Conservative confidence intervals for a single parameter

The method of constructing confidence intervals from hypothesis tests is studied in the case in which there is a single unknown parameter and is proved to provide confidence intervals with coverage probability that is at least the nominal level. The confidence intervals obtained by the method in several different contexts are seen to compare favorably with confidence intervals obtained by traditional methods. The traditional intervals are seen to have coverage probability less than the nominal level in several instances, This method can be applied to all confidence interval problems and reduces to the traditional method when an exact pivotal statistic is known.     

Nonparametric confidence intervals for Tmax in sequence-stratified crossover studies

Tmax is the time associated with the maximum serum or plasma drug concentration achieved following a dose. While Tmax is continuous in theory, it is usually discrete in practice because it is equated to a nominal sampling time in the noncompartmental pharmacokinetics approach. For a 2-treatment crossover design, a Hodges-Lehmann method exists for a confidence interval on treatment differences. For appropriately designed crossover studies with more than two treatments, a new median-scaling method is proposed to obtain estimates and confidence intervals for treatment effects. A simulation study was done comparing this new method with two previously described rank-based nonparametric methods, a stratified ranks method and a signed ranks method due to Ohrvik. The Normal theory, a nonparametric confidence interval approach without adjustment for periods, and a nonparametric bootstrap method were also compared. Results show that less dense sampling and period effects cause increases in confidence interval length. The Normal theory method can be liberal (i.e. less than nominal coverage) if there is a true treatment effect. The nonparametric methods tend to be conservative with regard to coverage probability and among them the median-scaling method is least conservative and has shortest confidence intervals. The stratified ranks method was the most conservative and had very long confidence intervals. The bootstrap method was generally less conservative than the median-scaling method, but it tended to have longer confidence intervals. Overall, the median-scaling method had the best combination of coverage and confidence interval length. All methods performed adequately with respect to bias.     

近单位根过程脉冲响应函数的置信区间

本文提出一个构造近单位根自回归过程脉冲响应函数的置信区间的新方法。新方法首先修正自回归系数估计的偏误,然后利用标准自举方法构造脉冲响应函数的置信区间。蒙特卡罗模拟结果表明在小样本时新方法的表现要明显优于已有的方法。新方法的实际覆盖率能够一致地达到或超过名义置信水平。     

一种简单有效的二项分布比例参数似然比置信区间的求法

对二项分布比例参数p的似然比置信区间,提出一种简便求解方法。在平均覆盖率、平均区间长度及区间长度的95%置信区间准则下与WScore、Plus4、Jeffreys置信区间进行模拟比较。试验表明,在二项分布b(n,p)的参数n≥20且p∈(0.1,0.9)时,该方法获取的似然比置信区间性能优良。当点估计p值不是接近于0或1且n≥20时,推荐使用本方法获取p的置信区间。     

Robust simultaneous confidence interval estimation of principal component loadings

We propose a method that integrates bootstrap into the forward search algorithm in the construction of robust confidence intervals for elements of the eigenvectors of the correlation matrix in the presence of outliers. Coverage probability of the bootstrap simultaneous confidence intervals was compared to the coverage probabilities of regular asymptotic confidence region and asymptotic confidence region based on the minimum covariance determinant (MCD) approach through a simulation study. The method produced more stable coverage probabilities for datasets with or without outliers and across several sample sizes compared to approaches based on asymptotic confidence regions.     

Confidence Intervals for Difference Between Two Poisson Rates

In this article, we develop four explicit asymptotic two-sided confidence intervals for the difference between two Poisson rates via a hybrid method. The basic idea of the proposed method is to estimate or recover the variances of the two Poisson rate estimates, which are required for constructing the confidence interval for the rate difference, from the confidence limits for the two individual Poisson rates. The basic building blocks of the approach are reliable confidence limits for the two individual Poisson rates. Four confidence interval estimators that have explicit solutions and good coverage levels are employed: the first normal with continuity correction, Rao score, Freeman and Tukey, and Jeffreys confidence intervals. Using simulation studies, we examine the performance of the four hybrid confidence intervals and compare them with three existing confidence intervals: the non-informative prior Bayes confidence interval, the t confidence interval based on Satterthwait's degrees of freedom, and the Bayes confidence interval based on Student's t confidence coefficient. Simulation results show that the proposed hybrid Freeman and Tukey, and the hybrid Jeffreys confidence intervals can be highly recommended because they outperform the others in terms of coverage probabilities and widths. The other methods tend to be too conservative and produce wider confidence intervals. The application of these confidence intervals are illustrated with three real data sets.     

On Confidence Intervals for Process Capability Indices in a One-Way Random Model

In this article, we investigated the bootstrap calibrated generalized confidence limits for process capability indices C _pk for the one-way random effect model. Also, we derived Bissell's approximation formula for the lower confidence limit using Satterthwaite's method and calculated its coverage probabilities and expected values. Then we compared it with standard bootstrap (SB) method and generalized confidence interval method. The simulation results indicate that the confidence limit obtained offers satisfactory coverage probabilities. The proposed method is illustrated with the help of simulation studies and data sets.     

Confidence sets of fixed size with predetermined confidence level

In this paper a three stage method to obtain a confidence sets of given form and size, with a preassigned confidence coefficient, is suggested for the case of normally distributed observations from populations with different means and common unknown variance. The method is quite general, and it allows for most common forms of confidence sets. Asymptotic properties of the random sample sizes of the method are studied and compared to the same properties of other methods with the same aim.     

On the lengths of t-based confidence intervals

Confidence interval is a basic type of interval estimation in statistics. When dealing with samples from a normal population with the unknown mean and the variance, the traditional method to construct t-based confidence intervals for the mean parameter is to treat the n sampled units as n groups and build the intervals. Here we propose a generalized method. We first divide them into several equal-sized groups and then calculate the confidence intervals with the mean values of these groups. If we define “better” in terms of the expected length of the confidence interval, then the first method is better because the expected length of the confidence interval obtained from the first method is shorter. We prove this intuition theoretically. We also specify when the elements in each group are correlated, the first method is invalid, while the second can give us correct results in terms of the coverage probability. We illustrate this with analytical expressions. In practice, when the data set is extremely large and distributed in several data centers, the second method is a good tool to get confidence intervals, in both independent and correlated cases. Some simulations and real data analyses are presented to verify our theoretical results.     

A class of confidence intervals for sequential phase II clinical trials with binary outcome

The phase II clinical trials often use the binary outcome. Thus, accessing the success rate of the treatment is a primary objective for the phase II clinical trials. Reporting confidence intervals is a common practice for clinical trials. Due to the group sequence design and relatively small sample size, many existing confidence intervals for phase II trials are much conservative. In this paper, we propose a class of confidence intervals for binary outcomes. We also provide a general theory to assess the coverage of confidence intervals for discrete distributions, and hence make recommendations for choosing the parameter in calculating the confidence interval. The proposed method is applied to Simon's [14] optimal two-stage design with numerical studies. The proposed method can be viewed as an alternative approach for the confidence interval for discrete distributions in general.     

Alternative Confidence Intervals on Variance Components in a Simple Regression Model with a Balanced Two-Fold Nested Error Structure

In applications using a linear regression model with a balanced two-fold nested error structure, interest focuses on inferences concerning variability of the effects associated with the levels of nesting. This article proposes confidence intervals on the variance components associated with the primary and secondary levels in the model. In order to construct the confidence intervals we use a modified large sample method, generalized inference method, and Satterthwaite approximation. Computer simulation is performed to compare the proposed confidence intervals. A numerical example is provided to demonstrate the intervals.     

Corrected profile likelihood confidence interval for binomial paired incomplete data

Clinical trials often use paired binomial data as their clinical endpoint. The confidence interval is frequently used to estimate the treatment performance. Tang et al. (2009) have proposed exact and approximate unconditional methods for constructing a confidence interval in the presence of incomplete paired binary data. The approach proposed by Tang et al. can be overly conservative with large expected confidence interval width (ECIW) in some situations. We propose a profile likelihood‐based method with a Jeffreys' prior correction to construct the confidence interval. This approach generates confidence interval with a much better coverage probability and shorter ECIWs. The performances of the method along with the corrections are demonstrated through extensive simulation. Finally, three real world data sets are analyzed by all the methods. Statistical Analysis System (SAS) codes to execute the profile likelihood‐based methods are also presented. Copyright © 2013 John Wiley & Sons, Ltd.     

Confidence band for percentile line in multiple linear regression

We deal with the problem of estimating constructing a confidence band for the 100γth percentile line in the multiple linear regression model with independent identically normally distributed errors. A method for computing the exact Scheffé type confidence band over a limited space of the particular covariates region is suggested. A confidence band depends on an estimator of the percentile line. The confidence bands based on the different estimators of the percentile line are compared with respect to the average bandwidth.     

Confidence Intervals for Survival Probabilities: A Comparison Study

The confidence interval of the Kaplan–Meier estimate of the survival probability at a fixed time point is often constructed by the Greenwood formula. This normal approximation-based method can be looked as a Wald type confidence interval for a binomial proportion, the survival probability, using the “effective” sample size defined by Cutler and Ederer. Wald-type binomial confidence interval has been shown to perform poorly comparing to other methods. We choose three methods of binomial confidence intervals for the construction of confidence interval for survival probability: Wilson's method, Agresti–Coull's method, and higher-order asymptotic likelihood method. The methods of “effective” sample size proposed by Peto et al. and Dorey and Korn are also considered. The Greenwood formula is far from satisfactory, while confidence intervals based on the three methods of binomial proportion using Cutler and Ederer's “effective” sample size have much better performance.     

Better approximate confidence intervals for a binomial parameter

This paper discusses five methods for constructing approximate confidence intervals for the binomial parameter Θ, based on Y successes in n Bernoulli trials. In a recent paper, Chen (1990) discusses various approximate methods and suggests a new method based on a Bayes argument, which we call method I here. Methods II and III are based on the normal approximation without and with continuity correction. Method IV uses the Poisson approximation of the binomial distribution and then exploits the fact that the exact confidence limits for the parameter of the Poisson distribution can be found through the x² distribution. The confidence limits of method IV are then provided by the Wilson-Hilferty approximation of the x². Similarly, the exact confidence limits for the binomial parameter can be expressed through the F distribution. Method V approximates these limits through a suitable version of the Wilson-Hilferty approximation. We undertake a comparison of the five methods in respect to coverage probability and expected length. The results indicate that method V has an advantage over Chen's Bayes method as well as over the other three methods.     

Computation of Two- and Three-Dimensional Confidence Regions With the Likelihood Ratio

The asymptotic results pertaining to the distribution of the log-likelihood ratio allow for the creation of a confidence region, which is a general extension of the confidence interval. Two- and three-dimensional regions can be displayed visually to describe the plausible region of the parameters of interest simultaneously. While most advanced statistical textbooks on inference discuss these asymptotic confidence regions, there is no exploration of how to numerically compute these regions for graphical purposes. This article demonstrates the application of a simple trigonometric transformation to compute two- and three-dimensional confidence regions; we transform the Cartesian coordinates of the parameters to create what we call the radial profile log-likelihood. The method is applicable to any distribution with a defined likelihood function, so it is not limited to specific data distributions or model paradigms. We describe the method along with the algorithm, follow with an example of our method, and end with an examination of computation time. Supplementary materials for this article are available online.     

Simultaneous Confidence Intervals for the Population Cell Means,for Two-by-Two Factorial Data,that Utilize Uncertain Prior Information

Consider a two-by-two factorial experiment with more than one replicate. Suppose that we have uncertain prior information that the two-factor interaction is zero. We describe new simultaneous frequentist confidence intervals for the four population cell means, with simultaneous confidence coefficient 1 ? α, that utilize this prior information in the following sense. These simultaneous confidence intervals define a cube with expected volume that (a) is relatively small when the two-factor interaction is zero and (b) has maximum value that is not too large. Also, these intervals coincide with the standard simultaneous confidence intervals obtained by Tukey’s method, with simultaneous confidence coefficient 1 ? α, when the data strongly contradict the prior information that the two-factor interaction is zero. We illustrate the application of these new simultaneous confidence intervals to a real data set.     

The automatic percentile method: Accurate confidence limits in parametric models

The problem of constructing confidence limits for a scalar parameter is considered. Under weak conditions, Efron's accelerated bias-corrected bootstrap confidence limits are correct to second order in parametric familles. In this article, a new method, called the automatic percentile method, for setting approximate confidence limits is proposed as an attempt to alleviate two problems inherent in Efron's method. The accelerated bias-corrected method is not fully automatic, since it requires the calculation of an analytical adjustment; furthermore, it is typically not exact, though for many situations, particularly scalar-parameter familles, exact answers are available. In broader generality, the proposed method is exact when exact answers exist, and it is second-order accurate otherwise. The automatic percentile method is automatic, and for scalar parameter models it can be iterated to achieve higher accuracy, with the number of computations being linear in the number of iterations. However, when nuisance parameters are present, only second-order accuracy seems obtainable.     

Empirical likelihood confidence regions for comparison distributions and roc curves

Abstract: The authors derive empirical likelihood confidence regions for the comparison distribution of two populations whose distributions are to be tested for equality using random samples. Another application they consider is to ROC curves, which are used to compare measurements of a diagnostic test from two populations. The authors investigate the smoothed empirical likelihood method for estimation in this context, and empirical likelihood based confidence intervals are obtained by means of the Wilks theorem. A bootstrap approach allows for the construction of confidence bands. The method is illustrated with data analysis and a simulation study.     

Adjusted empirical likelihood for right censored lifetime data

Adjusted empirical likelihood (AEL) is a method to improve the performance of the empirical likelihood (EL) particularly in the construction of the confidence interval based on completely observed data. In this paper, we extend AEL approach to the analysis of right censored data by adopting an influence function method. The main results include that the adjusted log-likelihood ratio is asymptotically Chi-squared distributed. Simulation results indicate that the proposed AEL-based confidence intervals perform better compared with normality-based or EL-based confidence intervals specifically for small sample size within the right-censoring setting. The proposed method is illustrated by analysis of survival time of patients after operation for spinal tumors.