A new test for high-dimensional regression coefficients in partially linear models

Partially linear regression models are semiparametric models that contain both linear and nonlinear components. They are extensively used in many scientific fields for their flexibility and convenient interpretability. In such analyses, testing the significance of the regression coefficients in the linear component is typically a key focus. Under the high-dimensional setting, i.e., “large p, small n,” the conventional F-test strategy does not apply because the coefficients need to be estimated through regularization techniques. In this article, we develop a new test using a U-statistic of order two, relying on a pseudo-estimate of the nonlinear component from the classical kernel method. Using the martingale central limit theorem, we prove the asymptotic normality of the proposed test statistic under some regularity conditions. We further demonstrate our proposed test's finite-sample performance by simulation studies and by analyzing some breast cancer gene expression data.     

Notes on two sample tests for partially correlated (paired) data

We provide several methods to compare two Gaussian distributed means in the two sample location problems under the assumption of partially dependent observations. Simulation studies indicate that our test procedure is frequently more powerful than other methods depending on the ratio of the unpaired data and the strength and direction of the correlation between the two variables. The tests used in our comparative study are illustrated with an example based on data from a small gynecological study.     

Generalized cochran-mantel-haenszel test statistics for correlated categorical data

Three new test statistics are introduced for correlated categorical data in stratified R×C tables. They are similar in form to the standard generalized Cochran-Mantel-Haenszel statistics but modified to handle correlated outcomes. Two of these statistics are asymptotically valid in both many-strata (sparse data) and large-strata limiting models. The third one is designed specifically for the many-strata case but is valid even with a small number of strata. This latter statistic is also appropriate when strata are assumed to be random.     

An extensive power evaluation of a novel two-sample density-based empirical likelihood ratio test for paired data with an application to a treatment study of attention-deficit/hyperactivity disorder and severe mood dysregulation

In many case-control studies, it is common to utilize paired data when treatments are being evaluated. In this article, we propose and examine an efficient distribution-free test to compare two independent samples, where each is based on paired observations. We extend and modify the density-based empirical likelihood ratio test presented by Gurevich and Vexler [7] to formulate an appropriate parametric likelihood ratio test statistic corresponding to the hypothesis of our interest and then to approximate the test statistic nonparametrically. We conduct an extensive Monte Carlo study to evaluate the proposed test. The results of the performed simulation study demonstrate the robustness of the proposed test with respect to values of test parameters. Furthermore, an extensive power analysis via Monte Carlo simulations confirms that the proposed method outperforms the classical and general procedures in most cases related to a wide class of alternatives. An application to a real paired data study illustrates that the proposed test can be efficiently implemented in practice.