Estimation in capture–recapture models when covariates are subject to measurement errors and missing data

For capture–recapture models when covariates are subject to measurement errors and missing data, a set of estimating equations is constructed to estimate population size and relevant parameters. These estimating equations can be solved by an algorithm similar to the EM algorithm. The proposed method is also applicable to the situation when covariates with no measurement errors have missing data. Simulation studies are used to assess the performance of the proposed estimator. The estimator is also applied to a capture–recapture experiment on the bird species Prinia flaviventris in Hong Kong. The Canadian Journal of Statistics 37: 645–658; 2009 © 2009 Statistical Society of Canada     

Assessing the stability of classification trees using Florida birth data

Using 1998 and 1999 singleton birth data of the State of Florida, we study the stability of classification trees. Tree stability depends on both the learning algorithm and the specific data set. In this study, test samples are used in statistical learning to evaluate both stability and predictive performance. We also use the resampling technique bootstrap, which can be regarded as data self-perturbation, to evaluate the sensitivity of the modeling algorithm with respect to the specific data set. We demonstrate that the selection of the cost function plays an important role in stability. In particular, classifiers with equal misclassification costs and equal priors are less stable compared to those with unequal misclassification costs and equal priors.     

Burden of bioinformatics in medical research: Statistical perspectives and controversies

The ongoing evolution of genomics and bioinformatics has an overwhelming impact on medical and clinical research, albeit this development is often marked by genuine controversies as well as lack of scientific clarities and acumen. The search for disease genes and the gene–environment interaction has drawn considerable interdisciplinary scientific attention: environmental health, clinical and medical sciences, biological as well as computational and statistical sciences are most noteworthy. Statistical reasoning (quantitative modeling and analysis perspectives) has a focal stand in this respect while data mining resolutions are far from being statistically fully understood or interpretable. The use of human subjects, though unavoidable, under various extraneous restraints, medical ethics perspectives, and human rights undercurrents, has raised concern all over the world, especially in the developing countries. In the genomics context, clinical trials may be designed on chips and yet there are greater challenges due to the curse of dimensionality perspectives. Some of these challenging statistical issues in medical and clinical research (with emphasis on clinical trials) are appraised in the light of existing statistical tools, which are available for less complex clinical research problems.     

Semiparametric inference for survival models with step process covariates

The authors consider Bayesian methods for fitting three semiparametric survival models, incorporating time‐dependent covariates that are step functions. In particular, these are models due to Cox [Cox ( 1972 ) Journal of the Royal Statistical Society, Series B, 34, 187–208], Prentice & Kalbfleisch and Cox & Oakes [Cox & Oakes ( 1984 ) Analysis of Survival Data, Chapman and Hall, London]. The model due to Prentice & Kalbfleisch [Prentice & Kalbfleisch ( 1979 ) Biometrics, 35, 25–39], which has seen very limited use, is given particular consideration. The prior for the baseline distribution in each model is taken to be a mixture of Polya trees and posterior inference is obtained through standard Markov chain Monte Carlo methods. They demonstrate the implementation and comparison of these three models on the celebrated Stanford heart transplant data and the study of the timing of cerebral edema diagnosis during emergency room treatment of diabetic ketoacidosis in children. An important feature of their overall discussion is the comparison of semi‐parametric families, and ultimate criterion based selection of a family within the context of a given data set. The Canadian Journal of Statistics 37: 60–79; © 2009 Statistical Society of Canada     

A reanalysis of a longitudinal scleroderma clinical trial using non-ignorable missingness models

When analyzing incomplete longitudinal clinical trial data, it is often inappropriate to assume that the occurrence of missingness is at random, especially in cases where visits are entirely missed. We present a framework that simultaneously models multivariate incomplete longitudinal data and a non-ignorable missingness mechanism using a Bayesian approach. A criterion measure is presented for comparing models. We demonstrate the feasibility of the methodology through reanalysis of two of the longitudinal measures from a clinical trial of penicillamine treatment for scleroderma patients. We compare the results for univariate and bivariate, ignorable and non-ignorable missingness models.     

Mixed‐scale models for survival/sacrifice experiments

Information derived from interim sacrifices or on cause of death is routinely used in the statistical analyses of carcinogenicity experiments involving occult tumours. The authors describe a simple semiparametric model which does not require this information. Natural deaths during the experiment and the usual terminal sacrifice provide sufficient information to ensure that the tumour incidence rates, which are of primary interest in occult‐tumour studies, can be estimated nonparametrically. The advantages of this semiparametric approach to the analysis of survival/sacrifice experiments are illustrated using data from a study on benzyl acetate conducted under the U. S. National Toxicology Program. The results derived compare favourably with those obtained using a previously published approach to the analysis of tumorigenicity data.     

Closed‐form likelihoods for stochastic differential equation growth models

The authors derive closed‐form expressions for the full, profile, conditional and modified profile likelihood functions for a class of random growth parameter models they develop as well as Garcia's additive model. These expressions facilitate the determination of parameter estimates for both types of models. The profile, conditional and modified profile likelihood functions are maximized over few parameters to yield a complete set of parameter estimates. In the development of their random growth parameter models the authors specify the drift and diffusion coefficients of the growth parameter process in a natural way which gives interpretive meaning to these coefficients while yielding highly tractable models. They fit several of their random growth parameter models and Garcia's additive model to stock market data, and discuss the results. The Canadian Journal of Statistics 38: 474–487; 2010 © 2010 Statistical Society of Canada     

On the estimation of the stochastic intensity and the parameters of neyman-scott trigger processes

In this paper we are concerned with a class of simple point processes, whose unobservable stochastic intensity is a shot-noise process. We derive a stochastic equation for the conditional moment generating function of the intensity, which can be solved in a recursive way. This yields explicit expression for the minimum variance estimate of the intensity as well as the likelihood ration with respect to the reference measure, on the basis of point process observations.     

Likelihood analysis of joint marginal and conditional models for longitudinal categorical data

The authors develop a Markov model for the analysis of longitudinal categorical data which facilitates modelling both marginal and conditional structures. A likelihood formulation is employed for inference, so the resulting estimators enjoy the optimal properties such as efficiency and consistency, and remain consistent when data are missing at random. Simulation studies demonstrate that the proposed method performs well under a variety of situations. Application to data from a smoking prevention study illustrates the utility of the model and interpretation of covariate effects. The Canadian Journal of Statistics © 2009 Statistical Society of Canada     

A linear transformation model for multivariate interval‐censored failure time data

This paper discusses multivariate interval‐censored failure time data observed when several correlated survival times of interest exist and only interval censoring is available for each survival time. Such data occur in many fields, for instance, studies of the development of physical symptoms or diseases in several organ systems. A marginal inference approach was used to create a linear transformation model and applied to bivariate interval‐censored data arising from a diabetic retinopathy study and an AIDS study. The results of simulation studies that were conducted to evaluate the performance of the presented approach suggest that it performs well. The Canadian Journal of Statistics 41: 275–290; 2013 © 2013 Statistical Society of Canada     

A stochastic graph process for epidemic modelling

A stochastic graph process with a Markov property is introduced to model the flow of an infectious disease over a known contact network. The model provides a probability distribution over unobserved infectious pathways. The basic reproductive number in compartmental models is generalized to a dynamic reproductive number based on the sequence of outdegrees in the graph process. The cumulative resistance and threat associated with each individual is also measured based on the cumulative indegree and outdegree of the graph process. The model is applied to the outbreak data from the 2001 foot‐and‐mouth (FMD) outbreak in the United Kingdom. The Canadian Journal of Statistics 40: 55–67; 2012 © 2012 Statistical Society of Canada     

Confidence regions for the common mean vector of several multivariate normal populations

Suppose that there are independent samples available from several multivariate normal populations with the same mean vector m? but possibly different covariance matrices. The problem of developing a confidence region for the common mean vector based on all the samples is considered. An exact confidence region centered at a generalized version of the well-known Graybill-Deal estimator of m? is developed, and a multiple comparison procedure based on this confidence region is outlined. Necessary percentile points for constructing the confidence region are given for the two-sample case. For more than two samples, a convenient method of approximating the percentile points is suggested. Also, a numerical example is presented to illustrate the methods. Further, for the bivariate case, the proposed confidence region and the ones based on individual samples are compared numerically with respect to their expected areas. The numerical results indicate that the new confidence region is preferable to the single-sample versions for practical use.     

Duration analysis in longitudinal studies with intermittent observation times and losses to followup

We consider the analysis of spell durations observed in event history studies where members of the study panel are seen intermittently. Challenges for analysis arise because losses to followup are frequently related to previous event history, and spells typically overlap more than one observation period. We provide methods of estimation based on inverse probability of censoring weighting for parametric and semiparametric Cox regression models. Selection of panel members through a complex survey design is also addressed, and the methods are illustrated in an analysis of jobless spell durations based on data from the Statistics Canada Survey of Labour and Income Dynamics. The Canadian Journal of Statistics 40: 1–21; 2012 © 2012 Statistical Society of Canada