Regression coefficient analysis for correlated binomial outcomes

At present, the generalized estimating equation (GEE) and weighted least-squares (WLS) regression methods are the most widely used methods for analyzing correlated binomial data; both are easily implemented using existing software packages. We propose an alternative technique, i.e. regression coefficient analysis (RCA), for this type of data. In RCA, a regression equation is computed for each of n individuals; regression coefficients are averaged across the n equations to produce a regression equation, which predicts marginal probabilities and which can be tested to address hypotheses of different slopes between groups, slopes different from zero, different intercepts, etc. The method is computationally simple and can be performed using standard software. Simulations and examples are used to compare the power and robustness of RCA with those of the standard GEE and WLS methods. We find that RCA is comparable with the GEE method under the conditions tested, and suggest that RCA, within specified limitations, is a viable alternative to the GEE and WLS methods in the analysis of correlated binomial data.     

A multivariate zero-inflated binomial model for the analysis of correlated proportional data

In this paper, a new multivariate zero-inflated binomial (MZIB) distribution is proposed to analyse the correlated proportional data with excessive zeros. The distributional properties of purposed model are studied. The Fisher scoring algorithm and EM algorithm are given for the computation of estimates of parameters in the proposed MZIB model with/without covariates. The score tests and the likelihood ratio tests are derived for assessing both the zero-inflation and the equality of multiple binomial probabilities in correlated proportional data. A limited simulation study is performed to evaluate the performance of derived EM algorithms for the estimation of parameters in the model with/without covariates and to compare the nominal levels and powers of both score tests and likelihood ratio tests. The whitefly data is used to illustrate the proposed methodologies.     

Monitoring correlated processes with binomial marginals

Few approaches for monitoring autocorrelated attribute data have been proposed in the literature. If the marginal process distribution is binomial, then the binomial AR(1) model as a realistic and well-interpretable process model may be adequate. Based on known and newly derived statistical properties of this model, we shall develop approaches to monitor a binomial AR(1) process, and investigate their performance in a simulation study. A case study demonstrates the applicability of the binomial AR(1) model and of the proposed control charts to problems from statistical process control.     

Semiparametric estimator for a secondary analysis with correlated outcomes

ABSTRACT

Researchers are often required to reuse data that have been collected and analyzed for other purposes. Issues may arise if the outcome of this secondary study is related to the outcome of the first study and traditional methods may fail to deliver a consistent estimate. Here we propose a semiparametric approach that takes this correlation into account and produces asymptotically consistent and normally distributed estimates. We discuss its performance through simulations and apply the proposed method to a real dataset.     

Regression analysis of longitudinal data with correlated censoring and observation times

Longitudinal data occur in many fields such as the medical follow-up studies that involve repeated measurements. For their analysis, most existing approaches assume that the observation or follow-up times are independent of the response process either completely or given some covariates. In practice, it is apparent that this may not be true. In this paper, we present a joint analysis approach that allows the possible mutual correlations that can be characterized by time-dependent random effects. Estimating equations are developed for the parameter estimation and the resulted estimators are shown to be consistent and asymptotically normal. The finite sample performance of the proposed estimators is assessed through a simulation study and an illustrative example from a skin cancer study is provided.     

Combined estimating function for random coefficient models with correlated errors

ABSTRACT

Estimating functionshave been shown to be convenient to study inference for non linear time series models. Recently, Thavaneswaran et al. (2012 Thavaneswaran, A., Liang, Y., Frank, J. (2012). Inference for random coefficient volatility models. Stat. Probab. Lett. 82(12):2086–2090.[Crossref], [Web of Science ®] , [Google Scholar]) used combined estimating functions to study inference for random coefficient autoregressive (RCA) models with generalized autoregressive heteroscedasticity errors. While most RCA modeling assumes that the random term and the error are independent, Chandra and Taniguchi (2001 Chandra, S.A., Taniguchi, M. (2001). Estimating functions for nonlinear time series models. Ann. Inst. Stat. Math 53(1):125–141.[Crossref], [Web of Science ®] , [Google Scholar]) studied inference for RCA models with correlated errors using linear estimating functions. In this paper, we derive the quadratic estimating functions for the joint estimation of the conditional mean, variance, and correlation parameters of the RCA models with correlated errors.     

Likelihood estimation for a longitudinal negative binomial regression model with missing outcomes

Joint damage in psoriatic arthritis can be measured by clinical and radiological methods, the former being done more frequently during longitudinal follow-up of patients. Motivated by the need to compare findings based on the different methods with different observation patterns, we consider longitudinal data where the outcome variable is a cumulative total of counts that can be unobserved when other, informative, explanatory variables are recorded. We demonstrate how to calculate the likelihood for such data when it is assumed that the increment in the cumulative total follows a discrete distribution with a location parameter that depends on a linear function of explanatory variables. An approach to the incorporation of informative observation is suggested. We present analyses based on an observational database from a psoriatic arthritis clinic. Although the use of the new statistical methodology has relatively little effect in this example, simulation studies indicate that the method can provide substantial improvements in bias and coverage in some situations where there is an important time varying explanatory variable.     

One-way analysis of proportions for misclassified binomial data

We consider data with a nominal grouping variable and a binary response variable. The grouping variable is measured without error, but the response variable is measured using a fallible device subject to misclassification. To achieve model identifiability, we use the double-sampling scheme which requires obtaining a subsample of the original data or another independent sample. This sample is then classified by both the fallible device and another infallible device regarding the response variable. We propose two Wald tests for testing the association between the two variables and illustrate the test using traffic data. The Type-I error rate and power of the tests are examined using simulations and a modified Wald test is recommended.     

Efficient Inference for Longitudinal Data Varying‐coefficient Regression Models

Informative identification of the within‐subject correlation is essential in longitudinal studies in order to forecast the trajectory of each subject and improve the validity of inferences. In this paper, we fit this correlation structure by employing a time adaptive autoregressive error process. Such a process can automatically accommodate irregular and possibly subject‐specific observations. Based on the fitted correlation structure, we propose an efficient two‐stage estimator of the unknown coefficient functions by using a local polynomial approximation. This procedure does not involve within‐subject covariance matrices and hence circumvents the instability of calculating their inverses. The asymptotic normality of resulting estimators is established. Numerical experiments were conducted to check the finite sample performance of our method and an example of an application involving a set of medical data is also illustrated.     

Analysis of all-zero binomial outcomes with borderline and equilibrium priors

This article is concerned with the analysis of a random sample from a binomial distribution when all the outcomes are zero (or unity). We discuss how elicitation of the prior can be reduced to asking the expert whether (and which of) the so-called borderline or equilibrium priors are plausible.     

Joint GEEs for multivariate correlated data with incomplete binary outcomes

This study considers a fully-parametric but uncongenial multiple imputation (MI) inference to jointly analyze incomplete binary response variables observed in a correlated data settings. Multiple imputation model is specified as a fully-parametric model based on a multivariate extension of mixed-effects models. Dichotomized imputed datasets are then analyzed using joint GEE models where covariates are associated with the marginal mean of responses with response-specific regression coefficients and a Kronecker product is accommodated for cluster-specific correlation structure for a given response variable and correlation structure between multiple response variables. The validity of the proposed MI-based JGEE (MI-JGEE) approach is assessed through a Monte Carlo simulation study under different scenarios. The simulation results, which are evaluated in terms of bias, mean-squared error, and coverage rate, show that MI-JGEE has promising inferential properties even when the underlying multiple imputation is misspecified. Finally, Adolescent Alcohol Prevention Trial data are used for illustration.     

Resistant fits for regression with correlated outcomes an estimating equations approach

The generalized estimating equations procedure of Liang and Zeger (1986) can be highly influenced by the presence of unusual data points. A generalization is introduced which yields parameter estimates and fitted values resistant to influential data. A diagonal weight matrix for each cluster is incorporated into the estimating equations which downweights the multivariate response vector element-wise. Efficiency of the procedure is investigated, including the case of correlated binary outcomes.     

Signed binomial approximation of binomial mixtures via differential calculus for linear operators

We obtain sharp estimates in signed binomial approximation of binomial mixtures with respect to the total variation distance. We provide closed form expressions for the leading terms, and show that the corresponding leading coefficients depend on the zeros of appropriate Krawtchouk polynomials. The special case of Pólya–Eggenberger distributions is discussed in detail. Our approach is based on a differential calculus for linear operators represented by stochastic processes, which allows us to give unified proofs.     

A class of observation-driven random coefficient INAR(1) processes based on negative binomial thinning

Integer-valued time series models and their applications have attracted a lot of attention over the last years. In this paper, we introduce a class of observation-driven random coefficient integer-valued autoregressive processes based on negative binomial thinning, where the autoregressive parameter depends on the observed values of the previous moment. Basic probability and statistics properties of the process are established. The unknown parameters are estimated by the conditional least squares and empirical likelihood methods. Specially, we consider three aspects of the empirical likelihood method: maximum empirical likelihood estimate, confidence region and EL test. The performance of the two estimation methods is compared through simulation studies. Finally, an application to a real data example is provided.     

Modified regression coefficient analysis for repeated binary measurements

Myers & Broyles (2000a, 2000b) illustrate that regression coefficient analysis (RCA) is a viable alternative to a generalized estimating equation (GEE) in the analysis of correlated binomial data. Since the regression coefficients (b i ' s ) may have different precisions, we modify RCA by weighting b i ' s by the inverses of their variances for statistical optimality. We perform the simulation study to evaluate the performance of RCA, modified RCA and GEE in terms of empirical type I errors and empirical powers of the regression coefficients in repeated binary measurement designs with and without dropouts. Two thousand data sets are generated using autoregressive (AR(1)) and compound symmetry (CS) correlation structures. We compare the type I errors and powers of RCA, modified RCA and GEE for the analysis of repeated binary measurement data as affected by different dropout mechanisms such as random dropouts and treatment dependent dropouts.     

Robust Bayesian analysis of the binomial empirical Bayes problem

Empirical Bayes estimation is considered for an i.i.d. sequence of binomial parameters θ_i arising from an unknown prior distribution G(.). This problem typically arises in industrial sampling, where samples from lots are routinely used to estimate the lot fraction defective of each lot. Two related issues are explored. The first concerns the fact that only the first few moments of G are typically estimable from the data. This suggests consideration of the interval of estimates (e.g., posterior means) corresponding to the different possible G with the specified moments. Such intervals can be obtained by application of well-known moment theory. The second development concerns the need to acknowledge the uncertainty in the estimation of the first few moments of G. Our proposal is to determine a credible set for the moments, and then find the range of estimates (e.g., posterior means) corresponding to the different possible G with moments in the credible set.