On the lengths of t-based confidence intervals

Confidence interval is a basic type of interval estimation in statistics. When dealing with samples from a normal population with the unknown mean and the variance, the traditional method to construct t-based confidence intervals for the mean parameter is to treat the n sampled units as n groups and build the intervals. Here we propose a generalized method. We first divide them into several equal-sized groups and then calculate the confidence intervals with the mean values of these groups. If we define “better” in terms of the expected length of the confidence interval, then the first method is better because the expected length of the confidence interval obtained from the first method is shorter. We prove this intuition theoretically. We also specify when the elements in each group are correlated, the first method is invalid, while the second can give us correct results in terms of the coverage probability. We illustrate this with analytical expressions. In practice, when the data set is extremely large and distributed in several data centers, the second method is a good tool to get confidence intervals, in both independent and correlated cases. Some simulations and real data analyses are presented to verify our theoretical results.     

The performance of model averaged tail area confidence intervals

We investigate the exact coverage and expected length properties of the model averaged tail area (MATA) confidence interval proposed by Turek and Fletcher, CSDA, 2012, in the context of two nested, normal linear regression models. The simpler model is obtained by applying a single linear constraint on the regression parameter vector of the full model. For given length of response vector and nominal coverage of the MATA confidence interval, we consider all possible models of this type and all possible true parameter values, together with a wide class of design matrices and parameters of interest. Our results show that, while not ideal, MATA confidence intervals perform surprisingly well in our regression scenario, provided that we use the minimum weight within the class of weights that we consider on the simpler model.     

Better approximate confidence intervals for a binomial parameter

This paper discusses five methods for constructing approximate confidence intervals for the binomial parameter Θ, based on Y successes in n Bernoulli trials. In a recent paper, Chen (1990) discusses various approximate methods and suggests a new method based on a Bayes argument, which we call method I here. Methods II and III are based on the normal approximation without and with continuity correction. Method IV uses the Poisson approximation of the binomial distribution and then exploits the fact that the exact confidence limits for the parameter of the Poisson distribution can be found through the x² distribution. The confidence limits of method IV are then provided by the Wilson-Hilferty approximation of the x². Similarly, the exact confidence limits for the binomial parameter can be expressed through the F distribution. Method V approximates these limits through a suitable version of the Wilson-Hilferty approximation. We undertake a comparison of the five methods in respect to coverage probability and expected length. The results indicate that method V has an advantage over Chen's Bayes method as well as over the other three methods.     

The large sample coverage probability of confidence intervals in general regression models after a preliminary hypothesis test

We derive a computationally convenient formula for the large sample coverage probability of a confidence interval for a scalar parameter of interest following a preliminary hypothesis test that a specified vector parameter takes a given value in a general regression model. Previously, this large sample coverage probability could only be estimated by simulation. Our formula only requires the evaluation, by numerical integration, of either a double or a triple integral, irrespective of the dimension of this specified vector parameter. We illustrate the application of this formula to a confidence interval for the odds ratio of myocardial infarction when the exposure is recent oral contraceptive use, following a preliminary test where two specified interactions in a logistic regression model are zero. For this real‐life data, we compare this large sample coverage probability with the actual coverage probability of this confidence interval, obtained by simulation.     

A class of confidence intervals for sequential phase II clinical trials with binary outcome

The phase II clinical trials often use the binary outcome. Thus, accessing the success rate of the treatment is a primary objective for the phase II clinical trials. Reporting confidence intervals is a common practice for clinical trials. Due to the group sequence design and relatively small sample size, many existing confidence intervals for phase II trials are much conservative. In this paper, we propose a class of confidence intervals for binary outcomes. We also provide a general theory to assess the coverage of confidence intervals for discrete distributions, and hence make recommendations for choosing the parameter in calculating the confidence interval. The proposed method is applied to Simon's [14] optimal two-stage design with numerical studies. The proposed method can be viewed as an alternative approach for the confidence interval for discrete distributions in general.     

Generalized confidence interval for the slope in linear measurement error model

A generalized confidence interval for the slope parameter in linear measurement error model is proposed in this article, which is based on the relation between the slope of classical regression model and the measurement error model. The performance of the confidence interval estimation procedure is studied numerically through Monte Carlo simulation in terms of coverage probability and expected length.     

On probit versus logit dynamic mixed models for binary panel data

In this paper, we consider inferences in a binary dynamic mixed model. The existing estimation approaches mainly estimate the regression effects and the dynamic dependence parameters either through the estimation of the random effects or by avoiding the random effects technically. Under the assumption that the random effects follow a Gaussian distribution, we propose a generalized quasilikelihood (GQL) approach for the estimation of the parameters of the dynamic mixed models. The proposed approach is computationally less cumbersome than the exact maximum likelihood (ML) approach. We also carry out the GQL estimation under two competitive, namely, probit and logit mixed models, and discuss both the asymptotic and small-sample behaviour of their estimators.     

A comparison of alternative methods to construct confidence intervals for the estimate of a break date in linear regression models

This article considers constructing confidence intervals for the date of a structural break in linear regression models. Using extensive simulations, we compare the performance of various procedures in terms of exact coverage rates and lengths of the confidence intervals. These include the procedures of Bai (1997 Bai, J. (1997). Estimation of a change point in multiple regressions. Review of Economics and Statistics 79:551–563.[Crossref], [Web of Science ®] , [Google Scholar]) based on the asymptotic distribution under a shrinking shift framework, Elliott and Müller (2007 Elliott, G., Müller, U. (2007). Confidence sets for the date of a single break in linear time series regressions. Journal of Econometrics 141:1196–1218.[Crossref], [Web of Science ®] , [Google Scholar]) based on inverting a test locally invariant to the magnitude of break, Eo and Morley (2015 Eo, Y., Morley, J. (2015). Likelihood-ratio-based confidence sets for the timing of structural breaks. Quantitative Economics 6:463–497.[Crossref], [Web of Science ®] , [Google Scholar]) based on inverting a likelihood ratio test, and various bootstrap procedures. On the basis of achieving an exact coverage rate that is closest to the nominal level, Elliott and Müller's (2007 Elliott, G., Müller, U. (2007). Confidence sets for the date of a single break in linear time series regressions. Journal of Econometrics 141:1196–1218.[Crossref], [Web of Science ®] , [Google Scholar]) approach is by far the best one. However, this comes with a very high cost in terms of the length of the confidence intervals. When the errors are serially correlated and dealing with a change in intercept or a change in the coefficient of a stationary regressor with a high signal-to-noise ratio, the length of the confidence interval increases and approaches the whole sample as the magnitude of the change increases. The same problem occurs in models with a lagged dependent variable, a common case in practice. This drawback is not present for the other methods, which have similar properties. Theoretical results are provided to explain the drawbacks of Elliott and Müller's (2007 Elliott, G., Müller, U. (2007). Confidence sets for the date of a single break in linear time series regressions. Journal of Econometrics 141:1196–1218.[Crossref], [Web of Science ®] , [Google Scholar]) method.     

Frailty modeling for clustered survival data: an application to birth interval in Bangladesh

The present work demonstrates an application of random effects model for analyzing birth intervals that are clustered into geographical regions. Observations from the same cluster are assumed to be correlated because usually they share certain unobserved characteristics between them. Ignoring the correlations among the observations may lead to incorrect standard errors of the estimates of parameters of interest. Beside making the comparisons between Cox's proportional hazards model and random effects model for analyzing geographically clustered time-to-event data, important demographic and socioeconomic factors that may affect the length of birth intervals of Bangladeshi women are also reported in this paper.     

Testing for sphericity in a two-way error components panel data model

This article is concerned with sphericity test for the two-way error components panel data model. It is found that the John statistic and the bias-corrected LM statistic recently developed by Baltagi et al. (2011 Baltagi, B. H., Feng, Q., Kao, C. (2011). Testing for sphericity in a fixed effects panel data model. Econometrics Journal 14:25–47.[Crossref], [Web of Science ®] , [Google Scholar])Baltagi et al. (2012 Baltagi, B. H., Feng, Q., Kao, C. (2012). A Lagrange multiplier test for cross-sectional dependence in a fixed effects panel data model. Journal of Econometrics 170:164–177.[Crossref], [Web of Science ®] , [Google Scholar], which are based on the within residuals, are not helpful under the present circumstances even though they are in the one-way fixed effects model. However, we prove that when the within residuals are properly transformed, the resulting residuals can serve to construct useful statistics that are similar to those of Baltagi et al. (2011 Baltagi, B. H., Feng, Q., Kao, C. (2011). Testing for sphericity in a fixed effects panel data model. Econometrics Journal 14:25–47.[Crossref], [Web of Science ®] , [Google Scholar])Baltagi et al. (2012 Baltagi, B. H., Feng, Q., Kao, C. (2012). A Lagrange multiplier test for cross-sectional dependence in a fixed effects panel data model. Journal of Econometrics 170:164–177.[Crossref], [Web of Science ®] , [Google Scholar]). Simulation results show that the newly proposed statistics perform well under the null hypothesis and several typical alternatives.     

How Cox models react to a study-specific confounder in a patient-level pooled dataset: random effects better cope with an imbalanced covariate across trials unless baseline hazards differ

Combining patient-level data from clinical trials can connect rare phenomena with clinical endpoints, but statistical techniques applied to a single trial may become problematical when trials are pooled. Estimating the hazard of a binary variable unevenly distributed across trials showcases a common pooled database issue. We studied how an unevenly distributed binary variable can compromise the integrity of fixed and random effects Cox proportional hazards (cph) models. We compared fixed effect and random effects cph models on a set of simulated datasets inspired by a 17-trial pooled database of patients presenting with ST segment elevation myocardial infarction (STEMI) and non-STEMI undergoing percutaneous coronary intervention. An unevenly distributed covariate can bias hazard ratio estimates, inflate standard errors, raise type I error, and reduce power. While uneveness causes problems for all cph models, random effects suffer least. Compared to fixed effect models, random effects suffer lower bias and trade inflated type I errors for improved power. Contrasting hazard rates between trials prevent accurate estimates from both fixed and random effects models.     

An evaluation of ridge estimator in linear mixed models: an example from kidney failure data

This paper is concerned with the ridge estimation of fixed and random effects in the context of Henderson's mixed model equations in the linear mixed model. For this purpose, a penalized likelihood method is proposed. A linear combination of ridge estimator for fixed and random effects is compared to a linear combination of best linear unbiased estimator for fixed and random effects under the mean-square error (MSE) matrix criterion. Additionally, for choosing the biasing parameter, a method of MSE under the ridge estimator is given. A real data analysis is provided to illustrate the theoretical results and a simulation study is conducted to characterize the performance of ridge and best linear unbiased estimators approach in the linear mixed model.     

An alternative competing risk model to the Weibull distribution for modelling aging in lifetime data analysis

A simple competing risk distribution as a possible alternative to the Weibull distribution in lifetime analysis is proposed. This distribution corresponds to the minimum between exponential and Weibull distributions. Our motivation is to take account of both accidental and aging failures in lifetime data analysis. First, the main characteristics of this distribution are presented. Then, the estimation of its parameters are considered through maximum likelihood and Bayesian inference. In particular, the existence of a unique consistent root of the likelihood equations is proved. Decision tests to choose between an exponential, Weibull and this competing risk distribution are presented. And this alternative model is compared to the Weibull model from numerical experiments on both real and simulated data sets, especially in an industrial context.