Comparison of Frailty Models for Acute Leukemia Data under Gompertz Baseline Distribution

In this article, we consider two different shared frailty regression models under the assumption of Gompertz as baseline distribution. Mostly assumption of gamma distribution is considered for frailty distribution. To compare the results with gamma frailty model, we consider the inverse Gaussian shared frailty model also. We compare these two models to a real life bivariate survival data set of acute leukemia remission times (Freireich et al., 1963 Freireich, E.J., Gehan, E., Frei, E., Schroeder, L.R., Wolman, I.J., Anbari, R., Burgert, E.O., Mills, S.D., Pinkel, D., Selawry, O.S., Moon, J.H., Gendel, B.R., Spurr, C.L., Storrs, R., Haurani, F., Hoogstraten, B., Lee, S. (1963). The effect of 6-mercaptopurine on the duration of steroid-induced remissions in acute leukemia: a model for evaluation of other potentially useful therapy. Blood 21:699–716.[Web of Science ®] , [Google Scholar]). Analysis is performed using Markov Chain Monte Carlo methods. Model comparison is made using Bayesian model selection criterion and a well-fitted model is suggested for the acute leukemia data.     

Estimating Incidence Rate on Current Status Data with Application to a Phase IV Cancer Trial

New drug discovery in the pediatrics has dramatically improved survival, but with long- term adverse events. This motivates the examination of adverse outcomes such as long-term toxicity in a phase IV trial. An ideal approach to monitor long-term toxicity is to systematically follow the survivors, which is generally not feasible. Instead, cross-sectional surveys are conducted in Hudson et al. (2007 Hudson , M. M. , Rai , S. N. , Nunez , C. , Merchant , T. E. , Marina , N. M. , Zalamea , N. , Cox , C. , Phipps , S. , Pompeu , R. , Rosenthal , D. ( 2007 ). Noninvasive evaluation of late anthracycline cardiac toxicity in childhood cancer survivors . J. Clin. Oncol. 25 : 3635 – 3643 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]), with one of the objectives to estimate the cumulative incidence rates along with specific interest in fixed-term (5 or 10 year) rates. We present inference procedures based on current status data to our motivating example with very interesting findings.     

Marginal correlation from an extended random-effects model for repeated and overdispersed counts

Vangeneugden et al. [15 Vangeneugden, T., Molenberghs, G., Laenen, A., Geys, H., Beunckens, C. and Sotto, C. 2007. Marginal correlation in longitudinal binary data based on generalized linear mixed models, Tech. Rep., Hasselt University. submitted for publication [Google Scholar]] derived approximate correlation functions for longitudinal sequences of general data type, Gaussian and non-Gaussian, based on generalized linear mixed-effects models (GLMM). Their focus was on binary sequences, as well as on a combination of binary and Gaussian sequences. Here, we focus on the specific case of repeated count data, important in two respects. First, we employ the model proposed by Molenberghs et al. [13 Molenberghs, G., Verbeke, G. and Demétrio, C. G.B. 2007. An extended random-effects approach to modeling repeated, overdispersed count data. Lifetime Data Anal., 13: 513–531. [Crossref], [PubMed], [Web of Science ®] [Google Scholar]], which generalizes at the same time the Poisson-normal GLMM and the conventional overdispersion models, in particular the negative-binomial model. The model flexibly accommodates data hierarchies, intra-sequence correlation, and overdispersion. Second, means, variances, and joint probabilities can be expressed in closed form, allowing for exact intra-sequence correlation expressions. Next to the general situation, some important special cases such as exchangeable clustered outcomes are considered, producing insightful expressions. The closed-form expressions are contrasted with the generic approximate expressions of Vangeneugden et al. [15 Vangeneugden, T., Molenberghs, G., Laenen, A., Geys, H., Beunckens, C. and Sotto, C. 2007. Marginal correlation in longitudinal binary data based on generalized linear mixed models, Tech. Rep., Hasselt University. submitted for publication [Google Scholar]]. Data from an epileptic-seizures trial are analyzed and correlation functions derived. It is shown that the proposed extension strongly outperforms the classical GLMM.     

Selection of Binary Variables and Classification by Boosting

We adopt boosting for classification and selection of high-dimensional binary variables for which classical methods based on normality and non singular sample dispersion are inapplicable. Boosting seems particularly well suited for binary variables. We present three methods of which two combine boosting with the relatively classical variable selection methods developed in Wilbur et al. (2002 Wilbur , J. D. , Ghosh , J. K. , Nakatsu , C. H. , Brouder , S. M. , Doerge , R. W. ( 2002 ). Variable selection in high-dimensional multivariate binary data with application to the analysis of microbial community DNA fingerprints . Biometrics 58 : 378 – 386 . [Google Scholar]). Our primary interest is variable selection in classification with small misclassification error being used as validation of proposed method for variable selection. Two of the new methods perform uniformly better than Wilbur et al. (2002 Wilbur , J. D. , Ghosh , J. K. , Nakatsu , C. H. , Brouder , S. M. , Doerge , R. W. ( 2002 ). Variable selection in high-dimensional multivariate binary data with application to the analysis of microbial community DNA fingerprints . Biometrics 58 : 378 – 386 . [Google Scholar]) in one set of simulated and three real life examples.     

Construction and Nonparametric Testing of Orthogonal Arrays through Algebraic Strata and Inequivalent Permutation Matrices

In this article we use a new methodology, based on algebraic strata, to generate the class of all the orthogonal arrays of given size and strength. From this class we extract all the non isomorphic orthogonal arrays. Then, using all these non isomorphic orthogonal arrays, we suggest a method based on the inequivalent matrices permutations testing procedures Basso et al. (2004 Basso , D. , Evangelaras , H. , Koukouvinos , C. , Salmaso , L. ( 2004 ). Nonparametric testing for main effects on inequivalent designs. Proc. 7th Int. Workshop Model-Oriented Design Anal. Heeze, Netherlands, June 14–18 . [Google Scholar]) in order to obtain separate permutation tests for the effects in unreplicated mixed level fractional factorial designs. In order to validate the proposed method we perform a Monte Carlo simulation study and find out that the permutation tests appear to be a valid solution for testing effects, in particular when the usual normality assumptions cannot be justified.     

Population Attributable Fraction as a Measure of Heritability in Dichotomous Twin Data

In many genetic analyses of dichotomous twin data, odds ratios have been used to test hypotheses on heritability and shared common environment effects of a given disease (Lichtenstein et al., 2000 Lichtenstein , P. , Holm , N. , Verkasalo , P. , Iliadou , A. , Kaprio , J. , Koskenvuo , M. , Pukkala , E. , Skytthe , A. , Hemminki , K. ( 2000 ). Environmental and heritable factors in the causation of cancer . New England Journal of Medicine 343 : 78 – 85 .[Crossref], [Web of Science ®] , [Google Scholar]; Ahlbom et al., 1997 Ahlbom , A. , Lichtenstein , P. , Malmström , H. , Feychting , M. , Hemminki , K. , Pedersen , N. L. ( 1997 ). Cancer in twins: genetic and nongenetic familial risk factors . Journal of the National Cancer Institute 89 : 287 – 93 . [Google Scholar]; Ramakrishnan et al., 1992 Ramakrishnan , V. , Goldberg , J. , Henderson , W. , Elsen , S. , True , W. , Lyons , M. , Tsuang , M. ( 1992 ). Elementary methods for the analysis of dichotomous outcomes in unselected samples of twins . Genetic Epidemiology 9 : 273 – 287 . [Google Scholar], 4). However, estimates of these two effects have not been dealt with in the literature. In epidemiology, the attributable fraction (AF), a function of the odds ratio and the prevalence of the risk factor has been used to describe the contribution of a risk factor to a disease in a given population (Leviton, 1973 Leviton , A. ( 1973 ). Definitions of attributable risk . American Journal of Epidemiology 98 : 231 . [Google Scholar]). In this article, we adapt the AF to quantify the heritability and the shared common environment. Twin data on cancer, gallstone disease and phobia are used to illustrate the applicability of the AF estimate as a measure of heritability.     

A Comparison of Procedures for Controlling the False Discovery Rate in the Presence of Small Variance Genes: A Simulation Study

The Significance Analysis of Microarrays (SAM; Tusher et al., 2001 Tusher , V. G. , Tibshirani , R. , Chu , G. ( 2001 ). Significance analysis of microarrys applied to the ionizing radiation response . Proceedings of the National Academy of Sciences 98 : 5116 – 5121 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) method is widely used in analyzing gene expression data while controlling the FDR by using resampling-based procedure in the microarray setting. One of the main components of the SAM procedure is the adjustment of the test statistic. The introduction of the fudge factor to the test statistic aims at deflating the large value of test statistics due to the small standard error of gene-expression. Lin et al. (2008 Lin , D. , Shkedy , Z. , Burzykowski , T. , Göhlmann , H. W. H. , De Bondt , A. , Perera , T. , Geerts , T. , Bijnens , L. ( 2008 ). Significance analysis of microarray (SAM) for comparisons of several treatments with one control . Biometric Journal, MCP 50 ( 5 ): 801 – 823 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) pointed out that the fudge factor does not effectively improve the power and the control of the FDR as compared to the SAM procedure without the fudge factor in the presence of small variance genes. Motivated by the simulation results presented in Lin et al. (2008 Lin , D. , Shkedy , Z. , Burzykowski , T. , Göhlmann , H. W. H. , De Bondt , A. , Perera , T. , Geerts , T. , Bijnens , L. ( 2008 ). Significance analysis of microarray (SAM) for comparisons of several treatments with one control . Biometric Journal, MCP 50 ( 5 ): 801 – 823 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]), in this article, we extend our study to compare several methods for choosing the fudge factor in the modified t-type test statistics and use simulation studies to investigate the power and the control of the FDR of the considered methods.     

On Complete Convergence for Arrays of Dependent Random Variables

A complete convergence theorem for an array of rowwise independent random variables was established by Sung et al. (2005 Sung , S. H. , Volodin , A. I. , Hu , T.-C. ( 2005 ). More on complete convergence for arrays . Statist. Probab. Lett. 71 : 303 – 311 .[Crossref], [Web of Science ®] , [Google Scholar]). This result has been generalized and extended by Kruglov et al. (2006 Kruglov , V. M. , Volodin , A. I. , Hu , T.-C. ( 2006 ). On complete convergence for arrays . Statist. Probab. Lett. 76 : 1631 – 1640 .[Crossref], [Web of Science ®] , [Google Scholar]) and Chen et al. (2007 Chen , P. , Hu , T.-C. , Liu , X. , Volodin , A. ( 2007 ). On complete convergence for arrays of rowwise negatively associated random variables . Theor. Probab. Appl. 52 : 393 – 397 . [Google Scholar]). In this article, we extend the results of Sung et al. (2005 Sung , S. H. , Volodin , A. I. , Hu , T.-C. ( 2005 ). More on complete convergence for arrays . Statist. Probab. Lett. 71 : 303 – 311 .[Crossref], [Web of Science ®] , [Google Scholar]), Kruglov et al. (2006 Kruglov , V. M. , Volodin , A. I. , Hu , T.-C. ( 2006 ). On complete convergence for arrays . Statist. Probab. Lett. 76 : 1631 – 1640 .[Crossref], [Web of Science ®] , [Google Scholar]), and Chen et al. (2007 Chen , P. , Hu , T.-C. , Liu , X. , Volodin , A. ( 2007 ). On complete convergence for arrays of rowwise negatively associated random variables . Theor. Probab. Appl. 52 : 393 – 397 . [Google Scholar]) to an array of dependent random variables satisfying Hoffmann-Jørgensen type inequalities.     

Measures of predictor sensitivity for order-insensitive partitioning of multiple correlation

Lindeman et al. [12 Lindeman, R. H., Merenda, P. F. and Gold, R. Z. 1980. Introduction to Bivariate and Multivariate Analysis, Glenview, IL: Scott Foresman.  [Google Scholar]] provide a unique solution to the relative importance of correlated predictors in multiple regression by averaging squared semi-partial correlations obtained for each predictor across all p! orderings. In this paper, we propose a series of predictor sensitivity statistics that complement the variance decomposition procedure advanced by Lindeman et al. [12 Lindeman, R. H., Merenda, P. F. and Gold, R. Z. 1980. Introduction to Bivariate and Multivariate Analysis, Glenview, IL: Scott Foresman.  [Google Scholar]]. First, we detail the logic of averaging over orderings as a technique of variance partitioning. Second, we assess predictors by conditional dominance analysis, a qualitative procedure designed to overcome defects in the Lindeman et al. [12 Lindeman, R. H., Merenda, P. F. and Gold, R. Z. 1980. Introduction to Bivariate and Multivariate Analysis, Glenview, IL: Scott Foresman.  [Google Scholar]] variance decomposition solution. Third, we introduce a suite of indices to assess the sensitivity of a predictor to model specification, advancing a series of sensitivity-adjusted contribution statistics that allow for more definite quantification of predictor relevance. Fourth, we describe the analytic efficiency of our proposed technique against the Budescu conditional dominance solution to the uneven contribution of predictors across all p! orderings.     

A Bayesian control chart for a common coefficient of variation

By using the medical data analyzed by Kang et al. (2007 Kang, C.W., Lee, M.S., Seong, Y.J., Hawkins, D.M. (2007). A control chart for the coefficient of variation. J. Qual. Technol. 39(2):151–158.[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]), a Bayesian procedure is applied to obtain control limits for the coefficient of variation. Reference and probability matching priors are derived for a common coefficient of variation across the range of sample values. By simulating the posterior predictive density function of a future coefficient of variation, it is shown that the control limits are effectively identical to those obtained by Kang et al. (2007 Kang, C.W., Lee, M.S., Seong, Y.J., Hawkins, D.M. (2007). A control chart for the coefficient of variation. J. Qual. Technol. 39(2):151–158.[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]) for the specific dataset they used. This article illustrates the flexibility and unique features of the Bayesian simulation method for obtaining posterior distributions, predictive intervals, and run-lengths in the case of the coefficient of variation. A simulation study shows that the 95% Bayesian confidence intervals for the coefficient of variation have the correct frequentist coverage.     

A Bottom-Up Dynamic Model of Portfolio Credit Risk with Stochastic Intensities and Random Recoveries

In Bielecki et al. (2014a Bielecki , T. R. , Cousin , A. , Crépey , S. , Herbertsson , A. ( 2014a ). Dynamic hedging of portfolio credit risk in a markov copula model . J. Optimiz. Theor. Applic . doi: DOI 10.1007/s10957-013-0318-4 (forthcoming) .[Crossref] , [Google Scholar]), the authors introduced a Markov copula model of portfolio credit risk where pricing and hedging can be done in a sound theoretical and practical way. Further theoretical backgrounds and practical details are developed in Bielecki et al. (2014b Bielecki , T. R. , Cousin , A. , Crépey , S. , Herbertsson , A. ( 2014b ). A bottom-up dynamic model of portfolio credit risk - Part I: Markov copula perspective . In: Recent Adv. Fin. Eng. 2012 , World Scientific (preprint version available at http://dx.doi.org/10.2139/ssrn.1844574) . [Google Scholar],c) where numerical illustrations assumed deterministic intensities and constant recoveries. In the present paper, we show how to incorporate stochastic default intensities and random recoveries in the bottom-up modeling framework of Bielecki et al. (2014a Bielecki , T. R. , Cousin , A. , Crépey , S. , Herbertsson , A. ( 2014a ). Dynamic hedging of portfolio credit risk in a markov copula model . J. Optimiz. Theor. Applic . doi: DOI 10.1007/s10957-013-0318-4 (forthcoming) .[Crossref] , [Google Scholar]) while preserving numerical tractability. These two features are of primary importance for applications like CVA computations on credit derivatives (Assefa et al., 2011 Assefa , S. , Bielecki , T. R. , Crépey , S. , Jeanblanc , M. ( 2011 ). CVA computation for counterparty risk assessment in credit portfolios . In: Bielecki , T.R. , Brigo , D. , Patras , F. , Eds., Credit Risk Frontiers . Hoboken : Wiley/Bloomberg-Press . [Google Scholar]; Bielecki et al., 2012 Bielecki , T. R. , Crépey , S. , Jeanblanc , M. , Zargari , B. ( 2012 ). Valuation and Hedging of CDS counterparty exposure in a markov copula model . Int. J. Theoret. Appl. Fin. 15 ( 1 ): 1250004 .[Crossref] , [Google Scholar]), as CVA is sensitive to the stochastic nature of credit spreads and random recoveries allow to achieve satisfactory calibration even for “badly behaved” data sets. This article is thus a complement to Bielecki et al. (2014a Bielecki , T. R. , Cousin , A. , Crépey , S. , Herbertsson , A. ( 2014a ). Dynamic hedging of portfolio credit risk in a markov copula model . J. Optimiz. Theor. Applic . doi: DOI 10.1007/s10957-013-0318-4 (forthcoming) .[Crossref] , [Google Scholar]), Bielecki et al. (2014b Bielecki , T. R. , Cousin , A. , Crépey , S. , Herbertsson , A. ( 2014b ). A bottom-up dynamic model of portfolio credit risk - Part I: Markov copula perspective . In: Recent Adv. Fin. Eng. 2012 , World Scientific (preprint version available at http://dx.doi.org/10.2139/ssrn.1844574) . [Google Scholar]) and Bielecki et al. (2014c Bielecki , T. R. , Cousin , A. , Crépey , S. , Herbertsson , A. ( 2014c ). A bottom-up dynamic model of portfolio credit risk - Part II: Common-shock interpretation, calibration and hedging issues . Recent Adv. Fin. Eng. 2012 , World Scientific (preprint version available at http://dx.doi.org/10.2139/ssrn.2245130) . [Google Scholar]).     

Step-Up Procedure for Multiple Comparison with a Control for Multivariate Normal Means

In this study, we consider the multiple comparison with a control for multivariate normal means. Specifically, we construct a step-up procedure by referring to Dunnett and Tamhane (1992 Dunnett , C. W. , Tamhane , A. C. ( 1992 ). A step-up multiple test procedure . Journal of the American Statistical Association 87 : 162 – 170 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]). We derive recursive formulae for determining the critical values of the step-up procedure for a specified significance level. Then we formulate the power of the test. Finally, we compare the step-up procedure with the single-step procedure proposed by Nakamura and Imada (2005 Nakamura , T. , Imada , T. ( 2005 ). Multiple comparison procedure of Dunnett's type for multivariate normal means . Journal of the Japanese Society of Computational Statistics 18 : 21 – 32 .[Crossref] , [Google Scholar]) and the step-down procedure proposed by Imada and Douke (2007 Imada , T. , Douke , H. ( 2007 ). Step down procedure for comparing several treatments with a control based on multivariate normal response . Biometrical Journal 49 ( 1 ): 18 – 29 .[Crossref], [Web of Science ®] , [Google Scholar]) in terms of numerical examples regarding the power of the test.     

Marginal Correlation from Logit- and Probit-Beta-Normal Models for Hierarchical Binary Data

In hierarchical data settings, be it of a longitudinal, spatial, multi-level, clustered, or otherwise repeated nature, often the association between repeated measurements attracts at least part of the scientific interest. Quantifying the association frequently takes the form of a correlation function, including but not limited to intraclass correlation. Vangeneugden et al. (2010 Vangeneugden, T., Molenberghs, G., Laenen, A., Geys, H., Beunckens, C., Sotto, C. (2010). Marginal correlation in longitudinal binary data based on generalized linear mixed models. Communi. Stati. Theory &; Methods. 39:3542–3557. [Google Scholar]) derived approximate correlation functions for longitudinal sequences of general data type, Gaussian and non-Gaussian, based on generalized linear mixed-effects models. Here, we consider the extended model family proposed by Molenberghs et al. (2010 Molenberghs, G., Verbeke, G., Demétrio, C., Vieira, A. (2010). A family of generalized linear models for repeated measures with normal and conjugate random effects. Stat. Sci. 25:325–347.[Crossref], [Web of Science ®] , [Google Scholar]). This family flexibly accommodates data hierarchies, intra-sequence correlation, and overdispersion. The family allows for closed-form means, variance functions, and correlation function, for a variety of outcome types and link functions. Unfortunately, for binary data with logit link, closed forms cannot be obtained. This is in contrast with the probit link, for which such closed forms can be derived. It is therefore that we concentrate on the probit case. It is of interest, not only in its own right, but also as an instrument to approximate the logit case, thanks to the well-known probit-logit ‘conversion.’ Next to the general situation, some important special cases such as exchangeable clustered outcomes receive attention because they produce insightful expressions. The closed-form expressions are contrasted with the generic approximate expressions of Vangeneugden et al. (2010 Vangeneugden, T., Molenberghs, G., Laenen, A., Geys, H., Beunckens, C., Sotto, C. (2010). Marginal correlation in longitudinal binary data based on generalized linear mixed models. Communi. Stati. Theory &; Methods. 39:3542–3557. [Google Scholar]) and with approximations derived for the so-called logistic-beta-normal combined model. A simulation study explores performance of the method proposed. Data from a schizophrenia trial are analyzed and correlation functions derived.     

Asymptotic Results for a Generalized Pólya Urn with “Multi-Updating” and Applications to Clinical Trials

In this article, a new Pólya urn model is introduced and studied; in particular, a strong law of large numbers and two central limit theorems are proved. This urn generalizes a model studied in Berti et al. (2004 Berti , P. , Pratelli , L. , Rigo , P. ( 2004 ). Limit theorems for a class of identically distributed random variables . Ann. Probab. 32 ( 3A ): 2029 – 2052 . [Google Scholar]), May et al. (2005 May , C. , Paganoni , A. M. , Secchi , P. ( 2005 ). On a two-color generalized Pólya urn . Metron 63 ( 1 ): 115 – 134 . [Google Scholar]), and in Crimaldi (2007 Crimaldi , I. ( 2007 ). Almost sure conditional convergence for a generalized Pólya urn. Submitted. Available at: http://amsacta.cib.unibo.it/archive/00002468  [Google Scholar]), and it has natural applications in clinical trials. Indeed, the model includes both delayed and missing (or null) responses. Moreover, a connection with the conditional identity in distribution of Berti et al. (2004 Berti , P. , Pratelli , L. , Rigo , P. ( 2004 ). Limit theorems for a class of identically distributed random variables . Ann. Probab. 32 ( 3A ): 2029 – 2052 . [Google Scholar]) is given.     

An Asymmetric Kernel Estimator of Density Function for Stationary Associated Sequences

Here, we apply the smoothing technique proposed by Chaubey et al. (2007 Chaubey , Y. P. , Sen , A. , Sen , P. K. ( 2007 ). A new smooth density estimator for non-negative random variables. Technical Report No. 1/07. Department of Mathematics and Statistics, Concordia University, Montreal, Canada . [Google Scholar]) for the empirical survival function studied in Bagai and Prakasa Rao (1991 Bagai , I. , Prakasa Rao , B. L. S. ( 1991 ). Estimation of the survival function for stationary associated processes . Statist. Probab. Lett. 12 : 385 – 391 .[Crossref], [Web of Science ®] , [Google Scholar]) for a sequence of stationary non-negative associated random variables.The derivative of this estimator in turn is used to propose a nonparametric density estimator. The asymptotic properties of the resulting estimators are studied and contrasted with some other competing estimators. A simulation study is carried out comparing the recent estimator based on the Poisson weights (Chaubey et al., 2011 Chaubey , Y. P. , Dewan , I. , Li , J. ( 2011 ). Smooth estimation of survival and density functions for a stationary associated process using poisson weights . Statist. Probab. Lett. 81 : 267 – 276 .[Crossref], [Web of Science ®] , [Google Scholar]) showing that the two estimators have comparable finite sample global as well as local behavior.     

Searching effective rotation patterns for population median using exponential type estimators in two-occasion rotation sampling

ABSTRACT

The present article is an attempt to explore the rotation patterns using exponential ratio type estimators for the estimation of finite population median at current occasion in two occasion rotation sampling. Properties of the proposed estimators including the optimum replacement strategies have been elaborated. The proposed estimators have been compared with sample median estimator when there is no matching from previous occasion as well with the ratio type estimator proposed by Singh et al. (2007 Singh, H.P., Tailor, R., Singh, S., Kim, Jong-Min. (2007). Quintile estimation in successive sampling. J. Kor. Stat. Soc. 36(4):543–556. [Google Scholar]) for second quantile. The behaviors of the proposed estimators are justified by empirical interpretations and validated by means of simulation study with the help of some natural populations.     

Hartley-Ross Type Estimators for Population Mean Using Known Parameters of Auxiliary Variate

This article proposes Hartley-Ross type unbiased estimators of finite population mean using information on known parameters of auxiliary variate when the study variate and auxiliary variate are positively correlated. The variances of the proposed unbiased estimators are obtained. It has been shown that the proposed estimators are more efficient than the simple mean estimator, usual ratio estimator and estimators proposed by Sisodia and Dwivedi (1981 Sisodia , B. V. S. , Dwivedi , V. K. ( 1981 ). A modified ratio estimator using coefficient of variation of auxiliary variable . J. Indian Soc. Agricultural Statist. 33 ( 1 ): 13 – 18 . [Google Scholar]), Kadilar and Cingi (2006 Kadilar , C. , Cingi , H. ( 2006 ). A new ratio estimator using correlation coefficient . Int. Statist. 1 – 11 . [Google Scholar]), and Kadilar et al. (2007 Kadilar , C. , Candan , M. , Cingi , H. ( 2007 ). Ratio estimators using robust regression . Hacet. J. Math. Statist. 36 ( 2 ): 181 – 188 .[Web of Science ®] , [Google Scholar]) under certain realistic conditions. Empirical studies are also carried out to demonstrate the merits of the proposed unbiased estimators over other estimators considered in this article.     

A Parametric Bootstrap Approach for One-Way ANOVA Under Unequal Variances with Unbalanced Data

This research is to provide a solution of one-way ANOVA without using transformation when variances are heteroscedastic and group sizes are unequal. Parametric bootstrap test (Krishnamoorthy et al., 2007 Krishnamoorthy, K., Lu, F., Mathew, T. (2007). A parametric bootstrap approach for anova with unequal variances: Fixed and random models. Computational Statistics and Data Analysis 51:5731–5742.[Crossref], [Web of Science ®] , [Google Scholar]) has been shown to be competitive with many other methods when testing the equality of group means. We extend the parametric bootstrap algorithm to a multiple comparison procedure. Simulation results show that the parametric bootstrap approach works well for one-way ANOVA.     

Adaptive tangent distance classifier on recognition of handwritten digits

Simard et al. [16 Simard, P. Y., LeCun, Y., Denker, J. S. and Victorri, B. 2000. Transformation invariance in pattern recognition: Tangent distance and tangent propagation. J. Imaging Syst. Technol., 11: 181–197.  [Google Scholar] 17 Sona, D., Sperduti, A. and Starita, A. 1997. A constructive learning algorithm for discriminant tangent models. Advances in Neural Information Processing Systems. 1997, Cambridge, MA. Edited by: Mozer, M. C., Jordan, M. I. and Petsche, T. Vol. 9, pp.786–792. MIT Press.  [Google Scholar]] proposed a transformation distance called “tangent distance” (TD) which can make pattern recognition be efficient. The key idea is to construct a distance measure which is invariant with respect to some chosen transformations. In this research, we provide a method using adaptive TD based on an idea inspired by “discriminant adaptive nearest neighbor” [7 Hastie, T., Tibshirani, R. and Friedman, J. 2009. The Elements of Statistical Learning, Data Mining, Inference, and Prediction, 2, New York, Berlin, Heidelberg: Springer. Available at http://www-stat.stanford.edu/ElemStatLearn [Google Scholar]]. This method is relatively easy compared with many other complicated ones. A real handwritten recognition data set is used to illustrate our new method. Our results demonstrate that the proposed method gives lower classification error rates than those by standard implementation of neural networks and support vector machines and is as good as several other complicated approaches.     

Steady-state Gibbs sampler estimation for lung cancer data

This paper is based on the application of a Bayesian model to a clinical trial study to determine a more effective treatment to lower mortality rates and consequently to increase survival times among patients with lung cancer. In this study, Qian et al. [13 J. Qian, D.K. Stangl, and S. George, A Weibull model for survival data: Using prediction to decide when to stop a clinical trial, in Bayesian Biostatistics, D. Berry and D. Stangl, eds., Marcel Dekker, New York, 1996, pp. 187–205. [Google Scholar]] strived to determine if a Weibull survival model can be used to decide whether to stop a clinical trial. The traditional Gibbs sampler was used to estimate the model parameters. This paper proposes to use the independent steady-state Gibbs sampling (ISSGS) approach, introduced by Dunbar et al. [3 M. Dunbar, H.M. Samawi, R. Vogel, and L. Yu, A more efficient Gibbs sampler estimation using steady state simulation: Application to public health studies, J. Stat. Simul. Comput. 10.1080/00949655.2013.770857.[Taylor &; Francis Online] , [Google Scholar]], to improve the original Gibbs sampler in multidimensional problems. It is demonstrated that ISSGS provides accuracy with unbiased estimation and improves the performance and convergence of the Gibbs sampler in this application.