Parametric Bootstrap Tests for Unbalanced Three-factor Nested Designs under Heteroscedasticity

In this article, we consider the three-factor unbalanced nested design model without the assumption of equal error variance. For the problem of testing “main effects” of the three factors, we propose a parametric bootstrap (PB) approach and compare it with the existing generalized F (GF) test. The Type I error rates of the tests are evaluated using Monte Carlo simulation. Our studies show that the PB test performs better than the generalized F-test. The PB test performs very satisfactorily even for small samples while the GF test exhibits poor Type I error properties when the number of factorial combinations or treatments goes up. It is also noted that the same tests can be used to test the significance of the random effect variance component in a three-factor mixed effects nested model under unequal error variances.     

A Parametric Bootstrap Solution to Two-way MANOVA without Interaction under Heteroscedasticity: Fixed and Mixed Models

In this article, we propose a parametric bootstrap (PB) test for heteroscedastic two-way multivariate analysis of variance without Interaction. For the problem of testing equal main effects of factors, we obtain a PB approach and compare it with existing modified Brown–Forsythe (MBF) test and approximate Hotelling T² (AHT) test by an extensive simulation study. The PB test is a symmetric function in samples, and does not depend on the chosen weights used to define the parameters uniquely. Simulation results indicate that the PB test performs satisfactorily for various cell sizes and parameter configurations when the homogeneity assumption is seriously violated, and tends to outperform the AHT test for moderate or larger samples in terms of power and controlling size. The MBF test, the AHT test, and the PB test have similar robustness to violations of underlying assumptions. It is also noted that the same PB test can be used to test the significance of random effect vector in a two-way multivariate mixed effects model with unequal cell covariance matrices.     

A Parametric Bootstrap Test for Comparing Heteroscedastic Regression Models

Testing equality of regression coefficients in several regression models is a common problem encountered in many applied fields. This article presents a parametric bootstrap (PB) approach and compares its performance to that of another simulation-based approach, namely, the generalized variable approach. Simulation studies indicate that the PB approach controls the Type I error rates satisfactorily regardless of the number of regression models and sample sizes whereas the generalized variable approach tends to be very liberal as the number of regression models goes up. The proposed PB approach is illustrated using a data set from stability study.     

A Parametric Bootstrap Approach for One-Way ANOVA Under Unequal Variances with Unbalanced Data

This research is to provide a solution of one-way ANOVA without using transformation when variances are heteroscedastic and group sizes are unequal. Parametric bootstrap test (Krishnamoorthy et al., 2007 Krishnamoorthy, K., Lu, F., Mathew, T. (2007). A parametric bootstrap approach for anova with unequal variances: Fixed and random models. Computational Statistics and Data Analysis 51:5731–5742.[Crossref], [Web of Science ®] , [Google Scholar]) has been shown to be competitive with many other methods when testing the equality of group means. We extend the parametric bootstrap algorithm to a multiple comparison procedure. Simulation results show that the parametric bootstrap approach works well for one-way ANOVA.     

A Joint Test for Conditional Heteroscedasticity in Dynamic Panel Data Models

This article proposes a joint test for conditional heteroscedasticity in dynamic panel data models. The test is constructed by checking the joint significance of estimates of second to pth-order serial correlation in the squares sequence of the first differenced errors. To avoid any distribution assumptions of the errors and the effects, we adopt the GMM estimation for the parameter coefficient and higher order moment estimation for the errors. Based on the estimations, a joint test is constructed for conditional heteroscedasticity in the error. The resulted test is asymptotically chi-squared under the null hypothesis and easy to implement. The small sample properties of the test are investigated by means of Monte Carlo experiments. The evidence shows that the test performs well in dynamic panel data with large number n of individuals and short periods T of time. A real data is analyzed for illustration.     

A Joint Score Test for Heteroscedasticity in the Two Way Error Components Model

This article extends the work by Holly and Gardiol (2000) (A score test for individual heteroscedasticity in a one-way error component model. In: Krishnakumar, J., Ronchetti, E., Eds. Panel Data Econometrics: Future Directions. Elsevier, North-Holland, Amsterdam, pp. 199–211, Ch. 10) to the two-way error components model. It deals exclusively with a joint heteroscedasticity test by first deriving Rao's efficient score statistics. Then, based on appropriate set of assumptions, we deduce the asymptotic distribution of the score under contiguous alternatives. Finally, we provide the expression for the score test statistic in the presence of heteroscedasticity and discuss its asymptotic local power.     

A Corrected Pseudo-score Approach for Additive Hazards Model with Longitudinal Covariates Measured with Error

In medical studies, it is often of interest to characterize the relationship between a time-to-event and covariates, not only time-independent but also time-dependent. Time-dependent covariates are generally measured intermittently and with error. Recent interests focus on the proportional hazards framework, with longitudinal data jointly modeled through a mixed effects model. However, approaches under this framework depend on the normality assumption of the error, and might encounter intractable numerical difficulties in practice. This motivates us to consider an alternative framework, that is, the additive hazards model, about which little research has been done when time-dependent covariates are measured with error. We propose a simple corrected pseudo-score approach for the regression parameters with no assumptions on the distribution of the random effects and the error beyond those for the variance structure of the latter. The estimator has an explicit form and is shown to be consistent and asymptotically normal. We illustrate the method via simulations and by application to data from an HIV clinical trial.