Estimation in Second-Order Models with Errors in the Factor Levels

The impact of errors in the factor levels is examined on the estimation of parameters in second-order response models. Errors can occur in setting the factor levels for response surface and robust parameter design models. These errors can lead to heterogeneity of variances in model errors that make ordinary least squares estimation inappropriate. Weighted least squares and maximum likelihood estimation approaches are developed as viable alternatives where it is assumed the variances and covariances of the errors are known. Performance of these estimation techniques are examined in simulation studies for two examples. Another example is given that applies these results.     

An Algorithmic Construction of Four-Level Response Surface Designs

Response surface methodology is widely used for developing, improving, and optimizing processes in various fields. In this article, we present a method for constructing four-level design matrices in order to explore and optimize response surfaces where the predictor variables are each at four equally spaced levels, by utilizing a genetic algorithm. The produced designs achieve both properties of near-rotatability and estimation efficiency.     

A Bayesian Approach for Multiple Response Surface Optimization in the Presence of Noise Variables

An approach for the multiple response robust parameter design problem based on a methodology by Peterson (2000) is presented. The approach is Bayesian, and consists of maximizing the posterior predictive probability that the process satisfies a set of constraints on the responses. In order to find a solution robust to variation in the noise variables, the predictive density is integrated not only with respect to the response variables but also with respect to the assumed distribution of the noise variables. The maximization problem involves repeated Monte Carlo integrations, and two different methods to solve it are evaluated. A Matlab code was written that rapidly finds an optimal (robust) solution in case it exists. Two examples taken from the literature are used to illustrate the proposed method.     

On Some Two- and Three-dimensional D-minimax Designs for Estimating Slopes of a Third-order Response Surface

Design of experiments is considered for the situation where estimation of the slopes of a response surface is the main interest. Under the D-minimax criterion, the objective is to minimize the generalized variance of the estimated axial slopes at a point maximized over all points in the region of interest in the factor space. For the third-order model over spherical regions, the D-minimax designs are derived in two and three dimensions. The efficiencies of some two- and three-dimensional designs available in the literature are also investigated.     

Maximum and Minimum Prediction Variance for Spherical and Cuboidal Split Plot Designs

The impact of restricted randomization on the information matrix has created challenges for the computation of design optimality criteria. This article focuses on the computation of the maximum and minimum prediction variance for Central Composite (CCD) and Box–Behnken (BBD) split plot designs (SPD). The approach is to analytically determine the exact maximum and minimum prediction variance for both spherical and cuboidal second-order SPD. A particular feature of these analytical functions is that they are functions of the design parameters. Finally, the application of these analytical functions is demonstrated for a CCD SPD.     

Response Surface Designs Where Levels of Some Factors are Difficult to Change

This article considers response surface designs in which the number of levels of some of the factors are constrained. Two general types of designs are examined: CUBE designs and STAR designs. The specific factor levels are chosen to give variance contours with a high level of sphericity, thus providing designs that are close to rotatable.     

Method of Moments Estimation in Linear Regression with Errors in both Variables

Recently, in this journal, there has been revised attention on estimating the parameters of the errors in variables, linear structural model. For example, O’Driscoll and Ramirez (2011) used a geometric approach to give insight into the performance of various slope estimators for the linear structural model as introduced by the present author. This article aims to provide a unified method of moments approach for estimating the parameters in the linear structural model, concentrating attention on estimators using the higher moments, which to date has received only little attention in the literature.     

Second-Order Response Surface Model with Neighbor Effects

This article considers the second-order response surface model in which the experimental units, i.e., plots experience the neighbor effects from immediate left and right neighboring plots assuming the plots to be placed adjacent linearly with no gaps. Conditions have been derived for the estimation of coefficients of second-order response surface model. A method of constructing designs for fitting second-order response surface in the presence of neighbor effects has been developed. The designs so obtained are found to be rotatable.     

Construction of New Three-Level Response Surface Designs

Response surface methodology is widely used for developing, improving, and optimizing processes in various fields. In this article, we present a method for constructing three-level designs in order to explore and optimize response surfaces combining orthogonal arrays and covering arrays in a particular manner. The produced designs achieve the properties of rotatability, predictive performance and efficiency for the estimation of a second-order model.     

Instrument Assisted Regression for Errors in Variables Models with Binary Response

We study errors‐in‐variables problems when the response is binary and instrumental variables are available. We construct consistent estimators through taking advantage of the prediction relation between the unobservable variables and the instruments. The asymptotic properties of the new estimator are established and illustrated through simulation studies. We also demonstrate that the method can be readily generalized to generalized linear models and beyond. The usefulness of the method is illustrated through a real data example.     

Minimization of model inadequacy when observations subject to shift in means and variances

In this article optimality of experimental design for fitting a lower-order polynomial to a higher order response function for the situation in which observations may be subject to shift in means as well as in variances is considered. It is found that Karson, Manson and Hader‘s (1969) optimum designs provide pro-tection, in some sense, against model inadequacies even when observations are subject to shift in means and variances.     

Polynomial Regression and Estimating Functions in the Presence of Multiplicative Measurement Error

We consider the polynomial regression model in the presence of multiplicative measurement error in the predictor. Two general methods are considered, with the methods differing in their assumptions about the distributions of the predictor and the measurement errors. Consistent parameter estimates and asymptotic standard errors are derived by using estimating equation theory. Diagnostics are presented for distinguishing additive and multiplicative measurement error. Data from a nutrition study are analysed by using the methods. The results from a simulation study are presented and the performances of the methods are compared.     

Extension of Central Composite Design for Second-Order Response Surface Model Building

The central composite design (CCD) is perhaps the most popular class of second-order response surface designs. Even though the CCDs are popular for response surface designs, this class of design has some limitations such as it does not sometimes possess good statistical properties, and it does not fit complicated models well. In this article, we propose extended central composite designs (ECCDs) to overcome these limitations. We compare ECCDs with CCDs in terms of average prediction variance, and find that ECCDs are better than CCDs.     

A Comparison of Spatial Designs for Field Variety Trials

Experimental designs can be constructed to be efficient in the presence of spatial correlation. Available construction methods include those based on autoregressive and linear variance models. This paper investigates spatial designs across a range of assumed autoregressive structures. Results show that when the spatial component is low relative to the independent error term, efficient spatial designs can be constructed without having to specify parameters for the spatial structure.     

Sequential Designs for Binary Data with the Purpose to Maximize the Probability of Response

Two kinds of sequential designs are proposed for finding the point that maximizes the probability of response assuming a binary response variable and a quadratic logistic regression model. One is a parametric optimal design approach, and the other one is a nonparametric stochastic approximation approach. The suggested sequential designs are evaluated and compared in a simulation study. In summary, the parametric approach performed very well whereas its competitor failed in some cases.     

Fraction of design space plots for generalized linear models

The use of graphical methods for comparing the quality of prediction throughout the design space of an experiment has been explored extensively for responses modeled with standard linear models. In this paper, fraction of design space (FDS) plots are adapted to evaluate designs for generalized linear models (GLMs). Since the quality of designs for GLMs depends on the model parameters, initial parameter estimates need to be provided by the experimenter. Consequently, an important question to consider is the design's robustness to user misspecification of the initial parameter estimates. FDS plots provide a graphical way of assessing the relative merits of different designs under a variety of types of parameter misspecification. Examples using logistic and Poisson regression models with their canonical links are used to demonstrate the benefits of the FDS plots.     

Response surface methodology in quality improvement

Recent work has lead to development of robust parameter design which alleviates criticisms of the Taguchi approach. A dual response surface approach is discussed and illustrated.     

Minimax Designs for the Stability of Slope Estimation on Second-order Response Surfaces

In this paper, designs for the stability of the slope estimation on a second-order response surface are considered. Minimization of the point dispersion measure, which is maximized over all points in the region of interest is taken as the optimality criterion, and the minimax properties in some class of designs are derived in spherical and cubic regions of interest. We study the efficiencies of the minimax designs relative to other optimal designs with various criteria.     

Designs to guard against outliers in the présence or absence of model bias

Optimality of experimental design is considered in the situation in which individual observations may be subject to a shift in mean. The criterion of minimum average integrated mean square error is examined in general and the consequences for first and second degree models in the présence or absence of model bias are discussed.     

The robustness of response surface designs with errors in factor levels

ABSRTACT

Since errors in factor levels affect the traditional statistical properties of response surface designs, an important question to consider is robustness of design to errors. However, when the actual design could be observed in the experimental settings, its optimality and prediction are of interest. Various numerical and graphical methods are useful tools for understanding the behavior of the designs. The D- and G-efficiencies and the fraction of design space plot are adapted to assess second-order response surface designs where the predictor variables are disturbed by a random error. Our study shows that the D-efficiencies of the competing designs are considerably low for big variance of the error, while the G-efficiencies are quite good. Fraction of design space plots display the distribution of the scaled prediction variance through the design space with and without errors in factor levels. The robustness of experimental designs against factor errors is explored through comparative study. The construction and use of the D- and G-efficiencies and the fraction of design space plots are demonstrated with several examples of different designs with errors.