Weighted Logrank Permutation Tests for Randomly Right Censored Life Science Data

In biomedical research, weighted logrank tests are frequently applied to compare two samples of randomly right censored survival times. We address the question how to combine a number of weighted logrank statistics to achieve good power of the corresponding survival test for a whole linear space or cone of alternatives, which are given by hazard rates. This leads to a new class of semiparametric projection tests that are motivated by likelihood ratio tests for an asymptotic model. We show that these tests can be carried out as permutation tests and discuss their asymptotic properties. A simulation study together with the analysis of a classical data set illustrates the advantages.     

Assessing the fit of finite mixture distributions

Mixture distributions have become a very flexible and common class of distributions, used in many different applications, but hardly any literature can be found on tests for assessing their goodness of fit. We propose two types of smooth tests of goodness of fit for mixture distributions. The first test is a genuine smooth test, and the second test makes explicit use of the mixture structure. In a simulation study the tests are compared to some traditional goodness of fit tests that, however, are not customised for mixture distributions. The first smooth test has overall good power and generally outperforms the other tests. The second smooth test is particularly suitable for assessing the fit of each component distribution separately. The tests are applicable to both continuous and discrete distributions and they are illustrated on three medical data sets.     

A survey of permutation tests for censored survival data

The present paper surveys tests with censored sur-vival data for 2-and k-samples and for association by a framework which classifies them into complete or restric-ted permutation tests and into tests based on U-or Savage-scores. The formulae of the resulting twelve tests are briefly described for quick reference. Some of the tests have been applied frequently in the past as the tests by Mantel, Breslow or Gehan; others have been developed rather recently, partly by the author. The concluding discussion presents the results of a simulation study, clarifying similarities and differences of the restricted and complete permutation approach, and deals with rela-tive efficiencies of the two scoring systems.     

A REVIEW OF SYSTEMS COINTEGRATION TESTS

The literature on systems cointegration tests is reviewed and the various sets of assumptions for the asymptotic validity of the tests are compared within a general unifying framework. The comparison includes likelihood ratio tests, Lagrange multiplier and Wald type tests, lag augmentation tests, tests based on canonical correlations, the Stock-Watson tests and Bierens' nonparametric tests. Asymptotic results regarding the power of these tests and previous small sample simulation studies are discussed. Further issues and proposals in the context of systems cointegration tests are also considered briefly. New simulations are presented to compare the tests under uniform conditions. Special emphasis is given to the sensitivity of the test performance with respect to the trending properties of the DGP.     

New invariant and consistent chi-squared type goodness-of-fit tests for multivariate normality and a related comparative simulation study

ABSTRACT

New invariant and consistent goodness-of-fit tests for multivariate normality are introduced. Tests are based on the Karhunen–Loève transformation of a multidimensional sample from a population. A comparison of simulated powers of tests and other well-known tests with respect to some alternatives is given. The simulation study demonstrates that power of the proposed McCull test almost does not depend on the number of grouping cells. The test shows an advantage over other chi-squared type tests. However, averaged over all of the simulated conditions examined in this article, the Anderson–Darling type and the Cramer–von Mises type tests seem to be the best.     

Portmanteau tests based on quadratic forms in the autocorrelations

Many white noise and goodness-of-fit tests are (asymptotically) written as quadratic forms in the ordinary autocorrelation estimates. The properties of such tests are studied by investigating the structure of the matrix of the quadratic form. We suggest to choose the matrix of the quadratic form in such a way that the power is maximized according to the information available about the alternative hypothesis. A simulation study sheds some light on the behavior of the test in finite samples. It is generally found more powerful than the most popular portmanteau tests, i.e., the Box and Pierce and the Ljung and Box tests.     

Multivariate outlier tests with structured co variance matrices

Outlier tests are developed for multivariate data where there is a structure to the covariance or correlation matrix. Particular structures considered are the block diagonal structure where there are reasons to assume that one set of variables is independent of another, and the equicorrelation structure where it may be assumed that all pairs of variables have the same correlation. Likelihood ratio tests for an outlier are derived for these situations and critical values, under the null hypothesis of no outliers present, are determined for selected sample sizes and dimensions, using Bonferroni bounds or simulation. The powers of the tests are compared with those of the Wilks′ statistic for a variety of situations. It is shown that the test procedures which incorporate knowledge of the correlation structure have considerably greater power than the usual tests particularly in relatively small samples with several dimensions.     

Entropy-based tests of uniformity: A Monte Carlo power comparison

In this article, we consider different entropy estimators and propose some entropy-based tests of uniformity. Critical values of the proposed test statistics are obtained by Monte Carlo simulation. Then the power values of the tests for various alternatives and sample sizes are compared. Finally, some recommendations for the application of the proposed tests in practice are presented.     

Modification of Tukey's additivity test

In this paper we discuss testing for an interaction in the two-way ANOVA with just one observation per cell. The known results are reviewed and a simulation study is performed to evaluate type I and type II risks of the tests. It is shown that the Tukey and Mandel additivity tests have very low power in case of more general interaction scheme. A modification of Tukey's test is developed to resolve this issue. All tests mentioned in the paper have been implemented in R package Additivity Tests.     

Cross-sectional correlation robust tests for panel cointegration

We use meta-analytic procedures to develop new tests for panel cointegration, combining p-values from time-series cointegration tests on the units of the panel. The tests are robust to heterogeneity and cross-sectional dependence between the panel units. To achieve the latter, we employ a sieve bootstrap procedure with joint resampling of the units’ residuals. A simulation study shows that the tests can have substantially smaller size distortion than tests ignoring the presence of cross-sectional dependence while preserving high power. We apply the tests to a panel of post-Bretton Woods data to test for weak purchasing power parity.     

Moments of nonparametric probability density functions of entropy estimators applied to testing the inverse Gaussian distribution

The inverse Gaussian (IG) distribution is widely used to model data and then it is important to develop efficient goodness of fit tests for this distribution. In this article, we introduce some new test statistics for examining the IG goodness of fit based on correcting moments of nonparametric probability density functions of entropy estimators. These tests are consistent against all alternatives. Critical points and power of the tests are explored by simulation. We show that the proposed tests are more powerful than competitor tests. Finally, the proposed tests are illustrated by real data examples.     

Goodness-of-Fit Tests Based on Correcting Moments of Entropy Estimators

In this article, we consider the entropy estimator introduced by Alizadeh Noughabi and Arghami (2010) and derive the nonparametric distribution function corresponding to our estimator as a piece-wise uniform distribution. We use the results to introduce goodness-of-fit tests for the normal and the exponential distributions. The critical values and powers for some alternatives are obtained by simulation. The powers of the proposed tests under various alternatives are compared with the competitors.     

Monte Carlo comparison of five exponentiality tests using different entropy estimates

The paper studies five entropy tests of exponentiality using five statistics based on different entropy estimates. Critical values for various sample sizes determined by means of Monte Carlo simulations are presented for each of the test statistics. By simulation, we compare the power of these five tests for various alternatives and sample sizes.     

Comparison of goodness of fit tests for the cox proportional hazards model

The proportional hazards regression model of Cox(1972) is widely used in analyzing survival data. We examine several goodness of fit tests for checking the proportionality of hazards in the Cox model with two-sample censored data, and compare the performance of these tests by a simulation study. The strengths and weaknesses of the tests are pointed out. The effects of the extent of random censoring on the size and power are also examined. Results of a simulation study demonstrate that Gill and Schumacher's test is most powerful against a broad range of monotone departures from the proportional hazards assumption, but it may not perform as well fail for alternatives of nonmonotone hazard ratio. For the latter kind of alternatives, Andersen's test may detect patterns of irregular changes in hazards.     

Testing for a change in repeated measures data

Four nonparametric test statistics for the change-point problem with repeated measures data are proposed. In a Monte Carlo simulation study, critical values for the proposed test statistics are simulated and the performances of the proposed tests are compared with the performances of some competitive tests in terms of asymptotic behavior and power. We provide appropriate recommendations for different occurrences of the change-point and illustrate the testing methods using a set of real data.     

The Asymptotic Power Of Jonckheere-Type Tests For Ordered Alternatives

For the c -sample location problem with ordered alternatives, the test proposed by Barlow et al . (1972 p. 184) is an appropriate one under the model of normality. For non-normal data, however, there are rank tests which have higher power than the test of Barlow et al ., e.g. the Jonckheere test or so-called Jonckheere-type tests recently introduced and studied by Büning & Kössler (1996). In this paper the asymptotic power of the Jonckheere-type tests is computed by using results of Hájek (1968) which may be considered as extensions of the theorem of Chernoff & Savage (1958). Power studies via Monte Carlo simulation show that the asymptotic power values provide a good approximation to the finite ones even for moderate sample sizes.     

Comparison of failure probabilities in the presence of competing risks

Typically, differences in the effect of treatment on competing risks are compared by a weighted log-rank test. This test compares the cause specific hazard rates between the groups. Often the test does not agree with the impressions gained from plots of the cumulative incidence functions. Here we discuss several K-sample tests allowing us to directly compare cumulative incidence functions. These include tests based on the weighted integrated difference between the subdistribution hazards or cumulative incidence functions, Kolmogorov-Smirnov type test, and Renyi type test. In addition to unadjusted comparison techniques, tests based on the regression modeling of the cumulative incidence functions are considered. A simulation study is used to compare the various tests and to assess their power against different alternatives. The methods are illustrated using real data examples.     

The Comparison of Performances of Widely Used Cointegration Tests

The aim of this study is to compare performances of commonly cointegration tests used in literature in terms of their empirical power and type I error probabilty for various sample sizes. As a result of the study, it has been found that some tests are not appropriate in testing cointegration in terms of empirical power and type I error probability. As a result of simulation study, λ_max test for any values of ρ and sample sizes have been found most appropriate test in conclusion.     

Small sample equivalence tests for exponentiality

We consider small sample equivalence tests for exponentialy. Statistical inference in this setting is particularly challenging since equivalence testing procedures typically require much larger sample sizes, in comparison with classical “difference tests,” to perform well. We make use of Butler's marginal likelihood for the shape parameter of a gamma distribution in our development of small sample equivalence tests for exponentiality. We consider two procedures using the principle of confidence interval inclusion, four Bayesian methods, and the uniformly most powerful unbiased (UMPU) test where a saddlepoint approximation to the intractable distribution of a canonical sufficient statistic is used. We perform small sample simulation studies to assess the bias of our various tests and show that all of the Bayes posteriors we consider are integrable. Our simulation studies show that the saddlepoint-approximated UMPU method performs remarkably well for small sample sizes and is the only method that consistently exhibits an empirical significance level close to the nominal 5% level.     

A progressive shift alternative to evaluate nonparametric tests for skewed data

ABSTRACT

When the power of different nonparametric tests is evaluated by simulation, the alternative hypothesis should be carefully designed to ensure validity of the results in the specific research field. In the article, we propose a probit-based progressive shift alternative that is more realistic than the simple shift alternative for skewed non-negative data that occur in many research areas. Our motivation comes from parasitology. The progressive shift alternative is used to compare the power of six location-scale tests and seven commonly used location tests for several skewed theoretical and empirical parasite distributions. It is shown that location-scale tests are more powerful than location tests. Programs for applying the methods studied in the article are freely available for download.