Testing order restricted hypotheses with proportional hazards

Inferences for survival curves based on right censored continuous or grouped data are studied. Testing homogeneity with an ordered restricted alternative and testing the order restriction as the null hypothesis are considered. Under a proportional hazards model, the ordering on the survival curves corresponds to an ordering on the regression coefficients. Approximate likelihood methods are obtained by applying order restricted procedures to the estimates of the regression coefficients. Ordered analogues to the log rank test which are based on the score statistics are considered also. Chi-bar-squared distributions, which have been studied extensively, are shown to provide reasonable approximations to the null distributions of these tests statistics. Using Monte Carlo techniques, the powers of these two types of tests are compared with those that are available in the literature.     

The power functions of the likelihood ratio tests for a simple tree ordering in normal means: unequal weights

Likelihood ratio tests are considered for two testing situations; testing for the homogeneity of k normal means against the alternative restricted by a simple tree ordering trend and testing the null hypothesis that the means satisfy the trend against all alternatives. Exact expressions are given for the power functions for k = 3 and 4 and unequal sample sizes, both for the case of known and unknown population variances, and approximations are discussed for larger k. Also, Bartholomew’s conjectures concerning minimal and maximal powers are investigated for the case of equal and unequal sample sizes. The power formulas are used to compute powers for a numerical example.     

Estimating Survival Curves Under Proportional Hazards Model with Covariate Measurement Errors

For the Cox proportional hazards model with additive covariate measurement errors, we propose a corrected cumulative baseline hazard estimator that reduces the bias of the na]ve Breslow estimator. We also derive corresponding modified estimators for the hazard functions and the survival functions of individuals with particular covariate values. Using a Monte Carlo technique developed by Lin et al . (1994), we construct confidence bands for such hazard and survival functions.     

Choice of Parametric Accelerated Life and Proportional Hazards Models for Survival Data: Asymptotic Results

We discuss the impact of misspecifying fully parametric proportional hazards and accelerated life models. For the uncensored case, misspecified accelerated life models give asymptotically unbiased estimates of covariate effect, but the shape and scale parameters depend on the misspecification. The covariate, shape and scale parameters differ in the censored case. Parametric proportional hazards models do not have a sound justification for general use: estimates from misspecified models can be very biased, and misleading results for the shape of the hazard function can arise. Misspecified survival functions are more biased at the extremes than the centre. Asymptotic and first order results are compared. If a model is misspecified, the size of Wald tests will be underestimated. Use of the sandwich estimator of standard error gives tests of the correct size, but misspecification leads to a loss of power. Accelerated life models are more robust to misspecification because of their log-linear form. In preliminary data analysis, practitioners should investigate proportional hazards and accelerated life models; software is readily available for several such models.     

A Multiple Three-Decision Procedures for Comparing Several Treatments with a Control Under Heteroscedasticity

In this article, the design-oriented two-stage multiple three-decision procedure is proposed to classify a set of normal populations with respect to a control under heteroscedasticity. The statistical tables of percentage points and the power-related design constants, to implement our new two-stage procedure, are given. Sometimes when the sample for the second stage is not available, the one-stage data analysis procedure is proposed. Classifying a treatment better than control when it is actually worse (and vice versa) is known as type III error. Both the two-stage and one-stage procedures control the type III error rate at a specified level. The relationship between the two-stage and one-stage procedures is discussed. Finally, the application of the proposed procedures is illustrated with an example.