Modified inference about the mean of the exponential distribution using moving extreme ranked set sampling

The maximum likelihood estimator (MLE) and the likelihood ratio test (LRT) will be considered for making inference about the scale parameter of the exponential distribution in case of moving extreme ranked set sampling (MERSS). The MLE and LRT can not be written in closed form. Therefore, a modification of the MLE using the technique suggested by Maharota and Nanda (Biometrika 61:601–606, 1974) will be considered and this modified estimator will be used to modify the LRT to get a test in closed form for testing a simple hypothesis against one sided alternatives. The same idea will be used to modify the most powerful test (MPT) for testing a simple hypothesis versus a simple hypothesis to get a test in closed form for testing a simple hypothesis against one sided alternatives. Then it appears that the modified estimator is a good competitor of the MLE and the modified tests are good competitors of the LRT using MERSS and simple random sampling (SRS).     

Cancer immunotherapy trial design with long-term survivors

Cancer immunotherapy often reflects the improvement in both short-term risk reduction and long-term survival. In this scenario, a mixture cure model can be used for the trial design. However, the hazard functions based on the mixture cure model between two groups will ultimately crossover. Thus, the conventional assumption of proportional hazards may be violated and study design using standard log-rank test (LRT) could lose power if the main interest is to detect the improvement of long-term survival. In this paper, we propose a change sign weighted LRT for the trial design. We derived a sample size formula for the weighted LRT, which can be used for designing cancer immunotherapy trials to detect both short-term risk reduction and long-term survival. Simulation studies are conducted to compare the efficiency between the standard LRT and the change sign weighted LRT.     

Asymptotic test of mixture model and its applications to QTL interval mapping

Quantitative trait loci (QTL) mapping has been a standard means in identifying genetic regions harboring potential genes underlying complex traits. Likelihood ratio test (LRT) has been commonly applied to assess the significance of a genetic locus in a mixture model content. Given the time constraint in commonly used permutation tests to assess the significance of LRT in QTL mapping, we study the behavior of the LRT statistic in mixture model when the proportions of the distributions are unknown. We found that the asymptotic null distribution is stationary Gaussian process after suitable transformation. The result can be applied to one-parameter exponential family mixture model. Under certain condition, such as in a backcross mapping model, the tail probability of the supremum of the process is calculated and the threshold values can be determined by solving the distribution function. Simulation studies were performed to evaluate the asymptotic results.     

Goodness-of-fit test for uniform stochastic ordering among several distributions

The likelihood-ratio test (LRT) is considered as a goodness-of-fit test for the null hypothesis that several distribution functions are uniformly stochastically ordered. Under the null hypothesis, H₁ : F₁ ? F₂ ?···? F_N, the asymptotic distribution of the LRT statistic is a convolution of several chi-bar-square distributions each of which depends upon the location parameter. The least-favourable parameter configuration for the LRT is not unique. It can be two different types and depends on the number of distributions, the number of intervals and the significance level α. This testing method is illustrated with a data set of survival times of five groups of male fruit flies.     

Discriminating between generalized exponential,geometric extreme exponential and Weibull distributions

Generalized exponential, geometric extreme exponential and Weibull distributions are three non-negative skewed distributions that are suitable for analysing lifetime data. We present diagnostic tools based on the likelihood ratio test (LRT) and the minimum Kolmogorov distance (KD) method to discriminate between these models. Probability of correct selection has been calculated for each model and for several combinations of shape parameters and sample sizes using Monte Carlo simulation. Application of LRT and KD discrimination methods to some real data sets has also been studied.     

Testing the equality of two normal percentiles

Two statistics are suggested for testing the equality of two normal percentiles where population means and variances are unknown. The first is based on the generalized likelihood ratio test (LRT), the second on Cochran's statistic used in the Behrens-Fisher problem. Size and power comparisons are made by using simulation and asympototic theory.     

Corrected likelihood-ratio tests in logistic regression using small-sample data

Likelihood-ratio tests (LRTs) are often used for inferences on one or more logistic regression coefficients. Conventionally, for given parameters of interest, the nuisance parameters of the likelihood function are replaced by their maximum likelihood estimates. The new function created is called the profile likelihood function, and is used for inference from LRT. In small samples, LRT based on the profile likelihood does not follow χ² distribution. Several corrections have been proposed to improve LRT when used with small-sample data. Additionally, complete or quasi-complete separation is a common geometric feature for small-sample binary data. In this article, for small-sample binary data, we have derived explicitly the correction factors of LRT for models with and without separation, and proposed an algorithm to construct confidence intervals. We have investigated the performances of different LRT corrections, and the corresponding confidence intervals through simulations. Based on the simulation results, we propose an empirical rule of thumb on the use of these methods. Our simulation findings are also supported by real-world data.     

A modified likelihood ratio test for the mean direction in the von mises distribution

The likelihood ratio test (LRT) for the mean direction in the von Mises distribution is modified for possessing a common asymptotic distribution both for large sample size and for large concentration parameter. The test statistic of the modified LRT is compared with the F distribution but not with the chi-square distribution usually employed, Good performances of the modified LRT are shown by analytical studies and Monte Carlo simulation studies, A notable advantage of the test is that it takes part in the unified likelihood inference procedures including both the marginal MLE and the marginal LRT for the concentration parameter.     

A modified likelihood ratio test for homogeneity in finite mixture models

Testing for homogeneity in finite mixture models has been investigated by many researchers. The asymptotic null distribution of the likelihood ratio test (LRT) is very complex and difficult to use in practice. We propose a modified LRT for homogeneity in finite mixture models with a general parametric kernel distribution family. The modified LRT has a χ-type of null limiting distribution and is asymptotically most powerful under local alternatives. Simulations show that it performs better than competing tests. They also reveal that the limiting distribution with some adjustment can satisfactorily approximate the quantiles of the test statistic, even for moderate sample sizes.     

Testing overdispersion in the zero-inflated Poisson model

The zero-inflated negative binomial (ZINB) model is used to account for commonly occurring overdispersion detected in data that are initially analyzed under the zero-inflated Poisson (ZIP) model. Tests for overdispersion (Wald test, likelihood ratio test [LRT], and score test) based on ZINB model for use in ZIP regression models have been developed. Due to similarity to the ZINB model, we consider the zero-inflated generalized Poisson (ZIGP) model as an alternate model for overdispersed zero-inflated count data. The score test has an advantage over the LRT and the Wald test in that the score test only requires that the parameter of interest be estimated under the null hypothesis. This paper proposes score tests for overdispersion based on the ZIGP model and illustrates that the derived score statistics are exactly the same as the score statistics under the ZINB model. A simulation study indicates the proposed score statistics are preferred to other tests for higher empirical power. In practice, based on the approximate mean–variance relationship in the data, the ZINB or ZIGP model can be considered, and a formal score test based on asymptotic standard normal distribution can be employed for assessing overdispersion in the ZIP model. We provide an example to illustrate the procedures for data analysis.     

Tests for the skewness parameter of two-piece double exponential distribution in the presence of nuisance parameters

In this paper, tests for the skewness parameter of the two-piece double exponential distribution are derived when the location parameter is unknown. Classical tests like Neyman structure test and likelihood ratio test (LRT), that are generally used to test hypotheses in the presence of nuisance parameters, are not feasible for this distribution since the exact distributions of the test statistics become very complicated. As an alternative, we identify a set of statistics that are ancillary for the location parameter. When the scale parameter is known, Neyman–Pearson's lemma is used, and when the scale parameter is unknown, the LRT is applied to the joint density function of ancillary statistics, in order to obtain a test for the skewness parameter of the distribution. Test for symmetry of the distribution can be deduced as a special case. It is found that power of the proposed tests for symmetry is only marginally less than the power of corresponding classical optimum tests when the location parameter is known, especially for moderate and large sample sizes.     

Testing equality of mean vectors in a one-way MANOVA with monotone missing data

In this study, testing the equality of mean vectors in a one-way multivariate analysis of variance (MANOVA) is considered when each dataset has a monotone pattern of missing observations. The likelihood ratio test (LRT) statistic in a one-way MANOVA with monotone missing data is given. Furthermore, the modified test (MT) statistic based on likelihood ratio (LR) and the modified LRT (MLRT) statistic with monotone missing data are proposed using the decomposition of the LR and an asymptotic expansion for each decomposed LR. The accuracy of the approximation for the Chi-square distribution is investigated using a Monte Carlo simulation. Finally, an example is given to illustrate the methods.     

Asymptotic properties of likelihood ratio test statistics in affected‐sib‐pair analysis

In an affected‐sib‐pair genetic linkage analysis, identical by descent data for affected sib pairs are routinely collected at a large number of markers along chromosomes. Under very general genetic assumptions, the IBD distribution at each marker satisfies the possible triangle constraint. Statistical analysis of IBD data should thus utilize this information to improve efficiency. At the same time, this constraint renders the usual regularity conditions for likelihood‐based statistical methods unsatisfied. In this paper, the authors study the asymptotic properties of the likelihood ratio test (LRT) under the possible triangle constraint. They derive the limiting distribution of the LRT statistic based on data from a single locus. They investigate the precision of the asymptotic distribution and the power of the test by simulation. They also study the test based on the supremum of the LRT statistics over the markers distributed throughout a chromosome. Instead of deriving a limiting distribution for this test, they use a mixture of chi‐squared distributions to approximate its true distribution. Their simulation results show that this approach has desirable simplicity and satisfactory precision.     

Bootstrap likelihood ratio test for Weibull mixture models fitted to grouped data

Abstract

Weibull mixture models are widely used in a variety of fields for modeling phenomena caused by heterogeneous sources. We focus on circumstances in which original observations are not available, and instead the data comes in the form of a grouping of the original observations. We illustrate EM algorithm for fitting Weibull mixture models for grouped data and propose a bootstrap likelihood ratio test (LRT) for determining the number of subpopulations in a mixture model. The effectiveness of the LRT methods are investigated via simulation. We illustrate the utility of these methods by applying them to two grouped data applications.     

Testing equality of generalized variances of k multivariate normal populations

Generalized variance is a measure of dispersion of multivariate data. Comparison of dispersion of multivariate data is one of the favorite issues for multivariate quality control, generalized homogeneity of multidimensional scatter, etc. In this article, the problem of testing equality of generalized variances of k multivariate normal populations by using the Bartlett's modified likelihood ratio test (BMLRT) is proposed. Simulations to compare the Type I error rate and power of the BMLRT and the likelihood ratio test (LRT) methods are performed. These simulations show that the BMLRT method has a better chi-square approximation under the null hypothesis. Finally, a practical example is given.     

A score test for overdispersion in Poisson regression based on the generalized Poisson-2 model

Overdispersion is a common phenomenon in Poisson modeling. The generalized Poisson (GP) regression model accommodates both overdispersion and underdispersion in count data modeling, and is an increasingly popular platform for modeling overdispersed count data. The Poisson model is one of the special cases in the collection of models which may be specified by GP regression. Thus, we may derive a test of overdispersion which compares the equi-dispersion Poisson model within the context of the more general GP regression model. The score test has an advantage over the likelihood ratio test (LRT) and over the Wald test in that the score test only requires that the parameter of interest be estimated under the null hypothesis (the Poisson model). Herein, we propose a score test for overdispersion based on the GP model (specifically the GP-2 model) and compare the power of the test with the LRT and Wald tests. A simulation study indicates the proposed score test based on asymptotic standard normal distribution is more appropriate in practical applications.     

On stochastic processes for quantitative trait locus mapping under selective genotyping

We consider the likelihood ratio test (LRT) process related to the test of the absence of QTL (a QTL denotes a quantitative trait locus, i.e. a gene with quantitative effect on a trait) on the interval [0, T] representing a chromosome. The originality of this study is that we are under selective genotyping: only the individuals with extreme phenotypes are genotyped. We give the asymptotic distribution of this LRT process under the null hypothesis that there is no QTL on [0, T] and under local alternatives with a QTL at t^☆ on [0, T]. We show that the LRT process is asymptotically the square of a ‘non-linear interpolated and normalized Gaussian process’. We have an easy formula in order to compute the supremum of the square of this interpolated process. We prove that we have to genotype symmetrically and that the threshold is exactly the same as in the situation where all the individuals are genotyped.     

A revisit to test the equality of variances of several populations

We revisit the problem of testing homoscedasticity (or, equality of variances) of several normal populations which has applications in many statistical analyses, including design of experiments. The standard text books and widely used statistical packages propose a few popular tests including Bartlett's test, Levene's test and a few adjustments of the latter. Apparently, the popularity of these tests have been based on limited simulation study carried out a few decades ago. The traditional tests, including the classical likelihood ratio test (LRT), are asymptotic in nature, and hence do not perform well for small sample sizes. In this paper we propose a simple parametric bootstrap (PB) modification of the LRT, and compare it against the other popular tests as well as their PB versions in terms of size and power. Our comprehensive simulation study bursts some popularly held myths about the commonly used tests and sheds some new light on this important problem. Though most popular statistical software/packages suggest using Bartlette's test, Levene's test, or modified Levene's test among a few others, our extensive simulation study, carried out under both the normal model as well as several non-normal models clearly shows that a PB version of the modified Levene's test (which does not use the F-distribution cut-off point as its critical value), and Loh's exact test are the “best” performers in terms of overall size as well as power.     

Testing a block exchangeable covariance matrix

Testing hypotheses about the structure of a covariance matrix for doubly multivariate data is often considered in the literature. In this paper the Rao's score test (RST) is derived to test the block exchangeable covariance matrix or block compound symmetry (BCS) covariance structure under the assumption of multivariate normality. It is shown that the empirical distribution of the RST statistic under the null hypothesis is independent of the true values of the mean and the matrix components of a BCS structure. A significant advantage of the RST is that it can be performed for small samples, even smaller than the dimension of the data, where the likelihood ratio test (LRT) cannot be used, and it outperforms the standard LRT in a number of contexts. Simulation studies are performed for the sample size consideration, and for the estimation of the empirical quantiles of the null distribution of the test statistic. The RST procedure is illustrated on a real data set from the medical studies.