Goodness of fit tests with misclassified data

The most popular goodness of fit test for a multinomial distribution is the chi-square test. But this test is generally biased if observations are subject to misclassification, In this paper we shall discuss how to define a new test procedure when we have double sample data obtained from the true and fallible devices. An adjusted chi-square test based on the imputation method and the likelihood ratio test are considered, Asymptotically, these two procedures are equivalent. However, an example and simulation results show that the former procedure is not only computationally simpler but also more powerful under finite sample situations.     

Bias correction of estimated proportions using inverse binomial group testing

Group testing, in which individuals are pooled together and tested as a group, can be combined with inverse sampling to estimate the prevalence of a disease. Alternatives to the MLE are desirable because of its severe bias. We propose an estimator based on the bias correction method of Firth (1993), which is almost unbiased across the range of prevalences consistent with the group testing design. For equal group sizes, this estimator is shown to be equivalent to that derived by applying the correction method of Burrows (1987), and better than existing methods. For unequal group sizes, the problem has some intractable elements, but under some circumstances our proposed estimator can be found, and we show it to be almost unbiased. Calculation of the bias requires computer‐intensive approximation because of the infinite number of possible outcomes.     

Analysis of binary data for the balanced one-way classification

A test is proposed for testing the equality of proportions based on the data available from a one-way classification having t treatment conditions and n binary observations per treatment. The test statistic B is a constant multiple of the F-statistic which results when the analysis of variance procedure for the one-way classification is applied to the data and, hence, is computationally simple. The statistic B from this binary analysis of variance (BIANOVA) is distributed asymptotically as a chi-square random variable. The proposed test is uniformly more powerful than either the F-test indicated above or the Pearson chi-square test; however, the attained empirical level of significance is frequently higher than for either of these competitors and usually higher than the stated level of significance for smaller values of n (say n ≤ 20).     

A unified sequential test procedure for simultaneous testing the equality of several binomial proportions to a specified standard

In this article, we propose a unified sequentially rejective test procedure for testing simultaneously the equality of several independent binomial proportions to a specified standard. The proposed test procedure is general enough to include some well-known multiple testing procedures such as the Ordinary Bonferroni procedure, Hochberg procedure and Rom procedure. It involves multiple tests of significance based on the simple binomial tests (exact or approximate) which can be easily found in many elementary standard statistics textbooks. Unlike the traditional Chi-square test of the overall hypothesis, the procedure can identify the subset of the binomial proportions, which are different from the prespecified standard with the control of the familywise type I error rate. Moreover, the power computation of the procedure is provided and the procedure is illustrated by two real examples from an ecological study and a carcinogenicity study.     

Sequential risk-efficient estimation for the ratio of two binomial proportions

A risk-efficient sequential point estimator is considered for the ratio of two independent binomial proportions based on maximum likelihood estimation under squared error loss and cost proportional to the observations. It is assumed that the cost per observation is constant. First-order asymptotic expansions are obtained for large-sample properties of the proposed procedure. Performance of the procedure is studied through the criteria of risk efficiency and regret analysis. Monte Carlo simulation is carried out to obtain the expected sample size that minimizes the risk and to examine its finite sample behavior. An example is provided to illustrate its use.     

Testing equality of proportions with incomplete correlated data

Let (ψ_i,φ_i) be independent, identically distributed pairs of zero-one random variables with (possible) dependence of ψ_i and φ_i within the pair. For n pairs, both variables are observed, but for m₁ additional pairs only ψ_i is observed and for m₂ others φ_i is observed. If π_1· = P{ψ_i = 1} and π_·1=P{φ_i, the problem is to test π_1·=π_·1. Maximum likelihood estimates of π_1· and π_·1 are obtained via the EM algorithm. A test statistic is developed whose null distribution is asymptotically chi-square with one degree of freedom (as n and either m₁ or m₂ tend to infinity). If m₁ = m₂ = 0 the statistic reduces to that of McNemar's test; if n = 0, it is equivalent to the statistic for testing equality of two independent proportions. This test is compared with other tests by means of Pitman efficiency. Examples are presented.     

Approximate confidence intervals for a linear combination of binomial proportions: A new variant

We propose a new adjustment for constructing an improved version of the Wald interval for linear combinations of binomial proportions, which addresses the presence of extremal samples. A comparative simulation study was carried out to investigate the performance of this new variant with respect to the exact coverage probability, expected interval length, and mesial and distal noncoverage probabilities. Additionally, we discuss the application of a criterion for interpreting interval location in the case of small samples and/or in situations in which extremal observations exist. The confidence intervals obtained from the new variant performed better for some evaluation measures.     

A Bayesian approach for misclassified ordinal response data

ABSTRACT

Motivated by a longitudinal oral health study, the Signal-Tandmobiel^® study, a Bayesian approach has been developed to model misclassified ordinal response data. Two regression models have been considered to incorporate misclassification in the categorical response. Specifically, probit and logit models have been developed. The computational difficulties have been avoided by using data augmentation. This idea is exploited to derive efficient Markov chain Monte Carlo methods. Although the method is proposed for ordered categories, it can also be implemented for unordered ones in a simple way. The model performance is shown through a simulation-based example and the analysis of the motivating study.     

Comparison of correlated proportions based on paired binary data from clustered samples

In this article, we explore hypothesis testing problems related to correlated proportions from clustered matched-pair binary data. Null hypotheses of equality in proportions, homogeneity, and non-inferiority of one to another are similar testing problems of linear contrasts of correlated proportions with suitable transformation. The covariance estimators of the test statistics are based on moment estimation under the null hypotheses. We present a general framework for testing linear contrasts of the correlated proportions from clustered matched-pair data based upon a class of unbiased estimators of the proportions. The corresponding testing procedures do not impose structure assumptions on the correlation matrix and are easy to use. Simulation results suggest that the proposed method is more likely to maintain the proper significance level and to improve power than the test proposed by Obuchowski.     

A comparative study of confidence intervals for negative binomial proportion

In this paper, we investigate four existing and three new confidence interval estimators for the negative binomial proportion (i.e., proportion under inverse/negative binomial sampling). An extensive and systematic comparative study among these confidence interval estimators through Monte Carlo simulations is presented. The performance of these confidence intervals are evaluated in terms of their coverage probabilities and expected interval widths. Our simulation studies suggest that the confidence interval estimator based on saddlepoint approximation is more appealing for large coverage levels (e.g., nominal level≤1% ) whereas the score confidence interval estimator is more desirable for those commonly used coverage levels (e.g., nominal level>1% ). We illustrate these confidence interval construction methods with a real data set from a maternal congenital heart disease study.     

Nearly optimal truncated group sequential test on binomial proportions

In this article, we systematically study the optimal truncated group sequential test on binomial proportions. Through analysis of the cost structure, average test cost is introduced as a new optimality criterion. According to the new criterion, the optimal tests on different design parameters including the boundaries, success discriminant value, stage sample vector, stage size, and the maximum sample size are defined. Since the computation time in finding optimal designs by exhaustive search is intolerably long, group sequential sample space sorting method and procedures are developed to find the near-optimal ones. In comparison with the international standard ISO2859-1, the truncated group sequential designs proposed in this article can reduce the average test costs around 20%.     

Analysis of proportions for clustered binary data in the presence of unequal dispersions

This paper investigates the test procedures for testing the homogeneity of the proportions in the analysis of clustered binary data in the context of unequal dispersions across the treatment groups. We introduce a simple test procedure based on adjusted proportions using a sandwich estimator of the variance of the proportion estimators obtained by the generalized estimating equations approach of Zeger and Liang (1986) [Biometrics 42, 121-130]. We also extend the exiting test procedures of testing the hypothesis of proportions in this context. These test procedures are then compared, by simulations, in terms of size and power. Moreover, we derive the score test for testing the homogeneity of the dispersion parameters among several groups of clustered binary data. An illustrative application of the recommended test procedures is also presented.     

Large sample results for tests of association ii. multinomial and stratified sampling

This paper deals with the asymptotics of a class of tests for association in 2-way contingency tables based on square forms in cell frequencies, given the total number of observations (multinomial sampling) or one set of marginal totals (stratified sampling). The case when both row and column marginal totals are fixed (hypergeometric sampling) was studied in Kulinskaya (1994), The class of tests under consideration includes a number of classical measures for association, Its two subclasses are the tests based on statistics using centralized cell frequencies (asymptotically distributed as weighted sums of central chi-squares) and those using the non-centralized cell frequencies (asymptotically normal). The parameters of asymptotic distributions depend on the sampling model and on true marginal probabilities. Maximum efficiency for asymptotically normal statistics is achieved under hypergeometric sampling, If the cell frequencies or the statistic as a whole are centralized using marginal proportions as estimates for marginal probabilities, the asymptotic distribution does not differ much between models and it is equivalent to that under hypergeometric sampling. These findings give an extra justification for the use of permutation tests for association (which are based on hypergeometric sampling). As an application, several well known measures of association are analysed.     

New asymptotic inferences about the difference,ratio, and linear combination of two independent proportions

In statistics it is customary to realize asymptotic inferences about the difference d, the ratio R or a linear combination L of two independent proportions. In this article the authors evaluate ten inference methods, and conclude that for α = 1% some of the new procedures behave better than the classical. In cases d, R, or L, the optimal method consists in adding 0.5, 0.5 or 1 to all the data, respectively, and then applying a modification of the arc-sine transformation (d or R) or the likelihood ratio test (L). A free program may be obtained at ULR http://www.ugr.es/local/bioest/Z_LINEAR_K.EXE.     

A multivariate zero-inflated binomial model for the analysis of correlated proportional data

In this paper, a new multivariate zero-inflated binomial (MZIB) distribution is proposed to analyse the correlated proportional data with excessive zeros. The distributional properties of purposed model are studied. The Fisher scoring algorithm and EM algorithm are given for the computation of estimates of parameters in the proposed MZIB model with/without covariates. The score tests and the likelihood ratio tests are derived for assessing both the zero-inflation and the equality of multiple binomial probabilities in correlated proportional data. A limited simulation study is performed to evaluate the performance of derived EM algorithms for the estimation of parameters in the model with/without covariates and to compare the nominal levels and powers of both score tests and likelihood ratio tests. The whitefly data is used to illustrate the proposed methodologies.     

Estimation of proportions for multinomial contingency tables subject to marginal constraints

For a two-way table of observed proportions we consider four approaches to the problem of fitting a new set of proportions which-subject to satisfying marginal constraints on row and column totals-corresponds as closely as possible to the original table, The approaches are known to be asymptotically equivalent; but our chief interest is in establishing, at least for the 2x2 table, a hierarchy of preferences under multinomial sampling for moderate sample sizes. Implementation of minimum chi-square is described and recommended.     

A novel approach based on multiple correspondence analysis for monitoring social networks with categorical attributed data

In in most cases, the distribution of communications is unknown and one may summarize social network communications with categorical attributes in a contingency table. Due to the categorical nature of the data and a large number of features, there are many parameters to be considered and estimated in the model. Hence, the accuracy of estimators decreases. To overcome the problem of high dimensionality and unknown communications distribution, multiple correspondence analysis is used to reduce the number of parameters. Then the rescaled data are studied in a Dirichlet model in which the parameters should be estimated. Moreover, two control charts, Hotelling’s T² and multivariate exponentially weighted moving average (MEWMA), are developed to monitor the parameters of the Dirichlet distribution. The performance of the proposed method is evaluated through simulation studies in terms of average run length criterion. Finally, the proposed method is applied to a real case.     

An asymptotic approximation for EPMC in linear discriminant analysis based on monotone missing data

In this paper, we propose an asymptotic approximation for the expected probabilities of misclassification (EPMC) in the linear discriminant function on the basis of k-step monotone missing training data for general k. We derive certain relations of the statistics in order to obtain the approximation. Finally, we perform Monte Carlo simulation to evaluate the accuracy of our result and to compare it with existing approximations.