Simultaneous Confidence Intervals for the Population Cell Means,for Two-by-Two Factorial Data,that Utilize Uncertain Prior Information

Consider a two-by-two factorial experiment with more than one replicate. Suppose that we have uncertain prior information that the two-factor interaction is zero. We describe new simultaneous frequentist confidence intervals for the four population cell means, with simultaneous confidence coefficient 1 ? α, that utilize this prior information in the following sense. These simultaneous confidence intervals define a cube with expected volume that (a) is relatively small when the two-factor interaction is zero and (b) has maximum value that is not too large. Also, these intervals coincide with the standard simultaneous confidence intervals obtained by Tukey’s method, with simultaneous confidence coefficient 1 ? α, when the data strongly contradict the prior information that the two-factor interaction is zero. We illustrate the application of these new simultaneous confidence intervals to a real data set.     

Multiple comparisons of matched proportions

It is well known (see, e.g., Scheffé (1959)) that if confidence intervals are desired for several treatment comparisons of interest, especially after a preliminary test of significance, then the appropriate technique is to consider simultaneous confidence intervals with a certain joint confidence coefficient. Goodman (1964) derived such simultaneous confidence intervals for contrasts among several multinomial populations, each with the same number, say J, of classes. The special case involving simultaneous confidence intervals for contrasts among several binomial populations on the basis of independent samples follows simply by taking J=2. This paper now deals with the problem of construction of simultaneous confidence intervals among probabilities of ‘success’ on the basis of matched samples.     

Coverage‐adjusted Confidence Intervals for a Binomial Proportion

We consider the classic problem of interval estimation of a proportion p based on binomial sampling. The ‘exact’ Clopper–Pearson confidence interval for p is known to be unnecessarily conservative. We propose coverage adjustments of the Clopper–Pearson interval that incorporate prior or posterior beliefs into the interval. Using heatmap‐type plots for comparing confidence intervals, we show that the coverage‐adjusted intervals have satisfying coverage and shorter expected lengths than competing intervals found in the literature.     

Coverage Properties of Confidence Intervals for Generalized Additive Model Components

Abstract. We study the coverage properties of Bayesian confidence intervals for the smooth component functions of generalized additive models (GAMs) represented using any penalized regression spline approach. The intervals are the usual generalization of the intervals first proposed by Wahba and Silverman in 1983 and 1985, respectively, to the GAM component context. We present simulation evidence showing these intervals have close to nominal ‘across‐the‐function’ frequentist coverage probabilities, except when the truth is close to a straight line/plane function. We extend the argument introduced by Nychka in 1988 for univariate smoothing splines to explain these results. The theoretical argument suggests that close to nominal coverage probabilities can be achieved, provided that heavy oversmoothing is avoided, so that the bias is not too large a proportion of the sampling variability. The theoretical results allow us to derive alternative intervals from a purely frequentist point of view, and to explain the impact that the neglect of smoothing parameter variability has on confidence interval performance. They also suggest switching the target of inference for component‐wise intervals away from smooth components in the space of the GAM identifiability constraints.     

The conditional level of confidence intervals for the normal variance and applications

Suppose we observe two independent random vectors each having a multivariate normal distribution with covariance matrix known up to an unknown scale factor σ . The first random vector has a known mean vector while the second has an unknown mean vector. Interest centers around finding confidence intervals for σ² with confidence coefficient 1 ? α. Standard results show that, when we only observe the first random vector, an optimal (i.e., smallest length) confidence interval C, based on the well-known chi- squared statistic, can be constructed for σ² . When we additionally observe the second random vector, the confidence interval C is no longer optimal for estimating σ². One criterion useful for detecting the non-optimality of a confidence interval C concerns whether C admits positively or negatively biased relevant subsets. This criterion has recently received a good deal of attention. It is shown here that under some conditions the confidence interval C admits positively biased relevant subsets.

Applications of this result to the construction of ‘better‘ unconditional confidence intervals for σ² are presented. Some simulation results are given to indicate the typical extent of improvement attained.     

Interval estimation of the mean in a two-stage nested model

The problem of constructing confidence intervals to estimate the mean in a two-stage nested model is considered. Several approximate intervals, which are based on both linear and nonlinear estimators of the mean are investigated. In particular, the method of bootstrap is used to correct the bias in the ‘usual’ variance of the nonlinear estimators. It is found that the intervals based on the nonlinear estimators did not achieve the nominal confidence coefficient for designs involving a small number of groups. Further, it turns out that the intervals are generally conservative, especially at small values of the intraclass correlation coefficient, and that the intervals based on the nonlinear estimators are more conservative than those based on the linear estimators. Compared with the others, the intervals based on the unweighted mean of the group means performed well in terms of coverage and length. For small values of the intraclass correlation coefficient, the ANOVA estimators of the variance components are recommended, otherwise the unweighted means estimator of the between groups variance component should be used. If one is fortunate enough to have control over the design, he is advised to increase the number of groups, as opposed to increasing group sizes, while avoiding groups of size one or two.     

Empirical Likelihood Inference for the Rao‐Hartley‐Cochran Sampling Design

The Hartley‐Rao‐Cochran sampling design is an unequal probability sampling design which can be used to select samples from finite populations. We propose to adjust the empirical likelihood approach for the Hartley‐Rao‐Cochran sampling design. The approach proposed intrinsically incorporates sampling weights, auxiliary information and allows for large sampling fractions. It can be used to construct confidence intervals. In a simulation study, we show that the coverage may be better for the empirical likelihood confidence interval than for standard confidence intervals based on variance estimates. The approach proposed is simple to implement and less computer intensive than bootstrap. The confidence interval proposed does not rely on re‐sampling, linearization, variance estimation, design‐effects or joint inclusion probabilities.     

TWO-SAMPLE NONPARAMETRIC TILTING METHOD

Efron introduced the one-sample nonparametric tilting method for constructing confidence intervals. The method enjoys some good features such as being range-respecting and having internal studentizing and good coverage accuracy. This paper presents a two-sample version of the one-sample non-parametric tilting method for dealing with two independent sample problems, whereby each of the two individual samples is ‘tilted’ separately by different amounts. The paper shows that careful choice of the two tilting parameters produces second-order accurate confidence limits. Further, saddlepoint approximations can be used to avoid extensive Monte Carlo simulations, and it turns out that the approximations are exceptionally easy to apply with the tilting parameters. Numerical examples illustrate the two-sample nonparametric tilting method.     

Bootstrapping a hedonic price index: experience from used cars data

Every hedonic price index is an estimate of an unknown economic parameter. It depends, in practice, on one or more random samples of prices and characteristics of a certain good. Bootstrap resampling methods provide a tool for quantifying sampling errors. Following some general reflections on hedonic elementary price indices, this paper proposes a case-based, a model-based, and a wild bootstrap approach for estimating confidence intervals for hedonic price indices. Empirical results are obtained for a data set on used cars in Switzerland. A simple and an enhanced adaptive semi-logarithmic model are fit to monthly samples, and bootstrap confidence intervals are estimated for Jevons-type hedonic elementary price indices.     

Inference for functions of parameters in discrete distributions based on fiducial approach: Binomial and Poisson cases

In this article, we propose a simple method of constructing confidence intervals for a function of binomial success probabilities and for a function of Poisson means. The method involves finding an approximate fiducial quantity (FQ) for the parameters of interest. A FQ for a function of several parameters can be obtained by substitution. For the binomial case, the fiducial approach is illustrated for constructing confidence intervals for the relative risk and the ratio of odds. Fiducial inferential procedures are also provided for estimating functions of several Poisson parameters. In particular, fiducial inferential approach is illustrated for interval estimating the ratio of two Poisson means and for a weighted sum of several Poisson means. Simple approximations to the distributions of the FQs are also given for some problems. The merits of the procedures are evaluated by comparing them with those of existing asymptotic methods with respect to coverage probabilities, and in some cases, expected widths. Comparison studies indicate that the fiducial confidence intervals are very satisfactory, and they are comparable or better than some available asymptotic methods. The fiducial method is easy to use and is applicable to find confidence intervals for many commonly used summary indices. Some examples are used to illustrate and compare the results of fiducial approach with those of other available asymptotic methods.     

Confidence Intervals for Quantiles of a Two-parameter Exponential Distribution under Progressive Type-II Censoring

Confidence intervals for the pth-quantile Q of a two-parameter exponential distribution provide useful information on the plausible range of Q, and only inefficient equal-tail confidence intervals have been discussed in the statistical literature so far. In this article, the construction of the shortest possible confidence interval within a family of two-sided confidence intervals is addressed. This shortest confidence interval is always shorter, and can be substantially shorter, than the corresponding equal-tail confidence interval. Furthermore, the computational intensity of both methodologies is similar, and therefore it is advantageous to use the shortest confidence interval. It is shown how the results provided in this paper can apply to data obtained from progressive Type II censoring, with standard Type II censoring as a special case. The applications of more complex confidence interval constructions through acceptance set inversions that can employ prior information are also discussed.     

On exact confidence intervals in a competing risks model with generalized hybrid type-I censored exponential data

In a recent paper by Mao, Shi and Sun that appeared in Journal of Statistical Computation and Simulation, the authors discuss, among other approaches, the construction of exact confidence intervals for the underlying parameters by ‘pivoting the cumulative distribution functions’ of the corresponding maximum likelihood estimators (MLEs). The authors assume that this method is applicable without providing the appropriate justification. In this short note the two requirements for the applicability of this method are discussed, namely, the stochastic monotonicity of the MLEs and the existence of solutions to the equations defining the exact confidence interval's endpoints.     

ESTIMATION OF THE CONDITIONAL PROBABILITY OF TUBERCULOSIS GIVEN THE RESPONSE OF A MANTOUX TEST

For the planning of community tuberculosis, prophylaxis one must know the prevalence of tuberculosis (TB) infection as a function of response to the Mantoux intradermal tuberculin test; the standard test for indicating Mycobacterium TB infection. The skin induration size used to select individuals for prophylaxis must be chosen carefully, in view of the costs associated with carrying out and supervising such prophylaxis. The Mantoux test was used to obtain measurements on adolescents in metropolitan Victoria and on a small sample of adolescents with clinical TB. These data are employed to obtain estimates and to construct upper confidence bounds for the conditional probability of TB infection, given the level of Mantoux response. Two conservative methods are presented; one is ‘nonparametric’, the other ‘semiparametric’. The analyses indicate that for responses up to and including 13 mm, the probability of TB infection is less than.07 with ninety-five percent confidence.     

Quantile regression via iterative least squares computations

We present an estimating framework for quantile regression where the usual L ₁-norm objective function is replaced by its smooth parametric approximation. An exact path-following algorithm is derived, leading to the well-known ‘basic’ solutions interpolating exactly a number of observations equal to the number of parameters being estimated. We discuss briefly possible practical implications of the proposed approach, such as early stopping for large data sets, confidence intervals, and additional topics for future research.     

Least significant spacing for ‘one versus the rest’ normal populations

Consider sample means from k(≥2) normal populations where the variances and sample sizes are equal. The problem is to find the ‘least significant difference’ or ‘spacing’ (LSS) between the two largest means, so that if an observed spacing is larger we have confidence 1 - α that the population with largest sample mean also has the largest population mean.

When the variance is known it is shown that the maximum LSS occurs when k = 2, provided a < .2723. In other words, for any value of k we may use the usual (one-tailed) least significant difference to demonstrate that one population has a population mean greater than (or equal to) the rest.

When the variance is estimated bounds are obtained for the confidence which indicate that this last result is approximately correct.     

Approximate Bayesianity of Frequentist Confidence Intervals for a Binomial Proportion

The well-known Wilson and Agresti–Coull confidence intervals for a binomial proportion p are centered around a Bayesian estimator. Using this as a starting point, similarities between frequentist confidence intervals for proportions and Bayesian credible intervals based on low-informative priors are studied using asymptotic expansions. A Bayesian motivation for a large class of frequentist confidence intervals is provided. It is shown that the likelihood ratio interval for p approximates a Bayesian credible interval based on Kerman’s neutral noninformative conjugate prior up to O(n^{? 1}) in the confidence bounds. For the significance level α ? 0.317, the Bayesian interval based on the Jeffreys’ prior is then shown to be a compromise between the likelihood ratio and Wilson intervals. Supplementary materials for this article are available online.     

Construction of fixed width confidence intervals for a Bernoulli success probability using sequential sampling: a simulation study

This article considers the construction of level 1?α fixed width 2d confidence intervals for a Bernoulli success probability p, assuming no prior knowledge about p and so p can be anywhere in the interval [0, 1]. It is shown that some fixed width 2d confidence intervals that combine sequential sampling of Hall [Asymptotic theory of triple sampling for sequential estimation of a mean, Ann. Stat. 9 (1981), pp. 1229–1238] and fixed-sample-size confidence intervals of Agresti and Coull [Approximate is better than ‘exact’ for interval estimation of binomial proportions, Am. Stat. 52 (1998), pp. 119–126], Wilson [Probable inference, the law of succession, and statistical inference, J. Am. Stat. Assoc. 22 (1927), pp. 209–212] and Brown et al. [Interval estimation for binomial proportion (with discussion), Stat. Sci. 16 (2001), pp. 101–133] have close to 1?α confidence level. These sequential confidence intervals require a much smaller sample size than a fixed-sample-size confidence interval. For the coin jamming example considered, a fixed-sample-size confidence interval requires a sample size of 9457, while a sequential confidence interval requires a sample size that rarely exceeds 2042.     

Improving early phase oncology clinical trial design: An opportunity for statisticians

This short communication supports that rule-based study designs such as the ‘3 + 3’ study design are still being used in early phase oncology development programs despite their inferior performance to model-based and model-assisted designs. Statisticians have an opportunity to shape and improve early phase oncology drug development programs by introducing newer, more efficient study designs that estimate the Optimal Biological dose to their oncology trialist colleges.