Longitudinal profiles of bounded outcome scores as predictors for disease activity in rheumatoid arthritis patients: a joint modeling approach

A variety of statistical approaches have been suggested in the literature for the analysis of bounded outcome scores (BOS). In this paper, we suggest a statistical approach when BOSs are repeatedly measured over time and used as predictors in a regression model. Instead of directly using the BOS as a predictor, we propose to extend the approaches suggested in [16 E. Lesaffre, D. Rizopoulos, and R. Tsonaka, The logistics-transform for bounded outcome scores, Biostatistics 8 (2007), pp. 72–85. doi: 10.1093/biostatistics/kxj034[Crossref], [PubMed], [Web of Science ®] , [Google Scholar],21 M. Molas and E. Lesaffre, A comparison of the three random effects approaches to analyse repeated bounded outcome scores with an application in a stroke revalidation study, Stat. Med. 27 (2008), pp. 6612–6633. doi: 10.1002/sim.3432[Crossref], [PubMed], [Web of Science ®] , [Google Scholar],28 R. Tsonaka, D. Rizopoulos, and E. Lesaffre, Power and sample size calculations for discrete bounded outcome scores, Stat. Med. 25 (2006), pp. 4241–4252. doi: 10.1002/sim.2679[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]] to a joint modeling setting. Our approach is illustrated on longitudinal profiles of multiple patients’ reported outcomes to predict the current clinical status of rheumatoid arthritis patients by a disease activities score of 28 joints (DAS28). Both a maximum likelihood as well as a Bayesian approach is developed.     

Estimators for the Population Mean in the Case of Missing Data

We propose a class of estimators for the population mean when there are missing data in the data set. Obtaining the mean square error equations of the proposed estimators, we show the conditions where the proposed estimators are more efficient than the sample mean, ratio-type estimators, and the estimators in Singh and Horn (2000 Singh , S. , Horn , S. ( 2000 ). Compromised imputation in survey sampling . Metrika 51 : 267 – 276 .[Crossref], [Web of Science ®] , [Google Scholar]) and Singh and Deo (2003 Singh , S. , Deo , B. (2003). Imputation by power transformation. Statist. Pap. 44:555–579.[Crossref], [Web of Science ®] , [Google Scholar]) in the case of missing data. These conditions are also supported by a numerical example.     

Evaluating the relative merits of competing models based on empirical likelihood ratio test

Competing models arise naturally in many research fields, such as survival analysis and economics, when the same phenomenon of interest is explained by different researcher using different theories or according to different experiences. The model selection problem is therefore remarkably important because of its great importance to the subsequent inference; Inference under a misspecified or inappropriate model will be risky. Existing model selection tests such as Vuong's tests [26 Q.H. Vuong, Likelihood ratio test for model selection and non-nested hypothesis, Econometrica 57 (1989), pp. 307–333. doi: 10.2307/1912557[Crossref], [Web of Science ®] , [Google Scholar]] and Shi's non-degenerate tests [21 X. Shi, A non-degenerate Vuong test, Quant. Econ. 6 (2015), pp. 85–121. doi: 10.3982/QE382[Crossref], [Web of Science ®] , [Google Scholar]] suffer from the variance estimation and the departure of the normality of the likelihood ratios. To circumvent these dilemmas, we propose in this paper an empirical likelihood ratio (ELR) tests for model selection. Following Shi [21 X. Shi, A non-degenerate Vuong test, Quant. Econ. 6 (2015), pp. 85–121. doi: 10.3982/QE382[Crossref], [Web of Science ®] , [Google Scholar]], a bias correction method is proposed for the ELR tests to enhance its performance. A simulation study and a real-data analysis are provided to illustrate the performance of the proposed ELR tests.     

Empirical Likelihood in Causal Inference

This paper discusses the estimation of average treatment effects in observational causal inferences. By employing a working propensity score and two working regression models for treatment and control groups, Robins et al. (1994 Robins , J. M. , Rotnitzky , A. , Zhao , L. P. ( 1994 ). Estimation of regression coefficients when some regressors are not always observed . Journal of the American Statistical Association 89 : 846 – 866 .[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar], 1995 Robins , J. M. , Rotnitzky , A. , Zhao , L. P. ( 1995 ). Analysis of semiparametric regression models for repeated outcomes in the presence of missing data . Journal of the American Statistical Association 90 : 106 – 121 .[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]) introduced the augmented inverse probability weighting (AIPW) method for estimation of average treatment effects, which extends the inverse probability weighting (IPW) method of Horvitz and Thompson (1952 Horvitz , D. G. , Thompson , D. J. ( 1952 ). A generalization of sampling without replacement from a finite universe . Journal of the American Statistical Association 47 : 663 – 685 .[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]); the AIPW estimators are locally efficient and doubly robust. In this paper, we study a hybrid of the empirical likelihood method and the method of moments by employing three estimating functions, which can generate estimators for average treatment effects that are locally efficient and doubly robust. The proposed estimators of average treatment effects are efficient for the given choice of three estimating functions when the working propensity score is correctly specified, and thus are more efficient than the AIPW estimators. In addition, we consider a regression method for estimation of the average treatment effects when working regression models for both the treatment and control groups are correctly specified; the asymptotic variance of the resulting estimator is no greater than the semiparametric variance bound characterized by the theory of Robins et al. (1994 Robins , J. M. , Rotnitzky , A. , Zhao , L. P. ( 1994 ). Estimation of regression coefficients when some regressors are not always observed . Journal of the American Statistical Association 89 : 846 – 866 .[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar], 1995 Robins , J. M. , Rotnitzky , A. , Zhao , L. P. ( 1995 ). Analysis of semiparametric regression models for repeated outcomes in the presence of missing data . Journal of the American Statistical Association 90 : 106 – 121 .[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]). Finally, we present a simulation study to compare the finite-sample performance of various methods with respect to bias, efficiency, and robustness to model misspecification.     

A comparison of alternative methods to construct confidence intervals for the estimate of a break date in linear regression models

This article considers constructing confidence intervals for the date of a structural break in linear regression models. Using extensive simulations, we compare the performance of various procedures in terms of exact coverage rates and lengths of the confidence intervals. These include the procedures of Bai (1997 Bai, J. (1997). Estimation of a change point in multiple regressions. Review of Economics and Statistics 79:551–563.[Crossref], [Web of Science ®] , [Google Scholar]) based on the asymptotic distribution under a shrinking shift framework, Elliott and Müller (2007 Elliott, G., Müller, U. (2007). Confidence sets for the date of a single break in linear time series regressions. Journal of Econometrics 141:1196–1218.[Crossref], [Web of Science ®] , [Google Scholar]) based on inverting a test locally invariant to the magnitude of break, Eo and Morley (2015 Eo, Y., Morley, J. (2015). Likelihood-ratio-based confidence sets for the timing of structural breaks. Quantitative Economics 6:463–497.[Crossref], [Web of Science ®] , [Google Scholar]) based on inverting a likelihood ratio test, and various bootstrap procedures. On the basis of achieving an exact coverage rate that is closest to the nominal level, Elliott and Müller's (2007 Elliott, G., Müller, U. (2007). Confidence sets for the date of a single break in linear time series regressions. Journal of Econometrics 141:1196–1218.[Crossref], [Web of Science ®] , [Google Scholar]) approach is by far the best one. However, this comes with a very high cost in terms of the length of the confidence intervals. When the errors are serially correlated and dealing with a change in intercept or a change in the coefficient of a stationary regressor with a high signal-to-noise ratio, the length of the confidence interval increases and approaches the whole sample as the magnitude of the change increases. The same problem occurs in models with a lagged dependent variable, a common case in practice. This drawback is not present for the other methods, which have similar properties. Theoretical results are provided to explain the drawbacks of Elliott and Müller's (2007 Elliott, G., Müller, U. (2007). Confidence sets for the date of a single break in linear time series regressions. Journal of Econometrics 141:1196–1218.[Crossref], [Web of Science ®] , [Google Scholar]) method.     

Matrix mean squared error comparisons of some biased estimators with two biasing parameters

To deal with multicollinearity problem, the biased estimators with two biasing parameters have recently attracted much research interest. The aim of this article is to compare one of the last proposals given by Yang and Chang (2010 Yang, H., and X. Chang. 2010. A new two-parameter estimator in linear regression. Communications in Statistics: Theory and Methods 39 (6):923–34.[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]) with Liu-type estimator (Liu 2003 Liu, K. 2003. Using Liu-type estimator to combat collinearity. Communications in Statistics: Theory and Methods 32 (5):1009–20.[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]) and k ? d class estimator (Sakallioglu and Kaciranlar 2008 Sakallioglu, S., and S. Kaciranlar. 2008. A new biased estimator based on ridge estimation. Statistical Papers 49:669–89.[Crossref], [Web of Science ®] , [Google Scholar]) under the matrix mean squared error criterion. As well as giving these comparisons theoretically, we support the results with the extended simulation studies and real data example, which show the advantages of the proposal given by Yang and Chang (2010 Yang, H., and X. Chang. 2010. A new two-parameter estimator in linear regression. Communications in Statistics: Theory and Methods 39 (6):923–34.[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]) over the other proposals with increasing multicollinearity level.     

Random Effects,Fixed Effects and Hausman's Test for the Generalized Mixed Regressive Spatial Autoregressive Panel Data Model

This article suggests random and fixed effects spatial two-stage least squares estimators for the generalized mixed regressive spatial autoregressive panel data model. This extends the generalized spatial panel model of Baltagi et al. (2013 Baltagi, B. H., Egger, P., Pfaffermayr, M. (2013). A generalized spatial panel data model with random effects. Econometric Reviews 32:650–685.[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]) by the inclusion of a spatial lag term. The estimation method utilizes the Generalized Moments method suggested by Kapoor et al. (2007 Kapoor, M., Kelejian, H. H., Prucha, I. R. (2007). Panel data models with spatially correlated error components. Journal of Econometrics 127(1):97–130.[Crossref], [Web of Science ®] , [Google Scholar]) for a spatial autoregressive panel data model. We derive the asymptotic distributions of these estimators and suggest a Hausman test a la Mutl and Pfaffermayr (2011 Mutl, J., Pfaffermayr, M. (2011). The Hausman test in a Cliff and Ord panel model. Econometrics Journal 14:48–76.[Crossref], [Web of Science ®] , [Google Scholar]) based on the difference between these estimators. Monte Carlo experiments are performed to investigate the performance of these estimators as well as the corresponding Hausman test.     

Testing for sphericity in a two-way error components panel data model

This article is concerned with sphericity test for the two-way error components panel data model. It is found that the John statistic and the bias-corrected LM statistic recently developed by Baltagi et al. (2011 Baltagi, B. H., Feng, Q., Kao, C. (2011). Testing for sphericity in a fixed effects panel data model. Econometrics Journal 14:25–47.[Crossref], [Web of Science ®] , [Google Scholar])Baltagi et al. (2012 Baltagi, B. H., Feng, Q., Kao, C. (2012). A Lagrange multiplier test for cross-sectional dependence in a fixed effects panel data model. Journal of Econometrics 170:164–177.[Crossref], [Web of Science ®] , [Google Scholar], which are based on the within residuals, are not helpful under the present circumstances even though they are in the one-way fixed effects model. However, we prove that when the within residuals are properly transformed, the resulting residuals can serve to construct useful statistics that are similar to those of Baltagi et al. (2011 Baltagi, B. H., Feng, Q., Kao, C. (2011). Testing for sphericity in a fixed effects panel data model. Econometrics Journal 14:25–47.[Crossref], [Web of Science ®] , [Google Scholar])Baltagi et al. (2012 Baltagi, B. H., Feng, Q., Kao, C. (2012). A Lagrange multiplier test for cross-sectional dependence in a fixed effects panel data model. Journal of Econometrics 170:164–177.[Crossref], [Web of Science ®] , [Google Scholar]). Simulation results show that the newly proposed statistics perform well under the null hypothesis and several typical alternatives.     

An objective Bayesian estimation in a two-period crossover design

Two-period crossover design is one of the commonly used designs in clinical trials. But, the estimation of treatment effect is complicated by the possible presence of carryover effect. It is known that ignoring the carryover effect when it exists can lead to poor estimates of the treatment effect. The classical approach by Grizzle (1965 Grizzle, J.E. (1965). The two-period change-over design and its use in clinical trials. Biometrics 21:467–480. See Grizzle (1974) for corrections.[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) consists of two stages. First, a preliminary test is conducted on carryover effect. If the carryover effect is significant, analysis is based only on data from period one; otherwise, analysis is based on data from both periods. A Bayesian approach with improper priors was proposed by Grieve (1985 Grieve, A.P. (1985). A Bayesian analysis of the two-period crossover design for clinical trials. Biometrics 41:979–990.[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) which uses a mixture of two models: a model with carryover effect and another without. The indeterminacy of the Bayes factor due to the arbitrary constant in the improper prior was addressed by assigning a minimally discriminatory value to the constant. In this article, we present an objective Bayesian estimation approach to the two-period crossover design which is also based on a mixture model, but using the commonly recommended Zellner–Siow g-prior. We provide simulation studies and a real data example and compare the numerical results with Grizzle (1965 Grizzle, J.E. (1965). The two-period change-over design and its use in clinical trials. Biometrics 21:467–480. See Grizzle (1974) for corrections.[Crossref], [PubMed], [Web of Science ®] , [Google Scholar])’s and Grieve (1985 Grieve, A.P. (1985). A Bayesian analysis of the two-period crossover design for clinical trials. Biometrics 41:979–990.[Crossref], [PubMed], [Web of Science ®] , [Google Scholar])’s approaches.     

Two-sided Confidence Bands with the Inferential Sensitivity of One-Sided Bands

In this article, we consider investigating whether any of k treatments are better than a control under the assumption of each treatment mean being no less than the control mean. A classic problem is to find the simultaneous confidence bounds for the difference between each treatment and the control. Compared with hypothesis testing, confidence bounds have the attractive advantage of telling more information about the effective treatment. Generally, the one-sided lower bounds are provided as it's enough for detecting effective treatment and the one-sided lower bounds has sharper lower bands than two-sided ones. However, a two-sided procedure provides both upper and lower bounds on the differences. In this article, we develop a new procedure which combines the good aspects of both the one-sided and the two-sided procedures. This new procedure has the same inferential sensitivity of the one-sided procedure proposed by Zhao (2007 Zhao , H. B. ( 2007 ). Comparing several treatments with a control . J. Statist. Plann. Infer. 137 : 2996 – 3006 .[Crossref], [Web of Science ®] , [Google Scholar]) while also providing simultaneous two-sided bounds for the differences between treatments and the control. By our computation results, we find the new procedure is better than Hayter, Miwa and Liu's procedure (Hayter et al., 2000 Hayter , A. J. , Miwa , T. , Liu , W. ( 2000 ). Combining the advantages of one-sided and two-sided procedures for comparing several treatments with a control . J. Statist. Plann. Infer. 86 : 81 – 99 .[Crossref], [Web of Science ®] , [Google Scholar]), when the sample size is balanced. We also illustrate the new procedure by an example.     

Test of Independence for Baker’s Bivariate Distributions

Baker (2008 Baker, R. (2008). An order-statistics-based method for constructing multivariate distributions with fixed marginals. Journal of Multivariate Analysis 99: 2312–2327.[Crossref], [Web of Science ®] , [Google Scholar]) introduced a new method for constructing multivariate distributions with given marginals based on order statistics. In this paper, we provide a test of independence for a pair of absolutely continuous random variables (X, Y) jointly distributed according to Baker’s bivariate distributions. Our purpose is to test the hypothesis that X and Y are independent versus the alternative that X and Y are positively (negatively) quadrant dependent. The asymptotic distribution of the proposed test statistic is investigated. Also, the powers of the proposed test and the class of distribution-free tests proposed by Kochar and Gupta (1987 Kochar, S. G., Gupta, R. P. (1987). Competitors of Kendall-tau test for testing independence against positive quadrant dependence. Biometrika 74(3): 664–666.[Crossref], [Web of Science ®] , [Google Scholar]) are compared empirically via a simulation study.     

Forward Moving Average Representations for MA Processes of Finite Order: Multivariate Stationary and Periodically Correlated

Soltani and Mohammadpour (2006 Soltani , A. R. , Mohammadpour , M. (2006). Moving average representations for multivariate stationary processes. J. Time Ser. Anal. 27(6):831–841.[Crossref], [Web of Science ®] , [Google Scholar]) observed that in general the backward and forward moving average coefficients, correspondingly, for the multivariate stationary processes, unlike the univariate processes, are different. This has stimulated researches concerning derivations of forward moving average coefficients in terms of the backward moving average coefficients. In this article we develop a practical procedure whenever the underlying process is a multivariate moving average (or univariate periodically correlated) process of finite order. Our procedure is based on two key observations: order reduction (Li, 2005 Li , L. M. ( 2005 ). Factorization of moving average spectral densities by state space representations and stacking . J. Multivariate Anal. 96 : 425 – 438 .[Crossref], [Web of Science ®] , [Google Scholar]) and first-order analysis (Mohammadpour and Soltani, 2010 Mohammadpour , M. , Soltani , A. R. ( 2010 ). Forward moving average representation for multivariate MA(1) processes . Commun. Statist. Theory Meth. 39 : 729 – 737 .[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]).     

Inference on locally ordered breaks in multiple regressions

We consider issues related to inference about locally ordered breaks in a system of equations, as originally proposed by Qu and Perron (2007 Qu, Z., Perron, P. (2007). Estimating and testing structural changes in multivariate regressions. Econometrica 75:459–502.[Crossref], [Web of Science ®] , [Google Scholar]). These apply when break dates in different equations within the system are not separated by a positive fraction of the sample size. This allows constructing joint confidence intervals of all such locally ordered break dates. We extend the results of Qu and Perron (2007 Qu, Z., Perron, P. (2007). Estimating and testing structural changes in multivariate regressions. Econometrica 75:459–502.[Crossref], [Web of Science ®] , [Google Scholar]) in several directions. First, we allow the covariates to be any mix of trends and stationary or integrated regressors. Second, we allow for breaks in the variance-covariance matrix of the errors. Third, we allow for multiple locally ordered breaks, each occurring in a different equation within a subset of equations in the system. Via some simulation experiments, we show first that the limit distributions derived provide good approximations to the finite sample distributions. Second, we show that forming confidence intervals in such a joint fashion allows more precision (tighter intervals) compared to the standard approach of forming confidence intervals using the method of Bai and Perron (1998 Bai, J., Perron, P. (1998). Estimating and testing linear models with multiple structural changes. Econometrica 66:47–78.[Crossref], [Web of Science ®] , [Google Scholar]) applied to a single equation. Simulations also indicate that using the locally ordered break confidence intervals yields better coverage rates than using the framework for globally distinct breaks when the break dates are separated by roughly 10% of the total sample size.     

Heteroskedasticity Robust Panel Unit Root Testing Under Variance Breaks in Pooled Regressions

Noting that many economic variables display occasional shifts in their second order moments, we investigate the performance of homogenous panel unit root tests in the presence of permanent volatility shifts. It is shown that in this case the test statistic proposed by Herwartz and Siedenburg (2008 Herwartz, H., Siedenburg, F. (2008). Homogenous panel unit root tests under cross-sectional dependence: Finite sample modifications and the wild bootstrap. Computational Statistics and Data Analysis 53(1):137–150.[Crossref], [Web of Science ®] , [Google Scholar]) is asymptotically standard Gaussian. By means of a simulation study we illustrate the performance of first and second generation panel unit root tests and undertake a more detailed comparison of the test in Herwartz and Siedenburg (2008 Herwartz, H., Siedenburg, F. (2008). Homogenous panel unit root tests under cross-sectional dependence: Finite sample modifications and the wild bootstrap. Computational Statistics and Data Analysis 53(1):137–150.[Crossref], [Web of Science ®] , [Google Scholar]) and its heteroskedasticity consistent Cauchy counterpart introduced in Demetrescu and Hanck (2012a Demetrescu, M., Hanck, C. (2012a). A simple nonstationary-volatility robust panel unit root test. Economics Letters 117(2):10–13.[Crossref], [Web of Science ®] , [Google Scholar]). As an empirical illustration, we reassess evidence on the Fisher hypothesis with data from nine countries over the period 1961Q2–2011Q2. Empirical evidence supports panel stationarity of the real interest rate for the entire subperiod. With regard to the most recent two decades, the test results cast doubts on market integration, since the real interest rate is diagnosed nonstationary.     

Bahadur Representation of Linear Kernel Quantile Estimator for Stationary Processes

In this article, we discuss the method of linear kernel quantile estimator proposed by Parzen (1979 Parzen, E. (1979). Nonparametric statistical data modeling. J. Amer. Statist. Assoc. 74:105121.[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]). We establish a Bahadur representation in sense of almost surely convergence with the rate log^{? α}n under the case of S-mixing random variable sequence which was proposed by Berkes (2009 Berkes, I., Hörmann, S., (2009). Asymptotic results for the itpirical process of stationary sequences. Stoch. Process. Their Applic. 119:12981324.[Crossref], [Web of Science ®] , [Google Scholar]). We also obtain the strong consistence of this estimator and its convergence rate.     

Stress–strength models with more than two states under exponential distribution

In the stress–strength models, analysis is based on the reliability of the system where the system is either in operational state or in failure state. Ery?lmaz (2011 Ery?lmaz, S. (2011). A new perspective to stress–strength models. Ann. Inst. Stat. Math. 63(1):101–115.[Crossref], [Web of Science ®] , [Google Scholar]) introduced the stress–strength reliability in a different framework assigning more than two states to the system depending on the difference between strength and stress values. Unlike Ery?lmaz (2011 Ery?lmaz, S. (2011). A new perspective to stress–strength models. Ann. Inst. Stat. Math. 63(1):101–115.[Crossref], [Web of Science ®] , [Google Scholar]), the present article deals with the ratio of the strength and stress values when the stress and strength follow independent exponential distributions. This article presents in detail the estimation aspect of the multistate stress–strength reliability function.     

Weighted simulated integrated conditional moment tests for parametric conditional distributions of stationary time series processes

In this article, we propose a weighted simulated integrated conditional moment (WSICM) test of the validity of parametric specifications of conditional distribution models for stationary time series data, by combining the weighted integrated conditional moment (ICM) test of Bierens (1984 Bierens, H. J. (1984). Model specification testing of time series regressions. Journal of Econometrics 26:323–353.[Crossref], [Web of Science ®] , [Google Scholar]) for time series regression models with the simulated ICM test of Bierens and Wang (2012 Bierens, H. J., Wang, L. (2012). Integrated conditional moment tests for parametric conditional distributions. Econometric Theory 28:328–362.[Crossref], [Web of Science ®] , [Google Scholar]) of conditional distribution models for cross-section data. To the best of our knowledge, no other consistent test for parametric conditional time series distributions has been proposed yet in the literature, despite consistency claims made by some authors.     

Relative Errors of Difference-Based Variance Estimators in Nonparametric Regression

Difference-based estimators for the error variance are popular since they do not require the estimation of the mean function. Unlike most existing difference-based estimators, new estimators proposed by Müller et al. (2003 Müller , U. , Schick , A. , Wefelmeyer , W. ( 2003 ). Estimating the error variance in nonparametric regression by a covariate-matched U-statistic . Statistics 37 : 179 – 188 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) and Tong and Wang (2005 Tong , T. , Wang , Y. ( 2005 ). Estimating residual variance in nonparametric regression using least squares . Biometrika 92 : 821 – 830 .[Crossref], [Web of Science ®] , [Google Scholar]) achieved the asymptotic optimal rate as residual-based estimators. In this article, we study the relative errors of these difference-based estimators which lead to better understanding of the differences between them and residual-based estimators. To compute the relative error of the covariate-matched U-statistic estimator proposed by Müller et al. (2003 Müller , U. , Schick , A. , Wefelmeyer , W. ( 2003 ). Estimating the error variance in nonparametric regression by a covariate-matched U-statistic . Statistics 37 : 179 – 188 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]), we develop a modified version by using simpler weights. We further investigate its asymptotic property for both equidistant and random designs and show that our modified estimator is asymptotically efficient.     

A Modification of a Percentile Estimation Procedure Based on Generalized Polya Urns

Adaptive designs find an important application in the estimation of unknown percentiles for an underlying dose-response curve. A nonparametric adaptive design was suggested by Mugno et al. (2004 Mugno, R.A., Zhus, W., Rosenberger, W.F. (2004). Adaptive urn designs for estimating several percentiles of a dose-response curve. Statist. Med. 23(13):2137–2150.[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) to simultaneously estimate multiple percentiles of an unknown dose-response curve via generalized Polya urns. In this article, we examine the properties of the design proposed by Mugno et al. (2004 Mugno, R.A., Zhus, W., Rosenberger, W.F. (2004). Adaptive urn designs for estimating several percentiles of a dose-response curve. Statist. Med. 23(13):2137–2150.[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) when delays in observing responses are encountered. Using simulations, we evaluate a modification of the design under varying group sizes. Our results demonstrate unbiased estimation with minimal loss in efficiency when compared to the original compound urn design.     

Likelihood-based panel cointegration test in the presence of a linear time trend and cross-sectional dependence

This article proposes a new likelihood-based panel cointegration rank test which extends the test of Örsal and Droge (2014 Örsal, D. D. K., Droge, B. (2014). Panel cointegration testing in the presence of a time trend. Computational Statistics and Data Analysis 76:377–390.[Crossref], [Web of Science ®] , [Google Scholar]) (henceforth panel SL test) to dependent panels. The dependence is modelled by unobserved common factors which affect the variables in each cross-section through heterogeneous loadings. The data are defactored following the panel analysis of nonstationarity in idiosyncratic and common components (PANIC) approach of Bai and Ng (2004 Bai, J., Ng, S. (2004). A PANIC attack on unit roots and cointegration. Econometrica 72(4):1127–1177.[Crossref], [Web of Science ®] , [Google Scholar]) and the cointegrating rank of the defactored data is then tested by the panel SL test. A Monte Carlo study demonstrates that the proposed testing procedure has reasonable size and power properties in finite samples.