Generalized Linear Failure Rate Distribution

The exponential and Rayleigh are the two most commonly used distributions for analyzing lifetime data. These distributions have several desirable properties and nice physical interpretations. Unfortunately, the exponential distribution only has constant failure rate and the Rayleigh distribution has increasing failure rate. The linear failure rate distribution generalizes both these distributions which may have non increasing hazard function also. This article introduces a new distribution, which generalizes linear failure rate distribution. This distribution generalizes the well-known (1) exponential distribution, (2) linear failure rate distribution, (3) generalized exponential distribution, and (4) generalized Rayleigh distribution. The properties of this distribution are discussed in this article. The maximum likelihood estimates of the unknown parameters are obtained. A real data set is analyzed and it is observed that the present distribution can provide a better fit than some other very well-known distributions.     

The Geometric Birnbaum-Saunders regression model with cure rate

In this paper, we propose a cure rate survival model by assuming the number of competing causes of the event of interest follows the Geometric distribution and the time to event follow a Birnbaum Saunders distribution. We consider a frequentist analysis for parameter estimation of a Geometric Birnbaum Saunders model with cure rate. Finally, to analyze a data set from the medical area.     

A model with long-term survivors: negative binomial Birnbaum-Saunders

Abstract

We propose a cure rate survival model by assuming that the number of competing causes of the event of interest follows the negative binomial distribution and the time to the event of interest has the Birnbaum-Saunders distribution. Further, the new model includes as special cases some well-known cure rate models published recently. We consider a frequentist analysis for parameter estimation of the negative binomial Birnbaum-Saunders model with cure rate. Then, we derive the appropriate matrices for assessing local influence on the parameter estimates under different perturbation schemes. We illustrate the usefulness of the proposed model in the analysis of a real data set from the medical area.     

Generalized log-gamma regression models with cure fraction

In this paper, the generalized log-gamma regression model is modified to allow the possibility that long-term survivors may be present in the data. This modification leads to a generalized log-gamma regression model with a cure rate, encompassing, as special cases, the log-exponential, log-Weibull and log-normal regression models with a cure rate typically used to model such data. The models attempt to simultaneously estimate the effects of explanatory variables on the timing acceleration/deceleration of a given event and the surviving fraction, that is, the proportion of the population for which the event never occurs. The normal curvatures of local influence are derived under some usual perturbation schemes and two martingale-type residuals are proposed to assess departures from the generalized log-gamma error assumption as well as to detect outlying observations. Finally, a data set from the medical area is analyzed.     

Failure Rate and Aging Properties of Generalized Beta- and Gamma-generated Distributions

In the present article we study several characteristics of the families of generalized beta- and gamma- generated distributions introduced by Alexander et al. (2011) and Zografos and Balakrishnan (2009), respectively. Simple formulas are established for calculating the failure rate of the members of the aforementioned families by exploiting the failure rate of the parent distribution. In addition, the aging properties of the generalized beta- and gamma-generated distributions are explored in terms of the corresponding aging behavior of the parent family.     

M-Estimator of a Generalized Linear Model with Measurement Errors

In this article, we propose a generalized linear model and estimate the unknown parameters using robust M-estimator. Under suitable conditions and by the strong law of large numbers and central limits theorem, the proposed M-estimators are proved to be consistent and asymptotically normal. We also evaluate the finite sample performance of our estimator through a Monte Carlo study.     

A new destructive Poisson odd log-logistic generalized half-normal cure rate model

We propose a new cure rate survival model by assuming that the initial number of competing causes of the event of interest follows a Poisson distribution and the time to event has the odd log-logistic generalized half-normal distribution. This survival model describes a realistic interpretation for the biological mechanism of the event of interest. We estimate the model parameters using maximum likelihood. For different sample sizes, various simulation scenarios are performed. We propose the diagnostics and residual analysis to verify the model assumptions. The potentiality of the new cure rate model is illustrated by means of a real data.     

A Note on Generalized Functional Linear Model and Its Application

Motivated by a biomarker study for colorectal neoplasia, we consider generalized functional linear models where the functional predictors are measured with errors at discrete design points. Assuming that the true functional predictor and the slope function are smooth, we investigate a two-step estimating procedure where both the true functional predictor and the slope function are estimated through spline smoothing. The operating characteristics of the proposed method are derived; the usefulness of the proposed method is illustrated by a simulation study as well as data analysis for the motivating colorectal neoplasia study.     

Lack-of-Fit Tests for Generalized Linear Models via Splines

Cubic B-splines are used to estimate the nonparametric component of a semiparametric generalized linear model. A penalized log-likelihood ratio test statistic is constructed for the null hypothesis of the linearity of the nonparametric function. When the number of knots is fixed, its limiting null distribution is the distribution of a linear combination of independent chi-squared random variables, each with one df. The smoothing parameter is determined by giving a specified value for its asymptotically expected value under the null hypothesis. A simulation study is conducted to evaluate its power performance; a real-life dataset is used to illustrate its practical use.     

Linear models with an inverse gaussian poisson error distribution

The inverse Gaussian-Poisson (two-parameter Sichel) distribution is useful in fitting overdispersed count data. We consider linear models on the mean of a response variable, where the response is in the form of counts exhibiting extra-Poisson variation, and assume an IGP error distribution. We show how maximum likelihood estimation may be carried out using iterative Newton-Raphson IRLS fitting, where GLIM is used for the IRLS part of the maximization. Approximate likelihood ratio tests are given.     

Generalized Empirical Likelihood Inference in Generalized Linear Models for Longitudinal Data

In this article, the generalized linear model for longitudinal data is studied. A generalized empirical likelihood method is proposed by combining generalized estimating equations and quadratic inference functions based on the working correlation matrix. It is proved that the proposed generalized empirical likelihood ratios are asymptotically chi-squared under some suitable conditions, and hence it can be used to construct the confidence regions of the parameters. In addition, the maximum empirical likelihood estimates of parameters are obtained, and their asymptotic normalities are proved. Some simulations are undertaken to compare the generalized empirical likelihood and normal approximation-based method in terms of coverage accuracies and average areas/lengths of confidence regions/intervals. An example of a real data is used for illustrating our methods.     

Likelihood Inference for Spatial Generalized Linear Mixed Models

Spatial modeling is widely used in environmental sciences, biology, and epidemiology. Generalized linear mixed models are employed to account for spatial variations of point-referenced data called spatial generalized linear mixed models (SGLMMs). Frequentist analysis of these type of data is computationally difficult. On the other hand, the advent of the Markov chain Monte Carlo algorithm has made the Bayesian analysis of SGLMM computationally convenient. Recent introduction of the method of data cloning, which leads to maximum likelihood estimate, has made frequentist analysis of mixed models also equally computationally convenient. Recently, the data cloning was employed to estimate model parameters in SGLMMs, however, the prediction of spatial random effects and kriging are also very important. In this article, we propose a frequentist approach based on data cloning to predict (and provide prediction intervals) spatial random effects and kriging. We illustrate this approach using a real dataset and also by a simulation study.     

Interval Estimations for the Mean of the Generalized Poisson and Generalized Negative Binomial Distributions

In this article, we extend the Wald, score, skewness-corrected score, likelihood ratio, and mid-P intervals for the means of the generalized Poisson and generalized negative binomial distributions. These distributions are the members of the discrete version of the natural exponential family (NEF) with cubic variance function (CVF). Also, the coverage probabilities, the distal and mesial noncoverage probabilities, and the lengths of the proposed confidence intervals are estimated by means of a Monte Carlo simulation study. Finally, some practical examples are provided to show the applicability of the proposed intervals in applied studies.     

The Exponentiated G Poisson Model

We study a new family of distributions defined by the minimum of the Poisson random number of independent identically distributed random variables having a general exponentiated G distribution. Some mathematical properties of the new family including ordinary and incomplete moments, quantile and generating functions, mean deviations, order statistics and their moments, reliability, and Shannon entropy are derived. Maximum likelihood estimation of the model parameters is investigated. Two special models of the new family are discussed. We perform an application to a real data set to show the potentiality of the proposed family.     

Standard Exponential Cure Rate Model with Noninformative or Informative Uniform-Exponential Censoring

In survival data analysis it is frequent the occurrence of a significant amount of censoring to the right indicating that there may be a proportion of individuals in the study for which the event of interest will never happen. This fact is not considered by the ordinary survival theory. Consequently, the survival models with a cure fraction have been receiving a lot of attention in the recent years. In this article, we consider the standard mixture cure rate model where a fraction p ₀ of the population is of individuals cured or immune and the remaining 1 ? p ₀ are not cured. We assume an exponential distribution for the survival time and an uniform-exponential for the censoring time. In a simulation study, the impact caused by the informative uniform-exponential censoring on the coverage probabilities and lengths of asymptotic confidence intervals is analyzed by using the Fisher information and observed information matrices.     

Testing overdispersion in the zero-inflated Poisson model

The zero-inflated negative binomial (ZINB) model is used to account for commonly occurring overdispersion detected in data that are initially analyzed under the zero-inflated Poisson (ZIP) model. Tests for overdispersion (Wald test, likelihood ratio test [LRT], and score test) based on ZINB model for use in ZIP regression models have been developed. Due to similarity to the ZINB model, we consider the zero-inflated generalized Poisson (ZIGP) model as an alternate model for overdispersed zero-inflated count data. The score test has an advantage over the LRT and the Wald test in that the score test only requires that the parameter of interest be estimated under the null hypothesis. This paper proposes score tests for overdispersion based on the ZIGP model and illustrates that the derived score statistics are exactly the same as the score statistics under the ZINB model. A simulation study indicates the proposed score statistics are preferred to other tests for higher empirical power. In practice, based on the approximate mean–variance relationship in the data, the ZINB or ZIGP model can be considered, and a formal score test based on asymptotic standard normal distribution can be employed for assessing overdispersion in the ZIP model. We provide an example to illustrate the procedures for data analysis.     

A Generalized Poisson Distribution

Cumulative probabilities of a Poisson distribution can be written in terms of incomplete gamma function where the parameter of the gamma function is an integer. From this definition a new generalization of the Poisson distribution is obtained with two parameters. Asymptotic behavior of this distribution is shown to be normal. Some order properties of this distribution are also studied.     

A weighted Poisson distribution and its application to cure rate models

The family of weighted Poisson distributions offers great flexibility in modeling discrete data due to its potential to capture over/under-dispersion by an appropriate selection of the weight function. In this paper, we introduce a flexible weighted Poisson distribution and further study its properties by using it in the context of cure rate modeling under a competing cause scenario. A special case of the new distribution is the COM-Poisson distribution which in turn encompasses the Bernoulli, Poisson, and geometric distributions; hence, many of the well-studied cure rate models may be seen as special cases of the proposed model. We focus on the estimation, through the maximum likelihood method, of the cured proportion and the properties of the failure time of the susceptibles/non cured individuals; a profile likelihood approach is also adopted for estimating the parameters of the weighted Poisson distribution. A Monte Carlo simulation study demonstrates the accuracy of the proposed inferential method. Finally, as an illustration, we fit the proposed model to a cutaneous melanoma data set.     

Semi Varying Coefficient Zero-Inflated Generalized Poisson Regression Model

In this paper, the semi varying coefficient zero-inflated generalized Poisson model is discussed based on penalized log-likelihood. All the coefficient functions are fitted by penalized spline (P-spline), and Expectation-maximization algorithm is used to drive these estimators. The estimation approach is rapid and computationally stable. Under some mild conditions, the consistency and the asymptotic normality of these resulting estimators are given. The score test statistics about dispersion parameter is discussed based on the P-spline estimation. Both simulated and real data example are used to illustrate our proposed methods.