How the one-way analysis of variance model is affected by the degree of precision of the data

The underlying theory upon which many statistical tests are based, assumes that the variables sampled are continuous. However, the data are often subject to rounding. Here we consider the effect of rounding on the significance level and power of the F test in the one-way analysis of variance with fixed effects, with respect to the degree of precision of recorded data, sample size and normality of the population. Even for coarse rounding the effects are small.     

A sequential conditional probability ratio test procedure for comparing diagnostic tests

In this paper, we derive sequential conditional probability ratio tests to compare diagnostic tests without distributional assumptions on test results. The test statistics in our method are nonparametric weighted areas under the receiver-operating characteristic curves. By using the new method, the decision of stopping the diagnostic trial early is unlikely to be reversed should the trials continue to the planned end. The conservatism reflected in this approach to have more conservative stopping boundaries during the course of the trial is especially appealing for diagnostic trials since the end point is not death. In addition, the maximum sample size of our method is not greater than a fixed sample test with similar power functions. Simulation studies are performed to evaluate the properties of the proposed sequential procedure. We illustrate the method using data from a thoracic aorta imaging study.     

Distribution-free partially sequential piacment procedures

The concept of a partially sequential hypothesis test was introduced by Wolfe (1977a), an{associated procedures were developed for both parametric and nonparametric assumptions. In this paper we consider distribution-free extensions of those indicator tests, based on the placements of the sequentially obtained observations among the previously collected fixed size sample. Exact and asymptotic, as the fixed sample size in¬creases to infinity, properties of these sequential placements procedures are obtained, including statements about the power and expected number of sequentially obtained observations. The results of a Monte Carlo study are used to differentiate be¬tween various placement scoring schemes.     

Some partially sequential nonparametric tests for detecting linear trend

In the present study, we develop two nonparametric partially sequential tests for detecting possible presence of linear trend among the incoming series of observations. We assume that a sample of fixed size is available a priori from some unknown univariate continuous population and there is no sign of trend among these historical observations. Our proposed tests can be viewed as the sequential type tests for monitoring structural changes. We use partial sequential sampling schemes based on usual ranks as well as on sequential ranks. We provide detailed discussion on asymptotic studies related to the proposed tests. We compare the two tests under various situations. We also present some numerical results based on simulation studies. Proposed tests are extremely important in profit making in volatile market through Margin Trading. We illustrate the mechanism with a detailed analysis of a stock price data.     

Hypothesis testing for Markov chain Monte Carlo

Testing between hypotheses, when independent sampling is possible, is a well developed subject. In this paper, we propose hypothesis tests that are applicable when the samples are obtained using Markov chain Monte Carlo. These tests are useful when one is interested in deciding whether the expected value of a certain quantity is above or below a given threshold. We show non-asymptotic error bounds and bounds on the expected number of samples for three types of tests, a fixed sample size test, a sequential test with indifference region, and a sequential test without indifference region. Our tests can lead to significant savings in sample size. We illustrate our results on an example of Bayesian parameter inference involving an ODE model of a biochemical pathway.     

A two- sample partially sequential probability ratio test

A two-sample partially sequential probability ratio test (PSPRT) is considered for the two-sample location problem with one sample fixed and the other sequential. Observations are assumed to come from two normal poptilatlons with equal and known variances. Asymptotically in the fixed-sample size the PSPRT is a truncated Wald one sample sequential probability test. Brownian motion approximations for boundary-crossing probabilities and expected sequential sample size are obtained. These calculations are compared to values obtained by Monte Carlo simulation.     

Testing the scale parameter of the exponential distribution with known coefficient of variation

Assuming that there is a linear relationship between the parameters of a two-parameter exponential distribution, the distribution reduces to the one with known coefficient of variation. The problem of testing the scale parameter is considered using fixed sample and sequential testing procedures. A comparison of the two procedures shows that the difference between the fixed sample sizes and the expected sample sizes in the null case is remarkable. Therefore, a truncated test is proposed and its expected sample sizes in the null case are compared with those of the sequential test.     

Bayesian sequential methods for choosing the best multinomial cell: some simulation results

Suboptimal Bayesian sequential methods for choosing the best (i.e. largest probability) multinomial cell are considered and their performance is studied using Monte Carlo simulation. Performance characteristics, such as the probability of correct selection and some other associated with the sample size distribution, are evaluated assuming a maximum sample size. Single observation sequential rules as well as rules, where groups of observations are taken, and fixed sample size rules are discussed.     

On a class of partially sequential two-sample test procedures for multivariate continuous data

In a two-sample testing problem, sometimes one of the sample observations are difficult and/or costlier to collect compared to the other one. Also, it may be the situation that sample observations from one of the populations have been previously collected and for operational advantages we do not wish to collect any more observations from the second population that are necessary for reaching a decision. Partially sequential technique is found to be very useful in such situations. The technique gained its popularity in statistics literature due to its very nature of capitalizing the best aspects of both fixed and sequential procedures. The literature is enriched with various types of partially sequential techniques useable under different types of data set-up. Nonetheless, there is no mention of multivariate data framework in this context, although very common in practice. The present paper aims at developing a class of partially sequential nonparametric test procedures for two-sample multivariate continuous data. For this we suggest a suitable stopping rule adopting inverse sampling technique and propose a class of test statistics based on the samples drawn using the suggested sampling scheme. Various asymptotic properties of the proposed tests are explored. An extensive simulation study is also performed to study the asymptotic performance of the tests. Finally the benefit of the proposed test procedure is demonstrated with an application to a real-life data on liver disease.     

Choice of alpha spending function and time points in clinical trials with one or two interim analyses

One characterization of group sequential methods uses alpha spending functions to allocate the false positive rate throughout a study. We consider and evaluate several such spending functions as well as the time points of the interim analyses at which they apply. In addition, we evaluate the double triangular test as an alternative procedure that allows for early termination of the trial not only due to efficacy differences between treatments, but also due to lack of such differences. We motivate and illustrate our work by reference to the analysis of survival data from a proposed oncology study. Such group sequential procedures with one or two interim analyses are only slightly less powerful than fixed sample trials, but provide for the strong possibility of early stopping. Therefore, in all situations where they can practically be applied, we recommend their routine use in clinical trials. The double triangular test provides a suitable alternative to the group sequential procedures in that they do not provide for early stopping with acceptance of the null hypothesis. Again, there is only a modest loss in power relative to fixed sample tests. Copyright © 2004 John Wiley & Sons, Ltd.     

An optimal sequential procedure in ethical allocation

In this paper, given an arbitrary fixed target sample size, we describe a sequential allocation scheme for comparing two competing treatments in clinical trials. The proposed scheme is a compromise between ethical and optimum allocations. Using some specific probability models, we have shown that, for estimating the risk difference (RD) between two treatment effects, the scheme provides smaller variance than that provided by the corresponding fixed sample size equal allocation sampling scheme.     

A sequential two sample t test using welch type modification for unequal variances

The sequential analogue of the Behrens-Fisher problem is considered, The pooled-variance two sample sequential t test is modified to account for unequal variances. Operating cha-racteristic and average-sample-number curves are calculated for both the pooled variance and the modified t tests by computer simulations, An example is given using data from a tissue assay for breast cancer tumors.     

Closed inverse sampling procedure for selecting the largest multinomial cell probability

A class of closed inverse sampling procedures R(n,m) for selecting the multinomial cell with the largest probability is considered; here n is the maximum sample size that an experimenter can take and m is the maximum frequency that a multinomial cell can have. The proposed procedures R(n,m) achieve the same probability of a correct selection as do the corresponding fixed sample size procedures and the curtailed sequential procedures when m is at least n/2. A monotonicity property on the probability of a correct selection is proved and it is used to find the least favorable configurations and to tabulate the necessary probabilities of a correct selection and corresponding expected sample sizes     

The Equivalence of Neyman Optimum Allocation for Sampling and Equal Proportions for Apportioning the U.S. House of Representatives

We present a surprising though obvious result that seems to have been unnoticed until now. In particular, we demonstrate the equivalence of two well-known problems—the optimal allocation of the fixed overall sample size n among L strata under stratified random sampling and the optimal allocation of the H = 435 seats among the 50 states for apportionment of the U.S. House of Representatives following each decennial census. In spite of the strong similarity manifest in the statements of the two problems, they have not been linked and they have well-known but different solutions; one solution is not explicitly exact (Neyman allocation), and the other (equal proportions) is exact. We give explicit exact solutions for both and note that the solutions are equivalent. In fact, we conclude by showing that both problems are special cases of a general problem. The result is significant for stratified random sampling in that it explicitly shows how to minimize sampling error when estimating a total T_Y while keeping the final overall sample size fixed at n; this is usually not the case in practice with Neyman allocation where the resulting final overall sample size might be near n + L after rounding. An example reveals that controlled rounding with Neyman allocation does not always lead to the optimum allocation, that is, an allocation that minimizes variance.     

The effect of rounding on the significance level and power of certain test statistics for non-normal data

In a previously published study, the effects of rounding on the significance and power of four test statistics were considered when the parent population was normal. Here we investigate how these tests will perform for rounded non-normal data. Guidelines are given on how the degree of precision recommended for normal populations can be applied when the population is non-normal.     

Non-parametric group sequential designs in randomized clinical trials

This paper examines some non‐parametric group sequential designs applicable for randomized clinical trials, for comparing two continuous treatment effects taking the observations in matched pairs, or applicable in event‐based analysis. Two inverse binomial sampling schemes are considered, of which the second one is an adaptive data‐dependent design. These designs are compared with some fixed sample size competitors. Power and expected sample sizes are calculated for the proposed procedures.     

A class of sequential tests for two‐sample composite hypotheses

The authors propose a class of statistics based on Rao's score for the sequential testing of composite hypotheses comparing two treatments (populations). Asymptotic approximations of the statistics lead them to propose sequential tests and to derive their monitoring boundaries. As special cases, they construct sequential versions of the two‐sample t‐test for normal populations and two‐sample z‐score tests for binomial populations. The proposed algorithms are simple and easy to compute, as no numerical integration is required. Furthermore, the user can analyze the data at any time regardless of how many inspections have been made. Monte Carlo simulations allow the authors to compare the power and the average stopping time (also known as average sample number) of the proposed tests to those of nonsequential and group sequential tests. A two‐armed comparative clinical trial in patients with adult leukemia allows them to illustrate the efficiency of their methods in the case of binary responses.     

ON TESTS OF SYMMETRY FOR DISCRETE POPULATIONS

In this paper problems of tests of symmetry about the origin with discrete samples are considered. Recently Vorli?ková established the asymptotic normality of linear rank statistics and signed rank statistics in [5] and [6]. Here we propose statistics which are conditionally the sum of independent variables, including the locally most powerful tests for a one sided one parameter family. Their asymptotic distributions are derived under the null hypothesis and the contiguous rounding off location alternatives. We propose four types of signed rank tests and investigate their properties.