Robust difference-based outlier detection

Abstract

In this paper, we propose an outlier-detection approach that uses the properties of an intercept estimator in a difference-based regression model (DBRM) that we first introduce. This DBRM uses multiple linear regression, and invented it to detect outliers in a multiple linear regression. Our outlier-detection approach uses only the intercept; it does not require estimates for the other parameters in the DBRM. In this paper, we first employed a difference-based intercept estimator to study the outlier-detection problem in a multiple regression model. We compared our approach with several existing methods in a simulation study and the results suggest that our approach outperformed the others. We also demonstrated the advantage of our approach using a real data application. Our approach can extend to nonparametric regression models for outliers detection.     

Estimation of the Variance Function in Heteroscedastic Linear Regression Models

Heteroscedasticity generally exists when a linear regression model is applied to analyzing some real-world problems. Therefore, how to accurately estimate the variance functions of the error term in a heteroscedastic linear regression model is of great importance for obtaining efficient estimates of the regression parameters and making valid statistical inferences. A method for estimating the variance function of heteroscedastic linear regression models is proposed in this article based on the variance-reduced local linear smoothing technique. Some simulations and comparisons with other method are conducted to assess the performance of the proposed method. The results demonstrate that the proposed method can accurately estimate the variance functions and therefore produce more efficient estimates of the regression parameters.     

Truncated location-scale non linear regression models

We present a class of truncated non linear regression models for location and scale where the truncated nature of the data is incorporated into the statistical model by assuming that the response variable follows a truncated distribution. The location parameter of the response variable is assumed to be modeled by a continuous non linear function of covariates and unknown parameters. In addition, the proposed model also allows for the scale parameter of the responses to be characterized by a continuous function of the covariates and unknown parameters. Three particular cases of the proposed models are presented by considering the response variable to follow a truncated normal, truncated skew normal, and truncated beta distribution. These truncated non linear regression models are constructed assuming fixed known truncation limits and model parameters are estimated by direct maximization of the log-likelihood using a non linear optimization algorithm. Standardized residuals and diagnostic metrics based on the cases deletion are considered to verify the adequacy of the model and to detect outliers and influential observations. Results based on simulated data are presented to assess the frequentist properties of estimates, and a real data set on soil-water retention from the Buriti Vermelho River Basin database is analyzed using the proposed methodology.     

Robust quasi-likelihood inference in generalized linear mixed models with outliers

It is well known that in a traditional outlier-free situation, the generalized quasi-likelihood (GQL) approach [B.C. Sutradhar, On exact quasilikelihood inference in generalized linear mixed models, Sankhya: Indian J. Statist. 66 (2004), pp. 261–289] performs very well to obtain the consistent as well as the efficient estimates for the parameters involved in the generalized linear mixed models (GLMMs). In this paper, we first examine the effect of the presence of one or more outliers on the GQL estimation for the parameters in such GLMMs, especially in two important models such as count and binary mixed models. The outliers appear to cause serious biases and hence inconsistency in the estimation. As a remedy, we then propose a robust GQL (RGQL) approach in order to obtain the consistent estimates for the parameters in the GLMMs in the presence of one or more outliers. An extensive simulation study is conducted to examine the consistency performance of the proposed RGQL approach.     

Estimating the p-values of robust tests for the linear model

In this paper, we study the estimation of p-values for robust tests for the linear regression model. The asymptotic distribution of these tests has only been studied under the restrictive assumption of errors with known scale or symmetric distribution. Since these robust tests are based on robust regression estimates, Efron's bootstrap (1979) presents a number of problems. In particular, it is computationally very expensive, and it is not resistant to outliers in the data. In other words, the tails of the bootstrap distribution estimates obtained by re-sampling the data may be severely affected by outliers.We show how to adapt the Robust Bootstrap (Ann. Statist 30 (2002) 556; Bootstrapping MM-estimators for linear regression with fixed designs, http://mathstat.carleton.ca/~matias/pubs.html) to this problem. This method is very fast to compute, resistant to outliers in the data, and asymptotically correct under weak regularity assumptions. In this paper, we show that the Robust Bootstrap can be used to obtain asymptotically correct, computationally simple p-value estimates. A simulation study indicates that the tests whose p-values are estimated with the Robust Bootstrap have better finite sample significance levels than those obtained from the asymptotic theory based on the symmetry assumption.Although this paper is focussed on robust scores-type tests (in: Directions in Robust Statistics and Diagnostics, Part I, Springer, New York), our approach can be applied to other robust tests (for example, Wald- and dispersion-type also discussed in Markatou et al., 1991).     

A SIMPLE VARIABLE SELECTION TECHNIQUE FOR NONLINEAR MODELS

Applying nonparametric variable selection criteria in nonlinear regression models generally requires a substantial computational effort if the data set is large. In this paper we present a selection technique that is computationally much less demanding and performs well in comparison with methods currently available. It is based on a polynomial approximation of the nonlinear model. Performing the selection only requires repeated least squares estimation of models that are linear in parameters. The main limitation of the method is that the number of variables among which to select cannot be very large if the sample is small and the order of an adequate polynomial at the same time is high. Large samples can be handled without problems.     

A comparison of two exact confidence regions for partially nonlinear regression models

Exact confidence regions for all the parameters in nonlinear regression models can be obtained by comparing the lengths of projections of the error vector into orthogonal subspaces of the sample space. In certain partially nonlinear models an alternative exact region is obtained by replacing the linear parameters by their conditional estimates in the projection matrices. An ellipsoidal approximation to the alternative region is obtained in terms of the tangent-plane coordinates, similar to one previously obtained for the more usual region. This ellipsoid can be converted to an approximate region for the original parameters and can be used to compare the two types of exact confidence regions.     

An Alternative Estimation Approach for the Heterogeneity Linear Mixed Model

In this article, an alternative estimation approach is proposed to fit linear mixed effects models where the random effects follow a finite mixture of normal distributions. This heterogeneity linear mixed model is an interesting tool since it relaxes the classical normality assumption and is also perfectly suitable for classification purposes, based on longitudinal profiles. Instead of fitting directly the heterogeneity linear mixed model, we propose to fit an equivalent mixture of linear mixed models under some restrictions which is computationally simpler. Unlike the former model, the latter can be maximized analytically using an EM-algorithm and the obtained parameter estimates can be easily used to compute the parameter estimates of interest.     

Bayesian composite quantile regression

One advantage of quantile regression, relative to the ordinary least-square (OLS) regression, is that the quantile regression estimates are more robust against outliers and non-normal errors in the response measurements. However, the relative efficiency of the quantile regression estimator with respect to the OLS estimator can be arbitrarily small. To overcome this problem, composite quantile regression methods have been proposed in the literature which are resistant to heavy-tailed errors or outliers in the response and at the same time are more efficient than the traditional single quantile-based quantile regression method. This paper studies the composite quantile regression from a Bayesian perspective. The advantage of the Bayesian hierarchical framework is that the weight of each component in the composite model can be treated as open parameter and automatically estimated through Markov chain Monte Carlo sampling procedure. Moreover, the lasso regularization can be naturally incorporated into the model to perform variable selection. The performance of the proposed method over the single quantile-based method was demonstrated via extensive simulations and real data analysis.     

Comparisons of computational methods for clustered binary data

Clustered binary data are common in medical research and can be fitted to the logistic regression model with random effects which belongs to a wider class of models called the generalized linear mixed model. The likelihood-based estimation of model parameters often has to handle intractable integration which leads to several estimation methods to overcome such difficulty. The penalized quasi-likelihood (PQL) method is the one that is very popular and computationally efficient in most cases. The expectation–maximization (EM) algorithm allows to estimate maximum-likelihood estimates, but requires to compute possibly intractable integration in the E-step. The variants of the EM algorithm to evaluate the E-step are introduced. The Monte Carlo EM (MCEM) method computes the E-step by approximating the expectation using Monte Carlo samples, while the Modified EM (MEM) method computes the E-step by approximating the expectation using the Laplace's method. All these methods involve several steps of approximation so that corresponding estimates of model parameters contain inevitable errors (large or small) induced by approximation. Understanding and quantifying discrepancy theoretically is difficult due to the complexity of approximations in each method, even though the focus is on clustered binary data. As an alternative competing computational method, we consider a non-parametric maximum-likelihood (NPML) method as well. We review and compare the PQL, MCEM, MEM and NPML methods for clustered binary data via simulation study, which will be useful for researchers when choosing an estimation method for their analysis.     

Efficient Computation of Reduced Regression Models

We consider settings where it is of interest to fit and assess regression submodels that arise as various explanatory variables are excluded from a larger regression model. The larger model is referred to as the full model; the submodels are the reduced models. We show that a computationally efficient approximation to the regression estimates under any reduced model can be obtained from a simple weighted least squares (WLS) approach based on the estimated regression parameters and covariance matrix from the full model. This WLS approach can be considered an extension to unbiased estimating equations of a first-order Taylor series approach proposed by Lawless and Singhal. Using data from the 2010 Nationwide Inpatient Sample (NIS), a 20% weighted, stratified, cluster sample of approximately 8 million hospital stays from approximately 1000 hospitals, we illustrate the WLS approach when fitting interval censored regression models to estimate the effect of type of surgery (robotic versus nonrobotic surgery) on hospital length-of-stay while adjusting for three sets of covariates: patient-level characteristics, hospital characteristics, and zip-code level characteristics. Ordinarily, standard fitting of the reduced models to the NIS data takes approximately 10 hours; using the proposed WLS approach, the reduced models take seconds to fit.     

Approximate bounded influence estimation for longitudinal data with outliers and measurement errors

Mixed effects models or random effects models are popular for the analysis of longitudinal data. In practice, longitudinal data are often complex since there may be outliers in both the response and the covariates and there may be measurement errors. The likelihood method is a common approach for these problems but it can be computationally very intensive and sometimes may even be computationally infeasible. In this article, we consider approximate robust methods for nonlinear mixed effects models to simultaneously address outliers and measurement errors. The approximate methods are computationally very efficient. We show the consistency and asymptotic normality of the approximate estimates. The methods can also be extended to missing data problems. An example is used to illustrate the methods and a simulation is conducted to evaluate the methods.     

Multiple outliers detection in sparse high-dimensional regression

The presence of outliers would inevitably lead to distorted analysis and inappropriate prediction, especially for multiple outliers in high-dimensional regression, where the high dimensionality of the data might amplify the chance of an observation or multiple observations being outlying. Noting that the detection of outliers is not only necessary but also important in high-dimensional regression analysis, we, in this paper, propose a feasible outlier detection approach in sparse high-dimensional linear regression model. Firstly, we search a clean subset by use of the sure independence screening method and the least trimmed square regression estimates. Then, we define a high-dimensional outlier detection measure and propose a multiple outliers detection approach through multiple testing procedures. In addition, to enhance efficiency, we refine the outlier detection rule after obtaining a relatively reliable non-outlier subset based on the initial detection approach. By comparison studies based on Monte Carlo simulation, it is shown that the proposed method performs well for detecting multiple outliers in sparse high-dimensional linear regression model. We further illustrate the application of the proposed method by empirical analysis of a real-life protein and gene expression data.     

ROBUST VARIABLE SELECTION IN REGRESSION IN THE PRESENCE OF OUTLIERS AND LEVERAGE POINTS

In linear regression, outliers and leverage points often have large influence in the model selection process. Such cases are downweighted with Mallows-type weights here, during estimation of submodel parameters by generalised M-estimation. A robust version of Mallows's Cp (Ronchetti &. Staudte, 1994) is then used to select a variety of submodels which are as informative as the full model. The methodology is illustrated on a new dataset concerning the agglomeration of alumina in Bayer precipitation.     

The heuristic approach in finding initial values for minimum density power divergence estimators

It is well known that in the presence of outliers the maximum likelihood estimates are very unstable. In these situations, an alternative is resorting to the estimators based on the minimum density power divergence criterion for which feasible, computationally closed-form expressions can be derived, so that solutions can be achieved by any standard nonlinear optimization code. But since the function to be minimized is often ill-behaved, the convergence of the algorithm to optimal solutions strongly depends on the choice of the configuration of the initial values. A new procedure based on a heuristic local search approach is introduced in order to survey the parameters space and hence obtaining an accurate set of starting guesses for the gradient-method minimization routine.     

Robust inference in generalized linear models for longitudinal data

The author develops a robust quasi‐likelihood method, which appears to be useful for down‐weighting any influential data points when estimating the model parameters. He illustrates the computational issues of the method in an example. He uses simulations to study the behaviour of the robust estimates when data are contaminated with outliers, and he compares these estimates to those obtained by the ordinary quasi‐likelihood method.     

Fast and robust bootstrap

In this paper we review recent developments on a bootstrap method for robust estimators which is computationally faster and more resistant to outliers than the classical bootstrap. This fast and robust bootstrap method is, under reasonable regularity conditions, asymptotically consistent. We describe the method in general and then consider its application to perform inference based on robust estimators for the linear regression and multivariate location-scatter models. In particular, we study confidence and prediction intervals and tests of hypotheses for linear regression models, inference for location-scatter parameters and principal components, and classification error estimation for discriminant analysis.     

Descriptive tests for the identification of outliers in the errors in variables linear model

In this paper the most commonly used diagnostic criteria for the identification of outliers or leverage points in the ordinary regression model are reviewed. Their use in the context of the errors-in-variables (e.v.) linear model is discussed and evidence is given that under the e.v. model assumptions the distinction between outliers and leverage points no longer exists.     

The Performance of Robust Two-Stage Estimator in Nonlinear Regression with Autocorrelated Error

Some statistics practitioners often ignore the underlying assumptions when analyzing a real data and employ the Nonlinear Least Squares (NLLS) method to estimate the parameters of a nonlinear model. In order to make reliable inferences about the parameters of a model, require that the underlying assumptions, especially the assumption that the errors are independent, are satisfied. However, in a real situation, we may encounter dependent error terms which prone to produce autocorrelated errors. A two-stage estimator (CTS) has been developed to remedy this problem. Nevertheless, it is now evident that the presence of outliers have an unduly effect on the least squares estimates. We expect that the CTS is also easily affected by outliers since it is based on the least squares estimator, which is not robust. In this article, we propose a Robust Two-Stage (RTS) procedure for the estimation of the nonlinear regression parameters in the situation where autocorrelated errors come together with the existence of outliers. The numerical example and simulation study signify that the RTS is more efficient than the NLLS and the CTS methods.     

Trajectory inference and parameter estimation in stochastic models with temporally aggregated data

Stochastic models are of fundamental importance in many scientific and engineering applications. For example, stochastic models provide valuable insights into the causes and consequences of intra-cellular fluctuations and inter-cellular heterogeneity in molecular biology. The chemical master equation can be used to model intra-cellular stochasticity in living cells, but analytical solutions are rare and numerical simulations are computationally expensive. Inference of system trajectories and estimation of model parameters from observed data are important tasks and are even more challenging. Here, we consider the case where the observed data are aggregated over time. Aggregation of data over time is required in studies of single cell gene expression using a luciferase reporter, where the emitted light can be very faint and is therefore collected for several minutes for each observation. We show how an existing approach to inference based on the linear noise approximation (LNA) can be generalised to the case of temporally aggregated data. We provide a Kalman filter (KF) algorithm which can be combined with the LNA to carry out inference of system variable trajectories and estimation of model parameters. We apply and evaluate our method on both synthetic and real data scenarios and show that it is able to accurately infer the posterior distribution of model parameters in these examples. We demonstrate how applying standard KF inference to aggregated data without accounting for aggregation will tend to underestimate the process noise and can lead to biased parameter estimates.