The Use of Noncentral F Approximations for Calculation of Power and Sample Size

Approximations to the noncentral F distribution yield surprisingly accurate results for power and sample size problems arising from linear hypotheses about normal random variables. The approximations are easy to use with a desk (or hand-held) calculator that computes cumulative F probabilities. These approximations are particularly advantageous for testing the hypothesis that differences among the means are small against the alternative that the differences are large.     

Sample Size Calculation and Blinded Sample Size Recalculation in Clinical Trials Where the Treatment Effect is Measured by the Relative Risk

In clinical trials with binary endpoints, the required sample size does not depend only on the specified type I error rate, the desired power and the treatment effect but also on the overall event rate which, however, is usually uncertain. The internal pilot study design has been proposed to overcome this difficulty. Here, nuisance parameters required for sample size calculation are re-estimated during the ongoing trial and the sample size is recalculated accordingly. We performed extensive simulation studies to investigate the characteristics of the internal pilot study design for two-group superiority trials where the treatment effect is captured by the relative risk. As the performance of the sample size recalculation procedure crucially depends on the accuracy of the applied sample size formula, we firstly explored the precision of three approximate sample size formulae proposed in the literature for this situation. It turned out that the unequal variance asymptotic normal formula outperforms the other two, especially in case of unbalanced sample size allocation. Using this formula for sample size recalculation in the internal pilot study design assures that the desired power is achieved even if the overall rate is mis-specified in the planning phase. The maximum inflation of the type I error rate observed for the internal pilot study design is small and lies below the maximum excess that occurred for the fixed sample size design.     

Power and Sample Size for Approximate Chi-Square Tests

Approximate chi-square tests for hypotheses concerning multinomial probabilities are considered in many textbooks. In this article power calculations and sample size based on power are discussed and illustrated for the three most frequently used tests of this type. Available noncentrality parameters and existing tables permit a relatively easy solution of these kinds of problems.     

Sample Size and Power Calculations for Left-Truncated Normal Distribution

Abstract

Sample size calculation is an important component in designing an experiment or a survey. In a wide variety of fields—including management science, insurance, and biological and medical science—truncated normal distributions are encountered in many applications. However, the sample size required for the left-truncated normal distribution has not been investigated, because the distribution of the sample mean from the left-truncated normal distribution is complex and difficult to obtain. This paper compares an ad hoc approach to two newly proposed methods based on the Central Limit Theorem and on a high degree saddlepoint approximation for calculating the required sample size with the prespecified power. As shown by use of simulations and an example of health insurance cost in China, the ad hoc approach underestimates the sample size required to achieve prespecified power. The method based on the high degree saddlepoint approximation provides valid sample size and power calculations, and it performs better than the Central Limit Theorem. When the sample size is not too small, the Central Limit Theorem also provides a valid, but relatively simple tool to approximate that sample size.     

Power and Sample Size for Fixed-Effects Inference in Reversible Linear Mixed Models

ABSTRACT

Despite the popularity of the general linear mixed model for data analysis, power and sample size methods and software are not generally available for commonly used test statistics and reference distributions. Statisticians resort to simulations with homegrown and uncertified programs or rough approximations which are misaligned with the data analysis. For a wide range of designs with longitudinal and clustering features, we provide accurate power and sample size approximations for inference about fixed effects in the linear models we call reversible. We show that under widely applicable conditions, the general linear mixed-model Wald test has noncentral distributions equivalent to well-studied multivariate tests. In turn, exact and approximate power and sample size results for the multivariate Hotelling–Lawley test provide exact and approximate power and sample size results for the mixed-model Wald test. The calculations are easily computed with a free, open-source product that requires only a web browser to use. Commercial software can be used for a smaller range of reversible models. Simple approximations allow accounting for modest amounts of missing data. A real-world example illustrates the methods. Sample size results are presented for a multicenter study on pregnancy. The proposed study, an extension of a funded project, has clustering within clinic. Exchangeability among the participants allows averaging across them to remove the clustering structure. The resulting simplified design is a single-level longitudinal study. Multivariate methods for power provide an approximate sample size. All proofs and inputs for the example are in the supplementary materials (available online).     

Regression Analysis of Restricted Mean Survival Time Based on Pseudo-Observations

Regression models for survival data are often specified from the hazard function while classical regression analysis of quantitative outcomes focuses on the mean value (possibly after suitable transformations). Methods for regression analysis of mean survival time and the related quantity, the restricted mean survival time, are reviewed and compared to a method based on pseudo-observations. Both Monte Carlo simulations and two real data sets are studied. It is concluded that while existing methods may be superior for analysis of the mean, pseudo-observations seem well suited when the restricted mean is studied.     

Power and Sample Size Determination When the Alternative Hypotheses are Given in Quantiles

The power of normal-theory tests about means depends on a noncentrality parameter which is a function of the unknown parameter σ. In order to calculate power and to solve sample-size problems based on power, differences between hypothesized and alternative values of the means are frequently selected as a multiple of σ, a choice which eliminates σ from the noncentrality parameter and permits a solution. Perhaps a more natural (but equivalent) way to express alternatives is to give one or more means as the quantile of order p (say Q_p ) of a distribution with another mean. As we will demonstrate, this kind of alternative also eliminates σ from the problem.     

Comparison of Operating Characteristics of Commonly Used Sample Size Re-Estimation Procedures in a Two-Stage Design

In group sequential clinical trials, there are several sample size re-estimation methods proposed in the literature that allow for change of sample size at the interim analysis. Most of these methods are based on either the conditional error function or the interim effect size. Our simulation studies compared the operating characteristics of three commonly used sample size re-estimation methods, Chen et al. (2004), Cui et al. (1999), and Muller and Schafer (2001). Gao et al. (2008) extended the CDL method and provided an analytical expression of lower and upper threshold of conditional power where the type I error is preserved. Recently, Mehta and Pocock (2010) extensively discussed that the real benefit of the adaptive approach is to invest the sample size resources in stages and increasing the sample size only if the interim results are in the so called “promising zone” which they define in their article. We incorporated this concept in our simulations while comparing the three methods. To test the robustness of these methods, we explored the impact of incorrect variance assumption on the operating characteristics. We found that the operating characteristics of the three methods are very comparable. In addition, the concept of promising zone, as suggested by MP, gives the desired power and smaller average sample size, and thus increases the efficiency of the trial design.     

连续性抽样调查中的样本轮换研究

 内容摘要：本文首先介?绍了样本轮换研究问题提出的背景和国内外研究现状。接着介绍了分层抽样下样本轮换的理论模型。包括分层抽样下样本轮换的估计量公式和最优样本轮换率的确定方法。再接着利用前面介绍的理论知识,结合上海市城镇住房空置率抽样调查数据进行实证分析。由于该抽样调查采取的是分层抽样,因此相应地用分层抽样下的样本轮换研究。先根据该抽样调查本身的特点和社会经济活动的规律确定样本轮换时间间隔为1年。再分别计算出各层的最优样本轮换率和总体的样本轮换率。最后分别对三层子总体样本轮换的效果进行分析,分析发现各层经过样本轮换以后的精度比不进行样本轮换或进行完全样本轮换的精度有了明显的提高,轮换效果显著。     

Sample Size and Power Calculation in Comparing Diagnostic Accuracy of Biomarkers with Pooled Assessments

When testing of a biomarker is costly, pooling of samples becomes a useful and efficient alternative (Faraggi et al., 2003). In this paper, we develop procedures for sample size and power calculations for planning a study comparing the accuracy of biomarkers in diagnosis of diseases with pooled samples. Explicit formulas are derived for several important pooling strategies. The effects of pooling samples on sample size and power of the test are also discussed.     

Estimation of Population Mean Using Known Coefficient of Variation of the Study Character in the Presence of Non Response

Using the known coefficient of variation of the study character, generalized and regression-type estimators for the population mean using two phase sampling in the presence of non response were proposed and their properties have been studied. The conditions under which the proposed estimators are more efficient than the relevant estimators have been obtained. The empirical studies were given in the support of the problems in the case of positive and negative correlation between the study and the auxiliary characters which show the increase in the efficiency of the proposed estimators using known coefficient of variation of the study character with respect to the relevant estimators.     

Bayesian Time Series Analysis of Structural Changes in Level and Trend

In this article we consider the problem of detecting changes in level and trend in time series model in which the number of change-points is unknown. The approach of Bayesian stochastic search model selection is introduced to detect the configuration of changes in a time series. The number and positions of change-points are determined by a sequence of change-dependent parameters. The sequence is estimated by its posterior distribution via the maximum a posteriori (MAP) estimation. Markov chain Monte Carlo (MCMC) method is used to estimate posterior distributions of parameters. Some actual data examples including a time series of traffic accidents and two hydrological time series are analyzed.     

Using Analysis of Variance and Factor Analysis for the Reduction of High Dimensional Variation in Time Series of Energy Consumption

Summary: In this paper the complexity of high dimensional data with cyclical variation is reduced using analysis of variance and factor analysis. It is shown that the prediction of a small number of main cyclical factors is more useful than forecasting all the time-points separately as it is usually done by seasonal time series models. To give an example for this approach we analyze the electricity demand per quarter of an hour of industrial customers in Germany. The necessity of such predictions results from the liberalization of the German electricity market in 1998 due to legal requirements of the EC in 1996.     

陕西省小城镇规模布局与经济发展要素关系的数量分析

文章应用双对数虚拟变量模型,研究了陕西省小城镇的发展规模、地域差异与经济要素之间的数量关系,分析了陕西省小城镇发展过程中存在的问题,并为陕西省政府制定小城镇规模布局的发展战略和政策提供了相关依据。