On group sequential tests for data in unequally sized groups and with unknown variance

We present a method to generalise the scope of application of group sequential tests designed for equally sized groups of normal observations with known variance. Preserving the significance levels against which standardised statistics are compared leads to tests for unequally grouped data which maintain Type I error probabilities to a high degree of accuracy. The same approach can be followed when observations have unknown variance by setting critical values for Studentised statistics at percentiles of the appropriate t-distributions. This significance level approach is equally applicable to group sequential one-sided tests and two-sided tests, possibly with early stopping permitted to accept the null hypothesis. In applications to equivalence testing, tests are required to maintain a specified power, rather than Type I error rate: such tests can be constructed by defining the standardised test statistics used in the significance level approach with respect to appropriately chosen hypotheses.     

Single Attribute Control Charts for a Markovian-Dependent Process

In a production process, sequence of observations related to the quality of a process need not be independent. In such situations, control charts based on the assumption of independence of the observations are not appropriate. When the characteristic under study is qualitative, the Markovian model serves as a simple model to account for the dependency of the observations. In this article, we develop two attribute control charts for a Markovian dependent process: the first is based on controlling the error probabilities; the second is based on minimizing the average time to get a correct signal.

The charts are developed under uniform sampling. Under uniform sampling, the two consecutive samples are far enough apart, so that for all practical purposes, two consecutive samples can be considered as if they are being independent. Optimal values of the design parameters of both the control charts are obtained. A procedure to estimate the values of the in-control parameters is also described. The chart's performance is evaluated using the probability of detecting shift. When we implement the proposed charts for the data simulated under given manufacturing environments, the charts exhibit the desired properties of error probabilities and average time to signal.     

Empirical study of some non-parametric tests for dispersion of correlated data

Results of a computer simulation study of power and robustness of three competitor tests for comparing scales, for use with correlated data: Rothstein, Richardson and Bell (RRB), Arvesen, and Pitman, are presented. It is found that unless one could ímprove the approximate null distributions for Arvesen's and Pitman's test, RRB's procedure is best, having simulated probabilities of Type I error closest to the test's nominal α and being reasonably robust and powerful, for all distributions considered.     

Certain observations on lot sensitive sampling plan

This paper compares the sample size efficiency of the lot sensitive plan over the equivalent double and multiple sampling plans. It is shown that a fully curtailed lot sensitive plan will involve smaller average sample number than the equivalent double and multiple plans.     

Designing of a mixed-chain sampling plan based on the process capability index with chain sampling as the attributes plan

In this article, we propose a new mixed chain sampling plan based on the process capability index C_pk, where the quality characteristic of interest having double specification limits and follows the normal distribution with unknown mean and variance. In the proposed mixed plan, the chain sampling inspection plan is used for the inspection of attribute quality characteristics. The advantages of this proposed mixed sampling plan are also discussed. Tables are constructed to determine the optimal parameters for practical applications by formulating the problem as a non linear programming in which the objective function to be minimized is the average sample number and the constraints are related to lot acceptance probabilities at acceptable quality level and limiting quality level under the operating characteristic curve. The practical application of the proposed mixed sampling plan is explained with an illustrative example. Comparison of the proposed sampling plan is also made with other existing sampling plans.     

A fixed sequence Bonferroni procedure for testing multiple endpoints

A method for controlling the familywise error rate combining the Bonferroni adjustment and fixed testing sequence procedures is proposed. This procedure allots Type I error like the Bonferroni adjustment, but allows the Type I error to accumulate whenever a null hypothesis is rejected. In this manner, power for hypotheses tested later in a prespecified order will be increased. The order of the hypothesis tests needs to be prespecified as in a fixed sequence testing procedure, but unlike the fixed sequence testing procedure all hypotheses can always be tested, allowing for an a priori method of concluding a difference in the various endpoints. An application will be in clinical trials in which mortality is a concern, but it is expected that power to distinguish a difference in mortality will be low. If the effect on mortality is larger than anticipated, this method allows a test with a prespecified method of controlling the Type I error rate. Copyright © 2003 John Wiley & Sons, Ltd.     

Optimal designing of an SkSP-R double sampling plan

In this article, we propose a method of planning and determining the optimum parameters of a SkSP-R skip-lot sampling plan by using the attribute double sampling plan as the reference plan. The SkSP-R plan is a new type of skip-lot sampling plan which has a provision for re-inspecting the submitted lots. The optimal plan parameters of the suggested sampling plan are estimated with the target that the average sample number be minimized and satisfying both the specified producer's as well as the consumer's risks simultaneously. In order to obtain the optimum parameters, tables are also built for different combinations of the acceptable quality level and the limiting quality level in conjunctions with different producer's and consumer's risks. An illustrative example is provided for the implementation of the suggested plan. The advantages of the suggested plan over the existing conventional sampling plans and other existing skip-lot sampling plans are also described.     

Application of Anbar's Approach to Hypothesis Testing to Detect the Difference between Two Proportions

In this paper, Anbar's (1983) approach for estimating a difference between two binomial proportions is discussed with respect to a hypothesis testing problem. Such an approach results in two possible testing strategies. While the results of the tests are expected to agree for a large sample size when two proportions are equal, the tests are shown to perform quite differently in terms of their probabilities of a Type I error for selected sample sizes. Moreover, the tests can lead to different conclusions, which is illustrated via a simple example; and the probability of such cases can be relatively large. In an attempt to improve the tests while preserving their relative simplicity feature, a modified test is proposed. The performance of this test and a conventional test based on normal approximation is assessed. It is shown that the modified Anbar's test better controls the probability of a Type I error for moderate sample sizes.     

Mixed Graphical Model Selection Using Holm's Procedure

The problem of selecting a graphical model is considered as a performing simultaneously multiple tests. The control of the overall Type I error on the selected graph is done using the so famous Holm's procedure. We prove that when we use a consistent edge exclusion test the selected graph is asymptotically equal to the true graph with probability at least equal to a fixed level 1 ? α. This method is then used for the selection of mixed concentration graph models by performing the χ²-edge exclusion test. We also apply the method to two classical examples and to simulated data. We compare the overall error of the selected model with the one obtained using the stepwise method. We establish that the control is better when we use the Holm's procedure.     

Robust tests for the equality of variances for clustered data

Tests for the equality of variances are often needed in applications. In genetic studies the assumption of equal variances of continuous traits, measured in identical and fraternal twins, is crucial for heritability analysis. To test the equality of variances of traits, which are non-normally distributed, Levene [H. Levene, Robust tests for equality of variances, in Contributions to Probability and Statistics, I. Olkin, ed. Stanford University Press, Palo Alto, California, 1960, pp. 278–292] suggested a method that was surprisingly robust under non-normality, and the procedure was further improved by Brown and Forsythe [M.B. Brown and A.B. Forsythe, Robust tests for the equality of variances, J. Amer. Statis. Assoc. 69 (1974), pp. 364–367]. These tests assumed independence of observations. However, twin data are clustered – observations within a twin pair may be dependent due to shared genes and environmental factors. Uncritical application of the tests of Brown and Forsythe to clustered data may result in much higher than nominal Type I error probabilities. To deal with clustering we developed an extended version of Levene's test, where the ANOVA step is replaced with a regression analysis followed by a Wald-type test based on a clustered version of the robust Huber–White sandwich estimator of the covariance matrix. We studied the properties of our procedure using simulated non-normal clustered data and obtained Type I error rates close to nominal as well as reasonable powers. We also applied our method to oral glucose tolerance test data obtained from a twin study of the metabolic syndrome and related components and compared the results with those produced by the traditional approaches.     

A Design of Attributes Double Sampling Plans for Three-class Products

In this article, a new attributes double sampling plan for three-class products (ADSPTP) is presented, and the corresponding operating characteristic function is constructed based on the given procedure of performing ADSPTP. Average sample numbers (ASN) for complete inspection and curtailed inspection of the second sample are derived and the extreme point is discussed on the three-dimensional ASN surface. In addition, the differences arising from different parameters are studied. Sampling plans are designed by a nonlinear optimization model. Finally, numerical examples and discussions are given to illustrate the obtained results, and tables of the designed plans under various conditions are provided.     

Parametric bootstrap inferences for unbalanced panel data models

This article presents parametric bootstrap (PB) approaches for hypothesis testing and interval estimation for the regression coefficients of panel data regression models with incomplete panels. Some simulation results are presented to compare the performance of the PB approaches with the approximate inferences. Our studies show that the PB approaches perform satisfactorily for various sample sizes and parameter configurations, and the performance of PB approaches is mostly better than the approximate methods with respect to the coverage probabilities and the Type I error rates. The PB inferences have almost exact coverage probabilities and Type I error rates. Furthermore, the PB procedure can be simply carried out by a few simulation steps, and the derivation is easier to understand and to be extended to the multi-way error component regression models with unbalanced panels. Finally, the proposed approaches are illustrated by using a real data example.     

New acceptance sampling plans based on life tests for Birnbaum–Saunders distributions

In this paper, we consider the Birnbaum–Saunders distribution as a life model to develop various acceptance sampling schemes based on the truncated life tests. We develop the double sampling plan and determine the design parameters satisfying both the producer's and consumer's risks simultaneously for the specified reliability levels in terms of the mean ratio to the specified life. We also propose a group sampling plan and determine the parameters by the above-mentioned two-point method. Tables are constructed for the proposed sampling plans and results are explained with examples.     

A frequentist assessment of Bayesian inclusion probabilities for screening predictors

Bayesian inclusion probabilities have become a popular tool for variable assessment. From a frequentist perspective, it is often difficult to evaluate these probabilities as typically no Type I error rates are considered, neither are any explorations of power of the methods given. This paper considers how a frequentist may evaluate Bayesian inclusion probabilities for screening predictors. This evaluation looks at both unrestricted and restricted model spaces and develops a framework which a frequentist can utilize inclusion probabilities that preserve Type I error rates. Furthermore, this framework is applied to an analysis of the Arabidopsis thaliana with respect to determining quantitative trait loci associated with cotelydon opening angle.     

A modified least-failures sampling procedure for bernoulli subset selection

We restrict attention to a class of Bernoulli subset selection procedures which take observations one-at-a-time and can be compared directly to the Gupta-Sobel single-stage procedure. For the criterion of minimizing the expected total number of observations required to terminate experimentation, we show that optimal sampling rules within this class are not of practical interest. We thus turn to procedures which, although not optimal, exhibit desirable behavior with regard to this criterion. A procedure which employs a modification of the so-called least-failures sampling rule is proposed, and is shown to possess many desirable properties among a restricted class of Bernoulli subset selection procedures. Within this class, it is optimal for minimizing the number of observations taken from populations excluded from consideration following a subset selection experiment, and asymptotically optimal for minimizing the expected total number of observations required. In addition, it can result in substantial savings in the expected total num¬ber of observations required as compared to a single-stage procedure, thus it may be de¬sirable to a practitioner if sampling is costly or the sample size is limited.     

Selection of conditional sampling plans for given AQL and LQL

This paper presents procedures and tables for the selection of conditional sampling plans, viz. conditional double sampling plan, chain-deferred sampling plan, link sampling plan, and ChSP-4A chain sampling plan for given acceptable quality level (AQL), producer's risk, limiting quality level and consumer's risk giving minimum sample size at AQL under the conditions of the Poisson model for the operating characteristic curve.     

Computing Probabilities of Type I Error and Type II Error of Sequential Bayesian Procedures for Testing One-Sided Hypotheses

In this article, it is shown how to compute, in an approximated way, probabilities of Type I error and Type II error of sequential Bayesian procedures for testing one-sided null hypotheses. First, some theoretical results are obtained, and then an algorithm is developed for applying these results. The prior predictive density plays a central role in this study.     

Bayesian Analysis of Multiple Hypothesis Testing with Applications to Microarray Experiments

Recently, the field of multiple hypothesis testing has experienced a great expansion, basically because of the new methods developed in the field of genomics. These new methods allow scientists to simultaneously process thousands of hypothesis tests. The frequentist approach to this problem is made by using different testing error measures that allow to control the Type I error rate at a certain desired level. Alternatively, in this article, a Bayesian hierarchical model based on mixture distributions and an empirical Bayes approach are proposed in order to produce a list of rejected hypotheses that will be declared significant and interesting for a more detailed posterior analysis. In particular, we develop a straightforward implementation of a Gibbs sampling scheme where all the conditional posterior distributions are explicit. The results are compared with the frequentist False Discovery Rate (FDR) methodology. Simulation examples show that our model improves the FDR procedure in the sense that it diminishes the percentage of false negatives keeping an acceptable percentage of false positives.     

Acceptance sampling plan based on an exponentially weighted moving average statistic with the yield index for autocorrelation between polynomial profiles

Acceptance sampling plans based on process yield indices provide a proven resource for the lot-sentencing problem when the required fraction defective is very low. In this study, a new sampling plan based on the exponentially weighted moving average (EWMA) model with yield index for lot sentencing for autocorrelation between polynomial profiles is proposed. The advantage of the EWMA statistic is the accumulation of quality history from previous lots. In addition, the number of profiles required for lot sentencing is more economical than in the traditional single sampling plan. Considering the acceptable quality level (AQL) at the producer's risk and the lot tolerance percent defective (LTPD) at the consumer's risk, we proposed a new search algorithm to determine the optimal plan parameters. The plan parameters are tabulated for various combinations of the smoothing constant of the EWMA statistic, AQL, LTPD, and two risks. A comparison study and two numerical examples are provided to show the applicability of the proposed sampling plan.     

Optimal design of variable acceptance sampling plans for mixture distribution

ABSTRACT

The paper investigates the design of single and sequential variable acceptance sampling plans for a mixture distribution. Mixture distributions are seen in many practical problems such as life testing experiments of electronic components and clinical trials. The sampling plans for this kind of situations are not well addressed in the literature. We first propose a single sampling plan for a distribution which is a mixture of two exponential distributions. An optimization problem which minimizes the total cost of testing at given producer's and consumer's risks is solved to obtain the plan parameters. Two different sequential sampling plans are also defined and plan parameters are obtained by solving corresponding optimization problems. Finally, a case study, a simulation study and a sensitivity analysis are presented to illustrate our sampling plans.