共查询到20条相似文献,搜索用时 15 毫秒
1.
A fully parametric multistate model is explored for the analysis of animal carcinogenicity experiments in which the time of tumour onset is not known. This model does not require assumptions about tumour lethality or cause of death judgements and can be fitted in the absence of sacrifice data. The model is constructed as a three-state model with simple parametric forms for the transition rates. Maximum likelihood methods are used to estimate the transition rates and different treatment groups are compared using likelihood ratio tests. Selection of an appropriate model and methods to assess the fit of the model are illustrated with data from animal experiments. Comparisons with standard methods are made. 相似文献
2.
We consider a Cox-type regression model with change-points in the covariates. A change-point specifies the unknown threshold at which the influence of a covariate shifts smoothly, i.e., the regression parameter may change over the range of a covariate and the underlying regression function is continuous but not differentiable. The model can be used to describe change-points in different covariates but also to model more than one change-point in a single covariate. Estimates of the change-points and of the regression parameters are derived and their properties are investigated. It is shown that not only the estimates of the regression parameters are [Formula: see text] -consistent but also the estimates of the change-points in contrast to the conjecture of other authors. Asymptotic normality is shown by using results developed for M-estimators. At the end of this paper we apply our model to an actuarial dataset, the PBC dataset of Fleming and Harrington (Counting processes and survival analysis, 1991) and to a dataset of electric motors. 相似文献
3.
Consider a set of real valued observations collected over time. We pro¬pose a simple hidden Markow model for these realizations in which the the predicted distribution of the next future observation given the past is easily computed. The hidden or unobservable set of parameters is assumed to have a Markov structure of a special type. The model is quite flexible and can be used to incorporate different types of prior information in straightforward and sensible ways. 相似文献
4.
Assuming a first-order Markov chain, we propose a structural model for the transition probabilities in vote intention. The proposed model utilizes the ordering among the categories representing vote intentions and carries the flavor of distance models. It also allows a stochastic ordering among distributions reflecting the extent of change. The model is easy to fit and provides a nice interpretation of the data. The model is applied to a panel study of vote intention acquired through six successive interviews before the 1940 Presidential election in Erie County, Ohio. 相似文献
5.
A new general class of exponentiated sinh Cauchy regression models for location, scale, and shape parameters is introduced and studied. It may be applied to censored data and used more effectively in survival analysis when compared with the usual models. For censored data, we employ a frequentist analysis for the parameters of the proposed model. Further, for different parameter settings, sample sizes, and censoring percentages, various simulations are performed. The extended regression model is very useful for the analysis of real data and could give more adequate fits than other special regression models. 相似文献
6.
Rachel J. Mackay 《Revue canadienne de statistique》2002,30(4):573-589
While the estimation of the parameters of a hidden Markov model has been studied extensively, the consistent estimation of the number of hidden states is still an unsolved problem. The AIC and BIC methods are used most commonly, but their use in this context has not been justified theoretically. The author shows that for many common models, the penalized minimum‐distance method yields a consistent estimate of the number of hidden states in a stationary hidden Markov model. In addition to addressing the identifiability issues, she applies her method to a multiple sclerosis data set and assesses its performance via simulation. 相似文献
7.
The enzymatic 18O-labelling is a useful technique for reducing the influence of the between-spectra variability on the results of mass-spectrometry experiments. A difficulty in applying the technique lies in the quantification of the corresponding peptides due to the possibility of an incomplete labelling, which may result in biased estimates of the relative peptide abundance. To address the problem, Zhu et al. [A Markov-chain-based heteroscedastic regression model for the analysis of high-resolution enzymatically 18O-labeled mass spectra, J. Proteome Res. 9(5) (2010), pp. 2669–2677] proposed a Markov-chain-based regression model with heteroscedastic residual variance, which corrects for the possible bias. In this paper, we extend the model by allowing for the estimation of the technical and/or biological variability for the mass spectra data. To this aim, we use a mixed-effects version of the model. The performance of the model is evaluated based on results of an application to real-life mass spectra data and a simulation study. 相似文献
8.
9.
Arun Kumar Adhikary 《统计学通讯:理论与方法》2013,42(7):2291-2297
For any varying probability sampling design the Horvitz-Thompson (1952) estimator is shown to be optimal within the class of all unbiased estimators of a finite population total under a Markov process model 相似文献
10.
Kung-Yee Liang Steven G. Self Karen J. Bandeen-Roche Scott L. Zeger 《Lifetime data analysis》1995,1(4):403-415
Cox's seminal 1972 paper on regression methods for possibly censored failure time data popularized the use of time to an event as a primary response in prospective studies. But one key assumption of this and other regression methods is that observations are independent of one another. In many problems, failure times are clustered into small groups where outcomes within a group are correlated. Examples include failure times for two eyes from one person or for members of the same family.This paper presents a survey of models for multivariate failure time data. Two distinct classes of models are considered: frailty and marginal models. In a frailty model, the correlation is assumed to derive from latent variables (frailties) common to observations from the same cluster. Regression models are formulated for the conditional failure time distribution given the frailties. Alternatively, marginal models describe the marginal failure time distribution of each response while separately modelling the association among responses from the same cluster.We focus on recent extensions of the proportional hazards model for multivariate failure time data. Model formulation, parameter interpretation and estimation procedures are considered. 相似文献
11.
Bradley E. Huitema 《统计学通讯:理论与方法》2013,42(8):789-797
A simple Markov model is described for the analysis of interrupted time series experiments that employ a control series. The procedure involves regressing the experimental preintervention series on the control preintervention series and then testing for change in the experimental postintervention series which is free of change in the control series. 相似文献
12.
In some survival studies, the exact time of the event of interest is unknown, but the event is known to have occurred during a particular period of time (interval-censored data). If the diagnostic tool used to detect the event of interest is not perfectly sensitive and specific, outcomes may be mismeasured; a healthy subject may be diagnosed as sick and a sick one may be diagnosed as healthy. In such cases, traditional survival analysis methods produce biased estimates for the time-to-failure distribution parameters (Paggiaro and Torelli 2004). In this context, we developed a parametric model that incorporates sensitivity and specificity into a grouped survival data analysis (a case of interval-censored data in which all subjects are tested at the same predetermined time points). Inferential aspects and properties of the methodology, such as the likelihood function and identifiability, are discussed in this article. Assuming known and non differential misclassification, Monte Carlo simulations showed that the proposed model performed well in the case of mismeasured outcomes; the estimates of the relative bias of the model were lower than those provided by the naive method that assumes perfect sensitivity and specificity. The proposed methodology is illustrated by a study related to mango tree lifetimes. 相似文献
13.
David D. Hanagal 《Statistical Papers》2006,47(1):137-147
The most natural parametric distribution to consider is the Weibull model because it allows for both the proportional hazard
model and accelerated failure time model. In this paper, we propose a new bivariate Weibull regression model based on censored
samples with common covariates. There are some interesting biometrical applications which motivate to study bivariate Weibull
regression model in this particular situation. We obtain maximum likelihood estimators for the parameters in the model and
test the significance of the regression parameters in the model. We present a simulation study based on 1000 samples and also
obtain the power of the test statistics. 相似文献
14.
Ao Yuan George E. Bonney 《Journal of the Royal Statistical Society. Series C, Applied statistics》2006,55(4):539-550
Summary. In many commonly used models for multivariate traits, the likelihood is specified as a mixture of nested sums of products over the unobserved genotypes of all the family members, in which the familial covariance matrices vary in size and structure for different families, and their sizes can be immense for large family units. These issues pose computational difficulties in many applications. Bonney's compound regressive model for univariate traits simplifies the familial covariance structure and reduces the mixture of nested sums only to the parent–offspring level, thus enhancing computation significantly. This model has been extended to the multivariate case in the absence of unobserved genotypes. Here, we further extend this model to incorporate major genes, covariates and multiple loci. As is typical in practice, this causes new computational difficulties. We study the computational issues and explore the behaviour of this extended model. 相似文献
15.
Haitham M. Yousof Mahdi Rasekhi Morad Alizadeh G. G. Hamedani M. Masoom Ali 《统计学通讯:模拟与计算》2019,48(1):264-286
In this article, we introduce a new extension of Burr XII distribution called Topp Leone Generated Burr XII distribution. We derive some of its properties. Useful characterizations are presented. Simulation study is performed to assess the performance of the maximum likelihood estimators. Censored maximum likelihood estimation is presented in the general case of multi-censored data. The new location-scale regression model based on the proposed distribution is introduced. The usefulness of the proposed models is illustrated empirically by means of three real datasets. 相似文献
16.
The hidden Markov model (HMM) provides an attractive framework for modeling long-term persistence in a variety of applications including pattern recognition. Unlike typical mixture models, hidden Markov states can represent the heterogeneity in data and it can be extended to a multivariate case using a hierarchical Bayesian approach. This article provides a nonparametric Bayesian modeling approach to the multi-site HMM by considering stick-breaking priors for each row of an infinite state transition matrix. This extension has many advantages over a parametric HMM. For example, it can provide more flexible information for identifying the structure of the HMM than parametric HMM analysis, such as the number of states in HMM. We exploit a simulation example and a real dataset to evaluate the proposed approach. 相似文献
17.
In this paper, the dependence of transition probabilities on covariates and a test procedure for covariate dependent Markov models are examined. The nonparametric test for the role of waiting time proposed by Jones and Crowley [M. Jones, J. Crowley, Nonparametric tests of the Markov model for survival data Biometrika 79 (3) (1992) 513–522] has been extended here to transitions and reverse transitions. The limitation of the Jones and Crowley method is that it does not take account of other covariates that might have association with the probabilities of transition. A simple test procedure is proposed that can be employed for testing: (i) the significance of association between covariates and transition probabilities, and (ii) the impact of waiting time on the transition probabilities. The procedure is illustrated using panel data on hospitalization of the elderly population in the USA from the Health and Retirement Survey (HRS). 相似文献
18.
Edwin M.M. Ortega Gauss M. Cordeiro Elizabeth M. Hashimoto Kahadawala Cooray 《Journal of applied statistics》2014,41(9):1859-1880
We introduce the log-odd Weibull regression model based on the odd Weibull distribution (Cooray, 2006). We derive some mathematical properties of the log-transformed distribution. The new regression model represents a parametric family of models that includes as sub-models some widely known regression models that can be applied to censored survival data. We employ a frequentist analysis and a parametric bootstrap for the parameters of the proposed model. We derive the appropriate matrices for assessing local influence on the parameter estimates under different perturbation schemes and present some ways to assess global influence. Further, for different parameter settings, sample sizes and censoring percentages, some simulations are performed. In addition, the empirical distribution of some modified residuals are given and compared with the standard normal distribution. These studies suggest that the residual analysis usually performed in normal linear regression models can be extended to a modified deviance residual in the proposed regression model applied to censored data. We define martingale and deviance residuals to check the model assumptions. The extended regression model is very useful for the analysis of real data. 相似文献
19.
The hidden Markov model regression (HMMR) has been popularly used in many fields such as gene expression and activity recognition. However, the traditional HMMR requires the strong linearity assumption for the emission model. In this article, we propose a hidden Markov model with non-parametric regression (HMM-NR), where the mean and variance of emission model are unknown smooth functions. The new semiparametric model might greatly reduce the modeling bias and thus enhance the applicability of the traditional hidden Markov model regression. We propose an estimation procedure for the transition probability matrix and the non-parametric mean and variance functions by combining the ideas of the EM algorithm and the kernel regression. Simulation studies and a real data set application are used to demonstrate the effectiveness of the new estimation procedure. 相似文献
20.
This paper considers a hierarchical Bayesian analysis of regression models using a class of Gaussian scale mixtures. This class provides a robust alternative to the common use of the Gaussian distribution as a prior distribution in particular for estimating the regression function subject to uncertainty about the constraint. For this purpose, we use a family of rectangular screened multivariate scale mixtures of Gaussian distribution as a prior for the regression function, which is flexible enough to reflect the degrees of uncertainty about the functional constraint. Specifically, we propose a hierarchical Bayesian regression model for the constrained regression function with uncertainty on the basis of three stages of a prior hierarchy with Gaussian scale mixtures, referred to as a hierarchical screened scale mixture of Gaussian regression models (HSMGRM). We describe distributional properties of HSMGRM and an efficient Markov chain Monte Carlo algorithm for posterior inference, and apply the proposed model to real applications with constrained regression models subject to uncertainty. 相似文献