A continuously adaptive nonparametric two–sample test

A two–sample test statistic for detecting shifts in location is developed for a broad range of underlying distributions using adaptive techniques. The test statistic is a linear rank statistics which uses a simple modification of the Wilcoxon test; the scores are Winsorized ranks where the upper and lower Winsorinzing proportions are estimated in the first stage of the adaptive procedure using sample the first stage of the adaptive procedure using sample measures of the distribution's skewness and tailweight. An empirical relationship between the Winsorizing proportions and the sample skewness and tailweight allows for a ‘continuous’ adaptation of the test statistic to the data. The test has good asymptotic properties, and the small sample results are compared with other populatr parametric, nonparametric, and two–stage tests using Monte Carlo methods. Based on these results, this proposed test procedure is recommended for moderate and larger sample sizes.     

A simple test procedure in standardizing the power of Hosmer–Lemeshow test in large data sets

The Hosmer–Lemeshow (H–L) test is a widely used method when assessing the goodness-of-fit of a logistic regression model. However, the H–L test is sensitive to the sample sizes and the number of groups in H–L test. Cautions need to be taken for interpreting an H–L test with a large sample size. In this paper, we propose a simple test procedure to evaluate the model fit of logistic regression model with a large sample size, in which a bootstrap method is used and the test result is determined by the power of H–L test at the target sample size. Simulation studies show that the proposed method can effectively standardize the power of the H–L test under the pre-specified level of type I error. Application to the two datasets illustrates the usefulness of the proposed model.     

The sample breakdown points of tests

Several authors have taken the worst case breakdown measures in analyzing the robustness of a test. In general, these kinds of measures give only a rough picture of breakdown robustness of a test. To overcome this limitation, a new kind of breakdown measure of a test is defined as the smallest proportion of arbitrary outliers in the sample that can distort the test decision. It is called as the sample breakdown point of a test in this paper. A distinct advantage of this new measure is that it is directly concerned with the test decision based on the present sample and with the critical region of the test. The sample breakdown points of several commonly used tests of one-sided or two-sided hypotheses are calculated and their asymptotic properties are also established. By Monte Carlo simulations and asymptotic analysis, we show that the acceptance breakdown of the t-test and the Hotelling T²-test is slightly better than that of the sample mean test. Finally, we prove that, for a one-sided hypothesis testing of location, the sign test has the maximum sample breakdown points asymptotically within a class of M-tests and score-tests.     

Robust Small Sample Inference for Generalised Estimating Equations: An Application of the Anova‐type Test

Asymptotically, the Wald‐type test for generalised estimating equations (GEE) models can control the type I error rate at the nominal level. However in small sample studies, it may lead to inflated type I error rates. Even with currently available small sample corrections for the GEE Wald‐type test, the type I error rate inflation is still serious when the tested contrast is multidimensional. This paper extends the ANOVA‐type test for heteroscedastic factorial designs to GEE and shows that the proposed ANOVA‐type test can also control the type I error rate at the nominal level in small sample studies while still maintaining robustness with respect to mis‐specification of the working correlation matrix. Differences of inference between the Wald‐type test and the proposed test are observed in a two‐way repeated measures ANOVA model for a diet‐induced obesity study and a two‐way repeated measures logistic regression for a collagen‐induced arthritis study. Simulation studies confirm that the proposed test has better control of the type I error rate than the Wald‐type test in small sample repeated measures models. Additional simulation studies further show that the proposed test can even achieve larger power than the Wald‐type test in some cases of the large sample repeated measures ANOVA models that were investigated.     

A test for bivariate two sample location problem

A consistent test for difference in locations between two bivariate populations is proposed, The test is similar as the Mann-Whitney test and depends on the exceedances of slopes of the two samples where slope for each sample observation is computed by taking the ratios of the observed values. In terms of the slopes, it reduces to a univariate problem, The power of the test has been compared with those of various existing tests by simulation. The proposed test statistic is compared with Mardia's(1967) test statistics, Peters-Randies(1991) test statistic, Wilcoxon's rank sum test. statistic and Hotelling' T² test statistic using Monte Carlo technique. It performs better than other statistics compared for small differences in locations between two populations when underlying population is population 7(light tailed population) and sample size 15 and 18 respectively. When underlying population is population 6(heavy tailed population) and sample sizes are 15 and 18 it performas better than other statistic compared except Wilcoxon's rank sum test statistics for small differences in location between two populations. It performs better than Mardia's(1967) test statistic for large differences in location between two population when underlying population is bivariate normal mixture with probability p=0.5, population 6, Pearson type II population and Pearson type VII population for sample size 15 and 18 .Under bivariate normal population it performs as good as Mardia' (1967) test statistic for small differences in locations between two populations and sample sizes 15 and 18. For sample sizes 25 and 28 respectively it performs better than Mardia's (1967) test statistic when underlying population is population 6, Pearson type II population and Pearson type VII population     

Sample size determination for testing equality in Poisson frequency data under an AB/BA crossover trial

Assuming that the frequency of occurrence follows the Poisson distribution, we develop sample size calculation procedures for testing equality based on an exact test procedure and an asymptotic test procedure under an AB/BA crossover design. We employ Monte Carlo simulation to demonstrate the use of these sample size formulae and evaluate the accuracy of sample size calculation formula derived from the asymptotic test procedure with respect to power in a variety of situations. We note that when both the relative treatment effect of interest and the underlying intraclass correlation between frequencies within patients are large, the sample size calculation based on the asymptotic test procedure can lose accuracy. In this case, the sample size calculation procedure based on the exact test is recommended. On the other hand, if the relative treatment effect of interest is small, the minimum required number of patients per group will be large, and the asymptotic test procedure will be valid for use. In this case, we may consider use of the sample size calculation formula derived from the asymptotic test procedure to reduce the number of patients needed for the exact test procedure. We include an example regarding a double‐blind randomized crossover trial comparing salmeterol with a placebo in exacerbations of asthma to illustrate the practical use of these sample size formulae. Copyright © 2013 John Wiley & Sons, Ltd.     

A nonparametric repeated significance test with adaptive target sample size

In this article a general result is derived that, along with a functional central limit theorem for a sequence of statistics, can be employed in developing a nonparametric repeated significance test with adaptive target sample size. This method is used in deriving a repeated significance test with adaptive target sample size for the shift model. The repeated significance test is based on a functional central limit theorem for a sequence of partial sums of truncated observations. Based on numerical results presented in this article one can conclude that this nonparametric sequential test performs quite well.     

Maximum Test versus Adaptive Tests for the Two-Sample Location Problem

For the non-parametric two-sample location problem, adaptive tests based on a selector statistic are compared with a maximum and a sum test, respectively. When the class of all continuous distributions is not restricted, the sum test is not a robust test, i.e. it does not have a relatively high power across the different possible distributions. However, according to our simulation results, the adaptive tests as well as the maximum test are robust. For a small sample size, the maximum test is preferable, whereas for a large sample size the comparison between the adaptive tests and the maximum test does not show a clear winner. Consequently, one may argue in favour of the maximum test since it is a useful test for all sample sizes. Furthermore, it does not need a selector and the specification of which test is to be performed for which values of the selector. When the family of possible distributions is restricted, the maximin efficiency robust test may be a further robust alternative. However, for the family of t distributions this test is not as powerful as the corresponding maximum test.     

Bivariate Sign Test for One-Sample Bivariate Location Model Using Ranked Set Sample

In this article, we introduce a bivariate sign test for the one-sample bivariate location model using a bivariate ranked set sample (BVRSS). We show that the proposed test is asymptotically more efficient than its counterpart sign test based on a bivariate simple random sample (BVSRS). The asymptotic null distribution and the non centrality parameter are derived. The asymptotic distribution of the vector of sample median as an estimator of the locations of the bivariate model is introduced. Theoretical and numerical comparisons of the asymptotic efficiency of the BVRSS sign test with respect to the BVSRS sign test are also given.     

Seme distributions and their implications for an internal pilot study with a univariate linear model

In planning a study, the choice of sample size may depend on a variance value based on speculation or obtained from an earlier study. Scientists may wish to use an internal pilot design to protect themselves against an incorrect choice of variance. Such a design involves collecting a portion of the originally planned sample and using it to produce a new variance estimate. This leads to a new power analysis and increasing or decreasing sample size. For any general linear univariate model, with fixed predictors and Gaussian errors, we prove that the uncorrected fixed sample F-statistic is the likelihood ratio test statistic. However, the statistic does not follow an F distribution. Ignoring the discrepancy may inflate test size. We derive and evaluate properties of the components of the likelihood ratio test statistic in order to characterize and quantify the bias. Most notably, the fixed sample size variance estimate becomes biased downward. The bias may inflate test size for any hypothesis test, even if the parameter being tested was not involved in the sample size re-estimation. Furthermore, using fixed sample size methods may create biased confidence intervals for secondary parameters and the variance estimate.     

C334. On the neutron and proton masses: a numerological case study

The intercomponent rank test suggested by Thompson (1991a) for the bivariate two sample problem is compared with the intracomponent rank test discussed by Puri and Sen (1971) and Hettmansperger (1984) and with the Hotelling T ² test. Asymptotic relative efficiencies are discussed and the results of a simulation study are presented. Power studies show that for small sample sizes and small Type 1 error rates, say n = 5 and α = .01, the intercomponent rank test of Thompson (1991a) is somewhat liberal and the intracomponent test is quite conservative. For larger sample sizes and larger Type 1 error rates, both rank tests have improved properties under the null hypothesis. In almost all simulated cases, the intercomponent test is more powerful. In light of these studies it is suggested that the intercomponent rank test of Thompson (1991a), which has the added advantage of being easily computed with standard statistical software, is a strong competitor to the intracomponent rank test.     

Randomized allocation procedure for testing a normal mean with known variance

This paper provides an alternative test procedure for the problem of testing normal mean against two-sided alternative with known variance for costly trials. The goal is to carry out the test procedure with a smaller sample size if the alternative is true. The sample size is determined in an adaptive fashion which takes all the previous observations into account for adaptation. Some exact and asymptotic results related to the test and design are studied.     

Optimal sample size planning for the Wilcoxon–Mann–Whitney and van Elteren tests under cost constraints

Sampling cost is a crucial factor in sample size planning, particularly when the treatment group is more expensive than the control group. To either minimize the total cost or maximize the statistical power of the test, we used the distribution-free Wilcoxon–Mann–Whitney test for two independent samples and the van Elteren test for randomized block design, respectively. We then developed approximate sample size formulas when the distribution of data is abnormal and/or unknown. This study derived the optimal sample size allocation ratio for a given statistical power by considering the cost constraints, so that the resulting sample sizes could minimize either the total cost or the total sample size. Moreover, for a given total cost, the optimal sample size allocation is recommended to maximize the statistical power of the test. The proposed formula is not only innovative, but also quick and easy. We also applied real data from a clinical trial to illustrate how to choose the sample size for a randomized two-block design. For nonparametric methods, no existing commercial software for sample size planning has considered the cost factor, and therefore the proposed methods can provide important insights related to the impact of cost constraints.     

On the procedure of hodges and lehmann for testing composite hypotheses of the mean of a normal distribution with unknown variance

In 1954 Hodges and Lehmann gave a test procedure for testing the hypothesis that the mean of an identically independently normally distributed random sample with unknown variance is contained within a certain interval [μ1, μ2]. The test is similar on the boundary of the zero-hypothesis and superior in power to the composite t-test usually applied to this problem. However Hodges and Lehmann could prove the unbiasedness of their test only for the special case that the sample consists of two elements. From numerical computations they guessed that unbiasedness would be valid for arbitrary sample sizes. This question is discussed here and partially answered.     

A Goodness-of-Fit Test for Location-Scale Max-Stable Distributions

In this article, a technique based on the sample correlation coefficient to construct goodness-of-fit tests for max-stable distributions with unknown location and scale parameters and finite second moment is proposed. Specific details to test for the Gumbel distribution are given, including critical values for small sample sizes as well as approximate critical values for larger sample sizes by using normal quantiles. A comparison by Monte Carlo simulation shows that the proposed test for the Gumbel hypothesis is substantially more powerful than some other known tests against some alternative distributions with positive skewness coefficient.     

Study design of single‐arm phase II immunotherapy trials with long‐term survivors and random delayed treatment effect

In the traditional study design of a single‐arm phase II cancer clinical trial, the one‐sample log‐rank test has been frequently used. A common practice in sample size calculation is to assume that the event time in the new treatment follows exponential distribution. Such a study design may not be suitable for immunotherapy cancer trials, when both long‐term survivors (or even cured patients from the disease) and delayed treatment effect are present, because exponential distribution is not appropriate to describe such data and consequently could lead to severely underpowered trial. In this research, we proposed a piecewise proportional hazards cure rate model with random delayed treatment effect to design single‐arm phase II immunotherapy cancer trials. To improve test power, we proposed a new weighted one‐sample log‐rank test and provided a sample size calculation formula for designing trials. Our simulation study showed that the proposed log‐rank test performs well and is robust of misspecified weight and the sample size calculation formula also performs well.     

A two sample ordered alternative test for means and variances

A two sample test of likelihood ratio type is proposed, assuming normal distribution theory, for testing the hypothesis that two samples come from identical normal populations versus the alternative that the populations are normal but vary in mean value and variance with one population having a smaller mean and smaller variance than the other. The small sample and large sample distribution of the proposed statistic are derived assuming normality. Some computations are presented which show the speed of convergence of small sample critical values to their asymptotic counterparts. Comparisons of local power of the proposed test are made with several potential competing tests. Asymptotics for the test statistic are derived when underlying distributions are not necessarily normal.     

An improved test of equality of mean directions for the Langevin‐von Mises‐Fisher distribution

A multi‐sample test for equality of mean directions is developed for populations having Langevin‐von Mises‐Fisher distributions with a common unknown concentration. The proposed test statistic is a monotone transformation of the likelihood ratio. The high‐concentration asymptotic null distribution of the test statistic is derived. In contrast to previously suggested high‐concentration tests, the high‐concentration asymptotic approximation to the null distribution of the proposed test statistic is also valid for large sample sizes with any fixed nonzero concentration parameter. Simulations of size and power show that the proposed test outperforms competing tests. An example with three‐dimensional data from an anthropological study illustrates the practical application of the testing procedure.     

A two- sample partially sequential probability ratio test

A two-sample partially sequential probability ratio test (PSPRT) is considered for the two-sample location problem with one sample fixed and the other sequential. Observations are assumed to come from two normal poptilatlons with equal and known variances. Asymptotically in the fixed-sample size the PSPRT is a truncated Wald one sample sequential probability test. Brownian motion approximations for boundary-crossing probabilities and expected sequential sample size are obtained. These calculations are compared to values obtained by Monte Carlo simulation.     

One-and two-sample sign tests for ranked set sample selective designs

Statistical inference based on a ranked set sample depends very much on the location of the quantified observations. A selective design which determines the location of the quantified observations in a ranked set sample is introduced. The paper investigates the effects of selective designs on one and two sample sign test statistics. The Pitman efficiencies of one- and two sample sign tests are calculated for selective designs and compared with ranked set samples of the same size. If the design quantifies observations at the center points, then the proposed procedure is superior to a ranked set sample of the same size in the sense of Pitman efficiency. Some practical problems are addressed for the two-sample sign test.