Linear scalar-on-surface random effects regression models

Many research fields increasingly involve analyzing data of a complex structure. Models investigating the dependence of a response on a predictor have moved beyond the ordinary scalar-on-vector regression. We propose a regression model for a scalar response and a surface (or a bivariate function) predictor. The predictor has a random component and the regression model falls in the framework of linear random effects models. We estimate the model parameters via maximizing the log-likelihood with the ECME (Expectation/Conditional Maximization Either) algorithm. We use the approach to analyze a data set where the response is the neuroticism score and the predictor is the resting-state brain function image. In the simulations we tried, the approach has better performance than two other approaches, a functional principal component regression approach and a smooth scalar-on-image regression approach.     

Pooled Cross-Sectional and Time Series Data: A Survey of Current Statistical Methodology

A data base that provides a multivariate statistical history for each of a number of individual entities is called a pooled cross-sectional and time series data base in the econometrics literature. In marketing and survey literature the terms panel data or longitudinal data are often used. In management science a convenient term might be management data base. Such a data base provides a particularly rich environment for statistical analysis. This article reviews methods for estimating multivariate relationships particular to each individual entity and for summarizing these relationships for a number of individuals. Inference to a larger population when the data base is viewed as a sample is also considered.     

Why a time effect often has a limited impact on capture‐recapture estimates in closed populations

The author is concerned with log‐linear estimators of the size N of a population in a capture‐recapture experiment featuring heterogeneity in the individual capture probabilities and a time effect. He also considers models where the first capture influences the probability of subsequent captures. He derives several results from a new inequality associated with a dispersive ordering for discrete random variables. He shows that in a log‐linear model with inter‐individual heterogeneity, the estimator N is an increasing function of the heterogeneity parameter. He also shows that the inclusion of a time effect in the capture probabilities decreases N in models without heterogeneity. He further argues that a model featuring heterogeneity can accommodate a time effect through a small change in the heterogeneity parameter. He demonstrates these results using an inequality for the estimators of the heterogeneity parameters and illustrates them in a Monte Carlo experiment     

Lack-of-fit testing of a regression model with response missing at random

This paper proposes a class of lack-of-fit tests for fitting a linear regression model when some response variables are missing at random. These tests are based on a class of minimum integrated square distances between a kernel type estimator of a regression function and the parametric regression function being fitted. These tests are shown to be consistent against a large class of fixed alternatives. The corresponding test statistics are shown to have asymptotic normal distributions under null hypothesis and a class of nonparametric local alternatives. Some simulation results are also presented.     

On the efficiency of a testimator for the weibull shape parameter

In estimating the shape parameter of a two-parameter Weibull distribution from a failure-censored sample, a recently popular procedure is to employ a testimator which is a shrinkage estimator based on a preliminary hypothesis test for a guessed value of the parameter. Such an adaptive testimator is a linear compound of the guessed value and a statistic. A new compounding coefficient is numerically shown to yield higher efficiency in many situations compared to some of the existing ones.     

Gaining insight with recursive partitioning of generalized linear models

Recursive partitioning algorithms separate a feature space into a set of disjoint rectangles. Then, usually, a constant in every partition is fitted. While this is a simple and intuitive approach, it may still lack interpretability as to how a specific relationship between dependent and independent variables may look. Or it may be that a certain model is assumed or of interest and there is a number of candidate variables that may non-linearly give rise to different model parameter values. We present an approach that combines generalized linear models (GLM) with recursive partitioning that offers enhanced interpretability of classical trees as well as providing an explorative way to assess a candidate variable's influence on a parametric model. This method conducts recursive partitioning of a GLM by (1) fitting the model to the data set, (2) testing for parameter instability over a set of partitioning variables, (3) splitting the data set with respect to the variable associated with the highest instability. The outcome is a tree where each terminal node is associated with a GLM. We will show the method's versatility and suitability to gain additional insight into the relationship of dependent and independent variables by two examples, modelling voting behaviour and a failure model for debt amortization, and compare it to alternative approaches.     

Adaptive Percolation Using Subjective Likelihoods

A phenomenon that I call “adaptive percolation” commonly arises in biology, business, economics, defense, finance, manufacturing, and the social sciences. Here one wishes to select a handful of entities from a large pool of entities via a process of screening through a hierarchy of sieves. The process is not unlike the percolation of a liquid through a porous medium. The probability model developed here is based on a nested and adaptive Bayesian approach that results in the product of beta-binomial distributions with common parameters. The common parameters happen to be the observed data. I call this the percolated beta-binomial distribution . The model turns out to be a slight generalization of the probabilistic model used in percolation theory. The generalization is a consequence of using a subjectively specified likelihood function to construct a probability model. The notion of using likelihoods for constructing probability models is not a part of the conventional toolkit of applied probabilists. To the best of my knowledge, a use of the product of beta-binomial distributions as a probability model for Bernoulli trials appears to be new. The development of the material of this article is illustrated via data from the 2009 astronaut selection program, which motivated this work.     

Median rankit control chart by the quantile approach

It is desirable that the data for a statistical control chart be normally distributed. However, if the data are not normal, then a transformation can be used, e.g. Box-Cox transformations, to produce a suitable control chart. In this paper we will discuss a quantile approach to produce a control chart and to estimate median rankit for various non-normal distributions. We will also provide examples of logistic data to indicate how a quantile approach could be used to construct a control chart for a non-normal distribution using a median rankit.     

A Five-Decision Testing Procedure to Infer the Value of a Unidimensional Parameter

ABSTRACT

A statistical test can be seen as a procedure to produce a decision based on observed data, where some decisions consist of rejecting a hypothesis (yielding a significant result) and some do not, and where one controls the probability to make a wrong rejection at some prespecified significance level. Whereas traditional hypothesis testing involves only two possible decisions (to reject or not a null hypothesis), Kaiser’s directional two-sided test as well as the more recently introduced testing procedure of Jones and Tukey, each equivalent to running two one-sided tests, involve three possible decisions to infer the value of a unidimensional parameter. The latter procedure assumes that a point null hypothesis is impossible (e.g., that two treatments cannot have exactly the same effect), allowing a gain of statistical power. There are, however, situations where a point hypothesis is indeed plausible, for example, when considering hypotheses derived from Einstein’s theories. In this article, we introduce a five-decision rule testing procedure, equivalent to running a traditional two-sided test in addition to two one-sided tests, which combines the advantages of the testing procedures of Kaiser (no assumption on a point hypothesis being impossible) and Jones and Tukey (higher power), allowing for a nonnegligible (typically 20%) reduction of the sample size needed to reach a given statistical power to get a significant result, compared to the traditional approach.     

Detecting a changed segment in DNA sequences

Non-coding deoxyribonucleic acid (DNA) can typically be modelled by a sequence of Bernoulli random variables by coding one base, e.g. T, as 1 and other bases as 0. If a segment of a sequence is functionally important, the probability of a 1 will be different in this changed segment from that in the surrounding DNA. It is important to be able to see whether such a segment occurs in a particular DNA sequence and to pin-point it so that a molecular biologist can investigate its possible function. Here we discuss methods for testing the occurrence of such a changed segment and how to estimate the end points of it. Maximum-likelihood-based methods are not very tractable and so a nonparametric method based on the approach of Pettitt has been developed. The problem and its solution are illustrated by a specific DNA example.     

Test for homogeneity in Hardy–Weinberg normal mixture model

The phenotype of a quantitative trait locus (QTL) is often modeled by a finite mixture of normal distributions. If the QTL effect depends on the number of copies of a specific allele one carries, then the mixture model has three components. In this case, the mixing proportions have a binomial structure according to the Hardy–Weinberg equilibrium. In the search for QTL, a significance test of homogeneity against the Hardy–Weinberg normal mixture model alternative is an important first step. The LOD score method, a likelihood ratio test used in genetics, is a favored choice. However, there is not yet a general theory for the limiting distribution of the likelihood ratio statistic in the presence of unknown variance. This paper derives the limiting distribution of the likelihood ratio statistic, which can be described by the supremum of a quadratic form of a Gaussian process. Further, the result implies that the distribution of the modified likelihood ratio statistic is well approximated by a chi-squared distribution. Simulation results show that the approximation has satisfactory precision for the cases considered. We also give a real-data example.     

A mixture of beta–Dirichlet processes prior for Bayesian analysis of event history data

In this paper, we propose a mixture of beta–Dirichlet processes as a nonparametric prior for the cumulative intensity functions of a Markov process. This family of priors is a natural extension of a mixture of Dirichlet processes or a mixture of beta processes which are devised to compromise advantages of parametric and nonparametric approaches. They give most of their prior mass to the small neighborhood of a specific parametric model. We show that a mixture of beta–Dirichlet processes prior is conjugate with Markov processes. Formulas for computing the posterior distribution are derived. Finally, results of analyzing credit history data are given.     

Seven useful designs

When designing a clinical trial there is a need to design a study that achieves the objectives of a trial both efficiently and with minimum resources. This paper describes seven trial designs that could possibly be used in clinical development and highlights how a design although not optimal for an individual study may be optimal for a wider clinical program.     

Kernel estimation of a distribution function

A distribution function is estimated by a kernel method with

a poinrwise mean squared error criterion at a point x. Relation- ships between the mean squared error, the point x, the sample size and the required kernel smoothing parazeter are investigated for several distributions treated by Azzaiini (1981). In particular it is noted that at a centre of symmetry or near a mode of the distribution the kernei method breaks down. Point- wise estimation of a distribution function is motivated as a more useful technique than a reference range for preliminary medical diagnosis.     

Generating random variates from a bicompositional Dirichlet distribution

A composition is a vector of positive components summing to a constant. The sample space of a composition is the simplex, and the sample space of two compositions, a bicomposition, is a Cartesian product of two simplices. We present a way of generating random variates from a bicompositional Dirichlet distribution defined on the Cartesian product of two simplices using the rejection method. We derive a general solution for finding a dominating density function and a rejection constant and also compare this solution to using a uniform dominating density function. Finally, some examples of generated bicompositional random variates, with varying number of components, are presented.     

Bounded-influence rank estimation in the linear model

We introduce and study a class of rank-based estimators for the linear model. The estimate may be roughly described as being calculated in the same manner as a generalized M-estimate, but with the residual being replaced by a function of its signed rank. The influence function can thus be bounded, both as a function of the residual and as a function of the carriers. Subject to such a bound, the efficiency at a particular model distribution can be optimized by appropriate choices of rank scores and carrier weights. Such choices are given, with respect to a variety of optimality criteria. We compare our estimates with several others, in a Monte Carlo study and on a real data set from the literature.     

Edge Estimation in the Population of a Binary Tree Using Node-Sampling

Suppose a finite population of several vertices, each connected to single or multiple edges. This constitutes a structure of graphical population of vertices and edges. As a special case, the graphical population like a binary tree having only two child vertices associated to parent vertex is taken into consideration. The entire binary tree is divided into two sub-graphs such as a group of left-nodes and a group of right-nodes. This paper takes into account a mixture of graph structured and population sampling theory together and presents a methodology for mean-edge-length estimation of left sub-graph using right edge sub-graph as an auxiliary source of information. A node-sampling procedure is developed for this purpose and a class of estimators is proposed containing several good estimators. Mathematical conditions for minimum bias and optimum mean squared error of the class are derived and theoretical results are numerically supported with a test of 99% confidence intervals. It is shown that suggested class has a sub-class of optimum estimators, and sample-based estimates are closer to the true value of the population parameter.     

Monitoring two-stage processes with a profile at the second stage

In the multistage processes, quality of a process or a product at each stage is related to the previous stage(s). This property is referred to as a cascade property. Sometimes, quality of a process is characterized by a profile. In this paper, we consider a two-stage process with a normal quality characteristic in the first stage and a simple linear regression profile in the second stage. Then we propose two methods to monitor quality characteristics in both stages. The performance of the proposed two methods is evaluated through a numerical example in terms of average run length criterion.     

On sequential closed testing dose groups with a control

Methods for a sequential test of a dose-response effect in pre-clinical studies are investigated. The objective of the test procedure is to compare several dose groups with a zero-dose control. The sequential testing is conducted within a closed family of one-sided tests. The procedures investigated are based on a monotonicity assumption. These closed procedures strongly control the familywise error rate while providing information about the shape of the dose-responce relationship. Performance of sequential testing procedures are compared via a Monte Carlo simulation study. We illustrae the procedures by application to a real data set.     

On evaluating how well a biomarker can predict treatment response with survival data

One of the objectives of personalized medicine is to take treatment decisions based on a biomarker measurement. Therefore, it is often interesting to evaluate how well a biomarker can predict the response to a treatment. To do so, a popular methodology consists of using a regression model and testing for an interaction between treatment assignment and biomarker. However, the existence of an interaction is not sufficient for a biomarker to be predictive. It is only necessary. Hence, the use of the marker‐by‐treatment predictiveness curve has been recommended. In addition to evaluate how well a single continuous biomarker predicts treatment response, it can further help to define an optimal threshold. This curve displays the risk of a binary outcome as a function of the quantiles of the biomarker, for each treatment group. Methods that assume a binary outcome or rely on a proportional hazard model for a time‐to‐event outcome have been proposed to estimate this curve. In this work, we propose some extensions for censored data. They rely on a time‐dependent logistic model, and we propose to estimate this model via inverse probability of censoring weighting. We present simulations results and three applications to prostate cancer, liver cirrhosis, and lung cancer data. They suggest that a large number of events need to be observed to define a threshold with sufficient accuracy for clinical usefulness. They also illustrate that when the treatment effect varies with the time horizon which defines the outcome, then the optimal threshold also depends on this time horizon.