On D-optimal robust second order slope-rotatable designs

Das and Park (2006) introduced slope-rotatable designs overall directions for correlated observations which is known as A-optimal robust slope-rotatable designs. This article focuses D-optimal slope-rotatable designs for second-order response surface model with correlated observations. It has been established that robust second-order rotatable designs are also D-optimal robust slope-rotatable designs. A class of D-optimal robust second-order slope-rotatable designs has been derived for special correlation structures of errors.     

A measure of robust slope-rotatability for second-order response surface experimental designs

In response surface methodology, rotatability and slope-rotatability are natural and highly desirable properties for second-order regression models. In this paper a measure of robust slope-rotatability for second-order response surface designs with a general correlated error structure is developed and illustrated with different examples for autocorrelated error structure.     

Slope-rotatable designs with equal maximum directional variance for second order response surface models

The concept of sloperotaiability with equal maximum directional vari ance for second order response surface models is introduced as a new design property. This requires that the maximum variance of the estimated slope over all possible directions be only a function of p, which is the distance from the design originif is shown that a rotatable design satisfies this property Also, minimization of tiie maximum variance of the estimated slope over all possible directions is proposed as a new design optirnality criterion, and op¬timal designs are called slope-directional minirnax designs. For the class of cquiradial designs, the slope-directional minirnax designs are compared with D— optimal designs.     

Robust first-order rotatable lifetime improvement experimental designs

Experimental designs are widely used in predicting the optimal operating conditions of the process parameters in lifetime improvement experiments. The most commonly observed lifetime distributions are log-normal, exponential, gamma and Weibull. In the present article, invariant robust first-order rotatable designs are derived for autocorrelated lifetime responses having log-normal, exponential, gamma and Weibull distributions. In the process, robust first-order D-optimal and rotatable conditions have been derived under these situations. For these lifetime distributions with correlated errors, it is shown that robust first-order D-optimal designs are always robust rotatable but the converse is not true. Moreover, it is observed that robust first-order D-optimal and rotatable designs depend on the respective error variance–covariance structure but are independent from these considered lifetime response distributions.     

Minimax Design for the Difference Between Estimated Responses for the Quadratic Model Over Hypercubic Regions

Abstract

A second-order model involving the intercept and only the pure quadratic terms is considered for regression over hypercubes. Minimization of the variance of the difference between estimated responses at two points, maximized over all pairs of points in the region of interest in factor space, is taken as the design criterion. Optimal design under the minimax criterion is derived and found to be the one which is also simultaneously A-, D-, and E-optimal for the parameters excluding the intercept. The minimax design is compared with other standard designs and is found to perform extremely well.     

Optimal designs for the Michaelis–Menten model with correlated observations

In this paper we investigate the problem of designing experiments for generalized least-squares analysis in the Michaelis–Menten model. We study the structure of exact D-optimal designs in a model with an autoregressive error structure. Explicit results for locally D-optimal designs are derived for the case where two observations can be taken per subject. Additionally standardized maximin D-optimal designs are obtained in this case. The results illustrate the enormous difficulties to find exact optimal designs explicitly for nonlinear regression models with correlated observations.     

Locally and maximin optimal designs for multi-factor nonlinear models

This paper considers the search for locally and maximin optimal designs for multi-factor nonlinear models from optimal designs for sub-models of a lower dimension. In particular, sufficient conditions are given so that maximin D-optimal designs for additive multi-factor nonlinear models can be built from maximin D-optimal designs for their sub-models with a single factor. Some examples of application are models involving exponential decay in several variables.     

On D-optimal robust designs for lifetime improvement experiments

Locating the optimal operating conditions of the process parameters is critical in a lifetime improvement experiment. For log-normal lifetime distribution with compound error structure (i.e., symmetry, inter-class and intra-class correlation error structures), we have developed methods for construction of D-optimal robust first order designs. It is shown that D-optimal robust first order designs are always robust first order rotatable but the converse is not always true.     

Optimal foldover designs

An obvious strategy for obtaining a Doptimal foldover design for p factors at two levels each in 2N runs is to fold a Doptimal main effects plan. We show that this strategy works except when N = 4t + 2 and s is even In that case there are two different classes of D-optimal main effects plans with N runs that have the same determinant. However folding them gives two different values foi the D-optimality criteiion One set of designs is D-optimal The other is not.     

Optimal designs for additive mixture model with heteroscedastic errors

This paper presents a study of D- and A-optimality of direct sum designs for additive mixture models when the errors are heteroscedastic. Sufficient conditions are given so that D- and A-optimal designs for additive mixture models can be constructed from the D- and A-optimal designs for homogeneous models in sub-mixture systems.     

Highly Efficient Designs for Logistic Models with Categorical Variables

Optimal designs for logistic models generally require prior information about the values of the regression parameters. However, experimenters usually do not have full knowledge of these parameters. We propose a design that is D-optimal on a restricted design region. This design assigns an equal weight to design points that contain more information and ignores those design points that contain less information about the regression parameters. The design can be constructed in practice by means of the rank order of the outcome variances. A numerical study compares the proposed design with the D-optimal and completely balanced designs in terms of efficiency.     

D- and V-optimal population designs for the quadratic regression model with a random intercept term

In this paper D- and V-optimal population designs for the quadratic regression model with a random intercept term and with values of the explanatory variable taken from a set of equally spaced, non-repeated time points are considered. D-optimal population designs based on single-point individual designs were readily found but the derivation of explicit expressions for designs based on two-point individual designs was not straightforward and was complicated by the fact that the designs now depend on ratio of the variance components. Further algebraic results pertaining to d-point D-optimal population designs where d≥3 and to V-optimal population designs proved elusive. The requisite designs can be calculated by careful programming and this is illustrated by means of a simple example.     

D-Optimal Designs for Covariate Parameters in Block Design Set Up

The problem considered is that of finding D-optimal design for the estimation of covariate parameters and the treatment and block contrasts in a block design set up in the presence of non stochastic controllable covariates, when N = 2(mod 4), N being the total number of observations. It is clear that when N ≠ 0 (mod 4), it is not possible to find designs attaining minimum variance for the estimated covariate parameters. Conditions for D-optimum designs for the estimation of covariate parameters were established when each of the covariates belongs to the interval [?1, 1]. Some constructions of D-optimal design have been provided for symmetric balanced incomplete block design (SBIBD) with parameters b = v, r = k = v ? 1, λ =v ? 2 when k = 2 (mod 4) and b is an odd integer.     

Optimal Designs for Random Coefficient Regression Models with Heteroscedastic Errors

The purpose of this article is to present the optimal designs based on D-, G-, A-, I-, and D _β-optimality criteria for random coefficient regression (RCR) models with heteroscedastic errors. A sufficient condition for the heteroscedastic structure is given to make sure that the search of optimal designs can be confined at extreme settings of the design region when the criteria satisfy the assumption of the real valued monotone design criteria. Analytical solutions of D-, G-, A-, I-, and D _β-optimal designs for the RCR models are derived. Two examples are presented for random slope models with specific heteroscedastic errors.     

COMPUTER-AIDED CONSTRUCTION OF SMALL (M, S)-OPTIMAL INCOMPLETE BLOCK DESIGNS

A new exchange algorithm for the construction of (M, S)-optimal incomplete block designs (IBDS) is developed. This exchange algorithm is used to construct 973 (M, S)-optimal IBDs (v, k, b) for v= 4,…,12 (varieties) with arbitrary v, k (block size) and b (number of blocks). The efficiencies of the “best” (M, S)-optimal IBDs constructed by this algorithm are compared with the efficiencies of the corresponding nearly balanced incomplete block designs (NBIBDs) of Cheng(1979), Cheng & Wu (1981) and Mitchell & John(1976).     

D-Optimal Two-Level Fractional Factorial Designs of Resolution III with Two Dispersion Factors

The problem of finding D-optimal designs, with two dispersion factors, for the estimation of all location main effects is investigated in the class of regular unreplicated two-level fractional factorial designs of resolution III. Designs having length three words involving both of the dispersion factors in the defining relation are shown to be inferior in terms of D-optimality. Tables of factors that are named as the two dispersion factors so that the resulting design is either D-optimal or has the largest determinant of the information matrix are provided. Rank-order of designs is studied when the number of length three words involving either one of the dispersion factors and the number of length four words involving both of the dispersion factors are fixed. Rank-order of designs when the numbers of aforementioned words are less than or equal to ten is given.     

The analytic construction of D-optimal designs for the two-variable binary logistic regression model without interaction

Candidate locally D-optimal designs for the binary two-variable logistic model with no interaction, which comprise 3 and 4 support points lying in the first quadrant of the two-dimensional Euclidean space, were introduced by Haines et al. (D-optimal designs for logistic regression in two variables. In: Lopez-Fidalgo J, Rodrigez-Diaz JM, Torsney B, editors. MODA8 – advances in model-oriented designs and analysis. Heidelberg: Physica-Verlag; 2007. p. 91–98). The authors proved algebraically the global D-optimality of the 3-point design for the special case in which the intercept parameter is equal to?1.5434. However for other selected values of the intercept parameter, the global D-optimality of the proposed 3- and 4-point designs was only demonstrated numerically. In this paper, we provide analytical proofs of the D-optimality of these 3- and 4-point designs for all negative and zero intercept parameters of the binary two-variable logistic model with no interaction. The results are extended to the construction of D-optimal designs on a rectangular design space and illustrated by means of two examples of which one is a real example taken from the literature.     

Conditions of Slope-Rotatability for Third-Order Polynomial Regression Models

In experimental design for response surface analysis, it is sometimes of interest to estimate the difference of responses at two points. If differences at points close together are involved, the design that reliably estimates the slope of the response surface is important. In particular, Hader and Park (1978 Hader , R. J. , Park , S. H. ( 1978 ). Slope-rotatable central composite designs . Technometrics 20 : 413 – 417 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) suggested the concept of slope-rotatability and studied slope rotatable central composite designs. Until now, many response surface designs including central composite designs have been suggested for fitting second order response surface models. However, we often need to fit third-order polynomial regression models. In this article, we suggest extended central composite designs (ECCDs) to fit third-order models and find the necessary and sufficient conditions for slope-rotatability over all directions in the third-order polynomial models.     

Locally optimal designs for some dose–response models with continuous endpoints

We consider the problem of constructing static (or non sequential), approximate optimal designs for a class of dose–response models with continuous outcomes. We obtain conditions for a design being D-optimal or c-optimal. The designs are locally optimal in that they depend on the model parameters. The efficiency studies show that these designs have high efficiency when the mis-specification of the initial values of model parameters is not severe. A case study indicates that using an optimal design may result in a significant saving of resources.     

On The Optimal Choice of Cube and Star Replications in Restricted Second-Order Designs

This article examines the central composite design in which some of the experimental runs are replicated. Three different classes of N-point designs are compared using the criterion of Schur's ordering under orthogonality, rotatablity, and slope- rotatablity conditions. The response surface designs with the star portion replicated seem to have more potential than others under orthogonality condition, while the designs with the cube portion replicated is preferable to the designs with their star portion or only the center point replicated under rotatable and slope-rotatable conditions.