Hazards Regression for Cancer Studies

The complication in analyzing tumor data is that the tumors detected in a screening program tend to be slowly progressive tumors, which is the so-called length-biased sampling that is inherent in screening studies. Under the assumption that all subjects have the same tumor growth function, Ghosh (2008 Ghosh , D. ( 2008 ). Proportional hazards regression for cancer studies . Biometrics 64 : 141 – 148 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) developed estimation procedures for proportional hazards model. In this article, by modeling growth function as a function of covariates, we demonstrate that Ghosh (2008 Ghosh , D. ( 2008 ). Proportional hazards regression for cancer studies . Biometrics 64 : 141 – 148 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar])'s approach can be extended to the case when each subject has a specific growth function. A simulation study is conducted to demonstrate the potential usefulness of the proposed estimators for the regression parameters in the proportional and additive hazards model.     

The Identification of Potential Longitudinal Biomarkers and Measurements of Effectiveness for Biomarkers as Surrogates in Multivariate Survival Data

A proposed method based on frailty models is used to identify longitudinal biomarkers or surrogates for a multivariate survival. This method is an extention of earlier models by Wulfsohn and Tsiatis (1997 Wulfsohn , M. S. , Tsiatis , A. A. ( 1997 ). A joint model for survival and longitudinal data measured with error . Biometrics 53 ( 1 ): 330 – 339 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) and Song et al. (2002 Song , X. , Davidian , M. , Tsiatis , A. A. ( 2002 ). A Semiparametric likelihood approach to joint modeling of longitudinal and time-to-event data . Biometrics 58 ( 4 ): 742 – 753 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]). In this article, similar to Henderson et al. (2002 Henderson , R. , Diggle , P. J. , Dobson , A. ( 2002 ). Identification and efficacy of longitudinal markers for survival . Biostatistics 3 ( 1 ): 33 – 50 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]), a joint likelihood function combines the likelihood functions of the longitudinal biomarkers and the multivariate survival times. We use simulations to explore how the number of individuals, the number of time points per individual and the functional form of the random effects from the longitudianl biomarkers influence the power to detect the association of a longitudinal biomarker and the multivariate survival time. The proposed method is illustrate by using the gastric cancer data.     

Generalized Scrambling in Quantitative Optional Randomized Response Models

Huang (2010 Huang , K. C. ( 2010 ). Unbiased estimators of mean, variance and sensitivity level for quantitative characteristics in finite population sampling . Metrika 71 : 341 – 352 .[Crossref], [Web of Science ®] , [Google Scholar]) proposed an optional randomized response model using a linear combination scrambling which is a generalization of the multiplicative scrambling of Eichhorn and Hayre (1983 Eichhorn , B. H. , Hayre , L. S. ( 1983 ). Scrambled randomized response methods for obtaining sensitive quantitative data . J. Statist. Plann. Infer. 7 : 307 – 316 .[Crossref], [Web of Science ®] , [Google Scholar]) and the additive scrambling of Gupta et al. (2006, 2010). In this article, we discuss two main issues. (1) Can the Huang (2010 Huang , K. C. ( 2010 ). Unbiased estimators of mean, variance and sensitivity level for quantitative characteristics in finite population sampling . Metrika 71 : 341 – 352 .[Crossref], [Web of Science ®] , [Google Scholar]) model be improved further by using a two-stage approach?; (2) Does the linear combination scrambling provide any benefit over the additive scrambling of Gupta et al. (2010 Gupta , S. N. , Shabbir , J. , Sehra , S. ( 2010 ). Mean and sensitivity estimation in optional randomized response models . J. Statist. Plann. Infer. 140 : 2870 – 2874 .[Crossref], [Web of Science ®] , [Google Scholar])? We will note that the answer to the first question is “yes” but the answer to the second question is “no.”     

Comment on Ridge Estimation to the Restricted Linear Model

In this note, we show that the estimator and the following results given by Zhong and Yang (2007 Zhong , Z. , Yang , H. ( 2007 ). Ridge estimation to the restricted linear model . Commun. Statist. Theor. Meth. 36 : 2099 – 2115 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) are the same with that of Groß (2003 Groß , J. ( 2003 ). Restricted ridge estimation . Statist. Probab. Lett. 65 : 57 – 64 .[Crossref], [Web of Science ®] , [Google Scholar]).     

A New Two-Parameter Estimator in Linear Regression

This article is concerned with the parameter estimation in linear regression model. To overcome the multicollinearity problem, a new two-parameter estimator is proposed. This new estimator is a general estimator which includes the ordinary least squares (OLS) estimator, the ridge regression (RR) estimator, and the Liu estimator as special cases. Necessary and sufficient conditions for the superiority of the new estimator over the OLS, RR, Liu estimators, and the two-parameter estimator proposed by Ozkale and Kaciranlar (2007 Ozkale , M. R. , Kaciranlar , S. ( 2007 ). The restricted and unrestricted two-parameter estimators . Commun. Statist. Theor. Meth. 36 : 2707 – 2725 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) in the mean squared error matrix (MSEM) sense are derived. Furthermore, we obtain the estimators of the biasing parameters and give a numerical example to illustrate some of the theoretical results.     

Additive Mixed Effect Model for Clustered Doubly Censored Data

Cai and Zeng (2011 Cai, J. and Zeng, D. 2011. Additive mixed effect model for clustered failure time data. Biometrics, 67(4): 1340–1351. [Crossref], [PubMed] , [Google Scholar]) proposed an additive mixed effect model to analyze clustered right-censored data. In this article, we demonstrate that the approach of Cai and Zeng (2011 Cai, J. and Zeng, D. 2011. Additive mixed effect model for clustered failure time data. Biometrics, 67(4): 1340–1351. [Crossref], [PubMed] , [Google Scholar]) can be extended to clustered doubly censored data. Furthermore, when both left- and right-censoring variables are always observed, we propose alternative estimators using the approach of Cai and Cheng (2004 Cai, T. and Cheng, S. C. 2004. Semiparametric regression analysis for doubly censored data. Biometrika, 91: 277–290. [Crossref], [Web of Science ®] , [Google Scholar]). A simulation study is conducted to investigate the performance of the proposed estimators.     

An Improved Solution for Multiple Comparisons with a Control in Response Surface Methodology with Two Predictor Variables

Sa and Edwards (1993 Sa , P. , Edwards , D. ( 1993 ). Multiple comparisons with a control in response surface methodology . Technometrics 35 ( 4 ): 436 – 445 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) first proposed the Multiple Comparisons with a Control problem in Response Surface Methodology. They provided an exact solution for one predictor variable and a conservative solution when number of predictor variables is more than one. Merchant et al. (1998 Merchant , A. , McCann , M. , Edwards , D. ( 1998 ). Improved multiple comparisons with a control in response surface analysis . Technometrics 40 ( 4 ): 291 – 303 .[Crossref], [Web of Science ®] , [Google Scholar]) improved the solution for the latter case. This article improves Merchant et al.'s solution for the case of rotatable designs in two predictor variables.     

A Note on Importance Resampling for Multi-Dimensional Statistics

Johns (1988 Johns , M. V. (1988). Importance sampling for bootstrap confidence intervals. Journal of the American Statistical Association 83:709–714.[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]), Davison (1988 Davison , A. C. ( 1988 ). Discussion of paper by D. V. Hinkley . Journal of the Royal Statistical Society Series B 50 : 356 – 357 . [Google Scholar]), and Do and Hall (1991 Do , K. A. , Hall , P. ( 1991 ). On importance sampling for the bootstrap . Biometrika 78 : 161 – 167 .[Crossref], [Web of Science ®] , [Google Scholar]) used importance sampling for calculating bootstrap distributions of one-dimensional statistics. Realizing that their methods can not be extended easily to multi-dimensional statistics, Fuh and Hu (2004 Fuh , C. D. , Hu , I. ( 2004 ). Efficient importance sampling for events of moderate deviations with applications . Biometrika 91 : 471 – 490 .[Crossref], [Web of Science ®] , [Google Scholar]) proposed an exponential tilting formula for statistics of multi-dimension, which is optimal in the sense that the asymptotic variance is minimized for estimating tail probabilities of asymptotically normal statistics. For one-dimensional statistics, Hu and Su (2008 Hu , J. , Su , Z. ( 2008 ). Adaptive resampling algorithms for estimating bootstrap distributions . Journal of Statistical Planning and Inference 138 ( 6 ): 1763 – 1777 .[Crossref], [Web of Science ®] , [Google Scholar]) proposed a multi-step variance minimization approach that can be viewed as a generalization of the two-step variance minimization approach proposed by Do and Hall (1991 Do , K. A. , Hall , P. ( 1991 ). On importance sampling for the bootstrap . Biometrika 78 : 161 – 167 .[Crossref], [Web of Science ®] , [Google Scholar]). In this article, we generalize the approach of Hu and Su (2008 Hu , J. , Su , Z. ( 2008 ). Adaptive resampling algorithms for estimating bootstrap distributions . Journal of Statistical Planning and Inference 138 ( 6 ): 1763 – 1777 .[Crossref], [Web of Science ®] , [Google Scholar]) to multi-dimensional statistics, which applies to general statistics and does not resort to asymptotics. Empirical results on a real survival data set show that the proposed algorithm provides significant computational efficiency gains.     

Tests of Multivariate Independence for Ordinal Data

Population and sample versions of Kendall and Spearman measures of association suitable for multivariate ordinal data are defined. The latter generalize the indices of dependence of Ruymgaart and van Zuijlen (1978 Ruymgaart , F. H. , van Zuijlen , M. C. A. ( 1978 ). Asymptotic normality of multivariate linear rank statistics in the non-i.i.d. case . Ann. Statist. 6 : 588 – 602 .[Crossref], [Web of Science ®] , [Google Scholar]), Joe (1990 Joe , H. ( 1990 ). Multivariate concordance . J. Multivariate Anal. 35 : 12 – 30 .[Crossref], [Web of Science ®] , [Google Scholar]), and Schmid and Schmidt (2007 Schmid , F. , Schmidt , R. ( 2007 ). Multivariate extensions of Spearman's rho and related statistics . Statist. Probab. Lett. 77 : 407 – 416 .[Crossref], [Web of Science ®] , [Google Scholar]) by allowing atoms in the underlying distribution. The representation of the proposed empirical measures as U-statistics enables to establish their asymptotic normality under general distributions. A special attention is given to tests of independence for multivariate ordinal data, where the power of the new methodologies are investigated under fixed and contiguous alternatives.     

GMM in linear regression for longitudinal data with multiple covariates measured with error

Griliches and Hausman 5 Griliches, Z. and Hausman, J. A. 1986. Errors in variables in panel data. J. Econometrics, 32: 93–118. [Crossref], [Web of Science ®] [Google Scholar] and Wansbeek 11 Wansbeek, T. J. 2001. GMM estimation in panel data models with measurement error. J. Econometrics, 104: 259–268. [Crossref], [Web of Science ®] [Google Scholar] proposed using the generalized method of moments (GMM) to obtain consistent estimators in linear regression models for longitudinal data with measurement error in one covariate, without requiring additional validation or replicate data. For usefulness of this methodology, we must extend it to the more realistic situation where more than one covariate are measured with error. Such an extension is not straightforward, since measurement errors across different covariates may be correlated. By a careful construction of the measurement error correlation structure, we are able to extend Wansbeek's GMM and show that the extended Griliches and Hausman's GMM is equivalent to the extended Wansbeek's GMM. For illustration, we apply the extended GMM to data from two medical studies, and compare it with the naive method and the method assuming only one covariate having measurement error.     

Panel Unit Root Tests in the Presence of Cross-Sectional Dependencies: Comparison and Implications for Modelling

Several panel unit root tests that account for cross-section dependence using a common factor structure have been proposed in the literature recently. Pesaran's (2007 Pesaran , M. H. ( 2007 ). A simple panel unit root test in the presence of cross section dependence . Journal of Applied Econometrics 22 : 265 – 312 .[Crossref], [Web of Science ®] , [Google Scholar]) cross-sectionally augmented unit root tests are designed for cases where cross-sectional dependence is due to a single factor. The Moon and Perron (2004 Moon , H. R. , Perron , B. (2004). Testing for a unit root in panels with dynamic factors. Journal of Econometrics 122:81–126.[Crossref], [Web of Science ®] , [Google Scholar]) tests which use defactored data are similar in spirit but can account for multiple common factors. The Bai and Ng (2004a Bai , J. , Ng , S. ( 2004a ). A PANIC attack on unit roots and cointegration . Econometrica 72 : 1127 – 1177 .[Crossref], [Web of Science ®] , [Google Scholar]) tests allow to determine the source of nonstationarity by testing for unit roots in the common factors and the idiosyncratic factors separately. Breitung and Das (2008 Breitung , J. , Das , S. ( 2008 ). Testing for unit roots in panels with a factor structure . Econometric Theory 24 : 88 – 108 .[Crossref], [Web of Science ®] , [Google Scholar]) and Sul (2007 Sul , D. ( 2007 ) . Panel Unit Root Tests Under Cross Section Dependence with Recursive Mean Adjustment . Mimeo : University of Auckland . [Google Scholar]) propose panel unit root tests when cross-section dependence is present possibly due to common factors, but the common factor structure is not fully exploited.

This article makes four contributions: (1) it compares the testing procedures in terms of similarities and differences in the data generation process, tests, null, and alternative hypotheses considered, (2) using Monte Carlo results it compares the small sample properties of the tests in models with up to two common factors, (3) it provides an application which illustrates the use of the tests, and (4) finally, it discusses the use of the tests in modelling in general.     

Computing the Exact Fisher Information Matrix of Periodic State-Space Models

The purpose of this article is to develop algorithms for computing the exact Fisher information matrix of periodic time-varying state-space models. We first present a relatively simple recursive algorithm which computes the elements of the exact information matrix without involving numerical differentiation, since all required derivatives are analytically evaluated. The proposed algorithm extends the procedure due to Cavanaugh and Shumway (1996 Cavanaugh , J. E. , Shumway , R. H. ( 1996 ). On computing the expected Fisher information matrix for state-space model parameters . Statist. Probab. Lett. 26 : 347 – 355 .[Crossref], [Web of Science ®] , [Google Scholar]) to the periodic state-space framework. Exploiting the approach used in Klein et al. (2000 Klein , A. , Mélard , G. , Zahaf , T. ( 2000 ). Construction of the exact Fisher information matrix of Gaussian time series models by means of matrix differential rules . Linear Alg. Applic. 321 : 209 – 232 .[Crossref], [Web of Science ®] , [Google Scholar]), a second algorithm is proposed in order to obtain the exact information matrix as a whole instead of element by element. The algorithms are first developed in a general framework and then specialized to the case of a periodic Gaussian vector autoregressive moving-average (PVARMA) model.     

A Comparison of Procedures for Controlling the False Discovery Rate in the Presence of Small Variance Genes: A Simulation Study

The Significance Analysis of Microarrays (SAM; Tusher et al., 2001 Tusher , V. G. , Tibshirani , R. , Chu , G. ( 2001 ). Significance analysis of microarrys applied to the ionizing radiation response . Proceedings of the National Academy of Sciences 98 : 5116 – 5121 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) method is widely used in analyzing gene expression data while controlling the FDR by using resampling-based procedure in the microarray setting. One of the main components of the SAM procedure is the adjustment of the test statistic. The introduction of the fudge factor to the test statistic aims at deflating the large value of test statistics due to the small standard error of gene-expression. Lin et al. (2008 Lin , D. , Shkedy , Z. , Burzykowski , T. , Göhlmann , H. W. H. , De Bondt , A. , Perera , T. , Geerts , T. , Bijnens , L. ( 2008 ). Significance analysis of microarray (SAM) for comparisons of several treatments with one control . Biometric Journal, MCP 50 ( 5 ): 801 – 823 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) pointed out that the fudge factor does not effectively improve the power and the control of the FDR as compared to the SAM procedure without the fudge factor in the presence of small variance genes. Motivated by the simulation results presented in Lin et al. (2008 Lin , D. , Shkedy , Z. , Burzykowski , T. , Göhlmann , H. W. H. , De Bondt , A. , Perera , T. , Geerts , T. , Bijnens , L. ( 2008 ). Significance analysis of microarray (SAM) for comparisons of several treatments with one control . Biometric Journal, MCP 50 ( 5 ): 801 – 823 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]), in this article, we extend our study to compare several methods for choosing the fudge factor in the modified t-type test statistics and use simulation studies to investigate the power and the control of the FDR of the considered methods.     

Correlation Structure and Model Selection for Negative Binomial Distribution in GEE

A new model selection criterion, termed as the “quasi-likelihood under the independence model criterion” (QIC), was proposed by Pan (2001 Pan , W. ( 2001 ). Akaike's information criterion in generalized estimating equations . Biometrics 57 : 120 – 125 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) for GEE models. Cui (2007 Cui , J. ( 2007 ). QIC program and model selection in GEE analyses . Stata Journal 7 : 209 – 220 .[Web of Science ®] , [Google Scholar]) developed a general computing program to implement the QIC method for a range of statistical distributions. However, only a special case of the negative binomial distribution was considered in Cui (2007 Cui , J. ( 2007 ). QIC program and model selection in GEE analyses . Stata Journal 7 : 209 – 220 .[Web of Science ®] , [Google Scholar]), where the dispersion parameter equals to unity. This article introduces a new computing program that can be applied for the general negative binomial model, where the dispersion parameter can be any fixed value. An example is also given in this article.     

An Inverse-Probability-Weighted Approach to the Estimation of Successive Duration Times under Left-Truncation and Right-Censoring

In incident cohort studies, survival data often include subjects who have had an initiate event at recruitment and may potentially experience two successive events (first and second) during the follow-up period. Since the second duration process becomes observable only if the first event has occurred, left-truncation and dependent censoring arise if the two duration times are correlated. To confront the two potential sampling biases, Chang and Tzeng (2006 Chang , S.-H. , Tzeng , S.-J. (2006). Noparametric estimation of sojourn time distributions for truncated serial event data- a weight-adjusted approach. Lifetime Data Anal. 53–67.[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) provided an inverse-probability-weighted (IPW) approach for estimating the joint probability function of successive duration times. In this note, an alternative IPW approach is proposed. A simulation study is conducted to compare the two IPW approaches.     

Simultaneous Confidence Intervals for the Parameters of Pareto Distribution under Progressive Censoring

In this article, we consider the progressive Type II right censored sample from Pareto distribution. We introduce a new approach for constructing the simultaneous confidence interval of the unknown parameters of this distribution under progressive censoring. A Monte Carlo study is also presented for illustration. It is shown that this confidence region has a smaller area than that introduced by Ku? and Kaya (2007 Ku? , C. , Kaya , M. F. ( 2007 ). Estimation for the parameters of the Pareto distribution under progressive censoring . Commun. Statist. Theor. Meth. 36 : 1359 – 1365 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]).     

A Generalization of the Skew-Normal Distribution: The Beta Skew-Normal

We consider a new generalization of the skew-normal distribution introduced by Azzalini (1985 Azzalini , A. ( 1985 ). A class of distributions which includes the normal ones . Scand. J. Statis. 12 ( 2 ): 171 – 178 .[Web of Science ®] , [Google Scholar]). We denote this distribution Beta skew-normal (BSN) since it is a special case of the Beta generated distribution (Jones, 2004 Jones , M. C. ( 2004 ). Families of distributions of order statistics . Test 13 ( 1 ): 1 – 43 .[Crossref], [Web of Science ®] , [Google Scholar]). Some properties of the BSN are studied. We pay attention to some generalizations of the skew-normal distribution (Bahrami et al., 2009 Bahrami , W. , Agahi , H. , Rangin , H. ( 2009 ). A two-parameter Balakrishnan skew-normal distribution . J. Statist. Res. Iran 6 : 231 – 242 . [Google Scholar]; Sharafi and Behboodian, 2008 Sharafi , M. , Behboodian , J. ( 2008 ). The Balakrishnan skew-normal density . Statist. Pap. 49 : 769 – 778 .[Crossref], [Web of Science ®] , [Google Scholar]; Yadegari et al., 2008 Yadegari , I. , Gerami , A. , Khaledi , M. J. ( 2008 ). A generalization of the Balakrishnan skew-normal distribution . Statist. Probab. Lett. 78 : 1165 – 1167 .[Crossref], [Web of Science ®] , [Google Scholar]) and to their relations with the BSN.     

Tests for Multiple Outliers in an Exponential Sample

By applying the recursion of Huffer (1988 Huffer, F. 1988. Divided differences and the joint distribution of linear combinations of spacings. Journal of Applied Probability, 25: 346–354. [Crossref], [Web of Science ®] , [Google Scholar]) repeatedly, we propose an algorithm for evaluating the null joint distribution of Dixon-type test statistics for testing discordancy of k upper outliers in exponential samples. By using the critical values of Dixon-type test statistics determined from the proposed algorithm and those of Cochran-type test statistics presented earlier by Lin and Balakrishnan (2009 Lin, C. T. and Balakrishnan, N. 2009. Exact computation of the null distribution of a test for multiple outliers in an exponential sample. Computational Statistics & Data Analysis, 53: 3281–3290. [Crossref], [Web of Science ®] , [Google Scholar]), we carry out an extensive Monte Carlo study to investigate the powers and the error probabilities for the effects of masking and swamping when the number of outliers k = 2 and 3. Based on our empirical findings, we recommend Rosner’s (1975 Rosner, B. 1975. On the detection of many outliers. Technometrics, 17: 221–227. [Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) sequential test procedure based on Dixon-type test statistics for testing multiple outliers from an exponential distribution.     

Local Linear Estimation of Second-Order Diffusion Models

In this article, we present the local linear estimations for diffusion coefficient and drift coefficient in the second-order diffusion model. We show that under mild conditions, the estimators are weak consistent. We also use a Monte Carlo experiment to compare our estimators with the ones in Nicolau (2007 Nicolau , J. ( 2007 ). Nonparametric estimation of scend-order stochastic differential equations . Econometric Theor. 23 : 880 – 898 .[Crossref], [Web of Science ®] , [Google Scholar]).     

Generalized Symmetric Divergence Measures and the Probability of Error

There are three classical divergence measures exist in the literature on information theory and statistics. These are namely, Jeffryes-Kullback-Leiber (Jeffreys, 1946 Jeffreys , H. ( 1946 ). An invariant form for the prior probability in estimation problems . Proc. Roy. Soc. Lon. Ser. A 186 : 453 – 461 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]; Kullback and Leibler, 1951 Kullback , S. , Leibler , R. A. ( 1951 ). On information and sufficiency . Ann. Math. Statist. 22 : 79 – 86 .[Crossref] , [Google Scholar]) J-divergence. Sibson-Burbea-Rao (Sibson, 1969 Sibson , R. ( 1969 ). Information radius . Z. Wahrs. und verw Geb. 14 : 149 – 160 .[Crossref], [Web of Science ®] , [Google Scholar]), Jensen-Shannon divegernce, (Burbea and Rao, 1982 Burbea , J. , Rao , C. R. ( 1982 ). On the convexity of some divergence measures based on entropy functions . IEEE Trans. Inform. Theor. IT-28 : 489 – 495 .[Crossref], [Web of Science ®] , [Google Scholar]), and Taneja (1995 Taneja , I.J. ( 1995 ). New developments in generalized information measures , In: Hawkes , P. W. , Ed., Advances in Imaging and Electron Physics . 91:37–136 . [Google Scholar]). Arithmetic-Geometric divergence. These three measures bear an interesting relationship among each other. The divergence measures like Hellinger (1909 Hellinger , H. ( 1909 ). Neue Begründung der theorie der quadratischen formen von unendlichen vielen Veränderlichen . J. Reine Aug. Math. 136 : 210 – 271 .[Crossref] , [Google Scholar]) discrimination, symmetric χ²-divergence, and triangular discrimination are also known in the literature. In this article, we have considered generalized symmetric divergence measures having the measures given above as particular cases. Bounds on the probability of error are obtained in terms of generalized symmetric divergence measures. Study of bounds on probability of error is extended for the difference of divergence measures.