Group sequential x2 statistic for testing the difference of two mean vectors in clinical trials

In this study we discuss the group sequential procedures for comparing two treatments based on multivariate observations in clinical trials. Also we suppose that a response vector on each of two treatments has a multivariate normal distribution with unknown covariance matrix. Then we propose a group sequential x² statistic in order to carry out repeated significance test for hypothesis of no difference between two population mean vectors. In order to realize the group sequential test where average sample number is reduced, we propose another modified group sequential x² statistic by extension of Jennison and Turnbull ( 1991 ). After construction of repeated confidence boundaries for making the repeated significance test, we compare two group sequential procedures based on two statistics regarding the average sample number and the power of the test in the simulations.     

On limiting distribution laws of statistics analogous to pearson's chi-square

Two test-statistics analogous to Pearson's chi-square test function - given in (1.6) and (1.7) - are investigated. These statistics utilize, apart from the number of sample elements lying in the respective intervals of the partition, their positions within the intervals too. It is shown that the test-statistics are asymptotically distributed - as the sample size N tends to infinity - according to the x ²distribution with parameter r, i.e. the number of intervals chosen. The limiting distribution of the test statistics under the null-hypothesis when N tends to the infinity and r =O(N ^α) (0<α<1), further the consistency of the tests based on these statistics is considered. Some remarks are made concerning the efficiency of the corresponding goodness of fit tests also; the authors intend to return to a more detailed treatment of the efficiency later.     

On a test of independence for contingency tables

Using the concept of distributional distance, a test statistic is proposed FOR the hypothesis of independence in multidimensional contingency tables. A Monte Carlo Study is done to empirically compare the power of the proposed test to the Pearson x² and the likelihood ratio test- Further, the nonnull distribution under various spike alternatives is tabulated     

SMOOTH TESTS FOR THE BIVARIATE POISSON DISTRIBUTION

A theorem of Rayner & Best (1989) is generalised to permit the construction of smooth tests of goodness of fit without requiring a set of orthonormal functions on the hypothesised distribution. This result is used to construct smooth tests for the bivariate Poisson distribution. The test due to Crockett (1979) is similar to a smooth test that assesses the variance structure under the bivariate Poisson model; the test due to Loukas & Kemp (1986) is related to a smooth test that seeks to detect a particular linear relationship between the variances and covariance under the bivariate Poisson model. Using focused smooth tests may be more informative than using previously suggested tests. The distribution of the Loukas & Kemp (1986) statistic is not well approximated by the x²distribution for larger correlations, and a revised statistic is suggested.     

A comparative simulation study of the small sample powers of several goodness fit test

Eight goodness of fit tests are compared with respect to their simulated small sample power of detecting an inbreeding alternative to the Hardy-Weinberg null hypothesis. The Pearson's x ² test is found to be most powerful, and the small rample levels of this test are close to the nominal (x ²) significance levels. The use of conditional expectations, rather than expected frequencies based on ML estimates, increases the power and improves thc x ² fit to the true significance level. The small sample powers are also compared to the asymptotic (Pitman) pourer, based on the noncenlral x ² distribution.     

Computations of Bayesian t-values for multiple comparisons

Results from a simulation study of the power of eight statistics for testing that a sample is form a uniform distribution on the unit interval are reported. Power is given for each statistic against four classes if alternatives. The statistics studied include the discrete Pearson chi-square with ten and twenty cells, X² ₁₀ and X² ₂₀; Kolmogorov-smirov, D; Cramer-Von Mises, W²; Watson, U²; Anderson-Darling, A; Greenwood. G;and a new statistic called O A modified form of each of these statistic is also studied by first transforming the sample using a transformation given by Durbin. On the basis of the results observed in this study, the Watson U² statistic is recommended as a general test for uniformity.     

Computation of the percentage points and the power for the two-sided Kolmogorov-Smirnov one sample test

Two recursive schemes are presented for the calculation of the probabilityP(g(x)≤S _n (x)≤h(x) for allx∈®), whereS _n is the empirical distribution function of a sample from a continuous distribution andh, g are continuous and isotone functions. The results are specialized for the calculation of the distribution and the corresponding percentage points of the test statistic of the two-sided Kolmogorov-Smirnov one sample test. The schemes allow the calculation of the power of the test too. Finally an extensive tabulation of percentage points for the Kolmogorov-Smirnov test is given.     

Testing the equality of correlation matrices

We present results that extend an existing test of equality of correlation matrices. A new test statistic is proposed and is shown to be asymptotically distributed as a linear combination of independent x ² random variables. This new formulation allows us to find the power of the existing test and our extensions by deriving the distribution under the alternative using a linear combination of independent non-central x ² random variables. We also investigate the null and the alternative distribution of two related statistics. The first one is a quadratic form in deviations from a control group with which the remaining k-1 groups are to be compared. The second test is designed for comparing adjacent groups. Several approximations for the null and the alternative distribution are considered and two illustrative examples are provided.     

The X2-goodness-of-fit tests with moment type estimators

In the x²-goodness-of-fit test the underlying null hypothesis usually involves unknown parameters. In this article we study the asymptotic distribution of the Pearson statistic when the unknown parameters are estimated by a moment type estimator based on the ungrouped data. As is expected the usual Pearson statistic is no longer asymptotically x²-distributed in this situation. We propose a statistic [Qcirc] which under certain regularity conditions is asymptotically x²-distributed. We also propose a statistic Q? for the goodness-of-fit test when the class boundaries are random. The asymptotic powers of [Qcirc] and [Qcirc]? tests are discussed.     

Correctings tests for trend in proportions for skewness

We develop the score test for the hypothesis that a parameter of a Markov sequence is constant over time, against the alternatives that it varies over time, i.e., θ_t = θ + U_t; t = 1,2,…, where {U_t; t = 1,2,...} is a sequence of independently and identically distributed random variables with mean zero and variance σ^z _u and θ is a fixed constant. The asymptotic null distribution of the test statistic is proved to be normal. We illustrate our procedure by examples and a real life data analysis.     

ON ASYMPTOTIC OPTIMALITY OF SOME TESTS FOR EXPONENTIAL DISTRIBUTIONS

The probability density function (pdf) of a two parameter exponential distribution is given by f(x; p, s?) =s?^-1 exp {-(x - ρ)/s?} for x≥ρ and 0 elsewhere, where 0 < ρ < ∞ and 0 < s?∞. Suppose we have k independent random samples where the ith sample is drawn from the ith population having the pdf f(x; ρ_i, s?_i), 0 < ρ_i < ∞, 0 < s?_i < s?_i < and f(x; ρ, s?) is as given above. Let X_i1 < X_i2 <… < X_iri denote the first r_i order statistics in a random sample of size n_i, drawn from the ith population with pdf f(x; ρ_i, s?_i), i = 1, 2,…, k. In this paper we show that the well known tests of hypotheses about the parameters ρ_i, s?_i, i = 1, 2,…, k based on the above observations are asymptotically optimal in the sense of Bahadur efficiency. Our results are similar to those for normal distributions.     

Testing for normality in linear regression models

The importance of the normal distribution for fitting continuous data is well known. However, in many practical situations data distribution departs from normality. For example, the sample skewness and the sample kurtosis are far away from 0 and 3, respectively, which are nice properties of normal distributions. So, it is important to have formal tests of normality against any alternative. D'Agostino et al. [A suggestion for using powerful and informative tests of normality, Am. Statist. 44 (1990), pp. 316–321] review four procedures Z ²(g ₁), Z ²(g ₂), D and K ² for testing departure from normality. The first two of these procedures are tests of normality against departure due to skewness and kurtosis, respectively. The other two tests are omnibus tests. An alternative to the normal distribution is a class of skew-normal distributions (see [A. Azzalini, A class of distributions which includes the normal ones, Scand. J. Statist. 12 (1985), pp. 171–178]). In this paper, we obtain a score test (W) and a likelihood ratio test (LR) of goodness of fit of the normal regression model against the skew-normal family of regression models. It turns out that the score test is based on the sample skewness and is of very simple form. The performance of these six procedures, in terms of size and power, are compared using simulations. The level properties of the three statistics LR, W and Z ²(g ₁) are similar and close to the nominal level for moderate to large sample sizes. Also, their power properties are similar for small departure from normality due to skewness (γ₁≤0.4). Of these, the score test statistic has a very simple form and computationally much simpler than the other two statistics. The LR statistic, in general, has highest power, although it is computationally much complex as it requires estimates of the parameters under the normal model as well as those under the skew-normal model. So, the score test may be used to test for normality against small departure from normality due to skewness. Otherwise, the likelihood ratio statistic LR should be used as it detects general departure from normality (due to both skewness and kurtosis) with, in general, largest power.     

A test of normality using nonparametrlic residuals

In this paper, we develop a test of the normality assumption of the errors using the residuals from a nonparametric kernel regression. Contrary to the existing tests based on the residuals from a parametric regression, our test is thus robust to misspecification of the regression function. The test statistic proposed here is a Bera-Jarque type test of skewness and kurtosis. We show that the test statistic has the usual x ²(2) limit distribution under the null hypothesis. In contrast to the results of Rilstone (1992), we provide a set of primitive assumptions that allow weakly dependent observations and data dependent bandwidth parameters. We also establish consistency property of the test. Monte Carlo experiments show that our test has reasonably good size and power performance in small samples and perfornu better than some of the alternative tests in various situations.     

A bivariate normal example where the locally most powerful and distantly most powerful test statistics are beaten everywhere from a median p-value standpoint

In the bivariate normal, n=2 case, when testing H₀:μ_x=μ_y=0,σ² _x=σ² _y=1, ρ=0 vs. H₁:μ_x=μ_y=0,σ² _x=σ² _y=1, 0<ρ<1, it is shown that the median p-values given by the locally most powerful test and the distantly most powerful test are both beaten everywhere by the median of a third test.     

Polynomial trends in time series

The J^* test which was previously proposed by the present author for the detection of a trend in a time series does not depend on any quantitative assumptions, but in the case of a polynomial trend it depends on its degree; if this degree is too high, the test cannot be applied. The author finds a bound of the significance level at which the test can be applied when the sample size, as well as a bound of the degree of the trend, are given. Asymptotic results are used only when we trust the asymptotic distribution of J^* under the null hypothesis.     

Local power of some tests in exponential family nonlinear models

In this paper we obtain asymptotic expansions up to order n^−1/2 for the nonnull distribution functions of the likelihood ratio, Wald, score and gradient test statistics in exponential family nonlinear models (Cordeiro and Paula, 1989), under a sequence of Pitman alternatives. The asymptotic distributions of all four statistics are obtained for testing a subset of regression parameters and for testing the dispersion parameter, thus generalising the results given in Cordeiro et al. (1994) and Ferrari et al. (1997). We also present Monte Carlo simulations in order to compare the finite-sample performance of these tests.     

A Permutation Test for Planar Regression

Oja (1987) presents some distribution-free tests applicable in the presence of covariates when treatment values are randomly assigned. The formulas and calculations are cumbersome, however, and implementation of the tests relies on using a x² approximation to the exact null distribution. In this paper a re-formulation of his test statistic is given which has the advantages of ease of calculation, explicit formulas for permutation moments, and allowing a Beta distribution to be fitted to the exact null distribution.     

New estimators of distribution functions

ABSTRACT

This article considers the estimation of a distribution function F_X(x) based on a random sample X₁, X₂, …, X_n when the sample is suspected to come from a close-by distribution F₀(x). The new estimators, namely the preliminary test (PTE) and Stein-type estimator (SE) are defined and compared with the “empirical distribution function” (edf) under local departure. In this case, we show that Stein-type estimators are superior to edf and PTE is superior to edf when it is close to F₀(x). As a by-product similar estimators are proposed for population quantiles.     

Chi-square tests for multivariate normality with application to common stock prices

The theory of chi-square tests with data-dependent cells is applied to provide tests of fit to the family of p-variate normal distributions. The cells are bounded by hyperellipses (x-[Xbar])'S^-1 (x-[Xbar]) = c_i centered at the sample mean [Xbar] and having shape deter-mined by the sample covariance matrix S. The Pearson statistic with these cells is affine-invariant, has a null distribution not depending on the true mean and covariance, and has asymptotic critical points between those of x² (M-1) and x² (M-2) when M cells are employed. The test is insensitive to lack of symmetry, but peakedness, broad shoulders and heavy tails are easily discerned in the cell counts. Multivariate normality of logarithms of relative prices of common stocks, a common assumption in finan-cial markets theory, is studied using the statistic described here and a large data base.