A Note on Importance Resampling for Multi-Dimensional Statistics

Johns (1988 Johns , M. V. (1988). Importance sampling for bootstrap confidence intervals. Journal of the American Statistical Association 83:709–714.[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]), Davison (1988 Davison , A. C. ( 1988 ). Discussion of paper by D. V. Hinkley . Journal of the Royal Statistical Society Series B 50 : 356 – 357 . [Google Scholar]), and Do and Hall (1991 Do , K. A. , Hall , P. ( 1991 ). On importance sampling for the bootstrap . Biometrika 78 : 161 – 167 .[Crossref], [Web of Science ®] , [Google Scholar]) used importance sampling for calculating bootstrap distributions of one-dimensional statistics. Realizing that their methods can not be extended easily to multi-dimensional statistics, Fuh and Hu (2004 Fuh , C. D. , Hu , I. ( 2004 ). Efficient importance sampling for events of moderate deviations with applications . Biometrika 91 : 471 – 490 .[Crossref], [Web of Science ®] , [Google Scholar]) proposed an exponential tilting formula for statistics of multi-dimension, which is optimal in the sense that the asymptotic variance is minimized for estimating tail probabilities of asymptotically normal statistics. For one-dimensional statistics, Hu and Su (2008 Hu , J. , Su , Z. ( 2008 ). Adaptive resampling algorithms for estimating bootstrap distributions . Journal of Statistical Planning and Inference 138 ( 6 ): 1763 – 1777 .[Crossref], [Web of Science ®] , [Google Scholar]) proposed a multi-step variance minimization approach that can be viewed as a generalization of the two-step variance minimization approach proposed by Do and Hall (1991 Do , K. A. , Hall , P. ( 1991 ). On importance sampling for the bootstrap . Biometrika 78 : 161 – 167 .[Crossref], [Web of Science ®] , [Google Scholar]). In this article, we generalize the approach of Hu and Su (2008 Hu , J. , Su , Z. ( 2008 ). Adaptive resampling algorithms for estimating bootstrap distributions . Journal of Statistical Planning and Inference 138 ( 6 ): 1763 – 1777 .[Crossref], [Web of Science ®] , [Google Scholar]) to multi-dimensional statistics, which applies to general statistics and does not resort to asymptotics. Empirical results on a real survival data set show that the proposed algorithm provides significant computational efficiency gains.     

Additive Mixed Effect Model for Clustered Doubly Censored Data

Cai and Zeng (2011 Cai, J. and Zeng, D. 2011. Additive mixed effect model for clustered failure time data. Biometrics, 67(4): 1340–1351. [Crossref], [PubMed] , [Google Scholar]) proposed an additive mixed effect model to analyze clustered right-censored data. In this article, we demonstrate that the approach of Cai and Zeng (2011 Cai, J. and Zeng, D. 2011. Additive mixed effect model for clustered failure time data. Biometrics, 67(4): 1340–1351. [Crossref], [PubMed] , [Google Scholar]) can be extended to clustered doubly censored data. Furthermore, when both left- and right-censoring variables are always observed, we propose alternative estimators using the approach of Cai and Cheng (2004 Cai, T. and Cheng, S. C. 2004. Semiparametric regression analysis for doubly censored data. Biometrika, 91: 277–290. [Crossref], [Web of Science ®] , [Google Scholar]). A simulation study is conducted to investigate the performance of the proposed estimators.     

Computing the Exact Fisher Information Matrix of Periodic State-Space Models

The purpose of this article is to develop algorithms for computing the exact Fisher information matrix of periodic time-varying state-space models. We first present a relatively simple recursive algorithm which computes the elements of the exact information matrix without involving numerical differentiation, since all required derivatives are analytically evaluated. The proposed algorithm extends the procedure due to Cavanaugh and Shumway (1996 Cavanaugh , J. E. , Shumway , R. H. ( 1996 ). On computing the expected Fisher information matrix for state-space model parameters . Statist. Probab. Lett. 26 : 347 – 355 .[Crossref], [Web of Science ®] , [Google Scholar]) to the periodic state-space framework. Exploiting the approach used in Klein et al. (2000 Klein , A. , Mélard , G. , Zahaf , T. ( 2000 ). Construction of the exact Fisher information matrix of Gaussian time series models by means of matrix differential rules . Linear Alg. Applic. 321 : 209 – 232 .[Crossref], [Web of Science ®] , [Google Scholar]), a second algorithm is proposed in order to obtain the exact information matrix as a whole instead of element by element. The algorithms are first developed in a general framework and then specialized to the case of a periodic Gaussian vector autoregressive moving-average (PVARMA) model.     

Bayesian Estimation of Parameters and Comparison of Shared Gamma Frailty Models

In this article, we introduce shared gamma frailty models with three different baseline distributions namely, Weibull, generalized exponential and exponential power distributions. We develop Bayesian estimation procedure using Markov Chain Monte Carlo(MCMC) technique to estimate the parameters involved in these models. We present a simulation study to compare the true values of the parameters with the estimated values. Also we apply these three models to a real life bivariate survival dataset of McGilchrist and Aisbett (1991 McGilchrist, C. A. and Aisbett, C. W. 1991. Regression with frailty in survival analysis. Biometrics, 47: 461–466. [Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) related to kidney infection data and a better model is suggested for the data.     

Is Each NPMLE of a Continuous Bivariate Distribution Function with Singly Right-Censored Data Really Inconsistent?

We consider non-parametric estimation of a continuous cdf of a random vector (X ₁, X ₂). With bivariate RC data, it is stated in van der Laan (1996 Van der Laan , M. J. ( 1996 ) Efficient estimation in the bivariate censoring model and repairing NPMLE . Ann. Statist. 24 : 596 – 627 .[Crossref], [Web of Science ®] , [Google Scholar], p. 598¹⁰, Ann. Statist.), Quale et al. (2006 Quale , C. M. , van der Laan , M. J. , Robins , J. R. ( 2006 ). Locally efficient estimation with bivariate right-censored data . JASA. 101 : 1076 – 1084 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar], JASA) etc. that “it is well known that the NPMLE for continuous data is inconsistent (Tsai et al. (1986 Tsai , W. Y. , Leurgans , S. , Crowley , J. ( 1986 ). Nonparametric estimation of a bivariate survival function in the presence of censoring . Ann. Statist. 14 : 1351 – 1365 .[Crossref], [Web of Science ®] , [Google Scholar])).” The claim is based on a result in Tsai et al. (1986 Tsai , W. Y. , Leurgans , S. , Crowley , J. ( 1986 ). Nonparametric estimation of a bivariate survival function in the presence of censoring . Ann. Statist. 14 : 1351 – 1365 .[Crossref], [Web of Science ®] , [Google Scholar], p.1352, Ann. Statist.) that if X ₁ is right censored but not X ₂, then common ways for defining one NPMLE lead to inconsistency. If X ₁ is right censored and X ₂ is type I right-censored (which includes the case in Tsai et al.), we present a consistent NPMLE. The result corrects a common misinterpretation of Tsai's example (Tsai et al., 1986 Tsai , W. Y. , Leurgans , S. , Crowley , J. ( 1986 ). Nonparametric estimation of a bivariate survival function in the presence of censoring . Ann. Statist. 14 : 1351 – 1365 .[Crossref], [Web of Science ®] , [Google Scholar], Ann. Statist.).     

Modeling of Inverse Gaussian Frailty Model for Bivariate Survival Data

Shared frailty models are often used to model heterogeneity in survival analysis. The most common shared frailty model is a model in which hazard function is a product of random factor (frailty) and baseline hazard function which is common to all individuals. There are certain assumptions about the baseline distribution and distribution of frailty. In this article, we consider inverse Gaussian distribution as frailty distribution and three different baseline distributions namely, Weibull, generalized exponential, and exponential power distribution. With these three baseline distributions, we propose three different inverse Gaussian shared frailty models. To estimate the parameters involved in these models we adopt Markov Chain Monte Carlo (MCMC) approach. We present a simulation study to compare the true values of the parameters with the estimated values. Also, we apply these three models to a real life bivariate survival data set of McGilchrist and Aisbett (1991 McGilchrist , C. A. , Aisbett , C. W. ( 1991 ). Regression with frailty in survival analysis . Biometrics 47 : 461 – 466 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) related to kidney infection and a better model is suggested for the data.     

Symmetric quantiles and their applications

To develop estimators with stronger efficiencies than the trimmed means which use the empirical quantile, Kim (1992) Kim, S. J. 1992. The metrically trimmed means as a robust estimator of location. Annals of Statistics, 20: 1534–1547. [Crossref], [Web of Science ®] [Google Scholar] and Chen & Chiang (1996) Chen, L. A. and Chiang, Y. C. 1996. Symmetric type quantile and trimmed means for location and linear regression model. Journal of Nonparametric Statistics, 7: 171–185. [Taylor & Francis Online] [Google Scholar], implicitly or explicitly used the symmetric quantile, and thus introduced new trimmed means for location and linear regression models, respectively. This study further investigates the properties of the symmetric quantile and extends its application in several aspects. (a) The symmetric quantile is more efficient than the empirical quantiles in asymptotic variances when quantile percentage α is either small or large. This reveals that for any proposal involving the α th quantile of small or large α s, the symmetric quantile is the right choice; (b) a trimmed mean based on it has asymptotic variance achieving a Cramer-Rao lower bound in one heavy tail distribution; (c) an improvement of the quantiles-based control chart by Grimshaw & Alt (1997) Grimshaw, S. D. and Alt, F. B. 1997. Control charts for quantile function values. Journal of Quality Technology, 29: 1–7. [Taylor & Francis Online] [Google Scholar] is discussed; (d) Monte Carlo simulations of two new scale estimators based on symmetric quantiles also support this new quantile.     

The Identification of Potential Longitudinal Biomarkers and Measurements of Effectiveness for Biomarkers as Surrogates in Multivariate Survival Data

A proposed method based on frailty models is used to identify longitudinal biomarkers or surrogates for a multivariate survival. This method is an extention of earlier models by Wulfsohn and Tsiatis (1997 Wulfsohn , M. S. , Tsiatis , A. A. ( 1997 ). A joint model for survival and longitudinal data measured with error . Biometrics 53 ( 1 ): 330 – 339 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) and Song et al. (2002 Song , X. , Davidian , M. , Tsiatis , A. A. ( 2002 ). A Semiparametric likelihood approach to joint modeling of longitudinal and time-to-event data . Biometrics 58 ( 4 ): 742 – 753 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]). In this article, similar to Henderson et al. (2002 Henderson , R. , Diggle , P. J. , Dobson , A. ( 2002 ). Identification and efficacy of longitudinal markers for survival . Biostatistics 3 ( 1 ): 33 – 50 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]), a joint likelihood function combines the likelihood functions of the longitudinal biomarkers and the multivariate survival times. We use simulations to explore how the number of individuals, the number of time points per individual and the functional form of the random effects from the longitudianl biomarkers influence the power to detect the association of a longitudinal biomarker and the multivariate survival time. The proposed method is illustrate by using the gastric cancer data.     

Model selection in regression based on pre-smoothing

In this paper, we investigate the effect of pre-smoothing on model selection. Christóbal et al 6 Christóbal Christóbal, J. A., Faraldo Roca, P. and González Manteiga, W. 1987. A class of linear regression parameter estimators constructed by nonparametric estimation. Ann. Statist.,, 15: 603–609. [Crossref], [Web of Science ®] [Google Scholar] showed the beneficial effect of pre-smoothing on estimating the parameters in a linear regression model. Here, in a regression setting, we show that smoothing the response data prior to model selection by Akaike's information criterion can lead to an improved selection procedure. The bootstrap is used to control the magnitude of the random error structure in the smoothed data. The effect of pre-smoothing on model selection is shown in simulations. The method is illustrated in a variety of settings, including the selection of the best fractional polynomial in a generalized linear model.     

On goodness-of-fit tests for Aalen's additive model based on left-truncated right-censored or doubly censored data

ABSTRACT

Gandy and Jensen (2005 Gandy, A., Jensen, U. (2005). On goodness-of-fit tests for Aalen's additive risk model. Scan. J. Stat. 32:425–445.[Crossref], [Web of Science ®] , [Google Scholar]) proposed goodness-of-fit tests for Aalen's additive risk model. In this article, we demonstrate that the approach of Gandy and Jensen (2005 Gandy, A., Jensen, U. (2005). On goodness-of-fit tests for Aalen's additive risk model. Scan. J. Stat. 32:425–445.[Crossref], [Web of Science ®] , [Google Scholar]) can be applied to left-truncated right-censored (LTRC) data and doubly censored data. A simulation study is conducted to investigate the performance of the proposed tests. The proposed tests are illustrated using heart transplant data.     

On Estimating the Finite Population Mean Using Two Auxiliary Variables in Two Phase Sampling in the Presence of Non Response

This article considers the problem of estimating the population mean using information on two auxiliary variables in the presence of non response under two-phase sampling. Some improved ratio-in-regression type estimators have been proposed in four different situations of non response along with their properties under large sample approximation. Efficiency comparisons of the proposed estimators with the usual unbiased estimator by Hansen and Hurwitz (1946 Hansen , M. H. , Hurwitz , W. N. ( 1946 ). The problem of non response in sample surveys . J. Amer. Statist. Assoc. 41 : 517 – 529 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]), conventional ratio and regression estimators using single auxiliary variable and Singh and Kumar (2010b Singh , H. P. , Kumar , S. ( 2010b ). Improved estimation of population mean under double sampling with sub-sampling the non-respondents . J. Statist. Plann. Infer. 140 ( 9 ): 2536 – 2550 .[Crossref], [Web of Science ®] , [Google Scholar]) estimators using two auxiliary variables have been made. Finally, these theoretical findings are illustrated by a numerical example.     

Performance Evaluation of Different Tests for Location Parameters

In this article, our objective is to evaluate the performance of different tests which are used to compare the equality of more than two location parameters. We have considered six tests (including some commonly used) in this study, one of which is parametric and the others are nonparametric. These tests include the usual F test (Fisher and Mackenzie, 1923 Fisher , R. A. , Mackenzie , M. A. ( 1923 ). Studies in crop variation. II. The manurial response of different potato . Journal of Agricultural Science 13 : 311 – 320 .[Crossref], [Web of Science ®] , [Google Scholar]), Kruskal–Wallis test (Kruskall and Wallis, 1952 Kruskall , W. H. , Wallis , W. A. ( 1952 ). Use of ranks in one-criterion variance analysis . Journal of American Statistical Association 47 : 583 – 621 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]), Kolmogorov–Smirnov test (David, 1958 David , H. T. ( 1958 ). Three-sample Kolnogorov–Smirnov test . The Annals of Mathematical Statistics 29 : 842 – 851 .[Crossref] , [Google Scholar]), the g test (Stekler, 1987 Stekler , H. O. ( 1987 ). Who forecasters better? Journal of Business and Economic Statistics 5 : 155 – 158 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]), f test (Batchelor, 1990 Batchelor , R. A. ( 1990 ). All forecasters are equal . Journal of Business and Economic Statistics 8 : 143 – 144 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]), and Extension of Median test (as given in Daniel, 1990 Daniel , W. W. ( 1990 ). Applied Nonparametric Statistics. , 2nd ed. Duxbury Classic Series , Boston . [Google Scholar]). Performance of these tests are compared under different symmetric, skewed and contaminated probability distributions that include Normal, Cauchy, Uniform, Laplace, Lognormal, Exponential, Weibull, Gamma, t, Chi-square, Half Normal, Mixed Weibull, and Mixed Normal. Performances of these tests are measured in terms of power. We have suggested appropriate tests which may perform better under different situations. It is expected that researchers will find these results useful in decision making.     

Simultaneous Tests for Independence Among Components of Random Vector by Step-Down Multiple Comparison Procedure

In this article, we consider testing independence among components of random vector in multivariate normal population. For testing independence, we use the modified likelihood ratio test statistic which is improved an approximation to χ² distribution of the likelihood ratio test statistic. In order to perform simultaneous tests for independence among components of random vector, we use the step-down multiple comparison procedure based on the closed testing procedure proposed by Marcus et al. (1976 Marcus , R. , Peritz , E. , Gabriel , K. R. ( 1976 ). On closed testing procedures with special reference to ordered analysis of variance . Biometrika 63 : 655 – 660 .[Crossref], [Web of Science ®] , [Google Scholar]). Finally, we perform Monte Carlo simulations and present numerical results.     

Conditions of Slope-Rotatability for Third-Order Polynomial Regression Models

In experimental design for response surface analysis, it is sometimes of interest to estimate the difference of responses at two points. If differences at points close together are involved, the design that reliably estimates the slope of the response surface is important. In particular, Hader and Park (1978 Hader , R. J. , Park , S. H. ( 1978 ). Slope-rotatable central composite designs . Technometrics 20 : 413 – 417 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) suggested the concept of slope-rotatability and studied slope rotatable central composite designs. Until now, many response surface designs including central composite designs have been suggested for fitting second order response surface models. However, we often need to fit third-order polynomial regression models. In this article, we suggest extended central composite designs (ECCDs) to fit third-order models and find the necessary and sufficient conditions for slope-rotatability over all directions in the third-order polynomial models.     

On a Generalization of Bivariate Cauchy Distribution

This paper addresses a generalization of the bivariate Cauchy distribution discussed by Fang et al. (1990 Fang , K. T. , Kotz , S. , Ng , K. W. ( 1990 ). Symmetric Multivariate and Related Distributions . London : Chapman and Hall .[Crossref] , [Google Scholar]), derived from a trivariate normal distribution with a general correlation matrix. We obtain explicit expressions for the joint distribution function and joint density function, and show that they reduce in a special case to the corresponding expressions of Fang et al. (1990 Fang , K. T. , Kotz , S. , Ng , K. W. ( 1990 ). Symmetric Multivariate and Related Distributions . London : Chapman and Hall .[Crossref] , [Google Scholar]). Finally, we show that this generalized distribution is useful in determining the orthant probability of a bivariate skew-normal distribution of Azzalini and Dalla Valle (1996 Azzalini , A. , Dalla Valle , A. ( 1996 ). The multivariate skew-normal distribution . Biometrika 83 : 715 – 726 .[Crossref], [Web of Science ®] , [Google Scholar]).     

Maximum Likelihood Estimation in Compound Geometric Failure Model with Changing Parameters From Type-I Two-Stage Progressively Censored and Group Censored Samples

Boardman and Kendell (1970 Boardman , T. J. , Kendell , P. J. ( 1970 ). Estimation in compound failure models . Technometrics 12 : 891 – 908 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) considered the problem of estimation with respect to Type-I censoring when an item is subjected to only one of the two causes of failure assuming exponential model. Patel and Gajjar (1992 Patel , M. N. , Gajjar , A. V. ( 1992 ). Maximum likelihood estimation in compound exponential failure model with changing failure rates from Type-I progressively censored and group censored samples . Commun. Statist. Theor. Meth. 21 ( 10 ): 2899 – 2908 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) considered extension of the Boardman and Kendell's results in case of two-stage progressive censoring. Here we have considered geometric competing risk failure model with two independent causes of failures. Maximum likelihood estimation of the parameters is carried out using Type-I two-stage progressively censored and group censored samples. Asymptotic standard errors of the estimators are obtained for both the cases. Two illustrative examples are cited for ungroup and group competing risk models.     

Exact Inference for the pth-Quantile and the Reliability of the Two-Parameter Exponential Distribution with Singly Type II Censoring: A Standard Approach

Starting from a standard pivot, exact inference for the pth-quantile and for the reliability of the two-parameter exponential distribution in case of singly Type II censored samples is developed in this article. Fernandez (2007 Fernandez , A. J. ( 2007 ). On calculating generalized confidence intervals for the two-parameter exponential reliability function . Statistics 41 : 129 – 135 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) first obtained some of the results proposed in this article, but, differently from what are proposed here, and developed his theory starting from a generalized pivot. An illustrative example shows that, with the expressions proposed in this article, it is also possible to overcome some shortcomings raising from the formulas by Fernandez (2007 Fernandez , A. J. ( 2007 ). On calculating generalized confidence intervals for the two-parameter exponential reliability function . Statistics 41 : 129 – 135 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]). Finally, a new expression for the moments of the pivot is obtained.     

Semiparametric analysis of transformation models with doubly censored data

Double censoring arises when T represents an outcome variable that can only be accurately measured within a certain range, [L, U], where L and U are the left- and right-censoring variables, respectively. In this note, using Martingale arguments of Chen et al. [3 Chen, K., Jin, Z. and Ying, Z. 2002. Semiparametric analysis of transformation models with censored data. Biometrika, 89: 659–668. [Crossref], [Web of Science ®] [Google Scholar]], we propose an estimator (denoted by ?β) for estimating regression coefficients of transformation model when L is always observed. Under Cox proportional hazards model, the proposed estimator is equivalent to the partial likelihood estimator for left-truncated and right-censored data if the left-censoring variables L were regarded as left-truncated variables. In this case, the estimator ?β can be obtained by the standard software. A simulation study is conducted to investigate the performance of ?β. For the purpose of comparison, the simulation study also includes the estimator proposed by Cai and Cheng [2 Cai, T. and Cheng, S. 2004. Semiparametric regression analysis for doubly censored data. Biometrika, 91: 277–290. [Crossref], [Web of Science ®] [Google Scholar]] for the case when L and U are always observed.     

Bayesian Inference in Dynamic Disequilibrium Models: An Application to the Polish Credit Market

We propose a Bayesian approach for inference in a dynamic disequilibrium model. To circumvent the difficulties raised by the Maddala and Nelson (1974 Maddala , G. , Nelson , F. ( 1974 ). Maximum likelihood methods for models of markets in disequilibrium . Econometrica 42 ( 6 ): 1013 – 1030 .[Crossref], [Web of Science ®] , [Google Scholar]) specification in the dynamic case, we analyze a dynamic extended version of the disequilibrium model of Ginsburgh et al. (1980 Ginsburgh , V. , Tishler , A. , Zang , I. ( 1980 ). Alternative estimation methods for two regime models . European Economic Review 13 : 207 – 228 .[Crossref], [Web of Science ®] , [Google Scholar]). We develop a Gibbs sampler based on the simulation of the missing observations. The feasibility of the approach is illustrated by an empirical analysis of the Polish credit market, for which we conduct a specification search using the posterior deviance criterion of Spiegelhalter et al. (2002 Spiegelhalter , D. J. , Best , N. G. , Carlin , B. P. , Van Der Linde , A. ( 2002 ). Bayesian measures of complexity and fit . Journal of the Royal Statistical Society, Ser. B 64 : 583 – 639 .[Crossref] , [Google Scholar]).     

Step-Up Procedure for Multiple Comparison with a Control for Multivariate Normal Means

In this study, we consider the multiple comparison with a control for multivariate normal means. Specifically, we construct a step-up procedure by referring to Dunnett and Tamhane (1992 Dunnett , C. W. , Tamhane , A. C. ( 1992 ). A step-up multiple test procedure . Journal of the American Statistical Association 87 : 162 – 170 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]). We derive recursive formulae for determining the critical values of the step-up procedure for a specified significance level. Then we formulate the power of the test. Finally, we compare the step-up procedure with the single-step procedure proposed by Nakamura and Imada (2005 Nakamura , T. , Imada , T. ( 2005 ). Multiple comparison procedure of Dunnett's type for multivariate normal means . Journal of the Japanese Society of Computational Statistics 18 : 21 – 32 .[Crossref] , [Google Scholar]) and the step-down procedure proposed by Imada and Douke (2007 Imada , T. , Douke , H. ( 2007 ). Step down procedure for comparing several treatments with a control based on multivariate normal response . Biometrical Journal 49 ( 1 ): 18 – 29 .[Crossref], [Web of Science ®] , [Google Scholar]) in terms of numerical examples regarding the power of the test.