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1.
The Significance Analysis of Microarrays (SAM; Tusher et al., 2001) method is widely used in analyzing gene expression data while controlling the FDR by using resampling-based procedure in the microarray setting. One of the main components of the SAM procedure is the adjustment of the test statistic. The introduction of the fudge factor to the test statistic aims at deflating the large value of test statistics due to the small standard error of gene-expression. Lin et al. (2008) pointed out that the fudge factor does not effectively improve the power and the control of the FDR as compared to the SAM procedure without the fudge factor in the presence of small variance genes. Motivated by the simulation results presented in Lin et al. (2008), in this article, we extend our study to compare several methods for choosing the fudge factor in the modified t-type test statistics and use simulation studies to investigate the power and the control of the FDR of the considered methods. 相似文献
2.
We propose a class of estimators for the population mean when there are missing data in the data set. Obtaining the mean square error equations of the proposed estimators, we show the conditions where the proposed estimators are more efficient than the sample mean, ratio-type estimators, and the estimators in Singh and Horn (2000) and Singh and Deo (2003) in the case of missing data. These conditions are also supported by a numerical example. 相似文献
3.
Oluseun Odumade 《统计学通讯:模拟与计算》2013,42(3):473-502
In this article, two new improved randomized response models have been proposed. The proposed models are found to be more efficient than the recent randomized response model studied by Bar-Lev et al. (2004). The relative efficiency of the proposed models has been studied with respect to the Bar-Lev et al. (2004) model under different situations. 相似文献
4.
Feng-Shou Ko 《统计学通讯:理论与方法》2013,42(15):2681-2698
A proposed method based on frailty models is used to identify longitudinal biomarkers or surrogates for a multivariate survival. This method is an extention of earlier models by Wulfsohn and Tsiatis (1997) and Song et al. (2002). In this article, similar to Henderson et al. (2002), a joint likelihood function combines the likelihood functions of the longitudinal biomarkers and the multivariate survival times. We use simulations to explore how the number of individuals, the number of time points per individual and the functional form of the random effects from the longitudianl biomarkers influence the power to detect the association of a longitudinal biomarker and the multivariate survival time. The proposed method is illustrate by using the gastric cancer data. 相似文献
5.
AbstractWhen the mixed chart proposed by Aslam et al. (2015) is in use, the sample items are classified as defective or not defective and, depending on the number of defectives, the quality characteristic X of the sample items are also measured. In this case, an Xbar chart decides the state of the process. The previous conforming/non-conforming classification truncates the X distribution and, because of that, the mathematical development to obtain the ARLs is complex. Aslam et al. (2015) didn’t pay attention to the fact that the X distribution is truncated and, due to that, they obtained incorrect ARLs. 相似文献
6.
Housila P. Singh 《统计学通讯:理论与方法》2013,42(6):1008-1023
This paper suggests an efficient class of ratio and product estimators for estimating the population mean in stratified random sampling using auxiliary information. It is interesting to mention that, in addition to many, Koyuncu and Kadilar (2009), Kadilar and Cingi (2003, 2005), and Singh and Vishwakarma (2007) estimators are identified as members of the proposed class of estimators. The expressions of bias and mean square error (MSE) of the proposed estimators are derived under large sample approximation in general form. Asymptotically optimum estimator (AOE) in the class is identified alongwith its MSE formula. It has been shown that the proposed class of estimators is more efficient than combined regression estimator and Koyuncu and Kadilar (2009) estimator. Moreover, theoretical findings are supported through a numerical example. 相似文献
7.
In this paper, we investigate the effect of pre-smoothing on model selection. Christóbal et al 6 showed the beneficial effect of pre-smoothing on estimating the parameters in a linear regression model. Here, in a regression setting, we show that smoothing the response data prior to model selection by Akaike's information criterion can lead to an improved selection procedure. The bootstrap is used to control the magnitude of the random error structure in the smoothed data. The effect of pre-smoothing on model selection is shown in simulations. The method is illustrated in a variety of settings, including the selection of the best fractional polynomial in a generalized linear model. 相似文献
8.
Difference-based estimators for the error variance are popular since they do not require the estimation of the mean function. Unlike most existing difference-based estimators, new estimators proposed by Müller et al. (2003) and Tong and Wang (2005) achieved the asymptotic optimal rate as residual-based estimators. In this article, we study the relative errors of these difference-based estimators which lead to better understanding of the differences between them and residual-based estimators. To compute the relative error of the covariate-matched U-statistic estimator proposed by Müller et al. (2003), we develop a modified version by using simpler weights. We further investigate its asymptotic property for both equidistant and random designs and show that our modified estimator is asymptotically efficient. 相似文献
9.
Pao-Sheng Shen 《统计学通讯:模拟与计算》2013,42(3):603-612
In this article, we consider the M-estimators for the linear regression model when both response and covariate variables are subject to double censoring. The proposed estimators are constructed as some functional of three types of estimators for a bivariate survival distribution. The first two estimators are the generalizations of the Campbell and Földes (1982) and Dabrowska (1988) estimators proposed by Shen (2009). The third estimator is the generalization of the Prentice and Cai (1992) estimator. The consistency of the proposed M-estimators is established. A simulation study is conducted to investigate the performance of the proposed estimators. Furthermore, the simple bootstrap methods are used to estimate standard deviations and construct interval estimators. 相似文献
10.
This article considers the problem of estimating the population mean using information on two auxiliary variables in the presence of non response under two-phase sampling. Some improved ratio-in-regression type estimators have been proposed in four different situations of non response along with their properties under large sample approximation. Efficiency comparisons of the proposed estimators with the usual unbiased estimator by Hansen and Hurwitz (1946), conventional ratio and regression estimators using single auxiliary variable and Singh and Kumar (2010b) estimators using two auxiliary variables have been made. Finally, these theoretical findings are illustrated by a numerical example. 相似文献
11.
Pao-Sheng Shen 《统计学通讯:模拟与计算》2013,42(10):2295-2307
Cai and Zeng (2011) proposed an additive mixed effect model to analyze clustered right-censored data. In this article, we demonstrate that the approach of Cai and Zeng (2011) can be extended to clustered doubly censored data. Furthermore, when both left- and right-censoring variables are always observed, we propose alternative estimators using the approach of Cai and Cheng (2004). A simulation study is conducted to investigate the performance of the proposed estimators. 相似文献
12.
Robert M. Adams 《统计学通讯:理论与方法》2013,42(13):2425-2442
This article generalizes results from Park et al. (1998) and Adams et al. (1999) on semiparametric efficient estimation of panel models. The form of semiparametric efficient estimators depends on the statistical assumptions imposed. Normality assumptions on the transitory error are sometimes inappropriate. We relax the normality assumption used in the articles above to derive more general semiparametric efficient estimators. These estimators are illustrated in a Monte Carlo simulation and an analysis of banking productivity. 相似文献
13.
Here, we apply the smoothing technique proposed by Chaubey et al. (2007) for the empirical survival function studied in Bagai and Prakasa Rao (1991) for a sequence of stationary non-negative associated random variables.The derivative of this estimator in turn is used to propose a nonparametric density estimator. The asymptotic properties of the resulting estimators are studied and contrasted with some other competing estimators. A simulation study is carried out comparing the recent estimator based on the Poisson weights (Chaubey et al., 2011) showing that the two estimators have comparable finite sample global as well as local behavior. 相似文献
14.
We consider non-parametric estimation of a continuous cdf of a random vector (X 1, X 2). With bivariate RC data, it is stated in van der Laan (1996, p. 59810, Ann. Statist.), Quale et al. (2006, JASA) etc. that “it is well known that the NPMLE for continuous data is inconsistent (Tsai et al. (1986)).” The claim is based on a result in Tsai et al. (1986, p.1352, Ann. Statist.) that if X 1 is right censored but not X 2, then common ways for defining one NPMLE lead to inconsistency. If X 1 is right censored and X 2 is type I right-censored (which includes the case in Tsai et al.), we present a consistent NPMLE. The result corrects a common misinterpretation of Tsai's example (Tsai et al., 1986, Ann. Statist.). 相似文献
15.
Feng-Shou Ko 《统计学通讯:理论与方法》2013,42(18):3222-3237
We introduce a score test to identify longitudinal biomarkers or surrogates for a time to event outcome. This method is an extension of Henderson et al. (2000, 2002). In this article, a score test is based on a joint likelihood function which combines the likelihood functions of the longitudinal biomarkers and the survival times. Henderson et al. (2000, 2002) assumed that the same random effect exists in the longitudinal component and in the Cox model and then they can derive a score test to determine if a longitudinal biomarker is associated with time to an event. We extend this work and our score test is based on a joint likelihood function which allows other random effects to be present in the survival function. Considering heterogeneous baseline hazards in individuals, we use simulations to explore how the factors can influence the power of a score test to detect the association of a longitudinal biomarker and the survival time. These factors include the functional form of the random effects from the longitudinal biomarkers, in the different number of individuals, and time points per individual. We illustrate our method using a prothrombin index as a predictor of survival in liver cirrhosis patients. 相似文献
16.
This article presents results concerning the performance of both single equation and system panel cointegration tests and estimators. The study considers the tests developed in Pedroni (1999, 2004), Westerlund (2005), Larsson et al. (2001), and Breitung (2005) and the estimators developed in Phillips and Moon (1999), Pedroni (2000), Kao and Chiang (2000), Mark and Sul (2003), Pedroni (2001), and Breitung (2005). We study the impact of stable autoregressive roots approaching the unit circle, of I(2) components, of short-run cross-sectional correlation and of cross-unit cointegration on the performance of the tests and estimators. The data are simulated from three-dimensional individual specific VAR systems with cointegrating ranks varying from zero to two for fourteen different panel dimensions. The usual specifications of deterministic components are considered. 相似文献
17.
Nonlinear heteroscedastic models are widely used in econometrics and statistical applications. We derive matrix formulae for the second-order biases of the maximum likelihood estimators of the parameters in the mean and variance response which generalize previous results by Cook et al. (1986) and Cordeiro (1993). The biases of the estimators are easily obtained as vectors of regression coefficients from suitable weighted linear regressions. The practical use of such biases is illustrated in a simulation study and in an application to a real data set. 相似文献
18.
Constantinos Petropoulos 《统计学通讯:理论与方法》2013,42(17):3153-3162
Under Stein's loss, a class of improved estimators for the scale parameter of a mixture of exponential distribution with unknown location is constructed. The method is analogous to Maruyama's (1998) construction for the variance of a normal distribution and also an extension of the result produced in Petropoulos and Kourouklis (2002). Also, robustness properties are considered. 相似文献
19.
Extending the bifurcating autoregressive (BAR) process (cf. Cowan and Staudte, 1986) to multi-casting (multi-splitting) data, Hwang and Choi (2009) introduced multi-casting autoregression (MCAR, for short) defined on multi-casting tree structured data. This article is concerned with the case when the MCAR model is partially specified only through conditional mean and variance without directly imposing autoregressive (AR) structure. The resulting class of models will be referred to as P-MCAR (partially specified MCAR). The P-MCAR considerably enlarges the class of multi-casting models including (as special cases) MCAR, random coefficient MCAR, conditionally heteroscedastic multi-casting models and binomial-thinning processes. Moment structures for this broad P-MCAR class are investigated. Least squares (LS) estimation method is discussed and asymptotic relative efficiency (ARE) of the generalized-LS over ordinary-LS is obtained in a closed form. A simulation study is conducted to illustrate results. 相似文献
20.
Shesh N. Rai Jianmin Pan Xiaobin Yuan Jianguo Sun Melissa M. Hudson Deo K. Srivastava 《统计学通讯:理论与方法》2013,42(17):3117-3133
New drug discovery in the pediatrics has dramatically improved survival, but with long- term adverse events. This motivates the examination of adverse outcomes such as long-term toxicity in a phase IV trial. An ideal approach to monitor long-term toxicity is to systematically follow the survivors, which is generally not feasible. Instead, cross-sectional surveys are conducted in Hudson et al. (2007), with one of the objectives to estimate the cumulative incidence rates along with specific interest in fixed-term (5 or 10 year) rates. We present inference procedures based on current status data to our motivating example with very interesting findings. 相似文献