Bias Correction in the Type I Generalized Logistic Distribution

Four strategies for bias correction of the maximum likelihood estimator of the parameters in the Type I generalized logistic distribution are studied. First, we consider an analytic bias-corrected estimator, which is obtained by deriving an analytic expression for the bias to order n ^?1; second, a method based on modifying the likelihood equations; third, we consider the jackknife bias-corrected estimator; and fourth, we consider two bootstrap bias-corrected estimators. All bias correction estimators are compared by simulation. Finally, an example with a real data set is also presented.     

Bias evaluation in the proportional hazards model

We consider two approaches for bias evaluation and reduction in the proportional hazards model proposed by Cox. The first one is an analytical approach in which we derive the n^-1 bias term of the maximum partial likelihood estimator. The second approach consists of resampling methods, namely the jackknife and the bootstrap. We compare all methods through a comprehensive set of Monte Carlo simulations. The results suggest that bias-corrected estimators have better finite-sample performance than the standard maximum partial likelihood estimator. There is some evidence oithe bootstrap-correction superiority over the jackknife-correction but its performance is similar to the analytical estimator. Finaily an application iliustrates the proposed approaches.     

Bias Reduction for the Maximum Likelihood Estimators of the Parameters in the Half-Logistic Distribution

We derive analytic expressions for the biases of the maximum likelihood estimators of the scale parameter in the half-logistic distribution with known location, and of the location parameter when the latter is unknown. Using these expressions to bias-correct the estimators is highly effective, without adverse consequences for estimation mean squared error. The overall performance of the first of these bias-corrected estimators is slightly better than that of a bootstrap bias-corrected estimator. The bias-corrected estimator of the location parameter significantly out-performs its bootstrapped-based counterpart. Taking computational costs into account, the analytic bias corrections clearly dominate the use of the bootstrap.     

Efficient mean estimation in log-normal linear models

Log-normal linear models are widely used in applications, and many times it is of interest to predict the response variable or to estimate the mean of the response variable at the original scale for a new set of covariate values. In this paper we consider the problem of efficient estimation of the conditional mean of the response variable at the original scale for log-normal linear models. Several existing estimators are reviewed first, including the maximum likelihood (ML) estimator, the restricted ML (REML) estimator, the uniformly minimum variance unbiased (UMVU) estimator, and a bias-corrected REML estimator. We then propose two estimators that minimize the asymptotic mean squared error and the asymptotic bias, respectively. A parametric bootstrap procedure is also described to obtain confidence intervals for the proposed estimators. Both the new estimators and the bootstrap procedure are very easy to implement. Comparisons of the estimators using simulation studies suggest that our estimators perform better than the existing ones, and the bootstrap procedure yields confidence intervals with good coverage properties. A real application of estimating the mean sediment discharge is used to illustrate the methodology.     

Approximate MLE for the scale parameter of the generalized exponential distribution under random censoring

In this paper, we consider the maximum likelihood estimator (MLE) of the scale parameter of the generalized exponential (GE) distribution based on a random censoring model. We assume the censoring distribution also follows a GE distribution. Since the estimator does not provide an explicit solution, we propose a simple method of deriving an explicit estimator by approximating the likelihood function. In order to compare the performance of the estimators, Monte Carlo simulation is conducted. The results show that the MLE and the approximate MLE are almost identical in terms of bias and variance.     

Delete-m Jackknife for Unequal m

In this paper, the delete-mj jackknife estimator is proposed. This estimator is based on samples obtained from the original sample by successively removing mutually exclusive groups of unequal size. In a Monte Carlo simulation study, a hierarchical linear model was used to evaluate the role of nonnormal residuals and sample size on bias and efficiency of this estimator. It is shown that bias is reduced in exchange for a minor reduction in efficiency. The accompanying jackknife variance estimator even improves on both bias and efficiency, and, moreover, this estimator is mean-squared-error consistent, whereas the maximum likelihood equivalents are not.     

Estimation of nonlinear errors-in-variables models: an approximate solution

We propose an easy to derive and simple to compute approximate least squares or maximum likelihood estimator for nonlinear errors-in-variables models that does not require the knowledge of the conditional density of the latent variables given the observables. Specific examples and Monte Carlo studies demonstrate that the bias of this approximate estimator is small even when the magnitude of the variance of measurement errors to the variance of measured covariates is large. Cheng Hsiao and Qing Wang's work was supported in part by National Science Foundation grant SeS91-22481 and SBR94-09540. Liqun Wang gratefully acknowledges the financial support from Swiss National Science Foundation. We wish to thank Professor H. Schneeweiss and a referee for helpful comments and suggestions.     

Efficient estimation of general linear mixed effects models

An extension of the linear growth curve model (Biometrics 38 (1982) 963) was proposed by Stukel and Demidenko (Biometrics 53 (1997) 720) to study the effects of population covariates on one or more characteristics of the curve, when the characteristics are expressed as linear combinations of the growth curve parameters. In the present paper, this general growth curve model receives a comprehensive theoretical treatment. A two-stage estimator, consisting of a generalized least squares estimator under constraints for the population parameters and a moment estimator for the variance parameters, is developed for application in the non-Gaussian error situation. Two likelihood based estimators, global maximum likelihood and second-stage maximum likelihood, are also developed. It is shown that all three estimators are consistent, asymptotically normally distributed, and efficient, and are equivalent when the number of individuals tends to infinity. An expression for the bias in the estimator of the population parameters is derived under second stage model misspecification. We show that if parameters that are not of primary interest are incorrectly specified, bias may occur in parameters that are of interest using the standard growth curve model. The general growth curve model does not require specification of such nuisance parameters and is robust in terms of bias. The general linear growth curve model is used to study the effects of host sex on pancreatic tumor growth in rats.     

Estimating the variance for heterogeneity in arm‐based network meta‐analysis

Network meta‐analysis can be implemented by using arm‐based or contrast‐based models. Here we focus on arm‐based models and fit them using generalized linear mixed model procedures. Full maximum likelihood (ML) estimation leads to biased trial‐by‐treatment interaction variance estimates for heterogeneity. Thus, our objective is to investigate alternative approaches to variance estimation that reduce bias compared with full ML. Specifically, we use penalized quasi‐likelihood/pseudo‐likelihood and hierarchical (h) likelihood approaches. In addition, we consider a novel model modification that yields estimators akin to the residual maximum likelihood estimator for linear mixed models. The proposed methods are compared by simulation, and 2 real datasets are used for illustration. Simulations show that penalized quasi‐likelihood/pseudo‐likelihood and h‐likelihood reduce bias and yield satisfactory coverage rates. Sum‐to‐zero restriction and baseline contrasts for random trial‐by‐treatment interaction effects, as well as a residual ML‐like adjustment, also reduce bias compared with an unconstrained model when ML is used, but coverage rates are not quite as good. Penalized quasi‐likelihood/pseudo‐likelihood and h‐likelihood are therefore recommended.     

Estimating the correlation coefficient in the presence of correlated observations from a bivariate normal population

Estimation of the correlation coefficient between two variates (p) in the presence of correlated observations from a bivar iate normal population is considered The estimated maximum likelihood estimator (EMLE), an estimate based on the maximum likelihood estimator (MLE), is proposed and studied for the estimation of p For the large sample case , approximate expressions foi the variance and the bias of the Pearson estimate of the correlation coefficient are derived. These expressions suggests that the Pearson’s estimator possesses high mean square error (MSE) in estimating ρ in comparison to the MLE The MSE is particularly high when the observations within clusters aie highly correlated. The Pearson’s estimate, the MLE, and the EMLE aie evaluated in a simulation study This study shows that the proposed EMLE pefoims bettei than the Pearson’s correlation coefficient except when the number of clusters is small.     

Estimation of regression parameters in generalized linear models for cluster correlated data with measurement error

Liang and Zeger (1986) introduced a class of estimating equations that gives consistent estimates of regression parameters and of their asymptotic variances in the class of generalized linear models for cluster correlated data. When the independent variables or covariates in such models are subject to measurement errors, the parameter estimates obtained from these estimating equations are no longer consistent. To correct for the effect of measurement errors, an estimator with smaller asymptotic bias is constructed along the lines of Stefanski (1985), assuming that the measurement error variance is either known or estimable. The asymptotic distribution of the bias-corrected estimator and a consistent estimator of its asymptotic variance are also given. The special case of a binary logistic regression model is studied in detail. For this case, methods based on conditional scores and quasilikelihood are also extended to cluster correlated data. Results of a small simulation study on the performance of the proposed estimators and associated tests of hypotheses are reported.     

Minimum variance unbiased estimation based on bootstrap iterations

Practical computation of the minimum variance unbiased estimator (MVUE) is often a difficult, if not impossible, task, even though general theory assures its existence under regularity conditions. We propose a new approach based on iterative bootstrap bias correction of the maximum likelihood estimator to accurately approximate the MVUE. Viewing bootstrap iteration as a Markov process, we develop a computational algorithm for bias correction based on arbitrarily many bootstrap iterations. The algorithm, when applied parametrically to finite sample spaces, does not involve Monte Carlo simulation. For infinite sample spaces, a nonparametric version of the algorithm is combined with a preliminary round of Monte Carlo simulation to yield an approximate MVUE. Both algorithms are computationally more efficient and stable than conventional simulation-based bootstrap iterations. Examples are given of both finite and infinite sample spaces to illustrate the effectiveness of our new approach. Supported by a grant from the Research Grants Council of the Hong Kong Special Administrative Region, China (Project No. HKU 7026/97P).     

Editorial collaborators

A simulation study of the binomial-logit model with correlated random effects is carried out based on the generalized linear mixed model (GLMM) methodology. Simulated data with various numbers of regression parameters and different values of the variance component are considered. The performance of approximate maximum likelihood (ML) and residual maximum likelihood (REML) estimators is evaluated. For a range of true parameter values, we report the average biases of estimators, the standard error of the average bias and the standard error of estimates over the simulations. In general, in terms of bias, the two methods do not show significant differences in estimating regression parameters. The REML estimation method is slightly better in reducing the bias of variance component estimates.     

On parameter estimation in Bernoulli trials with dependence

A simple estimator is proposed for the dependence parameter for the Klotz model of Bernoulli trials with Markov dependence and it is compared with the ratio estimator given by Price and the approximate maximum likelihood estimator given by Klotz. The proposed estimator is shown to have considerably smaller bias than the other two estimators with comparable mean squared errors, and has all the large sample optimal properties that the other two estimators have.     

Finite-Sample Properties of the Maximum Likelihood Estimator for the Poisson Regression Model With Random Covariates

We examine the small-sample behaviour of the maximum likelihood estimator for the Poisson regression model with random covariates. Analytic expressions for the second-order bias and mean squared error are derived, and we undertake some numerical evaluations to illustrate these results for the single covariate case. The properties of the bias-adjusted maximum likelihood estimator are investigated in a Monte Carlo experiment. Correcting the estimator for its second-order bias is found to be effective in the cases considered, and we recommend its use when the Poisson regression model is estimated by maximum likelihood with small samples.     

Reliability inference for a general lower-truncated family of distributions under records

Based on record values, point and interval estimators are proposed in this paper for the parameters of a general lower-truncated family of distributions. Maximum likelihood and bias-corrected estimators are obtained for unknown model parameters. Based on a sufficient and complete statistic, the bias-corrected estimator is also shown to be uniformly minimum variance unbiased estimator. Different exact confidence intervals and exact confidence regions are constructed for the both model and truncated parameters, and other confidence interval estimates based on asymptotic distribution theory and bootstrap approaches are obtained as well. Finally, two real-life examples and a numerical study are presented to illustrate the performance of our methods.     

Extreme value index estimator using maximum likelihood and moment estimation

ABSTRACT

When a distribution function is in the max domain of attraction of an extreme value distribution, its tail can be well approximated by a generalized Pareto distribution. Based on this fact we use a moment estimation idea to propose an adapted maximum likelihood estimator for the extreme value index, which can be understood as a combination of the maximum likelihood estimation and moment estimation. Under certain regularity conditions, we derive the asymptotic normality of the new estimator and investigate its finite sample behavior by comparing with several classical or competitive estimators. A simulation study shows that the new estimator is competitive with other estimators in view of average bias, average MSE, and coefficient of variance of the new device for the optimal selection of the threshold.     

A precise estimator for the log-normal mean

The log-normal distribution is frequently encountered in applications. The uniformly minimum variance unbiased (UMVU) estimator for the log-normal mean is given explicitly by a formula found by Finney in 1941. In contrast to this the most commonly used estimator for a log-normal mean is the sample mean. This is possibly due to the complexity of the formula given by Finney. A modified maximum likelihood estimator which approximates the UMVU estimator is derived here. It is sufficiently simple to be implemented in elementary spreadsheet applications. An elementary approximate formula for the root-mean-square error of the suggested estimator and the UMVU estimator is presented. The suggested estimator is compared with the sample mean, the maximum likelihood, and the UMVU estimators by Monte Carlo simulation in terms of root-mean-square error.     

Finite-sample properties of the maximum likelihood estimator for the binary logit model with random covariates

We examine the finite sample properties of the maximum likelihood estimator for the binary logit model with random covariates. Previous studies have either relied on large-sample asymptotics or have assumed non-random covariates. Analytic expressions for the first-order bias and second-order mean squared error function for the maximum likelihood estimator in this model are derived, and we undertake numerical evaluations to illustrate these analytic results for the single covariate case. For various data distributions, the bias of the estimator is signed the same as the covariate’s coefficient, and both the absolute bias and the mean squared errors increase symmetrically with the absolute value of that parameter. The behaviour of a bias-adjusted maximum likelihood estimator, constructed by subtracting the (maximum likelihood) estimator of the first-order bias from the original estimator, is examined in a Monte Carlo experiment. This bias-correction is effective in all of the cases considered, and is recommended for use when this logit model is estimated by maximum likelihood using small samples.     

Bias-corrected maximum semiparametric likelihood estimation under logistic regression models based on case–control data

We consider the corrective approach (Theoretical Statistics, Chapman & Hall, London, 1974, p. 310) and preventive approach (Biometrica 80 (1993) 27) to bias reduction of maximum likelihood estimators under the logistic regression model based on case–control data. The proposed bias-corrected maximum likelihood estimators are based on the semiparametric profile log likelihood function under a two-sample semiparametric model, which is equivalent to the assumed logistic regression model. We show that the prospective and retrospective analyses on the basis of the corrective approach to bias reduction produce identical bias-corrected maximum likelihood estimators of the odds ratio parameter, but this does not hold when using the preventive approach unless the case and control sample sizes are identical. We present some results on simulation and on the analysis of two real data sets.