Optimal split‐plot orthogonal arrays

It is well known that many industrial experiments have split‐plot structures. Compared to completely randomised experiments, split‐plot designs are more economical and thus have received much attention among researchers. Much work has been done for two‐level split‐plot designs. In this article, we consider split‐plot designs with factors of three, more than three, or mixed levels and with both qualitative and quantitative factors. We show that if two designs with both qualitative and quantitative factors are geometrically isomorphic, then their generalised wordlength patterns are identical. Three design scenarios are considered for optimal designs. The corresponding wordlength patterns are defined and the minimum aberration mixed‐level split‐plot designs having 18 and 36 runs are tabulated.     

Isomorphism check in fractional factorial designs via letter interaction pattern matrix

Two fractional factorial designs are considered isomorphic if one can be obtained from the other by relabeling the factors, reordering the runs, and/or switching the levels of factors. To identify the isomorphism of two designs is known as an NP hard problem. In this paper, we propose a three-dimensional matrix named the letter interaction pattern matrix (LIPM) to characterize the information contained in the defining contrast subgroup of a regular two-level design. We first show that an LIPM could uniquely determine a design under isomorphism and then propose a set of principles to rearrange an LIPM to a standard form. In this way, we can significantly reduce the computational complexity in isomorphism check, which could only take O(2^p)+O(3k³)+O(2^k) operations to check two 2^k−p designs in the worst case. We also find a sufficient condition for two designs being isomorphic to each other, which is very simple and easy to use. In the end, we list some designs with the maximum numbers of clear or strongly clear two-factor interactions which were not found before.     

An Optimality Probability Index for Correlated Multiple Responses

In the real problems, there are many cases which have correlated quality characteristics so multiple response optimization can be more realistic if we can consider correlation structure of responses. In this study we propose a new method which uses multivariate normal probability to find the optimal treatment in an experimental design. Moreover, a heuristic method is used to find better factors’ level in all possible combinations in the designs with large number of controllable factors and their levels. Some simulated numerical examples and a real case were studied by the proposed approach and the comparison of the results with previous methods show efficiency of the proposed method.     

Comparison of normal probability plots and dot plots in judging the significance of effects in two level factorial designs

In this article, we present a study carried out to compare the effectiveness of the normal probability plot (NPP) and a simple dot plot in assessing the significance of the effects in experimental designs with factors at two levels (2 ^k?p designs). Several groups of students who had just completed a course that covered factorial designs were asked to identify the significant effects in a total of 32 situations, 16 of which were represented using NPPs and the other 16 using dot plots. Although the 32 scenarios were said to be different, there were really only 16 different situations, each of which was represented using the two methods to be compared. A simple graphical analysis shows no evidence that there is a difference between the two procedures. However, in designs with 16 runs there are some cases where NPP seems to give slightly better results.     

A simple method to obtain minimum aberration split-plot designs

ABSTRACT

Split-plot designs have been utilized in factorial experiments with some factors applied to larger units and others to smaller units. Such designs with low aberration are preferred when the experimental size and the number of factors considered in both whole plot and subplot are determined. The minimum aberration split-plot designs can be obtained using either computer algorithms or the exhausted search. In this article, we propose a simple, easy-to-operate approach by using two ordered sequences of columns from two orthogonal arrays in obtaining minimum aberration split-plot designs for experiments of sizes 16 and 32.     

Orthogonal blocking of response surface split-plot designs

When all experimental runs cannot be performed under homogeneous conditions, blocking can be used to increase the power for testing the treatment effects. Orthogonal blocking provides the same estimator of the polynomial effects as the one that would be obtained by ignoring the blocks. In many real-life design scenarios, there is at least one factor that is hard to change, leading to a split-plot structure. This paper shows that for a balanced ordinary least square–generalized least square equivalent split-plot design, orthogonal blocking can be achieved. Orthogonally blocked split-plot central composite designs are constructed and a catalog is provided.     

A comparison of random balance and two-stage group screening designs: A case study

In this paper we focus on the problem of supersaturated (fewer runs than factors) screening experiments. We consider two major types of designs which have been proposed in this situ¬ation: random balance and two-stage group screening. We discuss the relative merits and demerits of each strategy. In addition, we compare the performance of these strategies by means of a case study in which 100 factors are screened in 20,42,62, and 84 runs.     

The construction of multi-factor crossover designs in animal husbandry studies

For ethical reasons it is important to try to obtain as much useful information as possible from an animal experiment whilst minimizing the number of animals used. Crossover designs, where applicable, provide an ideal framework for achieving this. If two or more treatment factors are included in the crossover design then the reduction in total animal usage can be considerable. In this paper we consider such designs, defined as multi-factor crossover designs. The designs are applicable when there are several different treatment factors, each at t levels, to be applied to the experimental units. The motivation for investigating these designs was a study conducted at GlaxoSmithKline to determine the preference of male and female dogs for t=5 different types of bed and t=5 different bedding conditions. A construction method is given for forming universally optimal designs for t not too large. Also given is an example for the special case where the number of treatment levels t=6.     

Nested Latin Hypercube Designs with Sliced Structures

In computer experiments, space-filling designs with a sliced structure or nested structure have received much recent interest and been studied separately. However, it is likely that designs with both structures are needed in some situations, but there are no suitable designs so far. In this paper, we construct a special class of nested Latin hypercube designs with sliced structures, in such a design, a small sliced Latin hypercube design is nested within a large one. The construction method is easy to implement and the number of factors is flexible. Numerical simulations show the usefulness of the newly proposed designs.     

Optimal blocked main effects plans

In this paper, we consider the construction of optimal blocked main effects designs where m two-level factors are to be studied in N runs which are partitioned into b blocks of equal size. For N ≡ 2±od4 sufficient conditions are derived for a design to be Φ _f optimal among all designs having main effects occurring equally often at their high and low levels within blocks and then this result is extended to the class of all designs for the case when the block size is two. Methods of constructing designs satisfying the sufficient conditions derived are also given.     

The robustness of response surface designs with errors in factor levels

ABSRTACT

Since errors in factor levels affect the traditional statistical properties of response surface designs, an important question to consider is robustness of design to errors. However, when the actual design could be observed in the experimental settings, its optimality and prediction are of interest. Various numerical and graphical methods are useful tools for understanding the behavior of the designs. The D- and G-efficiencies and the fraction of design space plot are adapted to assess second-order response surface designs where the predictor variables are disturbed by a random error. Our study shows that the D-efficiencies of the competing designs are considerably low for big variance of the error, while the G-efficiencies are quite good. Fraction of design space plots display the distribution of the scaled prediction variance through the design space with and without errors in factor levels. The robustness of experimental designs against factor errors is explored through comparative study. The construction and use of the D- and G-efficiencies and the fraction of design space plots are demonstrated with several examples of different designs with errors.     

Experimental design for product improvement

Fractional factorial designs have been used successfullyin industry and elsewhere todetect and estimate sparse factor effects , The effectsusually evisioned measure changes in location associated with the experimental factors . Here we consider the possibility of detecting and estimating sparse dispersion effects measuring changes in variance associated with the factors .

( 2 ) In industrial experimentation it is frequently true thata large proportion of process v ariation is associated with a smallproportion of the process variables . In such circum stancs of“effect sparsity”unreplicated fractional designs have frequently been effectivein islolating preponderant factors.A very useful graphical analysis for such experiments

due to Cuthbert Daniel(1959)employs normal probability plotting.A more formal analysis is presented here which might be used to supplement such plots.     

A multi-objective coordinate-exchange two-phase local search algorithm for multi-stratum experiments

A multi-stratum design is a useful tool for industrial experimentation, where factors that have levels which are harder to set than others, due to time or cost constraints, are frequently included. The number of different levels of hardness to set defines the number of strata that should be used. The simplest case is the split-plot design, which includes two strata and two sets of factors defined by their level of hardness-to-set. In this paper, we propose a novel computational algorithm which can be used to construct optimal multi-stratum designs for any number of strata and up to six optimality criteria simultaneously. Our algorithm allows the study of the entire Pareto front of the optimization problem and the selection of the designs representing the desired trade-off between the competing objectives. We apply our algorithm to several real case scenarios and we show that the efficiencies of the designs obtained present experimenters with several good options according to their objectives.     

A survey and evaluation of methods for determination of combinatorial equivalence of factorial designs

Equivalent factorial designs have identical statistical properties for estimation of factorial contrasts and for model fitting. Non-equivalent designs, however, may have the same statistical properties under one particular model but different properties under a different model. In this paper, we describe known methods for the determination of equivalence or non-equivalence of two-level factorial designs, whether they be regular factorial designs, non-regular orthogonal arrays, or have no particular structure. In addition, we evaluate a number of potential fast screening methods for detecting non-equivalence of designs. Although the paper concentrates mainly on symmetric designs with factors at two levels, we also evaluate methods of determining combinatorial equivalence and non-equivalence of three-level designs and indicate extensions to larger numbers of levels and to asymmetric designs.     

Experimentation order in factorial designs: new findings

Under some very reasonable hypotheses, it becomes evident that randomizing the run order of a factorial experiment does not always neutralize the effect of undesirable factors. Yet, these factors do have an influence on the response, depending on the order in which the experiments are conducted. On the other hand, changing the factor levels is many times costly; therefore it is not reasonable to leave to chance the number of changes necessary. For this reason, run orders that offer the minimum number of factor level changes and at the same time minimize the possible influence of undesirable factors on the experimentation have been sought. Sequences which are known to produce the desired properties in designs with 8 and 16 experiments can be found in the literature. In this paper, we provide the best possible sequences for designs with 32 experiments, as well as sequences that offer excellent properties for designs with 64 and 128 experiments. The method used to find them is based on a mixture of algorithmic searches and an augmentation of smaller designs.     

Constructing non-regular robust parameter designs

In recent years there has been considerable attention paid to robust parameter design as a strategy for variance reduction. Of particular concern is the selection of a good experimental plan in light of the two different types of factors in the experiment (control and noise) and the asymmetric manner in which effects of the same order are treated. Recent work has focussed on the selection of regular fractional factorial designs in this setting. In this article, we consider the construction and selection of optimal non-regular experiment plans for robust parameter design. Our approach defines the word-length pattern for non-regular fractional factorial designs with two different types of factors which allows for the choice of optimal design to emphasize the estimation of the effects of interest. We use this new word-length pattern to rank non-regular robust parameter designs. We show that one can easily find minimum aberration robust parameter designs from existing orthogonal arrays. The methodology is demonstrated by finding optimal assignments for control and noise factors for 12, 16 and 20-run orthogonal arrays.     

On the E-optimality of blocked main effects plans in blocks of different sizes

In this article, we consider experimental situations in which m 2-level factors are to be studied using a main effects plan where n runs are to be partitioned into b blocks having both even and odd sizes. For these cases, we give some simple methods for constructing E-optimal designs.     

Efficient circular neighbour designs for spatial interference model

We consider circular block designs for field-trials when there are two-sided spatial interference between neighbouring plots of the same blocks. The parameter of interest is total effects that is the sum of direct effect of treatment and neighbour effects, which correspond to the use of a single treatment in the whole field. We determine universally optimal approximate designs. When the number of blocks may be large, we propose efficient exact designs generated by a single sequence of treatment. We also give efficiency factors of the usual binary block neighbour balanced designs which can be used when the number of blocks is small.     

2(n1+n2)-(k1+k2) Fractional factorial split-plot designs containing clear effects

Whole-plot (WP) factors and sub-plot (SP) factors play different roles in fractional factorial split-plot (FFSP) designs. In this paper, we consider FFSP designs with resolution III or IV from the viewpoint of clear factorial effects, classify two-factor interactions (2FIs) into three types, and give sufficient and necessary conditions for the existence of FFSP designs containing various clear factorial effects, including two types of main effects and three types of 2FIs. The structures of these designs are also shown and illustrated with examples.     

On the use of partial confounding for the construction of alternative regular two-level blocked fractional factorial designs

In this paper, we consider experimental situations in which a regular fractional factorial design is to be used to study the effects of m two-level factors using n=2^m−k experimental units arranged in 2^p blocks of size 2^m−k−p. In such situations, two-factor interactions are often confounded with blocks and complete information is lost on these two-factor interactions. Here we consider the use of the foldover technique in conjunction with combining designs having different blocking schemes to produce alternative partially confounded blocked fractional factorial designs that have more estimable two-factor interactions or a higher estimation capacity or both than their traditional counterparts.