An empirical investigation of different operating characteristics of several estimators of the intraclass correlation in the analysis of binary data

This paper is concerned with properties (bias, standard deviation, mean square error and efficiency) of twenty six estimators of the intraclass correlation in the analysis of binary data. Our main interest is to study these properties when data are generated from different distributions. For data generation we considered three over-dispersed binomial distributions, namely, the beta-binomial distribution, the probit normal binomial distribution and a mixture of two binomial distributions. The findings regarding bias, standard deviation and mean squared error of all these estimators, are that (a) in general, the distributions of biases of most of the estimators are negatively skewed. The biases are smallest when data are generated from the beta-binomial distribution and largest when data are generated from the mixture distribution; (b) the standard deviations are smallest when data are generated from the beta-binomial distribution; and (c) the mean squared errors are smallest when data are generated from the beta-binomial distribution and largest when data are generated from the mixture distribution. Of the 26, nine estimators including the maximum likelihood estimator, an estimator based on the optimal quadratic estimating equations of Crowder (1987), and an analysis of variance type estimator is found to have least amount of bias, standard deviation and mean squared error. Also, the distributions of the bias, standard deviation and mean squared error for each of these estimators are, in general, more symmetric than those of the other estimators. Our findings regarding efficiency are that the estimator based on the optimal quadratic estimating equations has consistently high efficiency and least variability in the efficiency results. In the important range in which the intraclass correlation is small (≤0 5), on the average, this estimator shows best efficiency performance. The analysis of variance type estimator seems to do well for larger values of the intraclass correlation. In general, the estimator based on the optimal quadratic estimating equations seems to show best efficiency performance for data from the beta-binomial distribution and the probit normal binomial distribution, and the analysis of variance type estimator seems to do well for data from the mixture distribution.     

Calibration model with skew scale mixtures of normal distributions

This work presents a new linear calibration model with replication by assuming that the error of the model follows a skew scale mixture of the normal distributions family, which is a class of asymmetric thick-tailed distributions that includes the skew normal distribution and symmetric distributions. In the literature, most calibration models assume that the errors are normally distributed. However, the normal distribution is not suitable when there are atypical observations and asymmetry. The estimation of the calibration model parameters are done numerically by the EM algorithm. A simulation study is carried out to verify the properties of the maximum likelihood estimators. This new approach is applied to a real dataset from a chemical analysis.     

Flexible mixture modelling using the multivariate skew-t-normal distribution

This paper presents a robust probabilistic mixture model based on the multivariate skew-t-normal distribution, a skew extension of the multivariate Student’s t distribution with more powerful abilities in modelling data whose distribution seriously deviates from normality. The proposed model includes mixtures of normal, t and skew-normal distributions as special cases and provides a flexible alternative to recently proposed skew t mixtures. We develop two analytically tractable EM-type algorithms for computing maximum likelihood estimates of model parameters in which the skewness parameters and degrees of freedom are asymptotically uncorrelated. Standard errors for the parameter estimates can be obtained via a general information-based method. We also present a procedure of merging mixture components to automatically identify the number of clusters by fitting piecewise linear regression to the rescaled entropy plot. The effectiveness and performance of the proposed methodology are illustrated by two real-life examples.     

Robust mixture modeling using the skew <Emphasis Type="Italic">t</Emphasis> distribution

A finite mixture model using the Student's t distribution has been recognized as a robust extension of normal mixtures. Recently, a mixture of skew normal distributions has been found to be effective in the treatment of heterogeneous data involving asymmetric behaviors across subclasses. In this article, we propose a robust mixture framework based on the skew t distribution to efficiently deal with heavy-tailedness, extra skewness and multimodality in a wide range of settings. Statistical mixture modeling based on normal, Student's t and skew normal distributions can be viewed as special cases of the skew t mixture model. We present analytically simple EM-type algorithms for iteratively computing maximum likelihood estimates. The proposed methodology is illustrated by analyzing a real data example.     

The Impact of Measurement Error on Principal Component Analysis

We investigate the effect of measurement error on principal component analysis in the high‐dimensional setting. The effects of random, additive errors are characterized by the expectation and variance of the changes in the eigenvalues and eigenvectors. The results show that the impact of uncorrelated measurement error on the principal component scores is mainly in terms of increased variability and not bias. In practice, the error‐induced increase in variability is small compared with the original variability for the components corresponding to the largest eigenvalues. This suggests that the impact will be negligible when these component scores are used in classification and regression or for visualizing data. However, the measurement error will contribute to a large variability in component loadings, relative to the loading values, such that interpretation based on the loadings can be difficult. The results are illustrated by simulating additive Gaussian measurement error in microarray expression data from cancer tumours and control tissues.     

A multiple imputation approach to deal with the unity measure error

Unity measure errors (UME) in numerical survey data can determine serious bias in the estimates of interest. In this paper, a finite Gaussian mixture model is used to identify observations affected by UME and to robustly estimate the target parameters in presence of this type of error. In the proposed model, the mixture components are associated to the different error patterns across the variables. We follow a multiple imputation approach in a Bayesian setting that allows us to handle missing values in data. In this framework, the assessment of the uncertainty associated with both errors and missingness is based on repeatedly drawing from the predictive distribution of the true non contaminated data given the observed data. The draws are obtained through a suitable version of the data augmentation algorithm. Applications to both simulated and real data are presented.     

A robust multivariate measurement error model with skew-normal/independent distributions and Bayesian MCMC implementation

Skew-normal/independent distributions are a class of asymmetric thick-tailed distributions that include the skew-normal distribution as a special case. In this paper, we explore the use of Markov Chain Monte Carlo (MCMC) methods to develop a Bayesian analysis in multivariate measurement errors models. We propose the use of skew-normal/independent distributions to model the unobserved value of the covariates (latent variable) and symmetric normal/independent distributions for the random errors term, providing an appealing robust alternative to the usual symmetric process in multivariate measurement errors models. Among the distributions that belong to this class of distributions, we examine univariate and multivariate versions of the skew-normal, skew-t, skew-slash and skew-contaminated normal distributions. The results and methods are applied to a real data set.     

Finite mixtures of matrix normal distributions for classifying three-way data

Matrix-variate distributions represent a natural way for modeling random matrices. Realizations from random matrices are generated by the simultaneous observation of variables in different situations or locations, and are commonly arranged in three-way data structures. Among the matrix-variate distributions, the matrix normal density plays the same pivotal role as the multivariate normal distribution in the family of multivariate distributions. In this work we define and explore finite mixtures of matrix normals. An EM algorithm for the model estimation is developed and some useful properties are demonstrated. We finally show that the proposed mixture model can be a powerful tool for classifying three-way data both in supervised and unsupervised problems. A simulation study and some real examples are presented.     

A study of generalized normal distributions

In this work, first some distributional properties of extended two-piece skew normal distributions are presented. Next we revisit the special case, that is two-piece skew normal distributions. Then two distributions related to two-piece skew normal distributions are studied. More precisely, we give some properties about generalized half normal distributions as well as a generalized Cauchy distribution. Finally, we discuss the distributions of linear combinations of two independent skew normal random variables.     

A generalized skew two-piece skew-elliptical distribution

We present a new generalized family of skew two-piece skew-elliptical (GSTPSE) models and derive some its statistical properties. It is shown that the new family of distribution may be written as a mixture of generalized skew elliptical distributions. Also, a new representation theorem for a special case of GSTPSE-distribution is given. Next, we will focus on t kernel density and prove that it is a scale mixture of the generalized skew two-piece skew normal distributions. An explicit expression for the central moments as well as a recurrence relations for its cumulative distribution function and density are obtained. Since, this special case is a uni-/bimodal distribution, a sufficient condition for each cases is given. A real data set on heights of Australian females athletes is analysed. Finally, some concluding remarks and open problems are discussed.     

A heteroscedastic measurement error model based on skew and heavy-tailed distributions with known error variances

In this paper, we study inference in a heteroscedastic measurement error model with known error variances. Instead of the normal distribution for the random components, we develop a model that assumes a skew-t distribution for the true covariate and a centred Student's t distribution for the error terms. The proposed model enables to accommodate skewness and heavy-tailedness in the data, while the degrees of freedom of the distributions can be different. Maximum likelihood estimates are computed via an EM-type algorithm. The behaviour of the estimators is also assessed in a simulation study. Finally, the approach is illustrated with a real data set from a methods comparison study in Analytical Chemistry.     

Parameter estimation for mixtures of skew Laplace normal distributions and application in mixture regression modeling

In this article, we propose mixtures of skew Laplace normal (SLN) distributions to model both skewness and heavy-tailedness in the neous data set as an alternative to mixtures of skew Student-t-normal (STN) distributions. We give the expectation–maximization (EM) algorithm to obtain the maximum likelihood (ML) estimators for the parameters of interest. We also analyze the mixture regression model based on the SLN distribution and provide the ML estimators of the parameters using the EM algorithm. The performance of the proposed mixture model is illustrated by a simulation study and two real data examples.     

Identifiability and Comparison of Estimation Methods on Weibull Mixture Models

In this article, the finite mixture model of Weibull distributions is studied, the identifiability of the model with m components is proven, and the parameter estimators for the case of two components resulted by several algorithms are compared. The parameter estimators are obtained with maximum likelihood performing calculations with different algorithms: expectation-maximization (EM), Fisher scoring, backfitting, optimization of k-nearest neighbor approach, and random walk algorithm using Monte Carlo simulation. The Akaike information criterion and the log-likelihood value are used to compare models. In general, the proposed random walk algorithm shows better performance in mean square error and bias. Finally, the results are applied to electronic component lifetime data.     

A multivariate two-factor skew model

It is well known that many data, such as the financial or demographic data, exhibit asymmetric distributions. In recent years, researchers have concentrated their efforts to model this asymmetry. Skew normal model is one of such models that are skew and yet possess many properties of the normal model. In this paper, a new multivariate skew model is proposed, along with its statistical properties. It includes the multivariate normal distribution and multivariate skew normal distribution as special cases. The quadratic form of this random vector follows a χ² distribution. The roles of the parameters in the model are investigated using contour plots of bivariate densities.     

The generalized Gudermannian distribution: inference and volatility modelling

In this paper, we introduce a new distribution, called generalized Gudermannian (GG) distribution, and its skew extension for GARCH models in modelling daily Value-at-Risk (VaR). Basic structural properties of the proposed distribution are obtained including probability density and cumulative distribution functions, moments, and stochastic representation. The maximum likelihood method is used to estimate unknown parameters of the proposed model and finite sample performance of maximum likelihood estimates are evaluated by means of Monte-Carlo simulation study. The real data application on Nikkei 225 index is given to demonstrate the performance of GARCH model specified under skew extension of GG innovation distribution against normal, Student's-t, skew normal and generalized error and skew generalized error distributions in terms of the accuracy of VaR forecasts. The empirical results show that the GARCH model with GG innovation distribution produces the most accurate VaR forecasts for all confidence levels.     

Modelling mass-size particle data by finite mixtures

A minimum distance procedure, analogous to maximum likelihood for multinomial data, is employed to fit mixture models to mass-size relative frequencies recorded for some clay soils of southeastern Australia. Log hyperbolic component distributions are considered initially and it is shown how they can be fitted satisfactorily at least to ungrouped data using a generalized EM algorithm. A computationally more convenient model with log skew Laplace components is subsequently shown to suffice. It is demonstrated how it can be fitted to the data in their original grouped form. Consideration is given also to the provision of standard errors using the idea of a quasi-sample size.     

Maximum likelihood inference for mixtures of skew Student-t-normal distributions through practical EM-type algorithms

This paper deals with the problem of maximum likelihood estimation for a mixture of skew Student-t-normal distributions, which is a novel model-based tool for clustering heterogeneous (multiple groups) data in the presence of skewed and heavy-tailed outcomes. We present two analytically simple EM-type algorithms for iteratively computing the maximum likelihood estimates. The observed information matrix is derived for obtaining the asymptotic standard errors of parameter estimates. A small simulation study is conducted to demonstrate the superiority of the skew Student-t-normal distribution compared to the skew t distribution. The proposed methodology is particularly useful for analyzing multimodal asymmetric data as produced by major biotechnological platforms like flow cytometry. We provide such an application with the help of an illustrative example.     

A Sample Selection Model with Skew‐normal Distribution

Non‐random sampling is a source of bias in empirical research. It is common for the outcomes of interest (e.g. wage distribution) to be skewed in the source population. Sometimes, the outcomes are further subjected to sample selection, which is a type of missing data, resulting in partial observability. Thus, methods based on complete cases for skew data are inadequate for the analysis of such data and a general sample selection model is required. Heckman proposed a full maximum likelihood estimation method under the normality assumption for sample selection problems, and parametric and non‐parametric extensions have been proposed. We generalize Heckman selection model to allow for underlying skew‐normal distributions. Finite‐sample performance of the maximum likelihood estimator of the model is studied via simulation. Applications illustrate the strength of the model in capturing spurious skewness in bounded scores, and in modelling data where logarithm transformation could not mitigate the effect of inherent skewness in the outcome variable.     

Skew-probit measurement error models

In this paper we extend the structural probit measurement error model by considering the unobserved covariate to follow a skew-normal distribution. The new model is termed the structural skew-normal probit model. As in the normal case, the likelihood function is obtained analytically, and can be maximized by using existing statistical software. A Bayesian approach using Markov chain Monte Carlo techniques for generating from the posterior distributions is also developed. A simulation study demonstrates the usefulness of the approach in avoiding attenuation which arises with the naive procedure. Moreover, a comparison of predicted and true success probabilities indicates that it seems to be more efficient to use the skew probit model when the distribution of the covariate (predictor) is skew. An application to a real data set is also provided.     

A Better Alternative to Non-parametric Approaches for Adjusting for Covariate Measurement Errors in Logistic Regression

In this article, we propose a flexible parametric (FP) approach for adjusting for covariate measurement errors in regression that can accommodate replicated measurements on the surrogate (mismeasured) version of the unobserved true covariate on all the study subjects or on a sub-sample of the study subjects as error assessment data. We utilize the general framework of the FP approach proposed by Hossain and Gustafson in 2009 for adjusting for covariate measurement errors in regression. The FP approach is then compared with the existing non-parametric approaches when error assessment data are available on the entire sample of the study subjects (complete error assessment data) considering covariate measurement error in a multiple logistic regression model. We also developed the FP approach when error assessment data are available on a sub-sample of the study subjects (partial error assessment data) and investigated its performance using both simulated and real life data. Simulation results reveal that, in comparable situations, the FP approach performs as good as or better than the competing non-parametric approaches in eliminating the bias that arises in the estimated regression parameters due to covariate measurement errors. Also, it results in better efficiency of the estimated parameters. Finally, the FP approach is found to perform adequately well in terms of bias correction, confidence coverage, and in achieving appropriate statistical power under partial error assessment data.