Homogeneity Tests for Related Samples Under Censoring

We propose nonparametric homogeneity tests for related samples against much wider than location (or scale) class of alternatives including possible crossings of marginal cumulative distribution functions. The tests can be used in the case of complete and censored samples. Asymptotic distribution of the test statistics is investigated.     

Life table estimator revisited

We explore the standard life table (actuarial) estimator for grouped right-censored survival data and its extensions in order to consider its relationship with the Kaplan–Meier estimator, and to investigate the critical properties of the extended life table estimators (ELTEs). We discuss certain conditions for the ELTE to be consistent and develop a characterization of the standard life table estimator using the consistency property under any choice of at least two observation times of a finite interval. We also perform a comparative analysis of the ELTEs with the corresponding maximum likelihood estimators for grouped right-censored survival data.     

Large sample properties of nonparametric copula estimators under bivariate censoring

A new nonparametric estimator is proposed for the copula function of a bivariate survival function for data subject to random right-censoring. We consider two censoring models: univariate and copula censoring. We show strong consistency and we obtain an i.i.d. representation for the copula estimator. In a simulation study we compare the new estimator to the one of Gribkova and Lopez [Nonparametric copula estimation under bivariate censoring; doi:10.1111/sjos.12144].     

Approximate MLE for the scale parameter of the generalized exponential distribution under random censoring

In this paper, we consider the maximum likelihood estimator (MLE) of the scale parameter of the generalized exponential (GE) distribution based on a random censoring model. We assume the censoring distribution also follows a GE distribution. Since the estimator does not provide an explicit solution, we propose a simple method of deriving an explicit estimator by approximating the likelihood function. In order to compare the performance of the estimators, Monte Carlo simulation is conducted. The results show that the MLE and the approximate MLE are almost identical in terms of bias and variance.     

Inference for a Linear Functional of Cumulative Hazard Function Via Empirical Likelihood

This article discusses sampling plans, that is, the allocation of sampling units, for computing tolerance limits in a balanced one--way random-effects model. The expected width of the tolerance interval is derived and used as the basis for comparing different sampling plans. A well-known cost function and examples are used to facilitate the discussion.     

Non-parametric Estimation of a Survival Function with Two-stage Design Studies

Abstract.  The two-stage design is popular in epidemiology studies and clinical trials due to its cost effectiveness. Typically, the first stage sample contains cheaper and possibly biased information, while the second stage validation sample consists of a subset of subjects with accurate and complete information. In this paper, we study estimation of a survival function with right-censored survival data from a two-stage design. A non-parametric estimator is derived by combining data from both stages. We also study its large sample properties and derive pointwise and simultaneous confidence intervals for the survival function. The proposed estimator effectively reduces the variance and finite-sample bias of the Kaplan–Meier estimator solely based on the second stage validation sample. Finally, we apply our method to a real data set from a medical device postmarketing surveillance study.     

Generalized M-estimation for the accelerated failure time model

The accelerated failure time (AFT) model is an important regression tool to study the association between failure time and covariates. In this paper, we propose a robust weighted generalized M (GM) estimation for the AFT model with right-censored data by appropriately using the Kaplan–Meier weights in the GM–type objective function to estimate the regression coefficients and scale parameter simultaneously. This estimation method is computationally simple and can be implemented with existing software. Asymptotic properties including the root-n consistency and asymptotic normality are established for the resulting estimator under suitable conditions. We further show that the method can be readily extended to handle a class of nonlinear AFT models. Simulation results demonstrate satisfactory finite sample performance of the proposed estimator. The practical utility of the method is illustrated by a real data example.     

Modified spline regression based on randomly right-censored data: A comparative study

ABSTRACT

In this paper, we propose modified spline estimators for nonparametric regression models with right-censored data, especially when the censored response observations are converted to synthetic data. Efficient implementation of these estimators depends on the set of knot points and an appropriate smoothing parameter. We use three algorithms, the default selection method (DSM), myopic algorithm (MA), and full search algorithm (FSA), to select the optimum set of knots in a penalized spline method based on a smoothing parameter, which is chosen based on different criteria, including the improved version of the Akaike information criterion (AICc), generalized cross validation (GCV), restricted maximum likelihood (REML), and Bayesian information criterion (BIC). We also consider the smoothing spline (SS), which uses all the data points as knots. The main goal of this study is to compare the performance of the algorithm and criteria combinations in the suggested penalized spline fits under censored data. A Monte Carlo simulation study is performed and a real data example is presented to illustrate the ideas in the paper. The results confirm that the FSA slightly outperforms the other methods, especially for high censoring levels.     

ON THE ESTIMATION OF SURVIVAL FUNCTION UNDER RANDOM CENSORSHIP

ABSTRACT

The paper deals with an improvement of the well-known Kaplan–Meier estimator of survival function when the censoring mechanism is random and independent of the failure times. Small sample size properties of the new estimator, as well as the original Kaplan–Meier estimator are inspected by means of Monte Carlo simulations. It follows from the simulations that the proposed estimator prevails with respect to some basic statistical characteristics.     

Rank Regression Analysis of Multivariate Failure Time Data Based on Marginal Linear Models

Abstract.  Multivariate failure time data arises when each study subject can potentially ex-perience several types of failures or recurrences of a certain phenomenon, or when failure times are sampled in clusters. We formulate the marginal distributions of such multivariate data with semiparametric accelerated failure time models (i.e. linear regression models for log-transformed failure times with arbitrary error distributions) while leaving the dependence structures for related failure times completely unspecified. We develop rank-based monotone estimating functions for the regression parameters of these marginal models based on right-censored observations. The estimating equations can be easily solved via linear programming. The resultant estimators are consistent and asymptotically normal. The limiting covariance matrices can be readily estimated by a novel resampling approach, which does not involve non-parametric density estimation or evaluation of numerical derivatives. The proposed estimators represent consistent roots to the potentially non-monotone estimating equations based on weighted log-rank statistics. Simulation studies show that the new inference procedures perform well in small samples. Illustrations with real medical data are provided.     

Strong consistency result of a non parametric conditional mode estimator under random censorship for functional regressors

Abstract

Let (T, C, X) be a vector of random variables (rvs) where T, C, and X are the interest variable, a right censoring rv, and a covariate, respectively. In this paper, we study the kernel conditional mode estimation when the covariate takes values in an infinite dimensional space and is α-mixing. Under some regularity conditions, the almost complete convergence of the estimate with rates is established.     

Comparison of Several Confidence Intervals for Median Residual Lifetime with Left-truncated and Right-censored Data

For left-truncated and right-censored data, the technique proposed by Brookmeyer and Crowley (1982) is extended to construct a point-wise confidence interval for median residual lifetime. This procedure is computationally simpler than the score type confidence interval in Jeong et al. (2008) and empirical likelihood ratio confidence interval in Zhou and Jeong (2011). Further, transformations of the estimator are applied to improve the approximation to the asymptotic distribution for small sample sizes. A simulation study is conducted to investigate the accuracy of these confidence intervals and the implementation of these confidence intervals to two real datasets is illustrated.     

On the goodness-of-fit test based on the ratio of cumulative hazard functions with the Type II censored data

For comparing two cumulative hazard functions, we consider an extension of the Kullback–Leibler information to the cumulative hazard function, which is concerning the ratio of cumulative hazard functions. Then we consider its estimate as a goodness-of-fit test with the Type II censored data. For an exponential null distribution, the proposed test statistic is shown to outperform other test statistics based on the empirical distribution function in the heavy censoring case against the increasing hazard alternatives.     

On the asymptotic normality of the kernel estimators of the density function and its derivatives under censoring

In this paper, we study asymptotic normality of the kernel estimators of the density function and its derivatives as well as the mode in the randomly right censorship model. The mode estimator is defined as the random variable that maximizes the kernel density estimator. Our results are stated under some suitable conditions upon the kernel function, the smoothing parameter and both distributions functions that appear in this model. Here, the Kaplan–Meier estimator of the distribution function is used to build the estimates. We carry out a simulation study which shows how good the normality works.     

Central Limit Theorem for ISE of Kernel Density Estimators in Censored Dependent Model

In some long-term studies, a series of dependent and possibly censored failure times may be observed. Suppose that the failure times have a common continuous distribution function F. A popular stochastic measure of the distance between the density function f of the failure times and its kernel estimate f _n is the integrated square error(ISE). In this article, we derive a central limit theorem for the integrated square error of the kernel density estimators under a censored dependent model.     

Asymptotic Behaviors of the Lorenz Curve for Censored Data Under Strong Mixing

In this article, we consider a nonparametric estimator of the Lorenz curve under censored dependent model. We show that this estimator is uniformly strongly consistent for the associated Lorenz curve. Also, a strong Gaussian approximation for the associated Lorenz process are established under appropriate assumptions. A law of the iterated logarithm for the Lorenz process is also derived.     

Testing Censoring Point Independence

Identification in censored regression analysis and hazard models of duration outcomes relies on the condition that censoring points are conditionally independent of latent outcomes, an assumption which may be questionable in many settings. This article proposes a test for this assumption based on a Cramer–von-Mises-like test statistic comparing two different nonparametric estimators for the latent outcome cdf: the Kaplan–Meier estimator, and the empirical cdf conditional on the censoring point exceeding (for right-censored data) the cdf evaluation point. The test is consistent and has power against a wide variety of alternatives. Applying the test to unemployment duration data from the NLSY, the SIPP, and the PSID suggests the assumption is frequently suspect.     

Multivariate Excess Wealth Ordering of Generalized Order Statistics

The concept of generalized order statistics (GOSs) was introduced as a unified approach to a variety of models of ordered random variables. The purpose of this paper is to investigate conditions on the underlying distribution function and the parameters on which GOSs are based, to establish multivariate excess wealth ordering of GOSs from one sample and two samples, respectively.