Construction and selection of tightened–normal–tightened variables sampling scheme of type TNTVSS (n 1, n 2; k)

This paper provides tables for the construction and selection of tightened–normal–tightened variables sampling scheme of type TNTVSS (n ₁, n ₂; k). The method of designing the scheme indexed by (AQL, α) and (LQL, β) is indicated. The TNTVSS (n _T , n _N; k) is compared with conventional single sampling plans for variables and with TNT (n ₁, n ₂; c) scheme for attributes, and it is shown that the TNTVSS is more efficient.     

Estimation and comparison of the stress-strength models with more than two states under Weibull distribution and type II censoring scheme

This paper presents the extension of the inferences on the stress-strength reliability in more than two states to the system depending on the ratio of the strength and stress values when the stress and strength follow independent exponential distributions. The main objective of present paper is to consider different method of estimation, under Type II censoring, for the stress-strength models and to compare them, in more than two states, to the system depending on the ratio of the strength and stress values, when the stress and strength follow independent Weibull distributions, sharing the common shape parameter α.     

The uniformly minimum variance unbiased estimator of odds ratio in case–control studies under inverse sampling

The stated goal of this paper is to propose the uniformly minimum variance unbiased estimator of odds ratio in case–control studies under inverse sampling design. The problem of estimating odds ratio plays a central role in case–control studies. However, the traditional sampling schemes appear inadequate when the expected frequencies of not exposed cases and exposed controls can be very low. In such a case, it is convenient to use the inverse sampling design, which requires that random drawings shall be continued until a given number of relevant events has emerged. In this paper we prove that a uniformly minimum variance unbiased estimator of odds ratio does not exist under usual binomial sampling, while the standard odds ratio estimator is uniformly minimum variance unbiased under inverse sampling. In addition, we compare these two sampling schemes by means of large-sample theory and small-sample simulation.     

Statistical considerations in bioequivalence of two area under the concentration–time curves obtained from serial sampling data

In this paper, we study the bioequivalence (BE) inference problem motivated by pharmacokinetic data that were collected using the serial sampling technique. In serial sampling designs, subjects are independently assigned to one of the two drugs; each subject can be sampled only once, and data are collected at K distinct timepoints from multiple subjects. We consider design and hypothesis testing for the parameter of interest: the area under the concentration–time curve (AUC). Decision rules in demonstrating BE were established using an equivalence test for either the ratio or logarithmic difference of two AUCs. The proposed t-test can deal with cases where two AUCs have unequal variances. To control for the type I error rate, the involved degrees-of-freedom were adjusted using Satterthwaite's approximation. A power formula was derived to allow the determination of necessary sample sizes. Simulation results show that, when the two AUCs have unequal variances, the type I error rate is better controlled by the proposed method compared with a method that only handles equal variances. We also propose an unequal subject allocation method that improves the power relative to that of the equal and symmetric allocation. The methods are illustrated using practical examples.     

Covariance and variance evaluations of two estimators for drug–placebo difference in a trial with sequential parallel design

Chen et al. [Contemp. Clin. Trials, 32: 592–604 (2011)] heuristically proved that the covariance of two estimators is zero assuming equal correlation coefficients. In this article, the above covariance is analytically and rigorously re-derived without any strong assumption in equality between two correlation coefficients. Under rigorous analytic derivations plus assuming number of subjects continuing into Period 2 is a random variable, covariance is reconfirmed to be zero for both normal and binomial data.     

Estimating the variances of ratio estimates in complex sample surveys with two primary sampling units per stratum—a comparison of balanced replication and jackknife techniques

The balanced half-sample and jackknife variance estimation techniques are used to estimate the variance of the combined ratio estimate. An empirical sampling study is conducted using computer-generated populations to investigate the variance, bias and mean square error of these variance estimators and results are compared to theoretical results derived elsewhere for the linear case. Results indicate that either the balanced half-sample or jackknife method may be used effectively for estimating the variance of the combined ratio estimate.     

A comparison of the Hosmer–Lemeshow,Pigeon–Heyse,and Tsiatis goodness-of-fit tests for binary logistic regression under two grouping methods

Algebraic relationships between Hosmer–Lemeshow (HL), Pigeon–Heyse (J²), and Tsiatis (T) goodness-of-fit statistics for binary logistic regression models with continuous covariates were investigated, and their distributional properties and performances studied using simulations. Groups were formed under deciles-of-risk (DOR) and partition-covariate-space (PCS) methods. Under DOR, HL and T followed reported null distributions, while J² did not. Under PCS, only T followed its reported null distribution, with HL and J² dependent on model covariate number and partitioning. Generally, all had similar power. Of the three, T performed best, maintaining Type-I error rates and having a distribution invariant to covariate characteristics, number, and partitioning.     

A fractional version of the Cox–Ingersoll–Ross interest rate model and pricing double barrier option with Hurst index H∈(23,1)

In this work, we study the existence and uniqueness of the solution to a fractional version of the Cox–Ingersoll–Ross (fCIR) stochastic differential equation. The strong convergence of this equation is analyzed and according to it’s framework, we obtain the price of the double barrier option under transaction cost. Finally, we verify the effect of the parameters of the model on the value of the option.