Bivariate symmetry tests for complete and competing risks data: a saddlepoint approach

A class of bivariate symmetry tests for complete data and competing risks data is considered. Saddlepoint approximation for the exact p-values of the underlying permutation distribution of these tests is derived. Several simulation studies are conducted to evaluate the performance of the saddlepoint approximation and the asymptotic approximation. The saddlepoint approximation was found to be highly accurate and superior to the asymptotic approximations in replicating the exact permutation significance.     

Saddlepoint <Emphasis Type="Italic">p</Emphasis>-values and confidence intervals for a class of two sample permutation tests for current status and panel count data

The current status and panel count data frequently arise from cancer and tumorigenicity studies when events currently occur. A common and widely used class of two sample tests, for current status and panel count data, is the permutation class. We manipulate the double saddlepoint method to calculate the exact mid-p-values of the underlying permutation distributions of this class of tests. Permutation simulations are replaced by analytical saddlepoint computations which provide extremely accurate mid-p-values that are exact for most practical purposes and almost always more accurate than normal approximations. The method is illustrated using two real tumorigenicity panel count data. To compare the saddlepoint approximation with the normal asymptotic approximation, a simulation study is conducted. The speed and accuracy of the saddlepoint method facilitate the calculation of the confidence interval for the treatment effect. The inversion of the mid-p-values to calculate the confidence interval for the mean rate of development of the recurrent event is discussed.     

Saddlepoint approximations for some models of circular data

In this article we provide saddlepoint approximations for some important models of circular data. The particularity of these saddlepoint approximations is that they do not require solving the saddlepoint equation iteratively, so their evaluation is immediate. We first give very accurate approximations to P-values, critical values and power functions for some optimal tests regarding the concentration parameter under wrapped symmetric α-stable and circular normal models. Then, we consider an approximation to the distribution of a projection of the two-dimensional Pearson random walk with exponential step sizes.     

Saddlepoint p-values for group of linear rank tests

Many nonparametric tests in one sample problem, matched pairs, and competingrisks under censoring have the same underlying permutation distribution. This article proposes a saddlepoint approximation to the exact p-values of these tests instead of the asymptotic approximations. The performance of the saddlepoint approximation is assessed by using simulation studies that show the superiority of the saddlepoint methods over the asymptotic approximations in several settings. The use of the saddlepoint to approximate the p-values of class of two sample tests under complete randomized design is also discussed.     

Log‐rank permutation tests for trend: saddlepoint p‐values and survival rate confidence intervals

Suppose p + 1 experimental groups correspond to increasing dose levels of a treatment and all groups are subject to right censoring. In such instances, permutation tests for trend can be performed based on statistics derived from the weighted log‐rank class. This article uses saddlepoint methods to determine the mid‐P‐values for such permutation tests for any test statistic in the weighted log‐rank class. Permutation simulations are replaced by analytical saddlepoint computations which provide extremely accurate mid‐P‐values that are exact for most practical purposes and almost always more accurate than normal approximations. The speed of mid‐P‐value computation allows for the inversion of such tests to determine confidence intervals for the percentage increase in mean (or median) survival time per unit increase in dosage. The Canadian Journal of Statistics 37: 5‐16; 2009 © 2009 Statistical Society of Canada     

Saddlepoint Approximations for Stopped-Sum Distributions

One of the common used classes of distributions is the stopped-sum class. This class includes Hermite distribution, Polya–Aeppli distribution, Poisson-Gamma distribution, and Neyman type A. This article introduces the saddlepoint approximations to the stopped-sum class in continuous and discrete settings. We discuss approximations for mass/density and cumulative distribution functions of stopped-sum distributions. Examples of continuous and discrete distributions from the Poisson stopped-sum class are presented. Comparisons between saddlepoint approximations and the exact calculations show the great accuracy of the saddlepoint methods.     

Saddlepoint Approximations for the Difference of Order Statistics and Studentized Sample Quantiles

For a sample from a given distribution the difference of two order statistics and the Studentized quantile are statistics whose distribution is needed to obtain tests and confidence intervals for quantiles and quantile differences. This paper gives saddlepoint approximations for densities and saddlepoint approximations of the Lugannani–Rice form for tail probabilities of these statistics. The relative errors of the approximations are n ⁻¹ uniformly in a neighbourhood of the parameters and this uniformity is global if the densities are log-concave.     

The weighted log-rank class under truncated binomial design: saddlepoint p-values and confidence intervals

The randomization design used to collect the data provides basis for the exact distributions of the permutation tests. The truncated binomial design is one of the commonly used designs for forcing balance in clinical trials to eliminate experimental bias. In this article, we consider the exact distribution of the weighted log-rank class of tests for censored data under the truncated binomial design. A double saddlepoint approximation for p-values of this class is derived under the truncated binomial design. The speed and accuracy of the saddlepoint approximation over the normal asymptotic facilitate the inversion of the weighted log-rank tests to determine nominal 95% confidence intervals for treatment effect with right censored data.     

Approximate and estimated saddlepoint approximations

Classical saddlepoint methods, which assume that the cumulant generating function is known, result in an approximation to the distribution that achieves an error of order O(n^?1). The authors give a general theorem to address the accuracy of saddlepoint approximations in which the cumulant generating function has been estimated or approximated. In practice, the resulting saddlepoint approximations are typically of the order O(n^?1/2). The authors give simulation results for small sample examples to compare estimated saddlepoint approximations.     

Saddlepoint density and distribution functions for the ratio of two linear functions and the product of generalized gamma variates

The generalized gamma distribution is a flexible and attractive distribution because it incorporates several well-known distributions, i.e., gamma, Weibull, Rayleigh, and Maxwell. This article derives saddlepoint density and distribution functions for the ratio of two linear functions of generalized gamma variables and the product of n independent generalized gamma variables. Simulation studies are used to evaluate the accuracy of the saddlepoint approximations. The saddlepoint approximations are fast, easy, and very accurate.     

Saddlepoint approximations for subordinator processes

ABSTRACT

We develop the saddlepoint approximations in obtaining the transition functions for general subordinator processes. We derive explicit expressions of the first- and second-order approximations. Specifically, we consider some particular classes of subordinators including the Poisson processes, the Gamma processes, the α-stable subordinators, and the Poisson random integrals. We test this technique on the Poisson and Gamma processes, which have closed-form transition functions. Outcomes show that the approximate expressions are consistent with the true transition functions. We then use this method to predict transition density functions for the α-stable subordinator processes. Finally, we calculate approximated transition densities for some Poisson random integrations. Numerical analysis shows the perfect ability of the saddlepoint approximations to predict the transition densities of the α-stable processes and the Poisson random integrations.     

A Practical Procedure to Find Matching Priors for Frequentist Inference

We present a practical way to find matching priors via the use of saddlepoint approximations and obtain p-values of tests of an interest parameter in the presence of nuisance parameters. The advantages of our procedure are the flexibility in choosing different initial conditions so that one may adjust the performance of a test, and the less intensive computational efforts compared to a Markov Chain Monto Carlo method.     

Saddlepoint Approximations to the Density and the Distribution Functions of Linear Combinations of Ratios of Partial Sums

A class of ratios of partial sums, including Normal, Weibull, Gamma, and Exponential distributions, is considered. The distribution of a linear combination of ratios of partial sums from this class is characterized by the distribution of a linear combination of Dirichlet components. This article presents two saddlepoint approaches to calculate the density and the distribution function for such a class of linear combinations. A simulation study is conducted to assess the performance of the saddlepoint methods and shows the great accuracy of the approximations over the usual asymptotic approximation. Applications of the presented approximations in statistical inferences are discussed.     

Saddlepoint approximations for nonlinear statistics

It is well known that saddlepoint expansions lead to accurate approximations to the cumulative distributions and densities of a sample mean and other simple linear statistics. The use of such expansions is explored in a broader situation. The saddlepoint formula for the tail probability of a certain type of nonlinear statistic is derived. The relative error of O(n^–1), as in the linear case, is retained. A simple example is considered, to illustrate the great accuracy of the approximation.     

General saddlepoint approximations and normalizing transformations for multivariate statistics

The use of general saddlepoint approximations is investigated for the problem of approximating the tail probabilities of statistics in multivariate analysis. A method based on normalizing transformations is proposed to prevent po¬tential deficiencies in general saddlepoint approximations. The efficiency of the proposed method is illustrated through examples of the sample correlation     

Practical small sample inference for single lag subset autoregressive models

We propose a method for saddlepoint approximating the distribution of estimators in single lag subset autoregressive models of order one. By viewing the estimator as the root of an appropriate estimating equation, the approach circumvents the difficulty inherent in more standard methods that require an explicit expression for the estimator to be available. Plots of the densities reveal that the distributions of the Burg and maximum likelihood estimators are nearly identical. We show that one possible reason for this is the fact that Burg enjoys the property of estimation equation optimality among a class of estimators expressible as a ratio of quadratic forms in normal random variables, which includes Yule–Walker and least squares. By inverting a two-sided hypothesis test, we show how small sample confidence intervals for the parameters can be constructed from the saddlepoint approximations. Simulation studies reveal that the resulting intervals generally outperform traditional ones based on asymptotics and have good robustness properties with respect to heavy-tailed and skewed innovations. The applicability of the models is illustrated by analyzing a longitudinal data set in a novel manner.     

An empirical saddlepoint approximation based method for smoothing survival functions under right censoring

The Kaplan–Meier (KM) estimator is ubiquitously used for estimating survival functions, but it provides only a discrete approximation at the observation times and does not deliver a proper distribution if the largest observation is censored. Using KM as a starting point, we devise an empirical saddlepoint approximation‐based method for producing a smooth survival function that is unencumbered by choice of tuning parameters. The procedure inverts the moment generating function (MGF) defined through a Riemann–Stieltjes integral with respect to an underlying mixed probability measure consisting of the discrete KM mass function weights and an absolutely continuous exponential right‐tail completion. Uniform consistency, and weak and strong convergence results are established for the resulting MGF and its derivatives, thus validating their usage as inputs into the saddlepoint routines. Relevant asymptotic results are also derived for the density and distribution function estimates. The performance of the resulting survival approximations is examined in simulation studies, which demonstrate a favourable comparison with the log spline method (Kooperberg & Stone, 1992) in small sample settings. For smoothing survival functions we argue that the methodology has no immediate competitors in its class, and we illustrate its application on several real data sets. The Canadian Journal of Statistics 47: 238–261; 2019 © 2019 Statistical Society of Canada     

Bayesian prediction of waiting times in stochastic models

The authors show how saddlepoint techniques lead to highly accurate approximations for Bayesian predictive densities and cumulative distribution functions in stochastic model settings where the prior is tractable, but not necessarily the likelihood or the predictand distribution. They consider more specifically models involving predictions associated with waiting times for semi‐Markov processes whose distributions are indexed by an unknown parameter θ. Bayesian prediction for such processes when they are not stationary is also addressed and the inverse‐Gaussian based saddlepoint approximation of Wood, Booth & Butler (1993) is shown to accurately deal with the nonstationarity whereas the normal‐based Lugannani & Rice (1980) approximation cannot, Their methods are illustrated by predicting various waiting times associated with M/M/q and M/G/1 queues. They also discuss modifications to the matrix renewal theory needed for computing the moment generating functions that are used in the saddlepoint methods.     

Saddlepoint Approximation for Sample Quantiles with Some Applications

In this article, we use the integral form of the binomial distribution to derive saddlepoint approximations for sample quantiles. As an application, we present the calculation of the tail probability of the empirical log-likelihood ratio statistic for quantiles. Simulation results are also given to show that our approximations are extremely accurate.     

Calculating the density and distribution function for the singly and doubly noncentral F

Simple, closed form saddlepoint approximations for the distribution and density of the singly and doubly noncentral F distributions are presented. Their overwhelming accuracy is demonstrated numerically using a variety of parameter values. The approximations are shown to be uniform in the right tail and the associated limitating relative error is derived. Difficulties associated with some algorithms used for exact computation of the singly noncentral F are noted.