The Geometric Birnbaum-Saunders regression model with cure rate

In this paper, we propose a cure rate survival model by assuming the number of competing causes of the event of interest follows the Geometric distribution and the time to event follow a Birnbaum Saunders distribution. We consider a frequentist analysis for parameter estimation of a Geometric Birnbaum Saunders model with cure rate. Finally, to analyze a data set from the medical area.     

The destructive negative binomial cure rate model with a latent activation scheme

A new flexible cure rate survival model is developed where the initial number of competing causes of the event of interest (say lesions or altered cells) follows a compound negative binomial (NB) distribution. This model provides a realistic interpretation of the biological mechanism of the event of interest, as it models a destructive process of the initial competing risk factors and records only the damaged portion of the original number of risk factors. Besides, it also accounts for the underlying mechanisms that lead to cure through various latent activation schemes. Our method of estimation exploits maximum likelihood (ML) tools. The methodology is illustrated on a real data set on malignant melanoma, and the finite sample behavior of parameter estimates are explored through simulation studies.     

The Poisson Generalized Linear Failure Rate Model

We formulate a new cure rate survival model by assuming that the number of competing causes of the event of interest has the Poisson distribution, and the time to this event has the generalized linear failure rate distribution. A new distribution to analyze lifetime data is defined from the proposed cure rate model, and its quantile function as well as a general expansion for the moments is derived. We estimate the parameters of the model with cure rate in the presence of covariates for censored observations using maximum likelihood and derive the observed information matrix. We obtain the appropriate matrices for assessing local influence on the parameter estimates under different perturbation schemes and present some ways to perform global influence analysis. The usefulness of the proposed cure rate survival model is illustrated in an application to real data.     

A flexible model for survival data with a cure rate: a Bayesian approach

In this paper we deal with a Bayesian analysis for right-censored survival data suitable for populations with a cure rate. We consider a cure rate model based on the negative binomial distribution, encompassing as a special case the promotion time cure model. Bayesian analysis is based on Markov chain Monte Carlo (MCMC) methods. We also present some discussion on model selection and an illustration with a real data set.     

Influence diagnostics for the Weibull-Negative-Binomial regression model with cure rate under latent failure causes

In this paper, we propose a flexible cure rate survival model by assuming that the number of competing causes of the event of interest follows the Negative Binomial distribution and the time to event follows a Weibull distribution. Indeed, we introduce the Weibull-Negative-Binomial (WNB) distribution, which can be used in order to model survival data when the hazard rate function is increasing, decreasing and some non-monotonous shaped. Another advantage of the proposed model is that it has some distributions commonly used in lifetime analysis as particular cases. Moreover, the proposed model includes as special cases some of the well-know cure rate models discussed in the literature. We consider a frequentist analysis for parameter estimation of a WNB model with cure rate. Then, we derive the appropriate matrices for assessing local influence on the parameter estimates under different perturbation schemes and present some ways to perform global influence analysis. Finally, the methodology is illustrated on a medical data.     

A note on the EM algorithm for estimation in the destructive negative binomial cure rate model

In this note we present a modification in the EM algorithm for the destructive negative binomial cure rate model. This alteration enables us to obtain the estimates of the whole parameter vector from the complete log-likelihood function, avoiding the corresponding observed log-likelihood function, which is more involved. To achieve this goal, we resort to the mixture representation of the negative binomial distribution in terms of the Poisson and gamma distributions.     

The negative binomial–beta Weibull regression model to predict the cure of prostate cancer

In this article, for the first time, we propose the negative binomial–beta Weibull (BW) regression model for studying the recurrence of prostate cancer and to predict the cure fraction for patients with clinically localized prostate cancer treated by open radical prostatectomy. The cure model considers that a fraction of the survivors are cured of the disease. The survival function for the population of patients can be modeled by a cure parametric model using the BW distribution. We derive an explicit expansion for the moments of the recurrence time distribution for the uncured individuals. The proposed distribution can be used to model survival data when the hazard rate function is increasing, decreasing, unimodal and bathtub shaped. Another advantage is that the proposed model includes as special sub-models some of the well-known cure rate models discussed in the literature. We derive the appropriate matrices for assessing local influence on the parameter estimates under different perturbation schemes. We analyze a real data set for localized prostate cancer patients after open radical prostatectomy.     

Signed likelihood ratio tests in the Birnbaum-Saunders regression model

The Birnbaum-Saunders regression model is becoming increasingly popular in lifetime analyses and reliability studies. In this model, the signed likelihood ratio statistic provides the basis for testing inference and construction of confidence limits for a single parameter of interest. We focus on the small sample case, where the standard normal distribution gives a poor approximation to the true distribution of the statistic. We derive three adjusted signed likelihood ratio statistics that lead to very accurate inference even for very small samples. Two empirical applications are presented.     

Discrete Linnik Weibull distribution

Abstract

We introduce a new family of distributions using truncated discrete Linnik distribution. This family is a rich family of distributions which includes many important families of distributions such as Marshall–Olkin family of distributions, family of distributions generated through truncated negative binomial distribution, family of distributions generated through truncated discrete Mittag–Leffler distribution etc. Some properties of the new family of distributions are derived. A particular case of the family, a five parameter generalization of Weibull distribution, namely discrete Linnik Weibull distribution is given special attention. This distribution is a generalization of many distributions, such as extended exponentiated Weibull, exponentiated Weibull, Weibull truncated negative binomial, generalized exponential truncated negative binomial, Marshall-Olkin extended Weibull, Marshall–Olkin generalized exponential, exponential truncated negative binomial, Marshall–Olkin exponential and generalized exponential. The shape properties, moments, median, distribution of order statistics, stochastic ordering and stress–strength properties of the new generalized Weibull distribution are derived. The unknown parameters of the distribution are estimated using maximum likelihood method. The discrete Linnik Weibull distribution is fitted to a survival time data set and it is shown that the distribution is more appropriate than other competitive models.     

Confidence interval estimation for negative binomial group distribution

Negative binomial group distribution was proposed in the literature which was motivated by inverse sampling when considering group inspection: products are inspected group by group, and the number of non-conforming items of a group is recorded only until the inspection of the whole group is finished. The non-conforming probability p of the population is thus the parameter of interest. In this paper, the confidence interval construction for this parameter is investigated. The common normal approximation and exact method are applied. To overcome the drawbacks of these commonly used methods, a composite method that is based on the confidence intervals of the negative binomial distribution is proposed, which benefits from the relationship between negative binomial distribution and negative binomial group distribution. Simulation studies are carried out to examine the performances of our methods. A real data example is also presented to illustrate the application of our method.     

A new destructive Poisson odd log-logistic generalized half-normal cure rate model

We propose a new cure rate survival model by assuming that the initial number of competing causes of the event of interest follows a Poisson distribution and the time to event has the odd log-logistic generalized half-normal distribution. This survival model describes a realistic interpretation for the biological mechanism of the event of interest. We estimate the model parameters using maximum likelihood. For different sample sizes, various simulation scenarios are performed. We propose the diagnostics and residual analysis to verify the model assumptions. The potentiality of the new cure rate model is illustrated by means of a real data.     

The Poisson Birnbaum–Saunders model with long-term survivors

In this paper, we propose a cure rate survival model by assuming that the number of competing causes of the event of interest follows the Poisson distribution and the time to event has the Birnbaum–Saunders (BS) distribution. We define the Poisson BS distribution and provide two useful representations for its density function which facilitate to obtain some mathematical properties. Two closed-form expressions for the moments of the new distribution are given. We estimate the parameters of the model with cure rate using maximum likelihood. For different parameter settings, sample sizes and censoring percentages, several simulations are performed. We derive the appropriate matrices for assessing local influence on the parameter estimates under different perturbation schemes and present some ways to perform a global influence study. We analyse a real data set from the medical area.     

A bivariate mixture of negative binomial distributions and its applications

Abstract

We construct a new bivariate mixture of negative binomial distributions which represents over-dispersed data more efficiently. This is an extension of a univariate mixture of beta and negative binomial distributions. Characteristics of this joint distribution are studied including conditional distributions. Some properties of the correlation coefficient are explored. We demonstrate the applicability of our proposed model by fitting to three real data sets with correlated count data. A comparison is made with some previously used models to show the effectiveness of the new model.     

A moment-generating function with application to the birnbaum-saunders distribution

The Birnbaum-Saunders distribution is a fatigue life distribution that was derived from a model assuming that failure is due to the development and growth of a dominant crack. This distribution has been shown to be applicable not only for fatigue analysis but also in other areas of engineering science. Because of its increasing use, it would be desirable to obtain expressions for the expected value of different powers of this distribution.

In this article, the moment-generating function for the sinh-normal distribution is derived. It is shown that this moment-generating function can be used to obtain both integer and fractional moments for the Birnbaum-Saunders distribution. Thus it is now possible to obtain an expression for the expected value of the square root of a Birnbaum-Saunders random variable. A general expression for integer noncentral moments for the Birnbaum-Saunders distribution is derived using the moment-generating function of the sinh-normal distribution. Also included is an approximation of the moment-generating function that can be used fcx small values of the shape parameter.     

A Bayesian random effects model for analyzing mixed negative binomial and continuous longitudinal responses

ABSTRACT

A general Bayesian random effects model for analyzing longitudinal mixed correlated continuous and negative binomial responses with and without missing data is presented. This Bayesian model, given some random effects, uses a normal distribution for the continuous response and a negative binomial distribution for the count response. A Markov Chain Monte Carlo sampling algorithm is described for estimating the posterior distribution of the parameters. This Bayesian model is illustrated by a simulation study. For sensitivity analysis to investigate the change of parameter estimates with respect to the perturbation from missing at random to not missing at random assumption, the use of posterior curvature is proposed. The model is applied to a medical data, obtained from an observational study on women, where the correlated responses are the negative binomial response of joint damage and continuous response of body mass index. The simultaneous effects of some covariates on both responses are also investigated.     

A general long-term aging model with different underlying activation mechanisms: Modeling,Bayesian estimation,and case influence diagnostics

In this paper we propose a general cure rate aging model. Our approach enables different underlying activation mechanisms which lead to the event of interest. The number of competing causes of the event of interest is assumed to follow a logarithmic distribution. The model is parameterized in terms of the cured fraction which is then linked to covariates. We explore the use of Markov chain Monte Carlo methods to develop a Bayesian analysis for the proposed model. Moreover, some discussions on the model selection to compare the fitted models are given, as well as case deletion influence diagnostics are developed for the joint posterior distribution based on the ψ-divergence, which has several divergence measures as particular cases, such as the Kullback–Leibler (K-L), J-distance, L₁ norm, and χ²-square divergence measures. Simulation studies are performed and experimental results are illustrated based on a real malignant melanoma data.     

A Conway Maxwell Poisson type generalization of the negative hypergeometric distribution

Abstract

Negative hypergeometric distribution arises as a waiting time distribution when we sample without replacement from a finite population. It has applications in many areas such as inspection sampling and estimation of wildlife populations. However, as is well known, the negative hypergeometric distribution is over-dispersed in the sense that its variance is greater than the mean. To make it more flexible and versatile, we propose a modified version of negative hypergeometric distribution called COM-Negative Hypergeometric distribution (COM-NH) by introducing a shape parameter as in the COM-Poisson and COMP-Binomial distributions. It is shown that under some limiting conditions, COM-NH approaches to a distribution that we call the COM-Negative binomial (COMP-NB), which in turn, approaches to the COM Poisson distribution. For the proposed model, we investigate the dispersion characteristics and shape of the probability mass function for different combinations of parameters. We also develop statistical inference for this model including parameter estimation and hypothesis tests. In particular, we investigate some properties such as bias, MSE, and coverage probabilities of the maximum likelihood estimators for its parameters by Monte Carlo simulation and likelihood ratio test to assess shape parameter of the underlying model. We present illustrative data to provide discussion.     

The two-sided power-binomial distribution for modeling binary count data

The two-sided power (TSP) distribution is a flexible two-parameter distribution having uniform, power function and triangular as sub-distributions, and it is a reasonable alternative to beta distribution in some cases. In this work, we introduce the TSP-binomial model which is defined as a mixture of binomial distributions, with the binomial parameter p having a TSP distribution. We study its distributional properties and demonstrate its use on some data. It is shown that the newly defined model is a useful candidate for overdispersed binomial data.     

Modelling claim number using a new mixture model: negative binomial gamma distribution

ABSTRACT

In actuarial applications, mixed Poisson distributions are widely used for modelling claim counts as observed data on the number of claims often exhibit a variance noticeably exceeding the mean. In this study, a new claim number distribution is obtained by mixing negative binomial parameter p which is reparameterized as p?=?exp( ?λ) with Gamma distribution. Basic properties of this new distribution are given. Maximum likelihood estimators of the parameters are calculated using the Newton–Raphson and genetic algorithm (GA). We compared the performance of these methods in terms of efficiency by simulation. A numerical example is provided.     

A note on an integer valued time series model with Poisson–negative binomial marginal distribution

Abstract

This paper proposes a new model for autoregressive time series of counts in terms of a convolution of Poisson and negative binomial random variables, known as Poisson–negative binomial (PNB) distribution. The corresponding first-order integer valued time series models are developed and their properties are discussed. The geometric PNB and the geometric semi PNB distributions are also introduced and studied.