Quantile Regression For Longitudinal Biomarker Data Subject to Left Censoring and Dropouts

Quantile regression is increasingly used in biomarker analysis to handle nonnormal or heteroscedastic data. However, in some biomedical studies, the biomarker data can be censored by detection limits of the bioassay or missing when the subjects drop out from the study. Inappropriate handling of these two issues leads to biased estimation results. We consider the censored quantile regression approach to account for the censoring data and apply the inverse weighting technique to adjust for dropouts. In particular, we develop a weighted estimating equation for censored quantile regression, where an individual’s contribution is weighted by the inverse probability of dropout at the given occasion. We conduct simulation studies to evaluate the properties of the proposed estimators and demonstrate our method with a real data set from Genetic and Inflammatory Marker of Sepsis (GenIMS) study.     

面板数据的分位回归方法及其模拟研究

文章讨论了含有固定效应的面板数据模型,给出了3种估计未知参数的分位回归方法,蒙特卡洛模拟结果显示这些分位回归方法是处理面板数据的有效手段,且在误差非正态时优于均值回归方法。文章最后给出了一个真实数据的建模案例,得到了有利于决策的有用参考信息。     

Variable Selection in Semiparametric Quantile Modeling for Longitudinal Data

We propose a penalized quantile regression for partially linear varying coefficient (VC) model with longitudinal data to select relevant non parametric and parametric components simultaneously. Selection consistency and oracle property are established. Furthermore, if linear part and VC part are unknown, we propose a new unified method, which can do three types of selections: separation of varying and constant effects, selection of relevant variables, and it can be carried out conveniently in one step. Consistency in the three types of selections and oracle property in estimation are established as well. Simulation studies and real data analysis also confirm our method.     

Non-iterative Estimation and Variable Selection in the Single-index Quantile Regression Model

A new estimation procedure is proposed for the single-index quantile regression model. Compared to existing work, this approach is non-iterative and hence, computationally efficient. The proposed method not only estimates the index parameter and the link function but also selects variables simultaneously. The performance of the variable selection is enhanced by a fully adaptive penalty function motivated by the sliced inverse regression technique. Finite sample performance is studied through a simulation study that compares the proposed method with existing work under several criteria. A data analysis is given that highlights the usefulness of the proposed methodology.     

面板数据的自适应Lasso分位回归方法研究

如何在对参数进行估计的同时自动选择重要解释变量,一直是面板数据分位回归模型中讨论的热点问题之一。通过构造一种含多重随机效应的贝叶斯分层分位回归模型,在假定固定效应系数先验服从一种新的条件Laplace分布的基础上,给出了模型参数估计的Gibbs抽样算法。考虑到不同重要程度的解释变量权重系数压缩程度应该不同,所构造的先验信息具有自适应性的特点,能够准确地对模型中重要解释变量进行自动选取,且设计的切片Gibbs抽样算法能够快速有效地解决模型中各个参数的后验均值估计问题。模拟结果显示,新方法在参数估计精确度和变量选择准确度上均优于现有文献的常用方法。通过对中国各地区多个宏观经济指标的面板数据进行建模分析,演示了新方法估计参数与挑选变量的能力。     

非参数固定效应Panel Data模型的分位数回归推断

利用分位数回归方法,讨论了非参数固定效应Panel Data模型的估计和检验问题,得到了参数估计的渐近正态性及收敛速度。同时,建立一个秩得分(rank score)统计量来检验模型的固定效应,并证明了这个统计量渐近服从标准正态分布。     

Bayesian Elastic Net Tobit Quantile Regression

In this article, the problem of parameter estimation and variable selection in the Tobit quantile regression model is considered. A Tobit quantile regression with the elastic net penalty from a Bayesian perspective is proposed. Independent gamma priors are put on the l₁ norm penalty parameters. A novel aspect of the Bayesian elastic net Tobit quantile regression is to treat the hyperparameters of the gamma priors as unknowns and let the data estimate them along with other parameters. A Bayesian Tobit quantile regression with the adaptive elastic net penalty is also proposed. The Gibbs sampling computational technique is adapted to simulate the parameters from the posterior distributions. The proposed methods are demonstrated by both simulated and real data examples.     

基于贝叶斯方法的比例数据分位数推断及其应用

为了尝试使用贝叶斯方法研究比例数据的分位数回归统计推断问题,首先基于Tobit模型给出了分位数回归建模方法,然后通过选取合适的先验分布得到了贝叶斯层次模型,进而给出了各参数的后验分布并用于Gibbs抽样。数值模拟分析验证了所提出的贝叶斯推断方法对于比例数据分析的有效性。最后,将贝叶斯方法应用于美国加州海洛因吸毒数据,在不同的分位数水平下揭示了吸毒频率的影响因素。     

分位数回归技术综述

普通最小二乘回归建立了在自变量X=x下因变量Y的条件均值与X的关系的线性模型。而分位数回归（Quantile Regression）则利用自变量X和因变量y的条件分位数进行建模。与普通的均值回归相比,它能充分反映自变量X对于因变量y的分布的位置、刻度和形状的影响,有着十分广泛的应用,尤其是对于一些非常关注尾部特征的情况。文章介绍了分位数回归的概念以及分位数回归的估计、检验和拟合优度,回顾了分位数回归的发展过程以及其在一些经济研究领域中的应用,最后做了总结。     

基于分位回归的风险保费预测

风险保费预测是非寿险费率厘定的重要组成部分。在传统的分位回归厘定风险保费中,通常假设分位数水平是事先给定的,缺乏一定的客观性。为此,提出了一种应用分位回归厘定风险保费的新方法。基于破产概率确定保单组合的总风险保费,建立个体保单的分位回归模型,并与总风险保费建立等式关系,通过数值方法求解出分位数水平,实现对个体保单风险保费的预测。通过一组实际数据分析表明,该方法具有良好的预测效果。     

Consistent Estimation of the Regression Coefficient Through Weighted Arithmetic Mean of the Inconsistent Estimators in Replicated Ultrastructural Model

The problem of consistent estimation of the slope parameter in an ultrastructural model with replicated observations is considered in this article. A consistent estimator based on a weighted arithmetic mean of two inconsistent least squares estimators is proposed which is independent of any unknown quantity. The efficiency properties of this estimator are studied.     

Semiparametric Hierarchical Composite Quantile Regression

In biological, medical, and social sciences, multilevel structures are very common. Hierarchical models that take the dependencies among subjects within the same level are necessary. In this article, we introduce a semiparametric hierarchical composite quantile regression model for hierarchical data. This model (i) keeps the easy interpretability of the simple parametric model; (ii) retains some of the flexibility of the complex non parametric model; (iii) relaxes the assumptions that the noise variances and higher-order moments exist and are finite; and (iv) takes the dependencies among subjects within the same hierarchy into consideration. We establish the asymptotic properties of the proposed estimators. Our simulation results show that the proposed method is more efficient than the least-squares-based method for many non normally distributed errors. We illustrate our methodology with a real biometric data set.     

Nonlinear Censored Regression Using Synthetic Data

Abstract.  The problem of estimating a nonlinear regression model, when the dependent variable is randomly censored, is considered. The parameter of the model is estimated by least squares using synthetic data. Consistency and asymptotic normality of the least squares estimators are derived. The proofs are based on a novel approach that uses i.i.d. representations of synthetic data through Kaplan–Meier integrals. The asymptotic results are supported by a small simulation study.     

Non-parametric Quantile Regression with Censored Data

Abstract.  Censored regression models have received a great deal of attention in both the theoretical and applied statistics literature. Here, we consider a model in which the response variable is censored but not the covariates. We propose a new estimator of the conditional quantiles based on the local linear method, and give an algorithm for its numerical implementation. We study its asymptotic properties and evaluate its performance on simulated data sets.     

Influence Measures in Quantile Regression Models

In this article, we use the asymmetric Laplace distribution to define a new method to determine the influence of a certain observation in the fit of quantile regression models. Our measure is based on the likelihood displacement function and we propose two types of measures in order to determine influential observations in a set of conditional quantiles conjointly or in each conditional quantile of interest. We verify the validity of our average measure in a simulated data set as well in an illustrative example with data about air pollution.     

Confidence Corridors for Multivariate Generalized Quantile Regression

We focus on the construction of confidence corridors for multivariate nonparametric generalized quantile regression functions. This construction is based on asymptotic results for the maximal deviation between a suitable nonparametric estimator and the true function of interest, which follow after a series of approximation steps including a Bahadur representation, a new strong approximation theorem, and exponential tail inequalities for Gaussian random fields. As a byproduct we also obtain multivariate confidence corridors for the regression function in the classical mean regression. To deal with the problem of slowly decreasing error in coverage probability of the asymptotic confidence corridors, which results in meager coverage for small sample sizes, a simple bootstrap procedure is designed based on the leading term of the Bahadur representation. The finite-sample properties of both procedures are investigated by means of a simulation study and it is demonstrated that the bootstrap procedure considerably outperforms the asymptotic bands in terms of coverage accuracy. Finally, the bootstrap confidence corridors are used to study the efficacy of the National Supported Work Demonstration, which is a randomized employment enhancement program launched in the 1970s. This article has supplementary materials online.     

缺失数据下的逆概率多重加权分位回归估计及其应用

数据缺失问题普遍存在于应用研究中。在随机缺失机制假定下,本文从模型推断角度出发,针对线性缺失分位回归模型,提出一种新的有效估计方法——逆概率多重加权（IPMW）估计。该方法是在逆概率加权（IPW）估计的基础上,结合倾向得分匹配及模型平均思想,经过多次估计,加权确定最终参数估计结果。该方法适用于响应变量是独立同分布或独立非同分布的情形,并适用于绝大多数缺失场景。经过理论推导及模拟研究发现,IPMW估计量在继承IPW估计量的优势上具有更稳健的性质。最后,将该方法应用于含有缺失数据的微观调查数据中,研究了经济较发达的准一线城市中等收入群体消费水平的影响因素,对比两种估计方法的估计结果及置信带,发现逆概率多重加权估计量的标准偏差更小,估计结果更稳健。     

Efficient Estimation of an Additive Quantile Regression Model

Abstract. In this paper, two non‐parametric estimators are proposed for estimating the components of an additive quantile regression model. The first estimator is a computationally convenient approach which can be viewed as a more viable alternative to existing kernel‐based approaches. The second estimator involves sequential fitting by univariate local polynomial quantile regressions for each additive component with the other additive components replaced by the corresponding estimates from the first estimator. The purpose of the extra local averaging is to reduce the variance of the first estimator. We show that the second estimator achieves oracle efficiency in the sense that each estimated additive component has the same variance as in the case when all other additive components were known. Asymptotic properties are derived for both estimators under dependent processes that are strictly stationary and absolutely regular. We also provide a demonstrative empirical application of additive quantile models to ambulance travel times.     

Local Linear Additive Quantile Regression

Abstract.  We consider non-parametric additive quantile regression estimation by kernel-weighted local linear fitting. The estimator is based on localizing the characterization of quantile regression as the minimizer of the appropriate 'check function'. A backfitting algorithm and a heuristic rule for selecting the smoothing parameter are explored. We also study the estimation of average-derivative quantile regression under the additive model. The techniques are illustrated by a simulated example and a real data set.     

Rank Estimation of Log-Linear Regression with Interval-Censored Data

Interval-censored data arise in a wide variety of research and application fields such as cancer and AIDS studies. In this paper, we study a log-linear regression model when data are subject to interval censoring. We use a U-statistic based on ranks to estimate regression coefficients and establish large sample properties of the estimator. We illustrate the performance of the proposed estimate with simulations and a numerical example.