Generalized empirical likelihood inference in partial linear regression model for longitudinal data

In this paper, empirical likelihood inference for longitudinal data within the framework of partial linear regression models are investigated. The proposed procedures take into consideration the correlation within groups without involving direct estimation of nuisance parameters in the correlation matrix. The empirical likelihood method is used to estimate the regression coefficients and the baseline function, and to construct confidence intervals. A nonparametric version of Wilk's theorem for the limiting distribution of the empirical likelihood ratio is derived. Compared with methods based on normal approximations, the empirical likelihood does not require consistent estimators for the asymptotic variance and bias. The finite sample behaviour of the proposed method is evaluated with simulation and illustrated with an AIDS clinical trial data set.     

Empirical likelihood inference for a semiparametric hazards regression model

ABSTRACT

We investigated the empirical likelihood inference approach under a general class of semiparametric hazards regression models with survival data subject to right-censoring. An empirical likelihood ratio for the full 2p regression parameters involved in the model is obtained. We showed that it converged weakly to a random variable which could be written as a weighted sum of 2p independent chi-squared variables with one degree of freedom. Using this, we could construct a confidence region for parameters. We also suggested an adjusted version for the preceding statistic, whose limit followed a standard chi-squared distribution with 2p degrees of freedom.     

Dimension-reduced empirical likelihood inference for response mean with data missing at random

To make efficient inference for mean of a response variable when the data are missing at random and the dimension of covariate is not low, we construct three bias-corrected empirical likelihood (EL) methods in conjunction with dimension-reduced kernel estimation of propensity or/and conditional mean response function. Consistency and asymptotic normality of the maximum dimension-reduced EL estimators are established. We further study the asymptotic properties of the resulting dimension-reduced EL ratio functions and the corresponding EL confidence intervals for the response mean are constructed. The finite-sample performance of the proposed estimators is studied through simulation, and an application to HIV-CD4 data set is also presented.     

Adjusted empirical likelihood inference for additive hazards regression

ABSTRACT

This article develops an adjusted empirical likelihood (EL) method for the additive hazards model. The adjusted EL ratio is shown to have a central chi-squared limiting distribution under the null hypothesis. We also evaluate its asymptotic distribution as a non central chi-squared distribution under the local alternatives of order n^{? 1/2}, deriving the expression for the asymptotic power function. Simulation studies and a real example are conducted to evaluate the finite sample performance of the proposed method. Compared with the normal approximation-based method, the proposed method tends to have more larger empirical power and smaller confidence regions with comparable coverage probabilities.     

Empirical likelihood for the varying‐coefficient single‐index model

In this article the author investigates the application of the empirical‐likelihood‐based inference for the parameters of varying‐coefficient single‐index model (VCSIM). Unlike the usual cases, if there is no bias correction the asymptotic distribution of the empirical likelihood ratio cannot achieve the standard chi‐squared distribution. To this end, a bias‐corrected empirical likelihood method is employed to construct the confidence regions (intervals) of regression parameters, which have two advantages, compared with those based on normal approximation, that is, (1) they do not impose prior constraints on the shape of the regions; (2) they do not require the construction of a pivotal quantity and the regions are range preserving and transformation respecting. A simulation study is undertaken to compare the empirical likelihood with the normal approximation in terms of coverage accuracies and average areas/lengths of confidence regions/intervals. A real data example is given to illustrate the proposed approach. The Canadian Journal of Statistics 38: 434–452; 2010 © 2010 Statistical Society of Canada     

Empirical likelihood dimension reduction inference for partially non-linear error-in-responses models with validation data

ABSTRACT

In this article, partially non linear models when the response variable is measured with error and explanatory variables are measured exactly are considered. Without specifying any error structure equation, a semiparametric dimension reduction technique is employed. Two estimators of unknown parameter in non linear function are obtained and asymptotic normality is proved. In addition, empirical likelihood method for parameter vector is provided. It is shown that the estimated empirical log-likelihood ratio has asymptotic Chi-square distribution. A simulation study indicates that, compared with normal approximation method, empirical likelihood method performs better in terms of coverage probabilities and average length of the confidence intervals.     

Empirical likelihood for high-dimensional partially linear model with martingale difference errors

In this paper, we focus on the empirical likelihood (EL) inference for high-dimensional partially linear model with martingale difference errors. An empirical log-likelihood ratio statistic of unknown parameter is constructed and is shown to have asymptotically normality distribution under some suitable conditions. This result is different from those derived before. Furthermore, an empirical log-likelihood ratio for a linear combination of unknown parameter is also proposed and its asymptotic distribution is chi-squared. Based on these results, the confidence regions both for unknown parameter and a linear combination of parameter can be obtained. A simulation study is carried out to show that our proposed approach performs better than normal approximation-based method.     

Empirical likelihood inference for the bivariate survival function under univariate censoring

In this article, we apply the empirical likelihood method to make inference on the bivariate survival function of paired failure times by estimating the survival function of censored time with the Kaplan–Meier estimator. Adjusted empirical likelihood (AEL) confidence intervals for the bivariate survival function are developed. We conduct a simulation study to compare the proposed AEL method with other methods. The simulation study shows the proposed AEL method has better performance than other existing methods. We illustrate the proposed method by analyzing the skin graft data.     

Generalized empirical likelihood inference in partially linear model for longitudinal data with missing response variables and error-prone covariates

In this article, we consider statistical inference for longitudinal partial linear models when the response variable is sometimes missing with missingness probability depending on the covariate that is measured with error. A generalized empirical likelihood (GEL) method is proposed by combining correction attenuation and quadratic inference functions. The method that takes into consideration the correlation within groups is used to estimate the regression coefficients. Furthermore, residual-adjusted empirical likelihood (EL) is employed for estimating the baseline function so that undersmoothing is avoided. The empirical log-likelihood ratios are proven to be asymptotically Chi-squared, and the corresponding confidence regions for the parameters of interest are then constructed. Compared with methods based on NAs, the GEL does not require consistent estimators for the asymptotic variance and bias. The numerical study is conducted to compare the performance of the EL and the normal approximation-based method, and a real example is analysed.     

Empirical likelihood inference in the presence of measurement error

Suppose that several different imperfect instruments and one perfect instrument are used independently to measure some characteristic of a population. The authors consider the problem of combining this information to make statistical inference on parameters of interest, in particular the population mean and cumulative distribution function. They develop maximum empirical likelihood estimators and study their asymptotic properties. They also present simulation results on the finite sample efficiency of these estimators.     

Semi-empirical likelihood inference for the ROC curve with missing data

The receiver operating characteristic (ROC) curve is one of the most commonly used methods to compare the diagnostic performance of two or more laboratory or diagnostic tests. In this paper, we propose semi-empirical likelihood based confidence intervals for ROC curves of two populations, where one population is parametric and the other one is non-parametric and both have missing data. After imputing missing values, we derive the semi-empirical likelihood ratio statistic and the corresponding likelihood equations. It is shown that the log-semi-empirical likelihood ratio statistic is asymptotically scaled chi-squared. The estimating equations are solved simultaneously to obtain the estimated lower and upper bounds of semi-empirical likelihood confidence intervals. We conduct extensive simulation studies to evaluate the finite sample performance of the proposed empirical likelihood confidence intervals with various sample sizes and different missing probabilities.     

Empirical likelihood inference in mixture of semiparametric varying-coefficient models for longitudinal data with non-ignorable dropout

In this paper, empirical likelihood inference in mixture of semiparametric varying-coefficient models for longitudinal data with non-ignorable dropout is investigated. We estimate the non-parametric function based on the estimating equations and the local linear profile-kernel method. An empirical log-likelihood ratio statistic for parametric components is proposed to construct confidence regions and is shown to be an asymptotically chi-squared distribution. The non-parametric version of Wilk's theorem is also derived. A simulation study is undertaken to illustrate the finite sample performance of the proposed method.     

Empirical likelihood inference for a common mean in the presence of heteroscedasticity

The authors develop empirical likelihood (EL) based methods of inference for a common mean using data from several independent but nonhomogeneous populations. For point estimation, they propose a maximum empirical likelihood (MEL) estimator and show that it is n‐consistent and asymptotically optimal. For confidence intervals, they consider two EL based methods and show that both intervals have approximately correct coverage probabilities under large samples. Finite‐sample performances of the MEL estimator and the EL based confidence intervals are evaluated through a simulation study. The results indicate that overall the MEL estimator and the weighted EL confidence interval are superior alternatives to the existing methods.     

Full likelihood inference in the Cox model with LTRC data when covariates are discrete

For the regression parameter β in the Cox model, there have been several estimates based on different types of approximated likelihood. For right-censored data, Ren and Zhou [Full likelihood inferences in the Cox model: an empirical approach. Ann Inst Statist Math. 2011;63:1005–1018] derive the full likelihood function for (β, F₀), where F₀ is the baseline distribution function in the Cox model. In this article, we extend their results to left-truncated and right-censored data with discrete covariates. Using the empirical likelihood parameterization, we obtain the full-profile likelihood function for β when covariates are discrete. Simulation results indicate that the maximum likelihood estimator outperforms Cox's partial likelihood estimator in finite samples.     

Empirical likelihood inference for partial functional linear model with missing responses

In this paper, we consider the empirical likelihood inferences of the partial functional linear model with missing responses. Two empirical log-likelihood ratios of the parameters of interest are constructed, and the corresponding maximum empirical likelihood estimators of parameters are derived. Under some regularity conditions, we show that the proposed two empirical log-likelihood ratios are asymptotic standard Chi-squared. Thus, the asymptotic results can be used to construct the confidence intervals/regions for the parameters of interest. We also establish the asymptotic distribution theory of corresponding maximum empirical likelihood estimators. A simulation study indicates that the proposed methods are comparable in terms of coverage probabilities and average lengths of confidence intervals. An example of real data is also used to illustrate our proposed methods.     

Smoothed empirical likelihood confidence intervals for the relative distribution with left‐truncated and right‐censored data

The study of differences among groups is an interesting statistical topic in many applied fields. It is very common in this context to have data that are subject to mechanisms of loss of information, such as censoring and truncation. In the setting of a two‐sample problem with data subject to left truncation and right censoring, we develop an empirical likelihood method to do inference for the relative distribution. We obtain a nonparametric generalization of Wilks' theorem and construct nonparametric pointwise confidence intervals for the relative distribution. Finally, we analyse the coverage probability and length of these confidence intervals through a simulation study and illustrate their use with a real data set on gastric cancer. The Canadian Journal of Statistics 38: 453–473; 2010 © 2010 Statistical Society of Canada     

Empirical likelihood confidence regions in the single-index model with growing dimensions

This paper investigates statistical inference for the single-index model when the number of predictors grows with sample size. Empirical likelihood method for constructing confidence region for the index vector, which does not require a multivariate non parametric smoothing, is employed. However, the classical empirical likelihood ratio for this model does not remain valid because plug-in estimation of an infinite-dimensional nuisance parameter causes a non negligible bias and the diverging number of parameters/predictors makes the limit not chi-squared any more. To solve these problems, we define an empirical likelihood ratio based on newly proposed weighted estimating equations and show that it is asymptotically normal. Also we find that different weights used in the weighted residuals require, for asymptotic normality, different diverging rate of the number of predictors. However, the rate n^1/3, which is a possible fastest rate when there are no any other conditions assumed in the setting under study, is still attainable. A simulation study is carried out to assess the performance of our method.     

A log-linear regression model for the odd Weibull distribution with censored data

We introduce the log-odd Weibull regression model based on the odd Weibull distribution (Cooray, 2006). We derive some mathematical properties of the log-transformed distribution. The new regression model represents a parametric family of models that includes as sub-models some widely known regression models that can be applied to censored survival data. We employ a frequentist analysis and a parametric bootstrap for the parameters of the proposed model. We derive the appropriate matrices for assessing local influence on the parameter estimates under different perturbation schemes and present some ways to assess global influence. Further, for different parameter settings, sample sizes and censoring percentages, some simulations are performed. In addition, the empirical distribution of some modified residuals are given and compared with the standard normal distribution. These studies suggest that the residual analysis usually performed in normal linear regression models can be extended to a modified deviance residual in the proposed regression model applied to censored data. We define martingale and deviance residuals to check the model assumptions. The extended regression model is very useful for the analysis of real data.     

Asymptotic properties of mean survival estimate based on the Kaplan-Meier curve with an extrapolated tail

Asymptotic distribution of the mean survival time based on the Kaplan-Meier curve with an extrapolated 'tail' is derived. A closed formula of the variance estimate is provided. Asymptotic properties of the estimator were studied in a simulation study, which showed that this estimator was unbiased with proper coverage probability and followed a normal distribution. An example is used to demonstrate the application of this estimator.