Natural (Non‐)Informative Priors for Skew‐symmetric Distributions

In this paper, we present an innovative method for constructing proper priors for the skewness (shape) parameter in the skew‐symmetric family of distributions. The proposed method is based on assigning a prior distribution on the perturbation effect of the shape parameter, which is quantified in terms of the total variation distance. We discuss strategies to translate prior beliefs about the asymmetry of the data into an informative prior distribution of this class. We show via a Monte Carlo simulation study that our non‐informative priors induce posterior distributions with good frequentist properties, similar to those of the Jeffreys prior. Our informative priors yield better results than their competitors from the literature. We also propose a scale‐invariant and location‐invariant prior structure for models with unknown location and scale parameters and provide sufficient conditions for the propriety of the corresponding posterior distribution. Illustrative examples are presented using simulated and real data.     

Using Bayesian analysis in repeated preclinical in vivo studies for a more effective use of animals

Whilst innovative Bayesian approaches are increasingly used in clinical studies, in the preclinical area Bayesian methods appear to be rarely used in the reporting of pharmacology data. This is particularly surprising in the context of regularly repeated in vivo studies where there is a considerable amount of data from historical control groups, which has potential value. This paper describes our experience with introducing Bayesian analysis for such studies using a Bayesian meta‐analytic predictive approach. This leads naturally either to an informative prior for a control group as part of a full Bayesian analysis of the next study or using a predictive distribution to replace a control group entirely. We use quality control charts to illustrate study‐to‐study variation to the scientists and describe informative priors in terms of their approximate effective numbers of animals. We describe two case studies of animal models: the lipopolysaccharide‐induced cytokine release model used in inflammation and the novel object recognition model used to screen cognitive enhancers, both of which show the advantage of a Bayesian approach over the standard frequentist analysis. We conclude that using Bayesian methods in stable repeated in vivo studies can result in a more effective use of animals, either by reducing the total number of animals used or by increasing the precision of key treatment differences. This will lead to clearer results and supports the “3Rs initiative” to Refine, Reduce and Replace animals in research. Copyright © 2016 John Wiley & Sons, Ltd.     

Noninformative priors for linear combinations of the normal means

In this paper, we develop noninformative priors for linear combinations of the means under the normal populations. It turns out that among the reference priors the one-at-a-time reference prior satisfies a second order probability matching criterion. Moreover, the second order probability matching priors match alternative coverage probabilities up to the second order and are also HPD matching priors. Our simulation study indicates that the one-at-a-time reference prior performs better than the other reference priors in terms of matching the target coverage probabilities in a frequentist sense.     

A weakly informative prior for Bayesian dynamic model selection with applications in fMRI

In recent years, Bayesian statistics methods in neuroscience have been showing important advances. In particular, detection of brain signals for studying the complexity of the brain is an active area of research. Functional magnetic resonance imagining (fMRI) is an important tool to determine which parts of the brain are activated by different types of physical behavior. According to recent results, there is evidence that the values of the connectivity brain signal parameters are close to zero and due to the nature of time series fMRI data with high-frequency behavior, Bayesian dynamic models for identifying sparsity are indeed far-reaching. We propose a multivariate Bayesian dynamic approach for model selection and shrinkage estimation of the connectivity parameters. We describe the coupling or lead-lag between any pair of regions by using mixture priors for the connectivity parameters and propose a new weakly informative default prior for the state variances. This framework produces one-step-ahead proper posterior predictive results and induces shrinkage and robustness suitable for fMRI data in the presence of sparsity. To explore the performance of the proposed methodology, we present simulation studies and an application to functional magnetic resonance imaging data.     

Objective Priors for Parameters in a Normal Linear Regression with Measurement Error

We investigate certain objective priors for the parameters in a normal linear regression models with one of the explanatory variables subject to measurement error. We first show that the use of the standard non informative prior for normal linear regression without measurement error leads to an improper posterior in the measurement error model. We then derive the Jeffreys prior and reference priors, and show that they lead to proper posteriors. We use simulation study to compare the frequentist performance of the estimates derived using these priors, and the MLE.     

Addressing potential prior‐data conflict when using informative priors in proof‐of‐concept studies

Bayesian methods are increasingly used in proof‐of‐concept studies. An important benefit of these methods is the potential to use informative priors, thereby reducing sample size. This is particularly relevant for treatment arms where there is a substantial amount of historical information such as placebo and active comparators. One issue with using an informative prior is the possibility of a mismatch between the informative prior and the observed data, referred to as prior‐data conflict. We focus on two methods for dealing with this: a testing approach and a mixture prior approach. The testing approach assesses prior‐data conflict by comparing the observed data to the prior predictive distribution and resorting to a non‐informative prior if prior‐data conflict is declared. The mixture prior approach uses a prior with a precise and diffuse component. We assess these approaches for the normal case via simulation and show they have some attractive features as compared with the standard one‐component informative prior. For example, when the discrepancy between the prior and the data is sufficiently marked, and intuitively, one feels less certain about the results, both the testing and mixture approaches typically yield wider posterior‐credible intervals than when there is no discrepancy. In contrast, when there is no discrepancy, the results of these approaches are typically similar to the standard approach. Whilst for any specific study, the operating characteristics of any selected approach should be assessed and agreed at the design stage; we believe these two approaches are each worthy of consideration. Copyright © 2015 John Wiley & Sons, Ltd.     

Non-informative priors for the common mean in the one-way random effects model with heterogeneous error variances

The paper develops some objective priors for the common mean in the one-way random effects model with heterogeneous error variances. We derive the first and second order matching priors and reference priors. It turns out that the second order matching prior matches the alternative coverage probabilities up to the second order, and is also an HPD matching prior. However, derived reference priors just satisfy a first order matching criterion. Our simulation studies indicate that the second order matching prior performs better than the reference prior and the Jeffreys prior in terms of matching the target coverage probabilities in a frequentist sense. We also illustrate our results using real data.     

Application of an adaptive design to a randomized phase II selection trial in gastric cancer: a report of the study design

Randomized phase II selection trials seek to provide unbiased comparisons for the selection of the most promising treatment arm for evaluation in a future phase III trial. In this paper, we present an application of an adaptive design to a randomized phase II selection trial comparing three experimental treatments with a control arm in patients with advanced gastric cancer. The trial design continuously monitors multiple patient outcomes to protect future patients from treatments with unacceptably high toxicity and/or unacceptably low efficacy. We use a Bayesian approach to monitor the trial and carry out simulations to investigate operating characteristics of the trial design. The simulation study also evaluates the sensitivity of the design to the prior distribution by considering two alternative priors.     

Bayesian predictive power: choice of prior and some recommendations for its use as probability of success in drug development

Bayesian predictive power, the expectation of the power function with respect to a prior distribution for the true underlying effect size, is routinely used in drug development to quantify the probability of success of a clinical trial. Choosing the prior is crucial for the properties and interpretability of Bayesian predictive power. We review recommendations on the choice of prior for Bayesian predictive power and explore its features as a function of the prior. The density of power values induced by a given prior is derived analytically and its shape characterized. We find that for a typical clinical trial scenario, this density has a u‐shape very similar, but not equal, to a β‐distribution. Alternative priors are discussed, and practical recommendations to assess the sensitivity of Bayesian predictive power to its input parameters are provided. Copyright © 2016 John Wiley & Sons, Ltd.     

A matching prior for the product of normal means based on the modified profile likelihood

In this paper, we develop a matching prior for the product of means in several normal distributions with unrestricted means and unknown variances. For this problem, properly assigning priors for the product of normal means has been issued because of the presence of nuisance parameters. Matching priors, which are priors matching the posterior probabilities of certain regions with their frequentist coverage probabilities, are commonly used but difficult to derive in this problem. We developed the first order probability matching priors for this problem; however, the developed matching priors are unproper. Thus, we apply an alternative method and derive a matching prior based on a modification of the profile likelihood. Simulation studies show that the derived matching prior performs better than the uniform prior and Jeffreys’ prior in meeting the target coverage probabilities, and meets well the target coverage probabilities even for the small sample sizes. In addition, to evaluate the validity of the proposed matching prior, Bayesian credible interval for the product of normal means using the matching prior is compared to Bayesian credible intervals using the uniform prior and Jeffrey’s prior, and the confidence interval using the method of Yfantis and Flatman.     

Objective Bayesian inference for the ratio of the scale parameters of two Weibull distributions

The Weibull distribution is widely used due to its versatility and relative simplicity. In our paper, the non informative priors for the ratio of the scale parameters of two Weibull models are provided. The asymptotic matching of coverage probabilities of Bayesian credible intervals is considered, with the corresponding frequentist coverage probabilities. We developed the various priors for the ratio of two scale parameters using the following matching criteria: quantile matching, matching of distribution function, highest posterior density matching, and inversion of test statistics. One particular prior, which meets all the matching criteria, is found. Next, we derive the reference priors for groups of ordering. We see that all the reference priors satisfy a first-order matching criterion and that the one-at-a-time reference prior is a second-order matching prior. A simulation study is performed and an example given.     

Continuous event monitoring via a Bayesian predictive approach

In clinical trials, continuous monitoring of event incidence rate plays a critical role in making timely decisions affecting trial outcome. For example, continuous monitoring of adverse events protects the safety of trial participants, while continuous monitoring of efficacy events helps identify early signals of efficacy or futility. Because the endpoint of interest is often the event incidence associated with a given length of treatment duration (e.g., incidence proportion of an adverse event with 2 years of dosing), assessing the event proportion before reaching the intended treatment duration becomes challenging, especially when the event onset profile evolves over time with accumulated exposure. In particular, in the earlier part of the study, ignoring censored subjects may result in significant bias in estimating the cumulative event incidence rate. Such a problem is addressed using a predictive approach in the Bayesian framework. In the proposed approach, experts' prior knowledge about both the frequency and timing of the event occurrence is combined with observed data. More specifically, during any interim look, each event‐free subject will be counted with a probability that is derived using prior knowledge. The proposed approach is particularly useful in early stage studies for signal detection based on limited information. But it can also be used as a tool for safety monitoring (e.g., data monitoring committee) during later stage trials. Application of the approach is illustrated using a case study where the incidence rate of an adverse event is continuously monitored during an Alzheimer's disease clinical trial. The performance of the proposed approach is also assessed and compared with other Bayesian and frequentist methods via simulation. Copyright © 2015 John Wiley & Sons, Ltd.     

Predicting Home Run Production in Major League Baseball Using a Bayesian Semiparametric Model

This article attempts to predict home run hitting performance of Major League Baseball players using a Bayesian semiparametric model. Following Berry, Reese and Larkey we include in the model effects for era of birth, season of play, and home ball park. We estimate performance curves for each player using orthonormal quartic polynomials. We use a Dirichlet process prior on the unknown distribution for the coefficients of the polynomials, and parametric priors for the other effects. Dirichlet process priors are useful in prediction for two reasons: (1) an increased probability of obtaining more precise prediction comes with the increased flexibility of the prior specification, and (2) the clustering inherent in the Dirichlet process provides the means to share information across players. Data from 1871 to 2008 were used to fit the model. Data from 2009 to 2016 were used to test the predictive ability of the model. A parametric model was also fit to compare the predictive performance of the models. We used what we called “pure performance” curves to predict future performance for 22 players. The nonparametric method provided superior predictive performance.     

Bayesian Analysis of the Proportional Hazards Model with Time‐Varying Coefficients

We study a Bayesian analysis of the proportional hazards model with time‐varying coefficients. We consider two priors for time‐varying coefficients – one based on B‐spline basis functions and the other based on Gamma processes – and we use a beta process prior for the baseline hazard functions. We show that the two priors provide optimal posterior convergence rates (up to the term) and that the Bayes factor is consistent for testing the assumption of the proportional hazards when the two priors are used for an alternative hypothesis. In addition, adaptive priors are considered for theoretical investigation, in which the smoothness of the true function is assumed to be unknown, and prior distributions are assigned based on B‐splines.     

Noninformative priors for the common mean in the bivariate normal distribution

In this paper, we consider some noninformative priors for the common mean in a bivariate normal population. We develop the first-order and second-order matching priors and reference priors. We find that the second-order matching prior is also an HPD matching prior, and matches the alternative coverage probabilities up to the second order. It turns out that derived reference priors do not satisfy a second-order matching criterion. Our simulation study indicates that the second-order matching prior performs better than the reference priors in terms of matching the target coverage probabilities in a frequentist sense. We also illustrate our results using real data.     

Noninformative priors for the normal variance ratio

In this paper, we consider noninformative priors for the ratio of variances in two normal populations. We develop first and second order matching priors. We find that the second order matching prior matches alternative coverage probabilities up to the second order and is also a HPD matching prior. It turns out that among the reference priors, only one-at-a-time reference prior satisfies a second order matching criterion. Our simulation study indicates that the one-at-a-time reference prior performs better than other reference priors in terms of matching the target coverage probabilities in a frequentist sense. This work is supported by Korea Research Foundation Grant (KRF-2004-002-C00041).     

Reference priors for constrained rate models of count data

We derive reference priors for constrained rate models of count data using the sequential algorithm of Berger and Bernardo (1992b). The event counts for various groups of subjects are modeled as discrete random variables (Poisson, binomial, or negative binomial) with group specific rates. We consider situations in which the groups can be completely ordered according to one covariate. The priors enforce monotonicity (or monotonicity and convexity) of the rates with respect to the ordering. We use the priors to model a data set on mortality rates for men in different age groups assuming that the mortality rates increase with respect to age. We also consider the situation in which the parameter space is augmented to include rates corresponding to unobserved age groups, and the case of a random upper bound on the mortality rates. In addition, we provide an evaluation of the out-of-sample predictive performance of the proposed methods.     

Bayesian Instrumental Variables: Priors and Likelihoods

Instrumental variable (IV) regression provides a number of statistical challenges due to the shape of the likelihood. We review the main Bayesian literature on instrumental variables and highlight these pathologies. We discuss Jeffreys priors, the connection to the errors-in-the-variables problems and more general error distributions. We propose, as an alternative to the inverted Wishart prior, a new Cholesky-based prior for the covariance matrix of the errors in IV regressions. We argue that this prior is more flexible and more robust thanthe inverted Wishart prior since it is not based on only one tightness parameter and therefore can be more informative about certain components of the covariance matrix and less informative about others. We show how prior-posterior inference can be formulated in a Gibbs sampler and compare its performance in the weak instruments case for synthetic as well as two illustrations based on well-known real data.     

Predictive control of posterior robustness for sample size choice in a Bernoulli model

In this article we consider the sample size determination problem in the context of robust Bayesian parameter estimation of the Bernoulli model. Following a robust approach, we consider classes of conjugate Beta prior distributions for the unknown parameter. We assume that inference is robust if posterior quantities of interest (such as point estimates and limits of credible intervals) do not change too much as the prior varies in the selected classes of priors. For the sample size problem, we consider criteria based on predictive distributions of lower bound, upper bound and range of the posterior quantity of interest. The sample size is selected so that, before observing the data, one is confident to observe a small value for the posterior range and, depending on design goals, a large (small) value of the lower (upper) bound of the quantity of interest. We also discuss relationships with and comparison to non robust and non informative Bayesian methods.