Two Statistics for Unconditional Exact Tests in Matched-Pairs Design

Abstract

In a recent article Hsueh et al. (Hsueh, H.-M., Liu, J.-P., Chen, J. J. (2001 Hsueh, H.-M., Liu, J.-P. and Chen, J. J. 2001. Unconditional exact tests for equivalence or noninferiority for paired binary endpoints. Biometrics, 57: 478–483. [Crossref], [PubMed], [Web of Science ®] , [Google Scholar]). Unconditional exact tests for equivalence or noninferiority for paired binary endpoints. Biometrics 57:478–483.) considered unconditional exact tests for paired binary endpoints. They suggested two statistics one of which is based on the restricted maximum-likelihood estimator. Properties of these statistics and the related tests are treated in this article.     

An Independence Point Method of Confidence Band Construction for Multiple Linear Regression Models

This article addresses the problem of confidence band construction for a standard multiple linear regression model. An “independence point” method of construction is developed which generalizes the method of Gafarian (1964) for a simple linear regression model to a multiple linear regression model. Wynn (1984 Wynn , H. P. ( 1984 ). An exact confidence band for one-dimensional polynomial regression . Biometrika 71 : 375 – 9 .[Crossref], [Web of Science ®] , [Google Scholar]) pioneered the approach of basing confidence bands for a polynomial regression on a set of nodes where the function estimates are independent, and this approach is exploited in this article. This method requires only critical points from t-distributions so that the confidence bands are easy to construct. Both one-sided and two-sided confidence bands can be constructed using this method. An illustration of the new method is provided, and comparisons are made with other procedures.     

Computing the Exact Fisher Information Matrix of Periodic State-Space Models

The purpose of this article is to develop algorithms for computing the exact Fisher information matrix of periodic time-varying state-space models. We first present a relatively simple recursive algorithm which computes the elements of the exact information matrix without involving numerical differentiation, since all required derivatives are analytically evaluated. The proposed algorithm extends the procedure due to Cavanaugh and Shumway (1996 Cavanaugh , J. E. , Shumway , R. H. ( 1996 ). On computing the expected Fisher information matrix for state-space model parameters . Statist. Probab. Lett. 26 : 347 – 355 .[Crossref], [Web of Science ®] , [Google Scholar]) to the periodic state-space framework. Exploiting the approach used in Klein et al. (2000 Klein , A. , Mélard , G. , Zahaf , T. ( 2000 ). Construction of the exact Fisher information matrix of Gaussian time series models by means of matrix differential rules . Linear Alg. Applic. 321 : 209 – 232 .[Crossref], [Web of Science ®] , [Google Scholar]), a second algorithm is proposed in order to obtain the exact information matrix as a whole instead of element by element. The algorithms are first developed in a general framework and then specialized to the case of a periodic Gaussian vector autoregressive moving-average (PVARMA) model.     

A Euclidean Likelihood Estimator for Bivariate Tail Dependence

The spectral measure plays a key role in the statistical modeling of multivariate extremes. Estimation of the spectral measure is a complex issue, given the need to obey a certain moment condition. We propose a Euclidean likelihood-based estimator for the spectral measure which is simple and explicitly defined, with its expression being free of Lagrange multipliers. Our estimator is shown to have the same limit distribution as the maximum empirical likelihood estimator of Einmahl and Segers (2009 Einmahl , J. H. J. , Segers , J. ( 2009 ). Maximum empirical likelihood estimation of the spectral measure of an extreme-value distribution . Ann. Statist. 37 ( 5B ): 2953 – 2989 .[Crossref], [Web of Science ®] , [Google Scholar]). Numerical experiments suggest an overall good performance and identical behavior to the maximum empirical likelihood estimator. We illustrate the method in an extreme temperature data analysis.     

Shrinkage of Variance for Minimum Distance Based Tests

This paper promotes information theoretic inference in the context of minimum distance estimation. Various score test statistics differ only through the embedded estimator of the variance of estimating functions. We resort to implied probabilities provided by the constrained maximization of generalized entropy to get a more accurate variance estimator under the null. We document, both by theoretical higher order expansions and by Monte-Carlo evidence, that our improved score tests have better finite-sample size properties. The competitiveness of our non-simulation based method with respect to bootstrap is confirmed in the example of inference on covariance structures previously studied by Horowitz (1998 Horowitz , J. ( 1998 ). Bootstrap methods for covariance structures . The Journal of Human Resources 33 : 39 – 61 .[Crossref], [Web of Science ®] , [Google Scholar]).     

Bayesian Capture-Recapture Analysis: An Application in Modeling Semelparity of a Neotropical Didelphid Marsupial

We develop a series of Bayesian statistical models for estimating survival of a neotropic didelphid marsupial, the Brazilian gracile mouse opossum (Gracilinanus microtarsus). These models are based on the Cormack–Jolly–Seber model (Cormack, 1964 Cormack , R. M. ( 1964 ). Estimates of survival from the sighting of marked animals . Biometrika 51 : 429 – 438 .[Crossref], [Web of Science ®] , [Google Scholar]; Jolly 1965 Jolly , G. M. ( 1965 ). Explicit estimates from capture-recapture data with both death and immigration stochastic model . Biometrika 52 : 225 – 247 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]; Seber 1965 Seber , G. A. F. ( 1965 ). A note on the multiple recapture census . Biometrika 52 : 249 – 259 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) with both survival and recapture rates expressed as a function of covariates using a logit link. The proposed models allow taking into account heterogeneity in capture probability caused by the existence of different groups of individuals in the population. The models were applied to two cohorts (Cohort, 2000, 2001) with the first one including 14 and the second one 15 sampling occasions. The best models for each of the cohorts indicate that G. microtarsus is best described as partially semelparous, a condition in which mortality after the first mating is high but graded over time, with a fraction of males surviving for a second breeding season (Boonstra, 2005 Boonstra , R. ( 2005 ). Equipped for life: the adaptive role of the stress axis in male mammals . Journal of Mammalogy 86 : 236 – 247 .[Crossref], [Web of Science ®] , [Google Scholar]).     

The Identification of Potential Longitudinal Biomarkers and Measurements of Effectiveness for Biomarkers as Surrogates in Multivariate Survival Data

A proposed method based on frailty models is used to identify longitudinal biomarkers or surrogates for a multivariate survival. This method is an extention of earlier models by Wulfsohn and Tsiatis (1997 Wulfsohn , M. S. , Tsiatis , A. A. ( 1997 ). A joint model for survival and longitudinal data measured with error . Biometrics 53 ( 1 ): 330 – 339 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) and Song et al. (2002 Song , X. , Davidian , M. , Tsiatis , A. A. ( 2002 ). A Semiparametric likelihood approach to joint modeling of longitudinal and time-to-event data . Biometrics 58 ( 4 ): 742 – 753 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]). In this article, similar to Henderson et al. (2002 Henderson , R. , Diggle , P. J. , Dobson , A. ( 2002 ). Identification and efficacy of longitudinal markers for survival . Biostatistics 3 ( 1 ): 33 – 50 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]), a joint likelihood function combines the likelihood functions of the longitudinal biomarkers and the multivariate survival times. We use simulations to explore how the number of individuals, the number of time points per individual and the functional form of the random effects from the longitudianl biomarkers influence the power to detect the association of a longitudinal biomarker and the multivariate survival time. The proposed method is illustrate by using the gastric cancer data.     

On Testing Sample Selection Bias Under the Multicollinearity Problem

ABSTRACT

This paper reviews and extends the literature on the finite sample behavior of tests for sample selection bias. Monte Carlo results show that, when the “multicollinearity problem” identified by Nawata (1993 Nawata , K. ( 1993 ). A note on the estimation of models with sample-selection biases . Economics Letters 42 : 15 – 24 . [CSA] [CROSSREF] [Crossref], [Web of Science ®] , [Google Scholar]) is severe, (i) the t-test based on the Heckman–Greene variance estimator can be unreliable, (ii) the Likelihood Ratio test remains powerful, and (iii) nonnormality can be interpreted as severe sample selection bias by Maximum Likelihood methods, leading to negative Wald statistics. We also confirm previous findings (Leung and Yu, 1996 Leung , S. F. , Yu , S. ( 1996 ). On the choice between sample selection and two-part models . Journal of Econometrics 72 : 197 – 229 . [CSA] [CROSSREF] [Crossref], [Web of Science ®] , [Google Scholar]) that the standard regression-based t-test (Heckman, 1979 Heckman , J. J. ( 1979 ). Sample selection bias as a specification error . Econometrica 47 : 153 – 161 . [CSA] [Crossref], [Web of Science ®] , [Google Scholar]) and the asymptotically efficient Lagrange Multiplier test (Melino, 1982 Melino , A. ( 1982 ). Testing for sample selection bias . Review of Economic Studies 49 : 151 – 153 . [CSA] [Crossref], [Web of Science ®] , [Google Scholar]), are robust to nonnormality but have very little power.     

A Nonparametric Test for Symmetry Based on Freeman and Halton's Ideas on Contingency Tables

In this article, we propose a nonparametric method to test for symmetry in bivariate data. By using the extension of Fisher's exact treatment for 2 × 2 contingency tables proposed by Freeman and Halton (1951 Freeman , G. H. , Halton , J. H. ( 1951 ). Note on an exact treatment of contingency tables, goodness of fit and other problems of significance . Biometrika 38 : 141 – 149 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]), we can test the hypothesis of equal distribution for two samples of integer valued variables. Then, by counting the number of observations belonging to each cell of a symmetric, appropriately built grid, we can produce the two samples of integers required to use this test for equal distribution. The resulting test for symmetry is potentially extendible to higher dimensions. A simulation study is performed to compare with some known tests (Bowker, 1948 Bowker , A. H. ( 1948 ). A test for symmetry in contingency tables . Journal of the American Statistical Association 43 : 572 – 574 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]; Hollander, 1971 Hollander , M. ( 1971 ). A nonparametric test for bivariate symmetry . Biometrika 58-1 : 203 – 212 .[Crossref], [Web of Science ®] , [Google Scholar]; and its improvement given in Krampe and Kuhnt, 2007 Krampe , A. , Kuhnt , S. ( 2007 ). Bowker's test for symmetry and modifications within the algebraic framework . Computational Statistics and Data Analysis 51 : 4124 – 4142 .[Crossref], [Web of Science ®] , [Google Scholar]). Our proposal represents a competitive option as a test for symmetry.     

Extensions of Stein's Lemma for the Skew-Normal Distribution

When two random variables have a bivariate normal distribution, Stein's lemma (Stein, 1973 Stein , C. M. ( 1973 ). Estimation of the mean of a multivariate normal distribution . Proc. Prague Symp. Asymptotic Statist. 345 – 381 . [Google Scholar] 1981 Stein , C. M. ( 1981 ). Estimation of the mean of a multivariate normal distribution . Ann. Statist. 9 : 1135 – 1151 .[Crossref], [Web of Science ®] , [Google Scholar]), provides, under certain regularity conditions, an expression for the covariance of the first variable with a function of the second. An extension of the lemma due to Liu (1994 Liu , J. S. ( 1994 ). Siegel's formula via Stein's identities . Statist. Probab. Lett. 21 : 247 – 251 .[Crossref], [Web of Science ®] , [Google Scholar]) as well as to Stein himself establishes an analogous result for a vector of variables which has a multivariate normal distribution. The extension leads in turn to a generalization of Siegel's (1993 Siegel , A. F. ( 1993 ). A surprising covariance involving the minimum of multivariate normal variables . J. Amer. Statist. Assoc. 88 : 77 – 80 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) formula for the covariance of an arbitrary element of a multivariate normal vector with its minimum element. This article describes extensions to Stein's lemma for the case when the vector of random variables has a multivariate skew-normal distribution. The corollaries to the main result include an extension to Siegel's formula. This article was motivated originally by the issue of portfolio selection in finance. Under multivariate normality, the implication of Stein's lemma is that all rational investors will select a portfolio which lies on Markowitz's mean-variance efficient frontier. A consequence of the extension to Stein's lemma is that under multivariate skew-normality, rational investors will select a portfolio which lies on a single mean-variance-skewness efficient hyper-surface.     

The Exact General Formulas for the Moments of a Ridge Regression Estimator when the Regression Error Terms Follow a Multivariate t Distribution

Huang (1999 Huang , J. C. ( 1999 ). Improving the estimation precision for a selected parameter in multiple regression analysis: an algebraic approach . Econ. Lett. 62 : 261 – 264 .[Crossref], [Web of Science ®] , [Google Scholar]) proposed a feasible ridge regression (FRR) estimator to estimate a specific regression coefficient. Assuming that the error terms follow a normal distribution, Huang (1999 Huang , J. C. ( 1999 ). Improving the estimation precision for a selected parameter in multiple regression analysis: an algebraic approach . Econ. Lett. 62 : 261 – 264 .[Crossref], [Web of Science ®] , [Google Scholar]) examined the small sample properties of the FRR estimator. In this article, assuming that the error terms follow a multivariate t distribution, we derive an exact general formula for the moments of the FRR estimator to estimate a specific regression coefficient. Using the exact general formula, we obtain exact formulas for the bias, mean squared error (MSE), skewness, and kurtosis of the FRR estimator. Since these formulas are very complex, we compare the bias, MSE, skewness, and kurtosis of the FRR estimator with those of ordinary least square (OLS) estimator by numerical evaluations. Our numerical results show that the range of MSE dominance of the FRR estimator over the OLS estimator is widen under a fat tail distributional assumption.     

Generalized Scrambling in Quantitative Optional Randomized Response Models

Huang (2010 Huang , K. C. ( 2010 ). Unbiased estimators of mean, variance and sensitivity level for quantitative characteristics in finite population sampling . Metrika 71 : 341 – 352 .[Crossref], [Web of Science ®] , [Google Scholar]) proposed an optional randomized response model using a linear combination scrambling which is a generalization of the multiplicative scrambling of Eichhorn and Hayre (1983 Eichhorn , B. H. , Hayre , L. S. ( 1983 ). Scrambled randomized response methods for obtaining sensitive quantitative data . J. Statist. Plann. Infer. 7 : 307 – 316 .[Crossref], [Web of Science ®] , [Google Scholar]) and the additive scrambling of Gupta et al. (2006, 2010). In this article, we discuss two main issues. (1) Can the Huang (2010 Huang , K. C. ( 2010 ). Unbiased estimators of mean, variance and sensitivity level for quantitative characteristics in finite population sampling . Metrika 71 : 341 – 352 .[Crossref], [Web of Science ®] , [Google Scholar]) model be improved further by using a two-stage approach?; (2) Does the linear combination scrambling provide any benefit over the additive scrambling of Gupta et al. (2010 Gupta , S. N. , Shabbir , J. , Sehra , S. ( 2010 ). Mean and sensitivity estimation in optional randomized response models . J. Statist. Plann. Infer. 140 : 2870 – 2874 .[Crossref], [Web of Science ®] , [Google Scholar])? We will note that the answer to the first question is “yes” but the answer to the second question is “no.”     

Tests for Multiple Outliers in an Exponential Sample

By applying the recursion of Huffer (1988 Huffer, F. 1988. Divided differences and the joint distribution of linear combinations of spacings. Journal of Applied Probability, 25: 346–354. [Crossref], [Web of Science ®] , [Google Scholar]) repeatedly, we propose an algorithm for evaluating the null joint distribution of Dixon-type test statistics for testing discordancy of k upper outliers in exponential samples. By using the critical values of Dixon-type test statistics determined from the proposed algorithm and those of Cochran-type test statistics presented earlier by Lin and Balakrishnan (2009 Lin, C. T. and Balakrishnan, N. 2009. Exact computation of the null distribution of a test for multiple outliers in an exponential sample. Computational Statistics & Data Analysis, 53: 3281–3290. [Crossref], [Web of Science ®] , [Google Scholar]), we carry out an extensive Monte Carlo study to investigate the powers and the error probabilities for the effects of masking and swamping when the number of outliers k = 2 and 3. Based on our empirical findings, we recommend Rosner’s (1975 Rosner, B. 1975. On the detection of many outliers. Technometrics, 17: 221–227. [Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) sequential test procedure based on Dixon-type test statistics for testing multiple outliers from an exponential distribution.     

The Performance of Panel Cointegration Methods: Results from a Large Scale Simulation Study

This article presents results concerning the performance of both single equation and system panel cointegration tests and estimators. The study considers the tests developed in Pedroni (1999 Pedroni , P. ( 1999 ). Critical values for cointegration tests in heterogeneous panels with multiple regressors . Oxford Bulletin of Economics and Statistics 61 : 653 – 670 .[Crossref], [Web of Science ®] , [Google Scholar], 2004 Pedroni , P. ( 2004 ). Panel cointegration. Asymptotic and finite sample properties of pooled time series tests with an application to the PPP hypothesis . Econometric Theory 20 : 597 – 625 .[Crossref], [Web of Science ®] , [Google Scholar]), Westerlund (2005 Westerlund , J. ( 2005 ). New simple tests for panel cointegration . Econometric Reviews 24 : 297 – 316 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]), Larsson et al. (2001 Larsson , R. , Lyhagen , J. , Löthgren , M. ( 2001 ). Likelihood-based cointegration tests in heterogeneous panels . Econometrics Journal 4 : 109 – 142 .[Crossref] , [Google Scholar]), and Breitung (2005 Breitung , J. ( 2005 ). A parametric approach to the estimation of cointegration vectors in panel data . Econometric Reviews 24 : 151 – 173 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) and the estimators developed in Phillips and Moon (1999 Phillips , P. C. B. , Moon , H. R. ( 1999 ). Linear regression limit theory for nonstationary panel data . Econometrica 67 : 1057 – 1111 .[Crossref], [Web of Science ®] , [Google Scholar]), Pedroni (2000 Pedroni , P. ( 2000 ). Fully modified OLS for heterogeneous cointegrated panels . In: Baltagi , B. H. , ed. Nonstationary Panels, Panel Cointegration, and Dynamic Panels . Amsterdam : Elsevier , pp. 93 – 130 .[Crossref] , [Google Scholar]), Kao and Chiang (2000 Kao , C. , Chiang , M.-H. ( 2000 ). On the estimation and inference of a cointegrated regression in panel data . In: Baltagi , B. H. , ed. Nonstationary Panels, Panel Cointegration, and Dynamic Panels . Amsterdam : Elsevier , pp. 179 – 222 .[Crossref] , [Google Scholar]), Mark and Sul (2003 Mark , N. C. , Sul , D. ( 2003 ). Cointegration vector estimation by panel dynamic OLS and long-run money demand . Oxford Bulletin of Economics and Statistics 65 : 655 – 680 .[Crossref], [Web of Science ®] , [Google Scholar]), Pedroni (2001 Pedroni , P. ( 2001 ). Purchasing power parity tests in cointegrated panels . Review of Economics and Statistics 83 : 1371 – 1375 . [Google Scholar]), and Breitung (2005 Breitung , J. ( 2005 ). A parametric approach to the estimation of cointegration vectors in panel data . Econometric Reviews 24 : 151 – 173 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]). We study the impact of stable autoregressive roots approaching the unit circle, of I(2) components, of short-run cross-sectional correlation and of cross-unit cointegration on the performance of the tests and estimators. The data are simulated from three-dimensional individual specific VAR systems with cointegrating ranks varying from zero to two for fourteen different panel dimensions. The usual specifications of deterministic components are considered.     

Parametric Nonlinear Regression with Endogenous Switching

Based on the insightful work of Olsen (1980 Olsen , R. J. ( 1980 ). A least squares correction for selectivity bias . Econometrica 48 : 1815 – 1820 .[Crossref], [Web of Science ®] , [Google Scholar]) for the linear context, a generic and unifying framework is developed that affords a simple extension of the classical method of Heckman (1974 Heckman , J. ( 1974 ). Shadow prices, market wages, and labor supply . Econometrica 42 : 679 – 694 .[Crossref], [Web of Science ®] , [Google Scholar], 1976 Heckman , J. ( 1976 ). The common structure of statistical models of truncation sample selection and limited dependent variables and a simple estimator for such models . Annals of Economic and Social Measurement 5 : 475 – 492 . [Google Scholar], 1978 Heckman , J. ( 1978 ). Dummy endogenous variables in a simultaneous equation system . Econometrica 46 : 931 – 959 .[Crossref], [Web of Science ®] , [Google Scholar], 1979 Heckman , J. ( 1979 ). Sample selection bias as a specification error . Econometrica 47 : 153 – 161 .[Crossref], [Web of Science ®] , [Google Scholar]) to a broad class of nonlinear regression models involving endogenous switching and its two most common incarnations, endogenous sample selection and endogenous treatment effects. The approach should be appealing to applied researchers for three reasons. First, econometric applications involving endogenous switching abound. Secondly, the approach requires neither linearity of the regression function nor full parametric specification of the model. It can, in fact, be applied under the minimal parametric assumptions—i.e., specification of only the conditional means of the outcome and switching variables. Finally, it is amenable to relatively straightforward estimation methods. Examples of applications of the method are discussed.     

Aspects of Dependence in Generalized Farlie-Gumbel-Morgenstern Distributions

In this article, we obtained a dependence measure for generalized Farlie-Gumbel-Morgenstern (FGM) family in view of Kochar and Gupta (1987 Kochar , S. G. , Gupta , R. P. ( 1987 ). Competitors of Kendall-tau test for testing independence against PQD . Biometrika 74 ( 3 ): 664 – 669 .[Crossref], [Web of Science ®] , [Google Scholar]) and then compared this measure with Spearman's rho and Kendall's tau in FGM family. Moreover, we evaluated the empirical power of the class of distribution-free tests proposed by Kochar and Gupta (1987 Kochar , S. G. , Gupta , R. P. ( 1987 ). Competitors of Kendall-tau test for testing independence against PQD . Biometrika 74 ( 3 ): 664 – 669 .[Crossref], [Web of Science ®] , [Google Scholar], 1990 Kochar , S. G. , Gupta , R. P. ( 1990 ). Distribution-free tests based on sub-sample extrema for testing against positive dependence . Australian Journal of Statistics 32 : 45 – 51 .[Crossref] , [Google Scholar]) based on exact distribution of a U-statistics. This is derived via a simulation study for sample of sizes n = 6, 8, 10, 12, 16, and 20. Also, we compared our simulation results with those achieved by Amini et al. (2010 Amini , M. , Jabbari , H. , Mohtashami Borzadaran , G. R. , Azadbakhsh , M. ( 2010 ). Power comparison of independence test for the Farlie-Gumbel-Moregenstern family . Communications of the Korean Statistical Society 17 ( 4 ): 493 – 505 .[Crossref] , [Google Scholar]) and Güven and Kotz (2008 Güven , B. , Kotz , S. ( 2008 ). Test of independence for generalized Farlie-Gumbel-Morgenstern distributions . Journal of Computational and Applied Mathematics 212 : 102 – 111 .[Crossref], [Web of Science ®] , [Google Scholar]).     

Bias-Corrected Maximum Likelihood Estimators in Nonlinear Heteroscedastic Models

Nonlinear heteroscedastic models are widely used in econometrics and statistical applications. We derive matrix formulae for the second-order biases of the maximum likelihood estimators of the parameters in the mean and variance response which generalize previous results by Cook et al. (1986 Cook , D. R. , Tsai , C. L. , Wei , B. C. ( 1986 ). Bias in nonlinear regression . Biometrika 73 : 615 – 623 .[Crossref], [Web of Science ®] , [Google Scholar]) and Cordeiro (1993 Cordeiro , G. M. ( 1993 ). Bartlett corrections and bias correction for two heteroscedastic regression models . Commun. Statist. Theor. Meth. 22 : 169 – 188 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]). The biases of the estimators are easily obtained as vectors of regression coefficients from suitable weighted linear regressions. The practical use of such biases is illustrated in a simulation study and in an application to a real data set.     

Covariance Matrix Formula for Exponential Family Nonlinear Models

This article gives a matrix formula for second-order covariances of maximum likelihood estimators in exponential family nonlinear models, thus generalizing the result of Cordeiro (2004 Cordeiro , G. M. ( 2004 ). Second-order covariance matrix of maximum likelihood estimates in generalized linear models . Statist. Probab. Lett. 66 : 153 – 160 .[Crossref], [Web of Science ®] , [Google Scholar]) valid for generalized linear models with known dispersion parameter. Some simulations show that the second-order covariances for exponential family nonlinear models can be quite pronounced in small to moderate sample sizes.     

Hazards Regression for Cancer Studies

The complication in analyzing tumor data is that the tumors detected in a screening program tend to be slowly progressive tumors, which is the so-called length-biased sampling that is inherent in screening studies. Under the assumption that all subjects have the same tumor growth function, Ghosh (2008 Ghosh , D. ( 2008 ). Proportional hazards regression for cancer studies . Biometrics 64 : 141 – 148 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) developed estimation procedures for proportional hazards model. In this article, by modeling growth function as a function of covariates, we demonstrate that Ghosh (2008 Ghosh , D. ( 2008 ). Proportional hazards regression for cancer studies . Biometrics 64 : 141 – 148 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar])'s approach can be extended to the case when each subject has a specific growth function. A simulation study is conducted to demonstrate the potential usefulness of the proposed estimators for the regression parameters in the proportional and additive hazards model.     

An Improved Solution for Multiple Comparisons with a Control in Response Surface Methodology with Two Predictor Variables

Sa and Edwards (1993 Sa , P. , Edwards , D. ( 1993 ). Multiple comparisons with a control in response surface methodology . Technometrics 35 ( 4 ): 436 – 445 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) first proposed the Multiple Comparisons with a Control problem in Response Surface Methodology. They provided an exact solution for one predictor variable and a conservative solution when number of predictor variables is more than one. Merchant et al. (1998 Merchant , A. , McCann , M. , Edwards , D. ( 1998 ). Improved multiple comparisons with a control in response surface analysis . Technometrics 40 ( 4 ): 291 – 303 .[Crossref], [Web of Science ®] , [Google Scholar]) improved the solution for the latter case. This article improves Merchant et al.'s solution for the case of rotatable designs in two predictor variables.