The negative binomial–beta Weibull regression model to predict the cure of prostate cancer

In this article, for the first time, we propose the negative binomial–beta Weibull (BW) regression model for studying the recurrence of prostate cancer and to predict the cure fraction for patients with clinically localized prostate cancer treated by open radical prostatectomy. The cure model considers that a fraction of the survivors are cured of the disease. The survival function for the population of patients can be modeled by a cure parametric model using the BW distribution. We derive an explicit expansion for the moments of the recurrence time distribution for the uncured individuals. The proposed distribution can be used to model survival data when the hazard rate function is increasing, decreasing, unimodal and bathtub shaped. Another advantage is that the proposed model includes as special sub-models some of the well-known cure rate models discussed in the literature. We derive the appropriate matrices for assessing local influence on the parameter estimates under different perturbation schemes. We analyze a real data set for localized prostate cancer patients after open radical prostatectomy.     

Bayesian Parametric Accelerated Failure Time Spatial Model and its Application to Prostate Cancer

Prostate cancer is the most common cancer diagnosed in American men and the second leading cause of death from malignancies. There are large geographical variation and racial disparities existing in the survival rate of prostate cancer. Much work on the spatial survival model is based on the proportional hazards model, but few focused on the accelerated failure time model. In this paper, we investigate the prostate cancer data of Louisiana from the SEER program and the violation of the proportional hazards assumption suggests the spatial survival model based on the accelerated failure time model is more appropriate for this data set. To account for the possible extra-variation, we consider spatially-referenced independent or dependent spatial structures. The deviance information criterion (DIC) is used to select a best fitting model within the Bayesian frame work. The results from our study indicate that age, race, stage and geographical distribution are significant in evaluating prostate cancer survival.     

A comparison of efficiencies between quasi-likelihood and pseudo-likelihood estimates in non-separable spatial–temporal binary data

The goal of this paper is to compare the performance of two estimation approaches, the quasi-likelihood estimating equation and the pseudo-likelihood equation, against model mis-specification for non-separable binary data. This comparison, to the authors’ knowledge, has not been done yet. In this paper, we first extend the quasi-likelihood work on spatial data to non-separable binary data. Some asymptotic properties of the quasi-likelihood estimate are also briefly discussed. We then use the techniques of a truncated Gaussian random field with a quasi-likelihood type model and a Gibbs sampler with a conditional model in the Markov random field to generate spatial–temporal binary data, respectively. For each simulated data set, both of the estimation methods are used to estimate parameters. Some discussion about the simulation results are also included.     

Spatial generalized linear mixed models in small area estimation

In survey sampling, policy decisions regarding the allocation of resources to sub‐groups of a population depend on reliable predictors of their underlying parameters. However, in some sub‐groups, called small areas due to small sample sizes relative to the population, the information needed for reliable estimation is typically not available. Consequently, data on a coarser scale are used to predict the characteristics of small areas. Mixed models are the primary tools in small area estimation (SAE) and also borrow information from alternative sources (e.g., previous surveys and administrative and census data sets). In many circumstances, small area predictors are associated with location. For instance, in the case of chronic disease or cancer, it is important for policy makers to understand spatial patterns of disease in order to determine small areas with high risk of disease and establish prevention strategies. The literature considering SAE with spatial random effects is sparse and mostly in the context of spatial linear mixed models. In this article, small area models are proposed for the class of spatial generalized linear mixed models to obtain small area predictors and corresponding second‐order unbiased mean squared prediction errors via Taylor expansion and a parametric bootstrap approach. The performance of the proposed approach is evaluated through simulation studies and application of the models to a real esophageal cancer data set from Minnesota, U.S.A. The Canadian Journal of Statistics 47: 426–437; 2019 © 2019 Statistical Society of Canada     

Structured Spatio-Temporal Shot-Noise Cox Point Process Models, with a View to Modelling Forest Fires

Abstract.  Spatio-temporal Cox point process models with a multiplicative structure for the driving random intensity, incorporating covariate information into temporal and spatial components, and with a residual term modelled by a shot-noise process, are considered. Such models are flexible and tractable for statistical analysis, using spatio-temporal versions of intensity and inhomogeneous K -functions, quick estimation procedures based on composite likelihoods and minimum contrast estimation, and easy simulation techniques. These advantages are demonstrated in connection with the analysis of a relatively large data set consisting of 2796 days and 5834 spatial locations of fires. The model is compared with a spatio-temporal log-Gaussian Cox point process model, and likelihood-based methods are discussed to some extent.     

Bayesian inference for non-stationary spatial covariance structure via spatial deformations

Summary. In geostatistics it is common practice to assume that the underlying spatial process is stationary and isotropic, i.e. the spatial distribution is unchanged when the origin of the index set is translated and under rotation about the origin. However, in environmental problems, such assumptions are not realistic since local influences in the correlation structure of the spatial process may be found in the data. The paper proposes a Bayesian model to address the anisot- ropy problem. Following Sampson and Guttorp, we define the correlation function of the spatial process by reference to a latent space, denoted by D , where stationarity and isotropy hold. The space where the gauged monitoring sites lie is denoted by G . We adopt a Bayesian approach in which the mapping between G and D is represented by an unknown function d (·). A Gaussian process prior distribution is defined for d (·). Unlike the Sampson–Guttorp approach, the mapping of both gauged and ungauged sites is handled in a single framework, and predictive inferences take explicit account of uncertainty in the mapping. Markov chain Monte Carlo methods are used to obtain samples from the posterior distributions. Two examples are discussed: a simulated data set and the solar radiation data set that also was analysed by Sampson and Guttorp.     

Bayesian parametric accelerated failure time spatial model and its application to prostate cancer

Prostate cancer (PrCA) is the most common cancer diagnosed in American men and the second leading cause of death from malignancies. There are large geographical variation and racial disparities existing in the survival rate of PrCA. Much work on the spatial survival model is based on the proportional hazards (PH) model, but few focused on the accelerated failure time (AFT) model. In this paper, we investigate the PrCA data of Louisiana from the Surveillance, Epidemiology, and End Results program and the violation of the PH assumption suggests that the spatial survival model based on the AFT model is more appropriate for this data set. To account for the possible extra-variation, we consider spatially referenced independent or dependent spatial structures. The deviance information criterion is used to select a best-fitting model within the Bayesian frame work. The results from our study indicate that age, race, stage, and geographical distribution are significant in evaluating PrCA survival.     

Characterizing persistent disturbing behavior using longitudinal and multivariate techniques

Persistent disturbing behavior (PDB) refers to a chronic condition in therapy-resistant psychiatric patients. Since these patients are highly unstable and difficult to maintain in their natural living environment and even in hospital wards, it is important to properly characterize this group. Previous studies in the Belgian province of Limburg indicated that the size of this group was larger than anticipated. Here, using a score calculated from longitudinal psychiatric registration data in 611 patients, we characterize the difference between PDB patients and a set of control patients. These differences are studied both at a given point in time, using discriminant analysis, as well as in terms of the evolution of the score over time, using longitudinal data analysis methods. Further, using clustering techniques, the group of PDB patients is split into two subgroups, characterized in terms of a number of ordinal scores. Such findings are useful from a scientific as well as from an organizational point of view.     

Perfect value and outlier detection in logistic binary choice models

Tins paper discussed some diagnostic tools for logistics binary choice models using techniques based on perfect values. The concept of perfect value fit is defined for logistic models in an analogous approach used when dealing with non ignorable non-iespouse in contingency tables. Performance ol outlier diagnostics based on perfect values is illustrated on a set of data on incidents in pre-Challenger launches.     

Asymptotic properties of nonparametric regression for long memory random fields

The kernel estimator of spatial regression function is investigated for stationary long memory (long range dependent) random fields observed over a finite set of spatial points. A general result on the strong consistency of the kernel density estimator is first obtained for the long memory random fields, and then, under some mild regularity assumptions, the asymptotic behaviors of the regression estimator are established. For the linear long memory random fields, a weak convergence theorem is also obtained for kernel density estimator. Finally, some related issues on the inference of long memory random fields are discussed through a simulation example.     

Multilevel modelling of the geographical distributions of diseases

Multilevel modelling is used on problems arising from the analysis of spatially distributed health data. We use three applications to demonstrate the use of multilevel modelling in this area. The first concerns small area all-cause mortality rates from Glasgow where spatial autocorrelation between residuals is examined. The second analysis is of prostate cancer cases in Scottish counties where we use a range of models to examine whether the incidence is higher in more rural areas. The third develops a multiple-cause model in which deaths from cancer and cardiovascular disease in Glasgow are examined simultaneously in a spatial model. We discuss some of the issues surrounding the use of complex spatial models and the potential for future developments.     

Maximum likelihood estimation for directional conditionally autoregressive models

A spatial process observed over a lattice or a set of irregular regions is usually modeled using a conditionally autoregressive (CAR) model. The neighborhoods within a CAR model are generally formed using only the inter-distances or boundaries between the regions. To accommodate directional spatial variation, a new class of spatial models is proposed using different weights given to neighbors in different directions. The proposed model generalizes the usual CAR model by accounting for spatial anisotropy. Maximum likelihood estimators are derived and shown to be consistent under some regularity conditions. Simulation studies are presented to evaluate the finite sample performance of the new model as compared to the CAR model. Finally, the method is illustrated using a data set on the crime rates of Columbus, OH and on the elevated blood lead levels of children under the age of 72 months observed in Virginia in the year of 2000.     

A general hazard model for lifetime data in the presence of cure rate

Historically, the cure rate model has been used for modeling time-to-event data within which a significant proportion of patients are assumed to be cured of illnesses, including breast cancer, non-Hodgkin lymphoma, leukemia, prostate cancer, melanoma, and head and neck cancer. Perhaps the most popular type of cure rate model is the mixture model introduced by Berkson and Gage [1]. In this model, it is assumed that a certain proportion of the patients are cured, in the sense that they do not present the event of interest during a long period of time and can found to be immune to the cause of failure under study. In this paper, we propose a general hazard model which accommodates comprehensive families of cure rate models as particular cases, including the model proposed by Berkson and Gage. The maximum-likelihood-estimation procedure is discussed. A simulation study analyzes the coverage probabilities of the asymptotic confidence intervals for the parameters. A real data set on children exposed to HIV by vertical transmission illustrates the methodology.     

Validation of prognostic indices using the frailty model

A major issue when proposing a new prognostic index is its generalisibility to daily clinical practice. Validation is therefore required. Most validation techniques assess whether “on average” the results obtained by the prognostic index in classifying patients in a new sample of patients are similar to the results obtained in the construction set. We introduce a new important aspect of the generalisibility of a prognostic index: the heterogeneity of the prognostic index risk group hazard ratios over different centers. If substantial variability between centers exists, the prognostic index may have no discriminatory capability in some of the centers. To model such heterogeneity, we use a frailty model including a random center effect and a random prognostic index by center interaction. Statistical inference is based on a Bayesian approach using a Laplacian approximation for the marginal posterior distribution of the variances of the random effects. We investigate different ways to summarize the information available from this marginal posterior distribution. Our approach is applied to a real bladder cancer database for which we demonstrate how to investigate and interpret heterogeneity in prognostic index effect over centers.     

遥感和空间分析支持下的耕地、城镇动态变化空间采样方法研究

一、引言我国是一个地域广阔、资源类型多样、土地利用类型和土地利用结构复杂的国家,同时,又是一个发展中的国家,正处在工业化的过程中,土地资源的利用类型变化巨大,尤其是和国民经济发展密切相关的耕地、城镇等重要利用类型的动态变化程度极高,而国民经济的高速发展迫切要求及时掌握耕地、城镇的动态变化信息。如何获取耕地、城镇的动态变化尤其是年际变化数据,不仅涉及到相关技术手段,同时也涉及到各项社会经济指标,是一项复杂的综合工程。由于现阶段我国特有的社会发展状况以及复杂多变的自然条件,使得采用传统方法需要大量的…     

The Weibull–Pareto Composite Family with Applications to the Analysis of Unimodal Failure Rate Data

The Weibull distribution is composited with Pareto model to obtain a flexible, reliable long-tailed parametric distribution for modeling unimodal failure rate data. The hazard function of the composite family accommodates decreasing and unimodal failure rates, which are separated by the boundary line of the space of shape parameter, gamma, when it equals to a known constant. The least square and maximum likelihood parameter estimation techniques are discussed. The advantages of using the proposed family are demonstrated and compared by illustrating well-known examples: guinea pigs survival time data, head and neck cancer data, and nasopharynx cancer survival data.     

On the advantages of the non-concave penalized likelihood model selection method with minimum prediction errors in large-scale medical studies

Variable and model selection problems are fundamental to high-dimensional statistical modeling in diverse fields of sciences. Especially in health studies, many potential factors are usually introduced to determine an outcome variable. This paper deals with the problem of high-dimensional statistical modeling through the analysis of the trauma annual data in Greece for 2005. The data set is divided into the experiment and control sets and consists of 6334 observations and 112 factors that include demographic, transport and intrahospital data used to detect possible risk factors of death. In our study, different model selection techniques are applied to the experiment set and the notion of deviance is used on the control set to assess the fit of the overall selected model. The statistical methods employed in this work were the non-concave penalized likelihood methods, smoothly clipped absolute deviation, least absolute shrinkage and selection operator, and Hard, the generalized linear logistic regression, and the best subset variable selection.The way of identifying the significant variables in large medical data sets along with the performance and the pros and cons of the various statistical techniques used are discussed. The performed analysis reveals the distinct advantages of the non-concave penalized likelihood methods over the traditional model selection techniques.     

Accelerated hazards mixture cure model

We propose a new cure model for survival data with a surviving or cure fraction. The new model is a mixture cure model where the covariate effects on the proportion of cure and the distribution of the failure time of uncured patients are separately modeled. Unlike the existing mixture cure models, the new model allows covariate effects on the failure time distribution of uncured patients to be negligible at time zero and to increase as time goes by. Such a model is particularly useful in some cancer treatments when the treat effect increases gradually from zero, and the existing models usually cannot handle this situation properly. We develop a rank based semiparametric estimation method to obtain the maximum likelihood estimates of the parameters in the model. We compare it with existing models and methods via a simulation study, and apply the model to a breast cancer data set. The numerical studies show that the new model provides a useful addition to the cure model literature.     

A NONPARAMETRIC MIXED‐EFFECTS MODEL FOR CANCER MORTALITY

There are several ways to handle within‐subject correlations with a longitudinal discrete outcome, such as mortality. The most frequently used models are either marginal or random‐effects types. This paper deals with a random‐effects‐based approach. We propose a nonparametric regression model having time‐varying mixed effects for longitudinal cancer mortality data. The time‐varying mixed effects in the proposed model are estimated by combining kernel‐smoothing techniques and a growth‐curve model. As an illustration based on real data, we apply the proposed method to a set of prefecture‐specific data on mortality from large‐bowel cancer in Japan.     

Linear regression analysis of survival data with missing censoring indicators

Linear regression analysis has been studied extensively in a random censorship setting, but typically all of the censoring indicators are assumed to be observed. In this paper, we develop synthetic data methods for estimating regression parameters in a linear model when some censoring indicators are missing. We define estimators based on regression calibration, imputation, and inverse probability weighting techniques, and we prove all three estimators are asymptotically normal. The finite-sample performance of each estimator is evaluated via simulation. We illustrate our methods by assessing the effects of sex and age on the time to non-ambulatory progression for patients in a brain cancer clinical trial.