayesian decision problem.     

On optimal tests for general interval-hypotheses

Optimal statistical tests, using the normality assumptions for general interval hypotheses including equivalence testing and testing for nonzero difference (or for non-unit) are presented. These tests are based on the decision theory for Polya Type distributions and are compared with usual confidence tests and with ’two one-sided tests’- procedures. A formal relationship between some optimal tests and the Anderson and Hauck procedure as well as a procedure recommended by Patel and Gupta is given. A new procedure for a generalisation of Student's test as well as for equivalence testing for thet-statistics is shown.     

Statistical Properties of Model-Based Signal Extraction Diagnostic Tests

The problem of choosing the loss function in the Bayesian problem of many hypotheses testing is considered. It is shown that linear and quadratic loss functions are the most-used ones. For any kind of loss function, the risk function in the Bayesian problem of many hypotheses testing contains the errors of two kinds. The Bayesian decision rule minimizes the total effect of these errors. The share of each of them in the optimal value of risk function is unknown. When solving many important problems, the results caused by different errors significantly differ from each other. Therefore, it is necessary to guarantee the limitation on the most undesirable kind of these errors and to minimize the errors of the second kind. For solving these problems, this article are states and solves conditional Bayesian tasks of testing many hypotheses. The results of sensitivity analysis of the classical and conditional Bayesian problems are given and their advantages and drawbacks are considered.