Ordered Tests for Right–Censored Survival Data

In comparative clinical trials or animal carcinogenesis studies, the effect of increasing dose levels of an agent or an increasing number of additional modalities are frequently evaluated on the prolonged survival time of patients with a particular disease. It is of particular interest to test the ordered alternative that a treatment level increase leads to better survival. This paper considers an ordered test based on the two–sample weighted Kaplan–Meier statistics (Pepe & Fleming, 1989, 1991). It evaluates asymptotic relative efficiencies of the proposed ordered weighted Kaplan–Meier test, the competing ordered weighted logrank test (Liu et al., 1993) and modified ordered logrank test (Liu & Tsai, 1999) under Lehmann alternatives, for various piecewise exponential survival distributions. Finally, it demonstrates the proposed test on an appropriate dataset.     

Unmasking the Trend Sought by Jonckheere-Type Tests for Right-Censored Data

Medical and epidemiological studies often involve groups of subjects associated with increasing levels of exposure to a risk factor. Survival of the groups is expected to follow the same order as the level of exposure. Formal tests for this trend fall into the regression framework if one knows what function of exposure to use as a covariate. When unknown, a linear function of exposure level is often used. Jonckheere-type tests for trend have generated continued interest largely because they do not require specification of a covariate. This paper shows that the Jonckheere-type test statistics are special cases of a generalized linear rank statistic with time-dependent covariates which unfortunately depend on the initial group sizes and censoring distributions. Using asymptotic relative efficiency calculations, the Jonckheere tests are compared to standard linear rank tests based on a linear covariate over a spectrum of shapes for the true trend.     

Adaptively combining independent jonckheere statistics in a randomized block design with unequal scales

Jonckheere (1954) proposed a test statistic which is commonly used in testing for ordered alternatives in block designs.- We consider the application of Jonckheere's test statistic in block designs which have unequal scale parameters for the blocks. Estimates of the unknown scale parameters ar-fcrmed and are used to construct a modification of Jonckheere's test statistic using adaptive ideas. A Monte Carlo study shows that the modified Jonckheere is significantly more powerful than the original Jonckheere in many unequal scale situations.     

A rank test for stochastically ordered alternatives

A rank test based on the number of ‘near-matches’ among within-block rankings is proposed for stochastically ordered alternatives in a randomized block design with t treatments and b blocks. The asymptotic relative efficiency of this test with respect to the Page test is computed as number of blocks increases to infinity. A sequential analog of the above test procedure is also considered. A repeated significance test procedure is developed and average sample number is computed asymptotically under the null hypothesis as well as under a sequence of contiguous alternatives.     

Designing completely randomized experiments to detect ordered treatment effects: an empirical study

In designing experiments the researcher frequently must decide as to how to allocate fixed resources among k factor levels (Cox (1958)). This study investigates the effects on the power of a test caused by changes in: the sample size (n); the number of factor levels (k); the allocation of fixed total observations (N) among k and n: the shift parameter (ø); the type of parent population sampled; and, the type of ordered location alternative involved. Using Monte Carlo methods the powers of eight test procedures specifically devised to detect ordered treatment effects under completely randomized designs were evaluated along with those of the more general one-way F test. The results are of interest to researchers in all fields of application.     

The costs of using incomplete response data for the exponential regression model

This paper investigates the asymptotic and small sample costs of using incomplete response data, Situations are identified where the information loss is substantial, Moreover, the small sample properties of the estimators are even worse than suggested by their asymptotic counterparts. These results provide the practitioner with guidance as to the severity of the costs he can incur, This is especially helpful when he cars choose the type of incomplete data that he observes.     

The Two-interval Line-segment Problem

In this paper we define and study the non-parametric maximum likelihood estimator (NPMLE) in the one-dimensional line-segment problem, where we observe line-segments on the real line through an interval with a gap which is smaller than the two remaining intervals. We define the self-consistency equations for the NPMLE and provide a quick algorithm for solving them. We prove supremum norm weak convergence to a Gaussian process and efficiency of the NPMLE. The problem has a geological application in the study of the lifespan of species     

Book Reviews

Books reviewed:
R.R. Peck, L.D. Haugh and A. Goodman; Statistical Case Studies. A Collaboration between Academe and Industry
Christian Gouriéroux;ARCH Models and Financial Applications
E.L. Lehmann;Elements of Large-Sample Theory
R.B. Schinazi; Classical and Spatial Stochastic Processes     

Relative efficiency of a censored experiment in terms of fisher information matrix

Fisher information matrix is used to quantify information loss in the randomly right-censored model, A real value approach alternative to the matrix approach of Turrero (1988) is presented for obtaining real valued measures of the relative efficiency of the censored experiment. Properties of the proposed measures are examined. The connection between both approaches and the Bayesian approach to this problem is also studied. Results in the paper are exemplified by considering grouped survival data.     

Inefficiency of inferences with the partial likelihood

In two-sample semiparametric survival models other than the Cox proportional-hazards regression model, it is shown that partial-likelihood inference of structural parameters in the presence of fully nonpararnetric nuisance-hazards typically has relative efficiency zero compared with fuii-Iikelihood infer -ence. The practical Interpretation of efficiencies in the pres-ence of infinite-dimensional nuisance-parameters is discussed, with reference to two important examples, namely a recent sur-vival regression-model of Clayton and Cuzick and a class of additive excess-risk models. Under the excess-risk models, a formula is derived for the large-sample information [which here is the same as the limiting Fisher information when the nuisance-parameter dimension gets large] for estimating the parameter of difference between two samples, as the nuisance function becomes fully nonpararnetric.     

Guarded Weights of Evidence and Acceptability Profiles Based on Signs: II. Asymptotic Results

The concepts of guarded weights of evidence and acceptability profiles have been extended to the distribution-free setting in Dollinger, Kulinskaya & Staudte (1999). In that first of two parts the advantages of these concepts relative to traditional ones such as p -values and confidence intervals derived from hypothesis tests are emphasized for small samples. Here in Part II asymptotic expressions are found for guarded weights of evidence for hypothesesregarding the median of a symmetric distribution and related acceptability profiles for the median. It is also seen that for local alternatives the efficacy and Pitman asymptotic relative efficiency of the sign statistic for testing hypotheses carries over to the more general setting of guarded weights of evidence.     

Asymptotic normality of kernel estimators based upon incomplete data

In this paper, we are concerned with nonparametric estimation of the density and the failure rate functions of a random variable X which is at risk of being censored. First, we establish the asymptotic normality of a kernel density estimator in a general censoring setup. Then, we apply our result in order to derive the asymptotic normality of both the density and the failure rate estimators in the cases of right, twice and doubly censored data. Finally, the performance and the asymptotic Gaussian behaviour of the studied estimators, based on either doubly or twice censored data, are illustrated through a simulation study.     

Book Reviews

Books reviewed:
Janice Derr, Statistical Consulting: A Guide to Effective Communication
Helmet Lütkepohl, Handbook of Matrices
J.Y. Campbell, A.W. Lo & A.C. MacKinlay, The Econometrics of Financial Markets
Bo-Cheng Wei, Exponential Family Nonlinear Models
V. Ionescu & N. Limnios (eds.), Statistical and Probabilistic Models in Reliability
M. Bramson & R. Durrett (eds.), Perplexing Problems in Probability: Festschrift in Honor of Harry Kesten
John I. Marden, Analysing and Modeling Rank Data     

On the Gini Mean Difference Test for Circular Data

We introduce a new test of isotropy or uniformity on the circle, based on the Gini mean difference of the sample arc-lengths and obtain both the exact and asymptotic distributions under the null hypothesis of circular uniformity. We also provide a table of upper percentile values of the exact distribution for small to moderate sample sizes. Illustrative examples in circular data analysis are also given. It is shown that a “generalized” Gini mean difference test has better asymptotic efficiency than a corresponding “generalized” Rao's test in the sense of Pitman asymptotic relative efficiency.     

Augmenting lehmann alternatives for improving asymptotic efficiency of rank tests

Locally most powerful tests for augmented simple Lehmann alternatives are obtained. These tests turn out to be linearcombinations of the Savage and Mann-Whitney-Wilcoxon test criteria. We study their performance in terms of the asymptotic efficiency relative to their parametric competitors against location and scale alternatives. For small sample sizes, critical points of a couple of test procedures are given.     

Book Reviews

Books reviewed:
David Griffiths, W. Douglas Stirling, and K. Laurence Weldon, Understanding Data: Principles and Practice of Statistics
Ingwer Borg and Patrick Groenen, Modern Multidimensional Scaling: Theory and Applications
Jeffrey H. Dorfman, Bayesian Economics Through Numerical Methods: A Guide to Econometrics and Decision-making with Prior Information
Marek Musiela and Marek Rutkowski, Martingale Methods in Financial Modelling: Theory and Applications
Aad W. van der Vaart and Jon A. Wellner, Weak Convergence and Empirical Processes     

On testing exponentiality against new better than used of specified age

R.M. Hollander, D.H. Park and F. Proschan [A class of life distributions for aging, J. Amer. Statist. Assoc. 81 (1986) 91–95] introduced the concept of the larger class of life distributions called new better than used of specified age. In practice, one might be interested in the new better than used behaviour at an unknown but estimable age t₀. Here, we investigate the testing of new better than used of specified age t₀ (NBU-t₀) alternatives. A class of test statistics for testing NBU-t₀ (t₀ is known) based on a U-statistic whose kernel depends on sub-sample minima is proposed. A member of the class of tests proposed by N. Ebrahimi and M. Habbibullah [Testing whether the survival distribution is new better than used of specified age, Biometrika 77 (1990) 212–215] for this problem belongs to the class of tests proposed here. The distributional properties of the class of test statistics are studied. The performances of a few members of the proposed class of tests are studied in terms of Pitman asymptotic relative efficiency. The Pitman ARE values show that the members of the class perform well in comparison with the N. Ebrahimi and M. Habbibullah [Testing whether the survival distribution is new better than used of specified age, Biometrika 77 (1990) 212–215] tests. The proposed class of tests is shown to be consistent for NBU-t₀ alternatives.     

Combining the t test and Wilcoxon's rank-sum test

In the two-sample location-shift problem, Student's t test or Wilcoxon's rank-sum test are commonly applied. The latter test can be more powerful for non-normal data. Here, we propose to combine the two tests within a maximum test. We show that the constructed maximum test controls the type I error rate and has good power characteristics for a variety of distributions; its power is close to that of the more powerful of the two tests. Thus, irrespective of the distribution, the maximum test stabilizes the power. To carry out the maximum test is a more powerful strategy than selecting one of the single tests. The proposed test is applied to data of a clinical trial.     

Least Squares estimation for the multivariate weibull model of bougaard based on accelerated life test of system and component

Accelerated life testing of products quickly yields information on life. In this article, we present a simple method to incorporate the information collected from accelerated life tests of both components and (series) systems. The multivariate Weibull distribution of Hougaard is applied to model lifetimes of components. Least-squares (LS) estimators of the model parameters and their joint asymptotic distribution are derived. The effects of the dependence parameter and the proportion of the system-data to the asymptotic relative efficiencies of the LS estimators are investigated.     

The two-sample problem with multivariate censored data: a new rank test family

A new rank test family is proposed to test the equality of two multivariate failure times distributions with censored observations. The tests are very simple: they are based on a transformation of the multivariate rank vectors to a univariate rank score and the resulting statistics belong to the familiar class of the weighted logrank test statistics. The new procedure is also applicable to multivariate observations in general, such as repeated measures, some of which may be missing. To investigate the performance of the proposed tests, a simulation study was conducted with bivariate exponential models for various censoring rates. The size and power of these tests against Lehmann alternatives were compared to the size and power of two other tests (Wei and Lachin, 1984 and Wei and Knuiman, 1987). In all simulations the new procedures provide a relatively good power and an accurate control over the size of the test. A real example from the National Cooperative Gallstone Study is given