A case–control study relating railroad worker mortality to diesel exhaust exposure using a threshold regression model

A case–control study of lung cancer mortality in U.S. railroad workers in jobs with and without diesel exhaust exposure is reanalyzed using a new threshold regression methodology. The study included 1256 workers who died of lung cancer and 2385 controls who died primarily of circulatory system diseases. Diesel exhaust exposure was assessed using railroad job history from the US Railroad Retirement Board and an industrial hygiene survey. Smoking habits were available from next-of-kin and potential asbestos exposure was assessed by job history review. The new analysis reassesses lung cancer mortality and examines circulatory system disease mortality. Jobs with regular exposure to diesel exhaust had a survival pattern characterized by an initial delay in mortality, followed by a rapid deterioration of health prior to death. The pattern is seen in subjects dying of lung cancer, circulatory system diseases, and other causes. The unique pattern is illustrated using a new type of Kaplan–Meier survival plot in which the time scale represents a measure of disease progression rather than calendar time. The disease progression scale accounts for a healthy-worker effect when describing the effects of cumulative exposures on mortality.     

Inference using attributable risk for a 2×2 case–control study

Asymptotic variance plays an important role in the inference using interval estimate of attributable risk. This paper compares asymptotic variances of attributable risk estimate using the delta method and the Fisher information matrix for a 2×2 case–control study due to the practicality of applications. The expressions of these two asymptotic variance estimates are shown to be equivalent. Because asymptotic variance usually underestimates the standard error, the bootstrap standard error has also been utilized in constructing the interval estimates of attributable risk and compared with those using asymptotic estimates. A simulation study shows that the bootstrap interval estimate performs well in terms of coverage probability and confidence length. An exact test procedure for testing independence between the risk factor and the disease outcome using attributable risk is proposed and is justified for the use with real-life examples for a small-sample situation where inference using asymptotic variance may not be valid.     

Collective risk model: Poisson–Lindley and exponential distributions for Bayes premium and operational risk

In this paper the collective risk model with Poisson–Lindley and exponential distributions as the primary and secondary distributions, respectively, is developed in a detailed way. It is applied to determine the Bayes premium used in actuarial science and also to compute the regulatory capital in the analysis of operational risk. The results are illustrated with numerous examples and compared with other approaches proposed in the literature for these questions, with considerable differences being observed.     

Economic and economic–statistical designs of VSI Bayesian control chart using Monte Carlo method and ABC algorithm

The usual practice in using a Bayesian control chart to monitor a process is done by taking samples from the process with fixed sampling intervals. Recent studies on traditional control charts have shown that variable sampling interval (VSI) scheme compared to classical scheme (fixed ratio sampling, FRS) helps practitioners to detect process shifts more quickly. In this paper, the effectiveness of VSI scheme on performance of Bayesian control chart has been studied, based on economic (ED) and economic–statistical designs (ESD). Monte Carlo method and artificial bee colony algorithm have been utilized to obtain optimal design parameters of Bayesian control chart (sample size, sampling intervals, warning limit and control limit) since the statistic of this approach does not have any specified distribution. Finally, VSI Bayesian control chart has been compared to FRS Bayesian and VSI X-bar approaches based on ED and ESD, separately. According to the results, it has been found that the performance of VSI Bayesian scheme is better than FRS Bayesian and VSI X-bar approaches.     

Bayesian analysis of head and neck cancer data using generalized inverse Lindley stress–strength reliability model

In this article, we present the analysis of head and neck cancer data using generalized inverse Lindley stress–strength reliability model. We propose Bayes estimators for estimating P(X > Y), when X and Y represent survival times of two groups of cancer patients observed under different therapies. The X and Y are assumed to be independent generalized inverse Lindley random variables with common shape parameter. Bayes estimators are obtained under the considerations of symmetric and asymmetric loss functions assuming independent gamma priors. Since posterior becomes complex and does not possess closed form expressions for Bayes estimators, Lindley’s approximation and Markov Chain Monte Carlo techniques are utilized for Bayesian computation. An extensive simulation experiment is carried out to compare the performances of Bayes estimators with the maximum likelihood estimators on the basis of simulated risks. Asymptotic, bootstrap, and Bayesian credible intervals are also computed for the P(X > Y).     

Comparison of multiple imputation and two-phase logistic regression to analyse two-phase case–control studies with rich phase 1: a simulation study

Two-phase case–control studies cope with the problem of confounding by obtaining required additional information for a subset (phase 2) of all individuals (phase 1). Nowadays, studies with rich phase 1 data are available where only few unmeasured confounders need to be obtained in phase 2. The extended conditional maximum likelihood (ECML) approach in two-phase logistic regression is a novel method to analyse such data. Alternatively, two-phase case–control studies can be analysed by multiple imputation (MI), where phase 2 information for individuals included in phase 1 is treated as missing. We conducted a simulation of two-phase studies, where we compared the performance of ECML and MI in typical scenarios with rich phase 1. Regarding exposure effect, MI was less biased and more precise than ECML. Furthermore, ECML was sensitive against misspecification of the participation model. We therefore recommend MI to analyse two-phase case–control studies in situations with rich phase 1 data.     

Analysis of clustered spatially correlated binary data using autologistic model and Bayesian method with an application to dental caries of 3–5-year-old children

The autologistic model, first introduced by Besag, is a popular tool for analyzing binary data in spatial lattices. However, no investigation was found to consider modeling of binary data clustered in uncorrelated lattices. Owing to spatial dependency of responses, the exact likelihood estimation of parameters is not possible. For circumventing this difficulty, many studies have been designed to approximate the likelihood and the related partition function of the model. So, the traditional and Bayesian estimation methods based on the likelihood function are often time-consuming and require heavy computations and recursive techniques. Some investigators have introduced and implemented data augmentation and latent variable model to reduce computational complications in parameter estimation. In this work, the spatially correlated binary data distributed in uncorrelated lattices were modeled using autologistic regression, a Bayesian inference was developed with contribution of data augmentation and the proposed models were applied to caries experiences of deciduous dents.