Variance estimation of DEE and regression estimator when a first-phase cluster sample is restratified

We consider a variance estimation when a stratified single stage cluster sample is selected in the first phase and a stratified simple random element sample is selected in the second phase. We propose explicit formulas of (asymptotically), we propose explicit formulas of (asymptotically) unbiased variance estimators for the double expansion estimator and regression estimator. We perform a small simulation study to investigate the performance of the proposed variance estimators. In our simulation study, the proposed variance estimator showed better or comparable performance to the Jackknife variance estimator. We also extend the results to a two-phase sampling design in which a stratified pps with replacement cluster sample is selected in the first phase.     

VARIANCE ESTIMATION IN TWO-PHASE SAMPLING

Two‐phase sampling is often used for estimating a population total or mean when the cost per unit of collecting auxiliary variables, x, is much smaller than the cost per unit of measuring a characteristic of interest, y. In the first phase, a large sample s₁ is drawn according to a specific sampling design p(s₁) , and auxiliary data x are observed for the units i∈s₁ . Given the first‐phase sample s₁ , a second‐phase sample s₂ is selected from s₁ according to a specified sampling design {p(s₂∣s₁) } , and (y, x) is observed for the units i∈s₂ . In some cases, the population totals of some components of x may also be known. Two‐phase sampling is used for stratification at the second phase or both phases and for regression estimation. Horvitz–Thompson‐type variance estimators are used for variance estimation. However, the Horvitz–Thompson ( Horvitz & Thompson, J. Amer. Statist. Assoc. 1952 ) variance estimator in uni‐phase sampling is known to be highly unstable and may take negative values when the units are selected with unequal probabilities. On the other hand, the Sen–Yates–Grundy variance estimator is relatively stable and non‐negative for several unequal probability sampling designs with fixed sample sizes. In this paper, we extend the Sen–Yates–Grundy ( Sen , J. Ind. Soc. Agric. Statist. 1953; Yates & Grundy , J. Roy. Statist. Soc. Ser. B 1953) variance estimator to two‐phase sampling, assuming fixed first‐phase sample size and fixed second‐phase sample size given the first‐phase sample. We apply the new variance estimators to two‐phase sampling designs with stratification at the second phase or both phases. We also develop Sen–Yates–Grundy‐type variance estimators of the two‐phase regression estimators that make use of the first‐phase auxiliary data and known population totals of some of the auxiliary variables.     

Blinded sample size re‐estimation in superiority and noninferiority trials: bias versus variance in variance estimation

The internal pilot study design allows for modifying the sample size during an ongoing study based on a blinded estimate of the variance thus maintaining the trial integrity. Various blinded sample size re‐estimation procedures have been proposed in the literature. We compare the blinded sample size re‐estimation procedures based on the one‐sample variance of the pooled data with a blinded procedure using the randomization block information with respect to bias and variance of the variance estimators, and the distribution of the resulting sample sizes, power, and actual type I error rate. For reference, sample size re‐estimation based on the unblinded variance is also included in the comparison. It is shown that using an unbiased variance estimator (such as the one using the randomization block information) for sample size re‐estimation does not guarantee that the desired power is achieved. Moreover, in situations that are common in clinical trials, the variance estimator that employs the randomization block length shows a higher variability than the simple one‐sample estimator and in turn the sample size resulting from the related re‐estimation procedure. This higher variability can lead to a lower power as was demonstrated in the setting of noninferiority trials. In summary, the one‐sample estimator obtained from the pooled data is extremely simple to apply, shows good performance, and is therefore recommended for application. Copyright © 2013 John Wiley & Sons, Ltd.     

Efficient estimators for adaptive stratified sequential sampling

In stratified sampling, methods for the allocation of effort among strata usually rely on some measure of within-stratum variance. If we do not have enough information about these variances, adaptive allocation can be used. In adaptive allocation designs, surveys are conducted in two phases. Information from the first phase is used to allocate the remaining units among the strata in the second phase. Brown et al. [Adaptive two-stage sequential sampling, Popul. Ecol. 50 (2008), pp. 239–245] introduced an adaptive allocation sampling design – where the final sample size was random – and an unbiased estimator. Here, we derive an unbiased variance estimator for the design, and consider a related design where the final sample size is fixed. Having a fixed final sample size can make survey-planning easier. We introduce a biased Horvitz–Thompson type estimator and a biased sample mean type estimator for the sampling designs. We conduct two simulation studies on honey producers in Kurdistan and synthetic zirconium distribution in a region on the moon. Results show that the introduced estimators are more efficient than the available estimators for both variable and fixed sample size designs, and the conventional unbiased estimator of stratified simple random sampling design. In order to evaluate efficiencies of the introduced designs and their estimator furthermore, we first review some well-known adaptive allocation designs and compare their estimator with the introduced estimators. Simulation results show that the introduced estimators are more efficient than available estimators of these well-known adaptive allocation designs.     

Non-parametric Estimation of a Survival Function with Two-stage Design Studies

Abstract.  The two-stage design is popular in epidemiology studies and clinical trials due to its cost effectiveness. Typically, the first stage sample contains cheaper and possibly biased information, while the second stage validation sample consists of a subset of subjects with accurate and complete information. In this paper, we study estimation of a survival function with right-censored survival data from a two-stage design. A non-parametric estimator is derived by combining data from both stages. We also study its large sample properties and derive pointwise and simultaneous confidence intervals for the survival function. The proposed estimator effectively reduces the variance and finite-sample bias of the Kaplan–Meier estimator solely based on the second stage validation sample. Finally, we apply our method to a real data set from a medical device postmarketing surveillance study.     

Efficient estimation of the PDF and the CDF of the inverse Rayleigh distribution

In this paper, we consider the estimation of the probability density function and the cumulative distribution function of the inverse Rayleigh distribution. In this regard, the following estimators are considered: uniformly minimum variance unbiased estimator, maximum likelihood (ML) estimator, percentile estimator, least squares estimator and weighted least squares estimator. To do so, analytical expressions are derived for the mean integrated squared error. As the result of simulation studies and real data applications indicate, when the sample size is not very small the ML estimator performs better than the others.     

抽样调查中基于平衡样本的稳健预测

抽样调查中基于模型推断方法获得的估计量性质是依赖于模型的。在恰当的模型下比率估计和扩张估计是最优线性无偏估计。当模型设定错误时,比率估计和扩张估计是有偏估计,但如果样本是平衡的,可以消除偏倚,从而实现了复杂问题简单处理的思想。     

Second-order variance estimation in poststratified two-stage sampling

The linearization or Taylor series variance estimator and jackknife linearization variance estimator are popular for poststratified point estimators. In this note we propose a simple second-order linearization variance estimator for the poststratified estimator of the population total in two-stage sampling, using the second-order Taylor series expansion. We investigate the properties of the proposed variance estimator and its modified version and their empirical performance through some simulation studies in comparison to the standard and jackknife linearization variance estimators. Simulation studies are carried out on both artificially generated data and real data.     

Proportion estimation in mixtures with covariates

Linear maps of a single unclassified observation are used to estimate the mixing proportion in a mixture of two populations with homogeneous variances in the presence of covariates. with complete knowledge of the parameters of the individual populations, the linear map for which the estimator is unbiased and has minimum variance amongst all similar estimators can be determined. Plug-in estimator based on independent training samples from the component populations can be constructed and is asymptotically equivalent to Cochran's classification statistic V* for covariate classification; see Memon and Okamoto (1970). Under normality assumptions, asymptotic expansion of the distribution of the plug-in estimator is available. In the absence of covariates, our estimator reduces to that suggested by Walker (1980) who has investigated the problem based on information on large unclassified samples from a mixture of two populations with heterogeneous variances. In contrast, distribution of Walker's estimator seems intractable in moderate sample sizes even with normality assumption.     

Improved estimators for the location of double exponential distribution

In this paper, attention is focused on estimation of the location parameter in the double exponential case using a weighted linear combination of the sample median and pairs of order statistics, with symmetric distance to both sides from the sample median. Minimizing with respect to weights and distances we get smaller asymptotic variance in the second order. If the number of pairs is taken as infinite and the distances as null we attain the least asymptotic variance in this class of estimators. The Pitman estimator is also noted. Similarly improved estimators are scanned over their probability of concentration to investigate its bound. Numerical comparison of the estimators is shown.     

Semiparametric efficient estimation for the auxiliary outcome problem with the conditional mean model

The authors consider semiparametric efficient estimation of parameters in the conditional mean model for a simple incomplete data structure in which the outcome of interest is observed only for a random subset of subjects but covariates and surrogate (auxiliary) outcomes are observed for all. They use optimal estimating function theory to derive the semiparametric efficient score in closed form. They show that when covariates and auxiliary outcomes are discrete, a Horvitz‐Thompson type estimator with empirically estimated weights is semiparametric efficient. The authors give simulation studies validating the finite‐sample behaviour of the semiparametric efficient estimator and its asymptotic variance; they demonstrate the efficiency of the estimator in realistic settings.     

人口数目估计中的独立双系统估计量研究

利用存在统计相依关系的两份人口登记名单构造的非独立双系统估计量是目前估计总体实际人口数的前沿方法。该估计量由最初用于估计一个区域内的野生动物数目的捕获-再捕获模型移植而来。非独立双系统估计量的一个明显缺陷是低估总体实际人口数。用独立双系统估计量替代非独立双系统估计量属于人口数目估计领域的理论创新研究。采用数理分析与实证分析相结合的方法研究独立双系统估计量及其方差估计量。为便于读者理解,通过一个实证案例全面演示了独立双系统估计量的计算过程。研究表明,独立双系统估计量所估计的人口数平均接近于实际人口数,建议在未来人口数目估计中应用独立双系统估计量。     

Estimation of the slope in linear non-normal structural relationships

This paper studies the sensitivity to nonnormality of the normal-theory test for the null hypothesis that the slope is a specific value against a two-sided alternative. Edgeworth expansion and thus the asymptotic variance for the normal-theory maximum likelihood estimator of the slope are derived.     

Sample size re‐estimation incorporating prior information on a nuisance parameter

Prior information is often incorporated informally when planning a clinical trial. Here, we present an approach on how to incorporate prior information, such as data from historical clinical trials, into the nuisance parameter–based sample size re‐estimation in a design with an internal pilot study. We focus on trials with continuous endpoints in which the outcome variance is the nuisance parameter. For planning and analyzing the trial, frequentist methods are considered. Moreover, the external information on the variance is summarized by the Bayesian meta‐analytic‐predictive approach. To incorporate external information into the sample size re‐estimation, we propose to update the meta‐analytic‐predictive prior based on the results of the internal pilot study and to re‐estimate the sample size using an estimator from the posterior. By means of a simulation study, we compare the operating characteristics such as power and sample size distribution of the proposed procedure with the traditional sample size re‐estimation approach that uses the pooled variance estimator. The simulation study shows that, if no prior‐data conflict is present, incorporating external information into the sample size re‐estimation improves the operating characteristics compared to the traditional approach. In the case of a prior‐data conflict, that is, when the variance of the ongoing clinical trial is unequal to the prior location, the performance of the traditional sample size re‐estimation procedure is in general superior, even when the prior information is robustified. When considering to include prior information in sample size re‐estimation, the potential gains should be balanced against the risks.     

A consistent simulation-based estimator in generalized linear mixed models

We propose a strongly root-n consistent simulation-based estimator for the generalized linear mixed models. This estimator is constructed based on the first two marginal moments of the response variables, and it allows the random effects to have any parametric distribution (not necessarily normal). Consistency and asymptotic normality for the proposed estimator are derived under fairly general regularity conditions. We also demonstrate that this estimator has a bounded influence function and that it is robust against data outliers. A bias correction technique is proposed to reduce the finite sample bias in the estimation of variance components. The methodology is illustrated through an application to the famed seizure count data and some simulation studies.     

Variance Estimation under Two‐Phase Sampling

We consider the variance estimation of the weighted likelihood estimator (WLE) under two‐phase stratified sampling without replacement. Asymptotic variance of the WLE in many semiparametric models contains unknown functions or does not have a closed form. The standard method of the inverse probability weighted (IPW) sample variances of an estimated influence function is then not available in these models. To address this issue, we develop the variance estimation procedure for the WLE in a general semiparametric model. The phase I variance is estimated by taking a numerical derivative of the IPW log likelihood. The phase II variance is estimated based on the bootstrap for a stratified sample in a finite population. Despite a theoretical difficulty of dependent observations due to sampling without replacement, we establish the (bootstrap) consistency of our estimators. Finite sample properties of our method are illustrated in a simulation study.     

On estimation of the PDF and CDF of the Lindley distribution

This article addresses two methods of estimation of the probability density function (PDF) and cumulative distribution function (CDF) for the Lindley distribution. Following estimation methods are considered: uniformly minimum variance unbiased estimator (UMVUE) and maximum likelihood estimator (MLE). Since the Lindley distribution is more flexible than the exponential distribution, the same estimators have been found out for the exponential distribution and compared. Monte Carlo simulations and a real data analysis are performed to compare the performances of the proposed methods of estimation.     

Variance estimation for the finite population distribution function with complete auxiliary information

The authors develop jackknife and analytical variance estimators for the estimator of Chambers & Dunstan (1986) and Rao, Kovar & Mantel (1990) of the finite population distribution function, using complete auxiliary information. They also describe the associated model and show the design consistency of the variance estimators, whose small‐sample performance is examined through a limited simulation study. They highlight the operational advantages of the jackknife in the model‐based setting of Chambers & Dunstan (1986) and its better conditional performance in the design‐based setting of Rao, Kovar & Mantel (1990).     

Variance reduction for kernel estimators in clustered/longitudinal data analysis

We develop a variance reduction method for the seemingly unrelated (SUR) kernel estimator of Wang (2003). We show that the quadratic interpolation method introduced in Cheng et al. (2007) works for the SUR kernel estimator. For a given point of estimation, Cheng et al. (2007) define a variance reduced local linear estimate as a linear combination of classical estimates at three nearby points. We develop an analogous variance reduction method for SUR kernel estimators in clustered/longitudinal models and perform simulation studies which demonstrate the efficacy of our variance reduction method in finite sample settings.